UPMC

Codes de signaux intracellulaires pour le guidage axonal

Domaine de recherche principal: 

Neurogenetics / neurodevelopment

Mots clefs: 

Neuronal connectivity, Brain development and plasticity

Labelisation ENP: 

2016

Centre de recherche / Institut: 

Institut de la Vision

Code unité de recherche: 

UMRS968 UMR7210 UM80

The mature nervous system is an intricate network in which neurons are connected to specific partners. The choice of these partners is crucial for the correct behavior of the network (meaning the nervous system) and is determined at early stages of development. Abnormal development of neuronal connections is responsible for a large range of neuronal pathologies, some of them affecting vision. Research carried on by our team focuses on a better understanding of the development of sensory maps including the connection between the retina and the brain.

Leader

Leader: 

Établissements

Établissement de rattachement: 

CNRS

Établissements affiliés: 

Université Pierre et Marie Curie
Inserm

Université: 

UPMC

École doctorale: 

ED3C
Laboratory

Initiatives d'Excellence: 

Labex Lifesenses
Publications

publications: 

Averaimo S*, Assali A*, Couvet S, Zagar Y, Ioana Genescu I, Rebsam A, Nicol X. Local cAMP signaling restricted to lipid rafts isrequired for the developmental refinement of axonal arbors. In preparation. Under review, Nature Communications

Averaimo S, Nicol X. Intermingled cAMP, cGMP and calcium spatiotemporal dynamics in developing neuronal circuits. Front CellNeurosci. 2014 Nov 13.

Nicol X, Hong KP, Spitzer NC. Spatial and temporal second messenger codes for growth cone turning. Proc Natl Acad Sci U S A.2011 Aug 16;108(33):13776-81.

Nicol X, Voyatzis S, Muzerelle A, Narboux-Nême N, Südhof TC, Miles R, Gaspar P. cAMP oscillations and retinal activity arepermissive for ephrin signaling during the establishment of the retinotopic map. Nat Neurosci. 2007 Mar;10(3):340-7.

Nicol X, Muzerelle A, Rio JP, Métin C, Gaspar P. Requirement of adenylate cyclase 1 for the ephrin-A5-dependent retraction ofexuberant retinal axons. J Neurosci. 2006 Jan 18;26(3):862-72.

Multisensory signal processing: From whole-brain activity to behavior

Domaine de recherche principal: 

Neurophysiology / systems neuroscience

Labelisation ENP: 

2016

Centre de recherche / Institut: 

Laboratoire Jean Perrin

Code unité de recherche: 

UMR 8237

Our brain needs to constantly fuse sensory information detected by our multiple senses in order to produce a seamless coherent representation of the world. Rather than being the exception, this binding process is ubiquitous to sensory-motor integration and is implicated in most cognitive functions. Its impairment is a cause of various pathologies, such as schizophrenia or autism. Multisensory processing operates on all brain levels from primary cortices over subcortical structures up to higher associative centers, while the smallest operational units are single multisensory neurons.

Leader

Leader: 

Personnel

Membres de l'équipe: 

Thomas Panier (PostDoc)
Kris Severi (PostDoc)
Geoffrey Migault (PhD)
Hugo Trentenseaux (PhD)
Matthieu Dujany (Master)
Louis Chevalier (Master)
Établissements

Établissement de rattachement: 

Sorbonne Université

Établissements affiliés: 

CNRS

Université: 

UPMC

École doctorale: 

ED 564
Publications

publications: 

Bormuth, V., Barral, J., Joanny, J.F., Jülicher, F. & Martin, P.    Transduction channels gating controls friction on vibrating hair-cell bundles in the ear.

PNAS 111, 7185-90 (2014) 

Gardner, M.K.*, Zanic, M.*, Gell, C., Bormuth, V., & Howard J.    Depolymerizing Kinesins Kip3 and MCAK Shape
Cellular Microtubule Architecture by Differential Control of Catastrophe.

CELL 147, 1092-1103 (2011)

Bormuth, V., Varga, V., Howard, J., & Schäffer, E.    Protein friction limits diffusive and directed movements of kinesin motors on microtubules.

SCIENCE 325, 870 - 873 (2009)

Varga, V.*, Leduc, C.*, Bormuth, V., Diez, S., & Howard, J.    inesin-8 motors act cooperatively to mediate length-dependent microtubule depolymerization.

CELL 138, 1174-83 (2009) 

Bormuth, V.*, Otsu, Y.*, et al.      Optical monitoring of neuronal activity at high frame rate with a digital random-access multiphoton (RAMP) microscope.

