Université Pierre et Marie Curie

Equipe Audition

Domaine de recherche principal: 

Neurophysiology / systems neuroscience

Mots clefs: 

memory, learning, plasticity, human psychophysics, physiology in behaving ferrets

Labelisation ENP: 

2017

Centre de recherche / Institut: 

ENS Ecole Normale Supérieure

Code unité de recherche: 

UMR 8248

The Audition team is investigating the mechanisms of auditory perception, at the interface between low-level processing of acoustic features and high-level cognitive processes. We use a wide range of tools in order to address this research topic, from single unit recordings in behaving animals to advanced psychophysics and EEG in human subjects. Current projects in the lab revolve around three major threads:

Leader

Leader: 

Établissements

Établissement de rattachement: 

CNRS

Établissements affiliés: 

Ecole Normale Supérieure

Université: 

Université Pierre et Marie Curie

École doctorale: 

ED 3C - 158
Laboratory

Nom: 

Laboratoire des Systèmes Perceptifs

Initiatives d'Excellence: 

LabEx Institut d’Etude de la Cognition, IdEx Paris Sciences et Lettres
Publications

publications: 

Agus, T.R., Thorpe, S.J., & Pressnitzer, D. (2010). Rapid formation of auditory memories: Insights from noise. Neuron. 66, 610-618.

Andrillon, T., Pressnitzer, D., Léger, D., & Kouider, S. (2017).Formation and suppression of acoustic memories in human sleep. NatureCommunications, 8: 179.

Boubenec Y, Lawlor J, Górska U, Shamma S & Englitz B (2017). Detecting changes in dynamic and complex acoustic scenes. eLife 2017;10.7554/eLife.24910.

Chambers, C., Akram, S. Adam, V., Pelofi, C., Sahani, M., Shamma, S., & Pressnitzer, D. (2017). Prior context in audition informs binding and shapes simple features. Nature Communications, 8:15027.

Andrillon, T., Kouider, S., Agus, T., & Pressnitzer, D. (2015).Perceptual learning of acoustic noise generates memory-evoked potentials. Current Biology, 25: 2823-2829.

 

ORENDORFF Elaine

Session (mois année): 

September 2016

Niveau: 

Année 3

Date Graduate program year 2,3,4: 

10 January 2017 - 30 September 2020

Université de rattachement: 

Université Pierre et Marie Curie

Code école doctorale: 

ED158

Directeur de thèse: 

Intitulé de la thèse: 

Selective Amacrine Cell Stimulation, Imaging, and Downstream Recording Across Dedicated Circuits of the Retina

BEIRAN AMIGO Manuel

Session (mois année): 

September 2016

Niveau: 

Année 3

Date Graduate program year 2,3,4: 

1 October 2017 - 30 September 2020

Université de rattachement: 

ENS/PSL

Code école doctorale: 

ED158

Directeur de thèse: 

Intitulé de la thèse: 

Temporal computations in recurrent networks with adaptation

DEMORI SUSIN Eduarda

Session (mois année): 

Septembre 2016

Niveau: 

Année 3

Date Graduate program year 2,3,4: 

1 October 2017 - 30 September 2020

Université de rattachement: 

Université Pierre et Marie Curie

Code école doctorale: 

ED158

Directeur de thèse: 

Intitulé de la thèse: 

Biophysical Aspects of Rhythmical Activities in the Brain

BRYZGALOV Dimitri

Session (mois année): 

September 2016

Niveau: 

Année 3

Date Graduate program year 2,3,4: 

1 October 2017 - 30 September 2020

Université de rattachement: 

PSL

Code école doctorale: 

ED 158

Directeur de thèse: 

Intitulé de la thèse: 

Causal manipulation of aversive memories during sleep

CASSIM Sadiyah

Session (mois année): 

September 2016

Niveau: 

Année 3

Date Graduate program year 2,3,4: 

1 October 2017 - 30 September 2020

Université de rattachement: 

Université Paris Descartes

Code école doctorale: 

ED 158

Directeur de thèse: 

Intitulé de la thèse: 

The Source of Enkephalin and Consequences of delta opioid mediated iLTD on hippocampal learning

Functional imaging and behavior in zebrafish

Domaine de recherche principal: 

Neurophysiology / systems neuroscience

Mots clefs: 

light-sheet microscopy
neuroimaging
zebrafish
sensory-motor integration
circuit inference

Labelisation ENP: 

2016

Centre de recherche / Institut: 

Laboratoire Jean Perrin

Code unité de recherche: 

UMR 8237

The overall objective of the group is to unravel principles of neural computations underlying sensory-motor integration in the vertebrate brain. We use the zebrafish larva as it currently constitutes the only vertebrate system amenable to whole-brain recording with cellular resolution. Using one- or two-photon light-sheet microscopy, we are able to monitor the long-term activity of the quasi-entirety of the 100,000 neurons that comprise the animal brain, as it performs basic sensory-motor tasks.

