Février 2013  


We are happy to inform you that a new extranet functionality has been added to the ENP website. Thanks to Jean-Christophe Poncer’s precious input, this extranet, called TOOLS, allows all ENP scientists to exchange data in the form of databases. So far, three of them have been created :

  • a transgenic mouse database, created in collaboration with the Bio-Psy LabEx, provides information on all transgenic mouse strains available within Bio-Psy labs and will be extended to all ENP teams
  • an antisera database, aimed at providing information on antisera (either homemade or from commercial sources) used by ENP teams
  • a viral-based gene transfer database, providing information on all lentiviral constructs produced by THE former ENP Lentiviral Network and possibly any other viral construct available within ENP labs.

All databases are updated and moderated by a Regulator and allow users to post comments and/or data related to specific entries.
This new tool was designed to help improve communication and data dissemination among ENP members.
We therefore strongly encourage you to use this new tool, post data and comments on existing entries and update the databases with data from your labs.

ENP members who would like to receive a login and/or create additional databases for sharing other resources are welcome to send an email to


You will receive by next week an automatically generated email from the ENP website giving you a password to log into your account. You may have to look for it in your spam, so please contact us if you haven’t received anything by mid-February. Please refer to the tutorial before updating your personal and team’s information.


Following ENP Director and Team’s call for memberships last month, we are happy to announce that we already received around 40 positive answers.
We wish to thank you for your trust and commitment to ENP.


Alain Chédotal & Heike Blockus

Congratulations to Heike Blockus for her great commentary in Neuron (76, December 6th 2012)

Chédotal A., Blockus H., Dystroglycan Adds More Sugars to the Midline Cocktail

Abstract : In this issue of Neuron, Wright et al. (2012) identify two novel mediators of a-dystroglycan glycosylation in mouse and unravel a novel function of glycosylated dystroglycan in axon guidance by providing evidence for direct binding of a-DG to the midline chemorepellent Slit2.

Aurélien Bègue’s Feedback on the Graduate Program

The ENP graduate program offered me the possibility of coming back to France after spending my higher education years abroad. The application process was very selective and rigorous but it allowed me to access world class laboratories in Neuroscience. I will always be grateful to the ENP for letting me conduct research in an interdisciplinary team at the frontier between neuroscience and optics at a time which coincided with the beginning of optogenetics in France. The program served as a great opportunity to learn about very different approaches because the diversity in themes and methodology offered is so rich. It was particularly interesting to reconvene all together for the ENP days and/or Scientific Board meetings to follow the progress of the other PhD students and meet international scientists. A. Bègue - PhD 2012 - U. Paris Descartes


This Spring School organized by ENP members Brandon Stell, Federico Trigo, David Ogden, Stéphane Dieudonné and Boris Barbour gives a unique opportunity to 18 selected students to attend conferences and workshops offered by leading experts of techniques in optical research topics.
Such as Photophysics and photochemistry of fluorophores, Light sources and lasers for fluorescence excitation, Conventional and confocal microscopy, CCD cameras, Patch clamp and extracellular recording. Multi-electrode arrays. ln vivo electrical recording, Data analysis and image analysis, Two-photon confocal and other non-linear microscopy, Fluorescent indicators for calcium and other ions and membrane potential, Adaptive optics in microscopy, Photolysis, Brain slice and ln vivo imaging, Viral transfection of genetically encoded markers and indicators.

To be held from: Tuesday June 18th to Friday June 28th.
At: Université Paris Descartes 45 rue des Saints Pères 75006 Paris
Applications should be made on : before March 1st, 2013.
More information


ENP group leaders Sonia Garel and Thomas Préat were recognized in the past months by the EMBO. Garel will receive funds and benefits as a Young Investigator and Préat is now a member of the European Molecular Biology Organization for his research excellency. An EMBO distinction helps to raise the visibility of young researchers in the life science community.


To favor survival under food shortage, the brain disables costly memory, Plaçais PY, Préat T. Science. 2013 Jan 25;339 (6118):440-2. doi: 10.1126/science.1226018.

Source : Genes and Dynamics of Memory Systems, Neurobiology Unit, UMR 7637 École Supérieure de Physique et de Chimie Industrielles/CNRS, 10 rue Vauquelin, 75005 Paris, France.
Abstract : The brain regulates energy homeostasis in the organism. Under resource shortage, the brain takes priority over peripheral organs for energy supply. But can the brain also down-regulate its own consumption to favor survival? We show that the brain of Drosophila specifically disables the costly formation of aversive long-term memory (LTM) upon starvation, a physiological state required for appetitive LTM formation. At the neural circuit level, the slow oscillations normally triggered in two pairs of dopaminergic neurons to enable aversive LTM formation were abolished in starved flies. Transient artificial activation of these neurons during training restored LTM formation in starved flies but at the price of a reduced survival. LTM formation is thus subject to adaptive plasticity that helps survival under food shortage.


Brain Awareness Week, 7 days of activities in Paris to explore Human Brain and Neuroscience Research

As volunteering member of the Parisian BAW Comittee, the ENP invites you to two thematic evenings on Thursday 14th and Friday 15th, March. Come and discover what happens in the Brain when you savour a meal, and understand what influence Music has on your neurons, and vice versa!


Hirac Gurden from IMNC (CNRS) Bénédict Beaugé (food critic)

Can you smell the good meal simmering ? Taste it: Excitement of taste buds, ingestion, memory, emotions ... let’s travel together on the path of our senses, to the heart of our brain.

Thursday, March 14, 07:00 pm.
Collège Franco - Britannique, Cité internationale Universitaire de Paris
17, boulevard Jourdan Paris 14ème


A bilingual evening (English / French) with the participation of the ENP students.
Come and listen to three different conferences on Music:

  1. ‘EnSynCine. Creating physiological and individual soundtracks’ (Heike Blockus, PhD ENP): An exciting setup which permits to individually identify a subject’s emotional reaction to a visual stimulus by a digitalized musical output.
  2. ‘Synaptic symphony -Top Ten hits of the Brain’. Follow this special music charts and learn how neuroscience enlightens both creation and reception of music (Urs Lucas Boehm, Emma Cahill, Darinka Truebutschek, , Ana Filipa Teixeira Borges, Alma Mohebiany, Vasilisa Skvortsova, PhD ENP).
  3. ‘The Music of Neurons’ by Alain Destexhe (UNIC, CNRS). Working at the interface of biophysics, physics, computer science and neuroscience, A. Destexhe will introduce you to the melodies of the cortex.

Friday, March 15, 06:00 pm.
Auditorium de l’Institut du Cerveau et de la Moelle Épinière
47, boulevard de l'Hôpital Paris 13ème

More information :

Please send us your fresh news, networking occasions, coming scientific events, latest awards, beautiful cortex images, etc.
Contact Deborah Deslierres :

  École des Neurosciences de Paris-Ile de France
Réfectoire des Cordeliers - 15 rue de l'Ecole de Médecine - 75006 Paris -