plasticity

Physiopathologie des troubles de l'humeur : dépression et addiction

Domaine de recherche principal: 

Neurological and psychiatric diseases

Mots clefs: 

plasticity
Stress
Depression
serotonine/
alcohol

Labelisation ENP: 

2014

Code unité de recherche: 

UMRS 894

The goal of the research team is to analyze the roles played by environmental and genetic factors, as well as the interactions between these components, in the etiology and treatment of psychiatric disorders such as depression, anxiety and addiction. The main objective of the team is to identify cellular and molecular mechanisms underlying these pathologies which are associated with major dysfunctions of the monoamine and HPA systems and characterized by cellular plasticity alterations of different brain areas and in particular the hippocampus.

Établissements

Établissement de rattachement: 

Inserm
Publications

publications: 

Stragier E, Massart R, Salery M, Hamon M, Geny D, Martin V, Boulle F, Lanfumey L. Ethanol-induced epigenetic regulations at the Bdnf gene in C57BL/6J mice. Neuroscience. 2014 Jun 20;271:56-63. doi: 10.1016/j.neuroscience.2014.04.027. Epub 2014 Apr 26.

Doucet EL, Lanfumey L, et al. (2013) Sustained impairment of alpha2A-adrenergic autoreceptor signaling mediates neurochemical and behavioral sensitization to amphetamine. Biol Psychiatry. 74:90-98

Garcia Garcia Al, Lanfumey L, et al. (2013) Regulation of serotonin (5-HT) function by a VGLUT1 dependent glutamate pathway. Neuropharmacology. 70:190-199

Lanfumey L, et al (2012) Biological rhythms and melatonin in mood disorders and their treatments Pharmacol Ther. 138:176-184 Review

Lanteri C, ?, Lanfumey L, et al.. (2013) Repeated exposure to MDMA triggers long-term plasticity of noradrenergic and serotonergic neurons Mol Psychiatry. 2013 Aug 20.

Martin CBP, .. Lanfumey L, .. et al. (2012) RNA splicing and editing modulation of 5-HT2C receptor function: relevance to anxiety and aggression in VGV mice. Mol Psychiatry. 18:656-665

Molet J,  Lanfumey L. Juvenile ethanol exposure increases rewarding properties of cocaine and morphine in adult DBA/2J mice. Eur Neuropsychopharmacol. 2013 Apr 22.

Groupe Interactions cellules gliales/cellules gliales et cellules gliales/neurones

Domaine de recherche principal: 

Neurophysiology / systems neuroscience

Mots clefs: 

synaptic transmission
plasticity
astrocytes
GPCR signaling
neuron-glia interactions in physiology of the central nervous system
neuron-astrocyte interactions
glia in memory and sleep
glia in psychiatric and neurodegenerative diseases

Labelisation ENP: 

2012

Centre de recherche / Institut: 

INCC - UMR 8002 - Paris Descartes University

Code unité de recherche: 

FR3636

We are interested in understanding the role of glial cells in the mammalian central nervous system (CNS) and the mechanisms by which glial cells and neurons interact to support normal communication in the CNS.

Leader

Leader: 

Établissements

Établissement de rattachement: 

CNRS

Établissements affiliés: 

Université Paris Descartes

Université: 

Université Paris Descartes

École doctorale: 

ED3C
Laboratory

Nom: 

UFR Biomédicale

Initiatives d'Excellence: 

Institut Neuroscience et Cognition
Publications

publications: 

Agulhon C, Sun MY, Murphy T, Myers T, Lauderdale K, Fiacco TA. Calcium signaling and gliotransmission in normal versus reactive astrocytes, Frontiers in Neuropharmacology. In Press.

Agulhon C, Fiacco TA, McCarthy KD , Hippocampal short- and long-term plasticity are not modulated by astrocyte Ca2+ signaling, Science.327:1250-4, 2010.

