Alexandra Durr is university professor and consultant (PUPH) at the Hôpital de la Pitié-Salpêtrière in Paris. She has specialisation in neurology and genetics and has been developing translational neurogenetics for 25 years, based on a thorough clinical expertise that allowed her to identify the molecular bases of many pathologies. Alexandra Durr is a worldwide renowned expert of late-onset hereditary neurological diseases. She worked with premanifest individuals, i.e. mutation carriers without clinical signs of the disease, since 1992, pioneering the first presymptomatic structure in France. She has built up national and international collaborations from the beginning of her career (https://spatax.wordpress.com). Genetic advances are used by her team at the ICM (Institut du Cerveau et de la Moelle épinière) to understand pathophysiology and to set up innovative therapies.