J. Neurosci. Methods 173(2), 259-270 (2008)   

Désordres du neurodéveloppement

Domaine de recherche principal: 

Neurological and psychiatric diseases

Mots clefs: 

autism
speech & language
genes & cognition
social brain

Labelisation ENP: 

2016

Centre de recherche / Institut: 

IFM - Institut du Fer à Moulin

Code unité de recherche: 

UMR 839

Nous étudions les maladies neuro-développementales avec le but d'identifier au niveau moléculaire et cellulaire les mécanismes responsables de la formation des circuits neuronaux impliqués dans les comportements sociaux. Nos recherches actuelles se focalisent sur l'étude de facteurs de transcription dont les mutations entraînent des troubles de l'énonciation et du langage d'une part, et des microcéphalies et des handicaps mentaux d'autre part.

Leader

Leader: 

Établissements

Établissement de rattachement: 

Inserm

Établissements affiliés: 

UPMC

Université: 

UPMC

École doctorale: 

ED158 3C
Publications

publications: 

Kraushar ML, Viljetic B, Wijeratne HR, Thompson K, Jiao X, Pike JW, Medvedeva V, Groszer M, Kiledjian M, Hart RP, Rasin MR. Thalamic WNT3 Secretion Spatiotemporally Regulates the Neocortical Ribosome Signature and mRNA Translation to Specify Neocortical Cell Subtypes. J Neurosci. 2015 Aug 5;35(31):10911-26.

Schreiweis C, Bornschein U, Burguière E, Kerimoglu C, Schreiter S, Dannemann M, Goyal S, Rea E, French CA, Puliyadi R, Groszer M, Fisher SE, Mundry R, Winter C, Hevers W, Pääbo S, Enard W, Graybiel AM. Humanized Foxp2 accelerates learning by enhancing transitions from declarative to procedural performance. Proc Natl Acad Sci U S A. 2014 Sep 30;111(39):14253-8.

Ghosh T, Aprea J, Nardelli J, Engel H, Selinger C, Mombereau C, Lemonnier T, Moutkine I, Schwendimann L, Dori M, Irinopoulou T, Henrion-Caude A, Benecke AG, Arnold SJ, Gressens P, Calegari F, Groszer M. MicroRNAs establish robustness and adaptability of a critical gene network to regulate progenitor fate decisions during cortical neurogenesis. Cell Rep. 2014 Jun 26;7(6):1779-88.

Aprea J, Prenninger S, Dori M, Ghosh T, Monasor LS, Wessendorf E, Zocher S, Massalini S, Alexopoulou D, Lesche M, Dahl A, Groszer M, Hiller M, Calegari F. Transcriptome sequencing during mouse brain development identifies long non-coding RNAs functionally involved in neurogenic commitment. EMBO J. 2013 Dec 11;32(24):3145-60.

French CA, Jin X, Campbell TG, Gerfen E, Groszer M, Fisher SE, Costa RM. An aetiological Foxp2 mutation causes aberrant striatal activity and alters plasticity during skill learning. Mol Psychiatry. 2012 Nov;17(11):1077-85.

Neurogenèse et développement des circuits neuronaux

Domaine de recherche principal: 

Neurogenetics / neurodevelopment

Mots clefs: 

Brainbow
neural circuits
Development
imaging
neural progenitors

Labelisation ENP: 

2009

Centre de recherche / Institut: 

Institut de la Vision

Code unité de recherche: 

UMRS968

Le traitement de l’information par le cerveau et la rétine repose sur des assemblages extraordinairement complexes et précisément organisés de neurones et cellules gliales. Le développement de ces réseaux pose deux questions majeures : comment les cellules qui les composent sont-elles générées en nombre et types adéquats ? Comment ces cellules se répartissent-elles dans le tissu nerveux et s’interconnectent-elles ?

Leader

Leader: 

Personnel

Membres de l'équipe: 

Karine LOULIER, CR1 Inserm
Takuma Kumamoto, postdoc
Mickaël Le, IE
Jason Durand, AI
Solène CLAVREUL, PhD student
Franck MAURINOT, PhD student
Établissements

Établissement de rattachement: 

Inserm

Établissements affiliés: 

Université Pierre et Marie Curie
CNRS

Université: 

UPMC

École doctorale: 

ED3C - n°158
Laboratory

Nom: 

Fondation Voir et Entendre

Initiatives d'Excellence: 

Labex Lifesenses
Publications

publications: 

1.         Dumas L, Heitz-Marchaland C, Fouquet S, Suter U, Livet J, Moreau-Fauvarque C, Chédotal A. Multicolor analysis of oligodendrocyte morphology, interactions, and development with Brainbow. Glia (2015) 63:699-717.

2.         Loulier K, Barry R, Mahou P, Le Franc Y, Supatto W, Matho KS, Ieng S, Fouquet S, Dupin E, Benosman R, Chédotal A, Beaurepaire E, Morin X, Livet J. Multiplex lineage tracking with combinatorial labels. Neuron (2014) 81:505-20

3.         Roy E, Neufeld Z, Livet J, Khosrotehrani K. Concise review: understanding clonal dynamics in homeostasis and injury through multicolor lineage tracing. Stem Cells (2014) 32:3046-54.

