Madame
Patricia GASPAR
Directeur de recherche
Chercheur
ED 158

Neural Circuit Development

Mood disorders

11-03-2015
20-02-2015
20-10-2016
Available to host a PhD student
Critical period for the development of prefrontal connectivity: effects of early life stress and serotonin transmission.

Team

Patricia GASPAR
Des évidences croissantes montrent l'implication d'anomalies développementales à l'origine de pathologies neuropsychiatriques. En effet des circuits neuronaux sous-tendent tous nos comportements du...

Biographie / Publications

Patricia Gaspar is a Research Director (DR1), at Inserm in the "Institut du Fer à Moulin" a Neuroscience Center on brain development and plasticity. She is the current Director of Ecole de Neurosciences de Paris. She was trained as an MD in neurology in Paris at the Hôpital Pitié Salpêtrière and did her PhD at the University Pierre et Marie Curie in Paris on the anatomy of dopaminergic systems in the human brain in relation to Parkinson’s disease. Her team focuses on the developmental mechanisms underlying neurological and psychiatric disorders. The team discovered in particular unexpected developmental roles of serotonin on neural circuit development using genetic approaches in mice.

She now shares the direction of a team with Christine Métin at the Institut du Fer à Moulin.  Among the current research themes in the laboratory she directly supervises projects aimed to understand better the development of the serotonin circuits, in particular to identify subsystems that have different developmental trajectories and subserve different functions in adults.

The work of PG has led to 100 publications that have been cited more than  6000 times. 

Selected recent publications 


Narboux-Nême N, Evrard A, Ferezou I, Erzurumlu RS, Kaeser PS, Lainé J, RossierJ, Ropert N, Südhof TC, Gaspar P  Neurotransmitter release at the thalamocortical synapse instructs barrel formation but not axon patterning in the somatosensory cortex. J Neurosci., 2012 32:6183-6196. 

Vera Kiyasova*, Sebastian Fernandez*, Jeanne Laine, Lea Stakovski, Aude Muzerelle, Sephane Doly, Patricia Gaspar. A genetically defined morphologically and functionally unique subset of 5-HT neurons in the mouse raphe nuclei. J Neurosci, 2011, 31:2756-68..

Judith Homberg, Dirk Schubert, Patricia Gaspar. New perspectives on the neurodevelopmental effects of SSRIs. Trends in Pharmacological Sciences ,2010 Feb;31(2):60-65. Epub 2009.

Narboux-Nême N, Pavone LM, Avallone L, Zhuang X, Gaspar P. Serotonin transporter transgenic (SERTcre) mouse line reveals developmental targets of serotonin specific reuptake inhibitors (SSRIs). Neuropharmacology. 2008, Nov;55(6):994-1005

Nicol X, Voyatzis S, Muzerelle A, Narboux-Neme N, Sudhof TC, Miles R, Gaspar, P (2007). cAMP oscillations and retinal activity are permissive for ephrin signalling during the establishment of the retinotopic map. Nat Neurosci. 10:340-7 (Faculty of 1000).

Rebsam A, Seif I, Gaspar P (2005) Dissociating barrel development and lesion-induced plasticity in the mouse somatosensory cortex. J Neurosci. , 25:706-710.

Gaspar P, Cases O, Maroteaux L (2003) The developmental role of serotonin : news from mouse molecular genetics. Nature Reviews Neuroscience :1002-1012