Neuromodulation

NEURO-MODULATION (UVSQ)

Domaine de recherche principal: 

Cognitive neurosciences / neuropsychology /neuroeconomy

Mots clefs: 

Brain imaging
consciousness
Neurological disability
Neuromodulation
Translational neuroscience

Labelisation ENP: 

2014

The long-term objective of this project is to apply high field MRI eventually combined with other neuroscience approaches, to develop physical (e.g. electric neurostimulation) and/or chemical (e.g. pharmacological delivery) devices of neuromodulation that target neuronal sites and manipulate specific aspects of cognition, motor behavior or consciousness, leading ultimately to the development of treatments for patients with related diseases (e.g. disorders of consciousness, Parkinson's disease...).

Établissements

Établissement de rattachement: 

Inserm

Université: 

Univ Pierre et Marie Curie

École doctorale: 

ED158
Laboratory

Nom: 

Unicog Cognitive Neuroimaging Unit

Initiatives d'Excellence: 

IDEX Paris-Saclay / NeuroSaclay, IHU Handimedex
Publications

publications: 

-Arsenault J, Nelissen K, Jarraya B#, Vanduffel W. Dopaminergic reward signals selectively decrease fMRI activity in primate visual cortex. Neuron. Mars 2013.

-D. Le Bihan, O. Joly#, T. Aso, L. Uhrig#, C. Poupon, N. Tani#, H. Iwamuro#, S-I. Urayama, B. Jarraya# Brain tissue water comes in two pools: Evidence from diffusion and R2? measurements with USPIOs in non human primates. NeuroImage. 2012 May 11.

-K Nelissen*, B Jarraya* #, J Arsenault, B R. Rosen, L L. Wald, J B. Mandeville, J. J. Marota, W Vanduffel. Neural correlates of formation and retention of cocaine-induced stimulus-reward associations. Biological Psychiatry. 2012 Mar 20. * co-authoring

-L Ciobanu, O Reynaud, L Uhrig#, B Jarraya#, D Le Bihan. Effects of Anesthetic Agents on Brain Blood Oxygenation Level Revealed with Ultra-High Field MRI PlosONE. 2012;7(3):e32645.

- N Tani#, O Joly#, H Iwamuro#, L Uhrig#, C J. Wiggins, C Poupon, H Kolster, W Vanduffei, D Le Bihan, S Palfi#, B Jarraya# Direct visualization of non-human primate subcortical nuclei with contrast-enhanced high field MRI. NeuroImage 2011 Sep 1;58(1):60-8.

- Jarraya B#, Boulet S, Scott Ralph G, Jan C, Bonvento G, Azzouz M, E. Miskin J, Shin M, DelzescauxT, Drouot X, Hérard A.S, M. Day D, Brouillet E, M. Kingsman S, Hantraye P, A. Mitrophanous K, D. Mazarakis N, Palfi S#. Dopamine Gene Therapy for Parkinson?s Disease in a Nonhuman Primate Without Associated Dyskinesia. Science Translational Medicine Vol 1 2009.

Rythmes cérébraux et codage neural de la mémoire

Domaine de recherche principal: 

Neurophysiology / systems neuroscience

Mots clefs: 

Neurophysiology
Neuromodulation
neural oscillation
decision
visual handicap

Labelisation ENP: 

2012

Centre de recherche / Institut: 

Collège de France

Code unité de recherche: 

UMR7241 - U1050

Our research targets the neurophysiological basis of spatial navigation and memory, in particular the network processes that integrate internal signals (representations, expectations, emotions) and multisensory information from the environment to store and update memories, and guide behavior. We record large neuronal ensembles and local field potential oscillations in freely moving animals performing learning and memory tasks. We focus on the hippocampal system (affected in epilepsy and Alzheimer's disease), where neurons code for the position and direction of the head in space.

Leader

Leader: 

Personnel

Etudiants ENP: 

Membres de l'équipe: 

Sidney WIENER
Susan SARA
Chantal MILLERET
Établissements

Établissement de rattachement: 

Collège de France

Établissements affiliés: 

CNRS
Inserm

École doctorale: 

ED 158 - 474
Laboratory

Nom: 

Centre Interdisciplinaire Recherche Biologie

Initiatives d'Excellence: 

LabEx Memolife - ANR 2017
Publications

publications: 

Maingret N, Girardeau G, Todorova R, Goutierre M1,2,3,4, Zugaro M. Hippocampo-cortical coupling mediates memory consolidation during sleep. Nat Neurosci. 2016 Jul;19(7):959-64. doi: 10.1038/nn.4304. Epub 2016 May 16.

Catanese J, Viggiano A, Cerasti E, Zugaro MB, Wiener SI. (2014) Retrospectively and prospectively modulated hippocampal place responses are differentially distributed along a common path in a continuous T-maze. J Neurosci. 34(39):13163-9

Cei A, Girardeau G, Drieu C, Kanbi KE, Zugaro M. Reversed theta sequences of hippocampal cell assemblies during backward travel. Nat Neurosci. 2014 May;17(5):719-24.

Girardeau G, Cei A, Zugaro M. Learning-induced plasticity regulates hippocampal sharp wave-ripple drive. J Neurosci. 2014 Apr 9;34(15):5176-83.

Arleo A, Déjean C, Allegraud P, Khamassi M, Zugaro M, Wiener SI (2013) Optic flow stimuli update anterodorsal thalamus head direction neuronal activity in rats. J. Neuroscience 33(42):16790-5.

Catanese J, Cerasti E, Zugaro M, Viggiano A, Wiener S.I. (2012) Dynamics of decision-related activity in prospective hippocampal place cells. Hippocampus 22(9):1901-11