Monsieur
Pascal LEGENDRE
Directeur de recherche
Chercheur
ED158
31-01-2014
31-01-2014
12-05-2016

Team

Pascal LEGENDRE
L’objectif général de notre équipe de recherche est de mieux comprendre les mécanismes impliqués dans l’émergence des premiers réseaux synaptiques au cours du développement du système nerveux cetral...

Biographie / Publications

Diplomas :

Master in anthropology. Université de Bordeaux II 1979

Master in psychology. Université de Bordeaux II 1979

PhD. Université de Bordeaux II 1983

Habilitation à Diriger des Recherches (HDR). Université de Paris XII 1999

Professional Cursus:

1981 -1984 : assistant professor : Université Bordeaux II.

1985 : full research scientist : Chargé de recherche de 2ème classe INSERM.

1989 : full research scientist : Chargé de recherche de 1ère classe INSERM (CR1).

1999 : full research scientist : Directeur de Recherche INSERM (DR2).

Further training and postdoctoral fellowships:

1986 : postdoctoral fellowship 4 months AFRC, Cambridge GB Dr. WT Mason.

1989-1991 : postdoctoral fellowship, Vollum Institute, Portland USA. Dr. GLWestbrook.

1994 : postdoctoral fellowship 3 months Vollum Institute, Portland USA. Dr. GLWestbrook.

1997-1999 : Sabbatical 2 months per year (INSERM-FRSQ and MRC grants), Montréal, Dr. P Drapeau.

2003- : 1 or 2 journeys per year (INSERM-SFB grant; Tournesol grant since 2009) Liège University and Hasselt University,(collaboration Prof. JM Rigo).

Teaching:

since 2004 : 2h per year Master BIP (UPMC).

Team Leadership :

- 2000-2008 : Team leader « Synapse Dynamic » UMR CNRS 7102 (NPA).

- 2009-2013 : Team leader (co leadership with François Couraud) « Development and Pathologies of the Spinal Cord » INSERMU-952.

- 2014- : Team leader (co leadership with Jean Marie Mangin) « Development of Spinal Cord Organization» ; Unit Neurosciences Paris-Seine.

National or international expert evaluation.

- IR INSERM, 2008.

- ASI Université Paris VII, 2009.

- Telethon Italy (2008-2010).

- ANR, AFM, FRM, NERF, ville de Paris, Fondation motrice.

- AERS 2009 : INSERM U573.

- AERS 2010 : Institut Magendie (Bordeaux).

- AERS 2011 ; coordinator INMED (Marseille).

- Selection comity: Professor position Université Aix-Marseille INMED, 2010.

- Selection comity: associate professor position, Aix-Marseille INMED, 2012.

- Selection comity: associate professor position, UPMC, Paris, 2012.

- Thesis comity: 18 since 2007.

-referee for J Neurosci, JBC, EMBO, J Neurochem, Mol Pharmacol, J Physiol, J Neuophysiol, EJN, MCN, Frontiers etc.

Scientific comity.

- INSERM, ?Contrats d?interface?, since 2009

- INSERM, ?Postes d?accueil?, since 2009

- Scientific comity of Animal Physiology, INRA, 2007-2014 (nominated).

Symposium coordinator

-Symposium « role of microglia during their invasion of the developing central nervous system, a new field of research ». Glial

Meeting Berlin 2013.

National conferences : 10 since 2007

International conferences:

- Ottawa Health Research Institute, Ottawa, Canada, 2007.

- UCLA, Los Angeles, USA, 2007.

- Hasselt University, Belgique, 2008.

- University of Copenhague, Copenhague, Danemark, 2010.

- Italian Institute of Technology Genova, Italy, 2011.

- Institute of Pharmacology and Toxicology, University of Zurich, Zurich, Switzerland, 2012.

Invited speaker : international meeting (symposium).

- International Symposium «Glycine system», Louvain, Belgium, 2009.

- International motoneuron meeting, Paris, France, 2010.

- Symposium Belgium scientific network ELEXCITE, Gand, Belgium, 2011.

- International Symposium ?Cellular Neurobiology and Endocrine Signaling?, Honolulu, USA, 2012.

 

Theodosis DT, Legendre P, Vincent JD, Cooke IM (1983) Immunocytochemicallyidentified vasopressin neurons in culture show slow, calcium-dependent electrical responses. Science 221, 1052-1054.

Legendre P., Rosenmund C. And Westbrook GL. (1993) Inactivation of NMDA channels in cultured hippocampal neurons by intracellular calcium. J. Neurosci.13, 674-684.

Legendre P. (1998) A reluctant gating mode of glycine receptor-channels determines the time course of inhibitory miniature synaptic events in zebrafish hindbrain neurons. J. Neurosci. 18, 2856-2870.

Scain AL, Le-Corronc H, Allain AE, Muller E, Rigo JM, Meyrand P, Branchereau P, Legendre P. (2010) Glycine release from radial cells modulates the spontaneous activity and its propagation during early spinal cord development J. Neurosci. 30, 390-403

Rigato C, Swinnen N, Buckinx R, Couillin I, Magin JM, Rigo JM, Legendre P*, Le Corronc H*. (2012) Microglia proliferation is controlled by P2X7 receptors in a pannexin-1-independent manner during early embryonic spinal cord invasion. J. Neurosci. 32: 11559-11573. *co corresponding author