neuroimaging

Functional imaging and behavior in zebrafish

Domaine de recherche principal: 

Neurophysiology / systems neuroscience

Mots clefs: 

light-sheet microscopy
neuroimaging
zebrafish
sensory-motor integration
circuit inference

Labelisation ENP: 

2016

Centre de recherche / Institut: 

Laboratoire Jean Perrin

Code unité de recherche: 

UMR 8237

The overall objective of the group is to unravel principles of neural computations underlying sensory-motor integration in the vertebrate brain. We use the zebrafish larva as it currently constitutes the only vertebrate system amenable to whole-brain recording with cellular resolution. Using one- or two-photon light-sheet microscopy, we are able to monitor the long-term activity of the quasi-entirety of the 100,000 neurons that comprise the animal brain, as it performs basic sensory-motor tasks.

Leader

Leader: 

Personnel

Membres de l'équipe: 

Raphaël Candelier
Sergei Kruglik
Sébastien Wolf
Alexis Dubreuil
Sophia Karpenko
Guillaume Le Goc
Établissements

Établissement de rattachement: 

UPMC

Établissements affiliés: 

CNRS

Université: 

Université Pierre et Marie Curie

École doctorale: 

ED 564
Publications

publications: 

Sensorimotor Computation underlying phototaxis in zebrafish. Sébastien Wolf, Alexis M. Dubreuil, Tommaso Bertoni, Urs Lucas Böhm, Volker Bormuth, Raphaël Candelier, Sophia Karpenko, David G. C. Hildebrand, Isaac H. Bianco, Rémi Monasson, Georges Debrégeas. Nature Communication, in press

Whole-brain functional imaging with two-photon light-sheet microscopy, S Wolf, W. Supatto, G. Debrégeas, P. Mahou, S. G Kruglik,J-M. Sintes, E. Beaurepaire, R. Candelier Nature Methods 12, 379–380 (2015)

An Amplitude Modulation/Demodulation Scheme for Whisker-Based Texture Perception, Y. Boubenec, L. N. Claverie, D. E. Shulz,G. Debrégeas, J. Neurosci. 34(33): 10832-10843 (2014)

Fast functional imaging of multiple brain regions in intact zebrafish larvae using Selective Plane Illumination Microscopy. T. Panier,S. Romano, R. Olive, T. Pietri, G. sumbre, R. Candelier, G. Debrégeas, Frontiers in Neural Circuits 7, 0065 (2013)

The role of fingerprints in the coding of tactile information probed with a biomimetic sensor, J. Scheibert, S. Leurent, A. Prevost et G. Debrégeas, Science 323 1503-1506 (2009). Reviewed in Science news, Science Update (radio), Science signaling, Nature news, Nature Research highlights, Nature Methods,Analytical Chemistry, Atten. Percept & Psych.

Signatures of granular microstructure in dense shear flows. D. Mueth, G. Debregeas, G. Karczmar, P. Eng, S. Nagel & H. Jaeger,Nature 406, 385-388 (2000)

FRONTlab: the frontal systems, functions and dysfunctions

Domaine de recherche principal: 

Cognitive neurosciences / neuropsychology /neuroeconomy

Mots clefs: 

cognition
behavior
executive functions
neuroimaging
Prefrontal cortex

Labelisation ENP: 

2016

Centre de recherche / Institut: 

Institut du Cerveau et de la Moelle épinière

Code unité de recherche: 

UMRS 1127 UMR 7225

The prefrontal cortex (PFC) is a major challenge in Neurosciences. This brain region controls behavior adaptation and highercognitive functions that are needed for complex social interaction, abstract thinking, reasoning, planning or creativity.