Fiacco TA, Agulhon C, McCarthy KD. Sorting out astrocyte physiology from pharmacology, Annu Rev Pharmacol Toxicol. 49:151-174 2009.

Agulhon C, Petravicz J, McMullen AB, Sweger EJ, Minton SK, Taves SR, Casper KB, Fiacco TA, McCarthy KD. What is the role of astrocyte calcium in neurophysiology?, Neuron. 59:932-946, 2008.

Fiacco TA, Agulhon C, Taves S, Petravicz J, Casper K, Dong Xinzhong, Chen J, McCarthy KD. Selective stimulation of astrocyte calcium in situ does not affect neuronal excitatory synaptic activity, Neuron. 54:611-626, 2007.

Plasticité des Réseaux Corticaux et Epilepsie

Domaine de recherche principal: 

Neuropharmacology / cell signaling

Mots clefs: 

Epilepsie
Plasticité
Cortex
Epilepsy
transmission synaptique
plasticity
synaptic transmission

Labelisation ENP: 

2008

Centre de recherche / Institut: 

IFM - Institut du Fer à Moulin

Code unité de recherche: 

UMRS 839

Les interneurones GABAergiques corticaux jouent un rôle critique dans le contrôle de l'activité d'ensembles neuronaux. En particulier, dans l'hippocampe, la transmission synaptique GABAergique est nécessaire aux activités rythmiques associées à divers états comportementaux ou tâches cognitives. En revanche, une réduction même partielle de la transmission GABAergique entraîne une synchronisation anormale de l'activité du réseau qui est notamment à l'origine des activités épileptiques.

Leader

Leader: 

Co leader: 

Personnel

Membres de l'équipe: 

LEVI Sabine
EUGENE Emmanuel
HEUBL Martin
CHEVY Quentin
SCHWARTZ Eric
GOUTIERRE Marie
GOMEZ-CASTRO Ferran
Établissements

Établissement de rattachement: 

Inserm

Établissements affiliés: 

Université Pierre et Marie Curie

Université: 

Université Pierre et Marie Curie

École doctorale: 

ED158
Laboratory

Nom: 

Marianne Coutures

Initiatives d'Excellence: 

EraNet NEURON (2017-2020)
Publications

publications: 

Gauvain G, Chamma I, Chevy Q, Cabezas C, Irinopoulou T, Bodrug N, Carnaud M, Lévi S, Poncer JC (2011) The neuronal K-Cl cotransporter KCC2 influences postsynaptic AMPA receptor content and lateral diffusion in dendritic spines. Proc Natl Acad Sci USA 108:15474-9.

Heubl M, Zang J, Pressey JC, Al Awabdh S, Renner M, Gomez-Castro F, Moutkine I, Eugène E, Russeau M, Kahle KT, Poncer JC, Lévi S (2017) GABAA receptor-dependent synaptic inhibition rapidly tunes KCC2 activity via the Cl--sensitive WNK1 kinase. Nature Communications (in press)

Giralt A, Brito V, Chevy Q, Simonnet C, Otsu Y, Cifuentes-Diaz C, de Pins B, Coura R, Alberch J, Ginés S, Poncer JC, Girault JA (2017) Pyk2 modulates hippocampal excitatory synapses and contributes to cognitive deficits in a Huntington's disease model. Nature Communications 8:15592.

Chevy Q, Heubl M, Goutierre M, Backer S, Moutkine I, Eugène E, Bloch-Gallego E, Lévi S, Poncer JC (2015) KCC2 Gates Activity-Driven AMPA Receptor Traffic through Cofilin Phosphorylation. Journal of Neuroscience 35:15772-86.

Chamma I, Heubl M, Chevy Q, Renner M, Moutkine I, Eugène E, Poncer JC, Lévi S (2013) Activity-dependent regulation of the K/Cl transporter KCC2 membrane diffusion, clustering, and function in hippocampal neurons. Journal of Neuroscience  33:15488-503.