4.         Tabansky I, Lenarcic A, Draft R, Loulier K, Keskin DB, Rosains R, Rivera-Feliciano J, Lichtman J, Livet J, Stern JNH, Sanes JR, Eggan K. Developmental bias in cleavage-stage mouse blastomere. Current Biology (2013) 23:21-31.

5.         Mahou P, Zimmerley MS, Loulier K, Matho KS, Labroille G, Morin X, Supatto W, Livet J, Débarre D, and Beaurepaire E. Multicolor two-photon tissue imaging by wavelength mixing. Nature Methods (2012) 9:815-8.

6.         Jefferis GS, Livet J. Sparse, stochastic and combinatorial cell labeling. Current Opin Neurobiol (2012) 22:101-10.

7.         Weissman T, Lichtman JW, Sanes JR, Livet J. Generating and imaging multicolor Brainbow mice. Cold Spring Harb Protoc (2011) 7:763-856.

8.         Pan YA, Livet J, Sanes JR, Lichtman JW, and Schier AF. Multicolor Brainbow imaging in zebrafish (2011). Cold Spring Harb Protoc (2011) Jan 1:2011.

9.         Lichtman JW, Livet J, Sanes JR. A technicolour approach to the connectome. Nat Rev Neurosci (2008) 9:417-22.

10.       Livet J. The brain in color: transgenic "Brainbow" mice for visualizing neuronal circuits. Med Sci (2007) 23:1173-6.

11.       Livet J. Weissman TA, Kang H, Draft RW, Lu J, Bennis, RA, Sanes JR, Lichtman, JW. Transgenic strategies for combinatorial expression of fluorescent proteins in the nervous system. Nature (2007); 450:56-62.

URS LUCAS BOHM

Session (mois année): 

September 2011

Niveau: 

thèse

Situation professionnelle: 

PostDoc at Harvard University in Adam Cohen's lab.

Alumnus: 

Alumnus

Date Graduate program year 2,3,4: 

1 October 2012 - 30 September 2015

Université de rattachement: 

Université Pierre et Marie Curie

Code école doctorale: 

ED 158

Directeur de thèse: 

Intitulé de la thèse: 

Investigating the physiological recruitement of cerebrospinal fluid contacting neurons

Defense date: 

Friday, 16 September, 2016

KRAMAREK Maria

Session (mois année): 

September 2011

Niveau: 

thèse

Situation professionnelle: 

PostDoc at Unité de Neurosciences, Information et Complexité in Alain DESTEXHE's lab (France).

Alumnus: 

Alumnus

Date Graduate program year 2,3,4: 

1 October 2012 - 30 September 2015

Université de rattachement: 

Université Pierre et Marie Curie

Code école doctorale: 

ED 158

Directeur de thèse: 

Intitulé de la thèse: 

Impact of axonal ionic channels on action potentials and synaptic transmission.

Defense date: 

Friday, 23 September, 2016

BOUCHACOURT Flora

Session (mois année): 

September 2011

Niveau: 

thèse

Situation professionnelle: 

PostDoc at Princeton University, in Jonathan Cohen's lab. 

Alumnus: 

Alumnus

Date Graduate program year 2,3,4: 

1 October 2012 - 24 October 2016

Université de rattachement: 

Université Pierre et Marie Curie

Code école doctorale: 

ED 158

Directeur de thèse: 

Intitulé de la thèse: 

Neural mechanisms of rule-guided behavior - Dr Ostojic Srdjan Dr Koechlin Etienne

Defense date: 

Monday, 7 November, 2016

BLOCKUS Heike

Session (mois année): 

September 2011

Niveau: 

thèse

Situation professionnelle: 

Feb 2016 - : PostDoc at Columbia University, NY - Department of Neuroscience, in Franck Polleux's lab

Alumnus: 

Alumnus

Date Graduate program year 2,3,4: 

1 October 2012 - 30 September 2015

Université de rattachement: 

Université Pierre et Marie Curie

Code école doctorale: 

ED 158

Directeur de thèse: 

Intitulé de la thèse: 

Cellular and Molecular mechanism of Robo receptors in brain commissures

Defense date: 

Thursday, 24 September, 2015

BEGUE Aurélien

Session (mois année): 

September 2008

Niveau: 

thèse

Situation professionnelle: 

recruited as PostDoc at Harvard Medical School, Boston - Bernardo Sabatini's lab.

Alumnus: 

Alumnus

Date Graduate program year 2,3,4: 

1 October 2009 - 30 September 2012

Université de rattachement: 

Université Paris Descartes

Code école doctorale: 

ED 158

Directeur de thèse: 

Intitulé de la thèse: 

Two-photon optogenetics

The thesis abstract is available here

Defense: 

November 21, 2012

Defense date: 

Wednesday, 21 November, 2012