Leader

Leader: 

Personnel

Membres de l'équipe: 

Bruno DUBOIS Chef d'équipe
Antoni VALERO-CABRE
Benedicte BATRANCOURT
Emmanuelle VOLLE
Harald HAMPEL
Raffaella Lara MIGLIACCIO
Marc TEICHMAN
Michel THIEBAUT DE SCHOTTEN
Établissements

Établissement de rattachement: 

Inserm

Établissements affiliés: 

CNRS
UPMC
Publications

publications: 

Azuar C, Reyes P, Slachevsky A, Volle E, Kinkingnehun S, Kouneiher F, Bravo E, Dubois B, Koechlin E, Levy R. Testing the model of caudo-rostral organization of cognitive control in the human with frontal lesions. Neuroimage. 2014 Jan 1;84:1053-60. doi: 10.1016/j.neuroimage.2013.09.031.

Aichelburg C, Urbanski M, Thiebaut de Schotten M, Humbert F, Levy R, Volle E. Morphometry of Left Frontal and Temporal Poles Predicts Analogical Reasoning Abilities. Cereb Cortex. 2014 Oct 19. pii: bhu254. 

Lagarde J, Valabrègue R, Corvol JC, Garcin B, Volle E, Le Ber I, Vidailhet M, Dubois B, Levy R. Why do patients with neurodegenerative frontal syndrome fail to answer: ‘In what way are an orange and a banana alike?’. Brain. 2015 Feb;138(Pt 2):456-71. doi: 10.1093/brain/awu359. 

Gil Gonen-Yaacovi Leonardo Cruz de Souza Richard Levy Marika Urbanski Goulven Josse Emmanuelle Volle. Rostral and caudal prefrontal contribution to creativity: A meta-analysis of functional imaging data. Front. Hum. Neurosci. Published on 14 Aug 2013, doi:10.3389/fnhum.2013.00465. 

Thiebaut de Schotten M., Dell’Acqua F., Forkel S.J., Simmons A., Vergani F., Murphy D.G.M., Catani M. (2011) A lateralized brain network for visuospatial attentionNat Neurosci 14:1245-1246.(IF 14.191).

Cerveau et conscience

Domaine de recherche principal: 

Cognitive neurosciences / neuropsychology /neuroeconomy

Mots clefs: 

consciousness
perception
neuroimaging
Psychophysics
Brain function

Labelisation ENP: 

2014

Centre de recherche / Institut: 

ENS Ecole Normale Supérieure

Code unité de recherche: 

UMR 8554

Our team is composed of cognitive scientists working on the neurobiological and psychological foundations of consciousness. We are especially interested in how conscious and unconscious processes differ at both the psychological and neural level. We use various behavioral methods (e.g., priming, psychophysics) and brain imaging techniques (e.g., fMRI, EEG) to study how humans process things unconsciously (e.g., as in situations of subliminal perception, sleep or hypnosis) and compare it to situations of conscious processing.

Leader

Leader: 

Établissements

Établissement de rattachement: 

ENS

Établissements affiliés: 

CNRS
EHESS

Université: 

Université Paris Descartes - Université Pierre et Marie Curie

École doctorale: 

ED158 ED 474
Laboratory

Nom: 

Laboratoire de Sciences Cognitives et Psycholinguistique

Initiatives d'Excellence: 

Institut d'Etudes Cognitives
Publications

publications: 

Goupil L, Romand-Monnier M, Kouider S. Infants ask for help when they know they don't know. Proc Natl Acad Sci U S A. 2016 Mar 29;113(13):3492-6. doi: 10.1073/pnas.1515129113. Epub 2016 Mar 7.

#Bastian, M., #Sackur, J. (2013). Mind-Wandering at the fingertips: automatic parsing of subjective states based on response time variability. Frontiers in Psychology, 4, 1 -- 11.

#Kouider, S., Stahlhut, C., Gelskov, S., #Barbosa, L, de Gardelle, V., Dutat, M., Dehaene, S., & Dehaene-Lambertz, G. (2013).A neural marker of perceptual consciousness in infants. Science, 50(14), 3736?3744.

#Sackur, J.(2013). Two dimensions of visibility revealed by multidimensional scaling of metacontrast, Cognition, (in press).

Faivre, N., Charron, S., Roux, P., Lehericy, S., & #Kouider, S. (2012). Nonconscious Emotional Processing Involves Distinct Neural Pathways for Pictures and Videos. Neuropsychologia, 50(14), 3736?3744.

