The long-term objective of this project is to apply high field MRI eventually combined with other neuroscience approaches, to develop physical (e.g. electric neurostimulation) and/or chemical (e.g. pharmacological delivery) devices of neuromodulation that target neuronal sites and manipulate specific aspects of cognition, motor behavior or consciousness, leading ultimately to the development of treatments for patients with related diseases (e.g. disorders of consciousness, Parkinson's disease...).
Our research targets the neurophysiological basis of spatial navigation and memory, in particular the network processes that integrate internal signals (representations, expectations, emotions) and multisensory information from the environment to store and update memories, and guide behavior. We record large neuronal ensembles and local field potential oscillations in freely moving animals performing learning and memory tasks. We focus on the hippocampal system (affected in epilepsy and Alzheimer's disease), where neurons code for the position and direction of the head in space.