reward

Synapses et physiopathologie de la récompense

Domaine de recherche principal: 

Neurophysiology / systems neuroscience

Mots clefs: 

Synaptic plasticity
dopamine
reward
addiction
receptor trafficking

Labelisation ENP: 

2011

Code unité de recherche: 

UMRS 839

The general interest of the lab is to dissect the neuronal circuits implicated in reward learning and to understand how drugs co-opt these connections.

Goal directed actions, aimed to obtain a reward, motivate our behaviors and influence our decisions.

Établissements

Établissement de rattachement: 

Inserm

Établissements affiliés: 

Université Pierre et Marie Curie

Université: 

Université Pierre et Marie Curie

École doctorale: 

ED158
Laboratory

Nom: 

Marianne Coutures

Initiatives d'Excellence: 

Biopsy
Publications

publications: 

Mameli M., Bellone C., Brown T.C., Lüscher C. Cocaine inverts rules for synaptic plasticity of glutamate transmission in the VTA. Nature Neuroscience. 2011 In press

Brown T.C., Bellone C., Mameli M., Balland B., Dahan L., Lujan R., Deisseroth K., Lüscher C. Drug-driven AMPA receptor redistribution mimicked by selective dopamine neuron stimulation. PLoSOne. 2010 5(12):e15870.

Mameli M., Halbout B., Creton C., Engblom D., Parkitna J. R., Spanagel R., Lüscher C.. Cocaine-evoked synaptic plasticity: persistence in the VTA triggers adaptations in the NAc. Nat Neurosci. 2009 12:1036-41.

Engblom D., Bilbao A., Sanchis-Segura C., Dahan L., Pereau-lenz S., Balland B., Parkitna J.R., Lujan R., Halbout B., Mameli M., Parlato R., Sprengel R., Lüscher C., Schütz G., Spanagel R.. Glutamate receptors on dopamine neurons control the persistence of cocaine-seeking. Neuron 2008 59:497-508.

Mameli M., Balland B., Lujan R., Lüscher C.. Rapid synthesis and synaptic insertion of GluR2 for mGluR-LTD in the ventral tegmental area. Science. 2007 317:530-3.