Physiopathologie des troubles de l'humeur : dépression et addiction

Domaine de recherche principal: 

Neurological and psychiatric diseases

Mots clefs: 


Labelisation ENP: 


Code unité de recherche: 

UMRS 894

The goal of the research team is to analyze the roles played by environmental and genetic factors, as well as the interactions between these components, in the etiology and treatment of psychiatric disorders such as depression, anxiety and addiction. The main objective of the team is to identify cellular and molecular mechanisms underlying these pathologies which are associated with major dysfunctions of the monoamine and HPA systems and characterized by cellular plasticity alterations of different brain areas and in particular the hippocampus.


Établissement de rattachement: 



Stragier E, Massart R, Salery M, Hamon M, Geny D, Martin V, Boulle F, Lanfumey L. Ethanol-induced epigenetic regulations at the Bdnf gene in C57BL/6J mice. Neuroscience. 2014 Jun 20;271:56-63. doi: 10.1016/j.neuroscience.2014.04.027. Epub 2014 Apr 26.

Doucet EL, Lanfumey L, et al. (2013) Sustained impairment of alpha2A-adrenergic autoreceptor signaling mediates neurochemical and behavioral sensitization to amphetamine. Biol Psychiatry. 74:90-98

Garcia Garcia Al, Lanfumey L, et al. (2013) Regulation of serotonin (5-HT) function by a VGLUT1 dependent glutamate pathway. Neuropharmacology. 70:190-199

Lanfumey L, et al (2012) Biological rhythms and melatonin in mood disorders and their treatments Pharmacol Ther. 138:176-184 Review

Lanteri C, ?, Lanfumey L, et al.. (2013) Repeated exposure to MDMA triggers long-term plasticity of noradrenergic and serotonergic neurons Mol Psychiatry. 2013 Aug 20.

Martin CBP, .. Lanfumey L, .. et al. (2012) RNA splicing and editing modulation of 5-HT2C receptor function: relevance to anxiety and aggression in VGV mice. Mol Psychiatry. 18:656-665

Molet J,  Lanfumey L. Juvenile ethanol exposure increases rewarding properties of cocaine and morphine in adult DBA/2J mice. Eur Neuropsychopharmacol. 2013 Apr 22.