Leader

Leader: 

Personnel

Membres de l'équipe: 

Raphaël Candelier
Sergei Kruglik
Sébastien Wolf
Alexis Dubreuil
Sophia Karpenko
Guillaume Le Goc
Établissements

Établissement de rattachement: 

UPMC

Établissements affiliés: 

CNRS

Université: 

Université Pierre et Marie Curie

École doctorale: 

ED 564
Publications

publications: 

Sensorimotor Computation underlying phototaxis in zebrafish. Sébastien Wolf, Alexis M. Dubreuil, Tommaso Bertoni, Urs Lucas Böhm, Volker Bormuth, Raphaël Candelier, Sophia Karpenko, David G. C. Hildebrand, Isaac H. Bianco, Rémi Monasson, Georges Debrégeas. Nature Communication, in press

Whole-brain functional imaging with two-photon light-sheet microscopy, S Wolf, W. Supatto, G. Debrégeas, P. Mahou, S. G Kruglik,J-M. Sintes, E. Beaurepaire, R. Candelier Nature Methods 12, 379–380 (2015)

An Amplitude Modulation/Demodulation Scheme for Whisker-Based Texture Perception, Y. Boubenec, L. N. Claverie, D. E. Shulz,G. Debrégeas, J. Neurosci. 34(33): 10832-10843 (2014)

Fast functional imaging of multiple brain regions in intact zebrafish larvae using Selective Plane Illumination Microscopy. T. Panier,S. Romano, R. Olive, T. Pietri, G. sumbre, R. Candelier, G. Debrégeas, Frontiers in Neural Circuits 7, 0065 (2013)

The role of fingerprints in the coding of tactile information probed with a biomimetic sensor, J. Scheibert, S. Leurent, A. Prevost et G. Debrégeas, Science 323 1503-1506 (2009). Reviewed in Science news, Science Update (radio), Science signaling, Nature news, Nature Research highlights, Nature Methods,Analytical Chemistry, Atten. Percept & Psych.

Signatures of granular microstructure in dense shear flows. D. Mueth, G. Debregeas, G. Karczmar, P. Eng, S. Nagel & H. Jaeger,Nature 406, 385-388 (2000)

Gènes Circuits Rythmes et Neuropathologies

Domaine de recherche principal: 

Neuropharmacology / cell signaling

Mots clefs: 

dopamine
Neurodegeneration
Parkinson disease
Locomotor aging
Drosophila
oxidative stress

Labelisation ENP: 

2016

Centre de recherche / Institut: 

ESPCI Paris Tech -Ecole Supérieure de Physique et de Chimie Industrielles

Code unité de recherche: 

UMR 8249

Our research program is focused on the role of dopamine in behaviour control and neurodegenerative mechanisms in the fruit fly Drosophila melanogaster. Our approach combines Drosophila genetics, molecular biology, brain imaging and behavioral assays. We recently generated and characterized brain dopamine-deficient mutants and developed new models to study pathogenic mechanisms related to genetic and environmental factors of Parkinson disease.

Leader

Leader: 

Personnel

Membres de l'équipe: 

André Klarsfeld
Baya Chérif-Zahar
Ali Mteyrek
Abdul-Raouf Issa
Alexandra Vaccaro
Mathilde Lecompte
Jun Sun
Établissements

Établissement de rattachement: 

CNRS

Établissements affiliés: 

ESPCI

Université: 

Université Pierre et Marie Curie

École doctorale: 

ED 158 3C
Laboratory

Nom: 

Laboratoire Plasticité du Cerveau

Initiatives d'Excellence: 

Labex MemoLife, Idex PSL
Publications

publications: 

Cassar M., Issa A.-R., Riemensperger T., Petitgas C., Rival T., Coulom H., Iché-Torres M., Han K.-A. & Birman S. (2015) A dopamine receptor contributes to paraquat-induced neurotoxicity in Drosophila. Hum. Mol. Genet. 24(1):197-212

Lavista-Llanos S., Svatoš A., Kai M., Riemensperger T., Birman S., Stensmyr M. C. & Hansson B. S. (2014) Dopamine drives Drosophila sechellia adaptation to its toxic host. eLife Dec 9;3

Riemensperger T., Issa A.-R., Pech U., Coulom H., Nguyen M.-V., Cassar M., Jacquet M., Fiala A. & Birman S. (2013) A single dopamine pathway underlies progressive locomotor deficits in a Drosophila model of Parkinson disease. Cell Rep. 5:952–960

Humphrey D. M., Parsons R. B., Ludlow Z. N., Riemensperger T., Esposito G., Verstreken P., Jacobs H. T., Birman S. & Hirth F. (2012) Alternative oxidase rescues mitochondria-mediated dopaminergic cell loss in Drosophila. Hum. Mol. Genet. 21(12): 2698-2712

Riemensperger T., Isabel G., Coulom H., Neuser K., Seugnet L., Kume K., Iché-Torres M., Cassar M., Strauß R., Préat T., Hirsh J. & Birman S. (2011) Behavioral consequences of dopamine deficiency in the Drosophila central nervous system. Proc. Natl. Acad. Sci. USA 108(2):834-39 



GOETHALS Sarah

Session (mois année): 

September 2015

Niveau: 

Année 4

Date Graduate program year 2,3,4: 

1 October 2016 - 30 September 2019

Université de rattachement: 

Université Pierre et Marie Curie

Code école doctorale: 

ED 158

Directeur de thèse: 

Intitulé de la thèse: 

Impact of axon initial segment geometry on excitability

WU Mingyue

Session (mois année): 

September 2015

Niveau: 

Année 4

Date Graduate program year 2,3,4: 

1 October 2016 - 30 September 2019

Université de rattachement: 

Université Pierre et Marie Curie

Code école doctorale: 

ED 158

Directeur de thèse: 

Intitulé de la thèse: 

Investigation of the mechano- and chemo-sensory properties of CSF-contacting neurons