Faivre, N., Berthet, V. & #Kouider, S. (2012). Nonconscious influences from emotional faces: a comparison of visual crowding, masking, and continuous flash suppression. Frontiers in Consciousness Research, 3, 1?13.

Social Cognition Group

Domaine de recherche principal: 

Cognitive neurosciences / neuropsychology /neuroeconomy

Mots clefs: 

social cognition
neuroimaging
Social Behaviour
Affective processes
Non verbal Communication

Labelisation ENP: 

2014

Centre de recherche / Institut: 

ENS Ecole Normale Supérieure

Code unité de recherche: 

U960

Our primary interest is to study the neural time course and correlates underpinning the processing of the early stages of social interactions. We have now set out to address several key issues important to our understanding of the processing of social interactions, for example (i) what is the biological function of spontaneous and involuntary facial reactions when facing emotional events; (ii) how and when do we perceive / decide that we are the target of a communicative intention (iii) how we (decide to) prepare an adapted motor response.

Leader

Leader: 

Établissements

Établissement de rattachement: 

Inserm

Université: 

Université Pierre et Marie Curie

École doctorale: 

ED158
Laboratory

Nom: 

Laboratoire de Neurosciences Cognitives

Initiatives d'Excellence: 

Paris-Science Lettre (ANR-11-0001-02 PSL), Laboratoire d’excellence : Institut des Sciences Cognitives (IEC) – Ecole Normale (ANR-10-LABX-0087)
Publications

publications: 

Dezecache G, Grèzes J and Dahl C. The nature and distribution of affiliative behaviour during exposure to mild threat. Royal Society Open Science (in press)

Ioannou C., El Zein M., Wyatt V., Scheid I., Amsellem F., Delorme R., Chevallier C. & Grèzes J. Shared mechanism for emotion processing in adolescents with and without autism. Scientific Reports 7:42696 (2017).

El Zein M., Wyart V., Grèzes J.  Anxiety dissociates the adaptive functions of sensory and motor response enhancements to social threats. Elife, 4:e10274 (2015).

Grèzes J., Valabregue R., Gholipour B., Chevallier C.A direct amygdala-motor pathway for emotional displays to influence action: a Diffusion Weighted Imaging study. Human Brain Mapping. 35(12):5974-83 (2014).

Conty L., Dezecache G., Hugueville L., Grèzes J. Early binding of gaze, gesture and emotion: neural time course and correlates. Journal of Neuroscience, 32(13):4531-9 (2012).

Social and Affective Neuroscience Team (SAN)

Domaine de recherche principal: 

Cognitive neurosciences / neuropsychology /neuroeconomy

Mots clefs: 

Affective processes
social processes
neuroimaging
Depressive disorders
Self Processing
Emotional Vision
Social contact

Labelisation ENP: 

2014

Centre de recherche / Institut: 

Institut du Cerveau et de la Moelle épinière

Code unité de recherche: 

UMRS 1127 UMR 7225

The SAN team gathers together three PIs with complementary expertise in affective neuroscience, social neuroscience, and psychiatry. Our project focuses on the functional neuroanatomy of the emotional brain. We study the brain systems of emotion detection, evaluation, and regulation, with an emphasis on how social processes (eg social inclusion) activate and regulate the emotional brain. Dysfunction of the emotional brain is central to many mental disorders and in particular to major depressive disorder (MDD).

Leader

Leader: 

Personnel

Membres de l'équipe: 

MILLET Bruno
Établissements

Établissement de rattachement: 

Inserm

Établissements affiliés: 

CNRS
Université Pierre et Marie Curie

Université: 

Université Pierre et Marie Curie

École doctorale: 

ED 158
Laboratory

Initiatives d'Excellence: 

Institute for Translational Neuroscience (IHU-A-ICM), Paris
Publications

publications: 

Mauras, T., Masson, M., Fossati, P*., & Pessiglione, M*. (2016). Incentive Sensitivity as a Behavioral Marker of Clinical Remission From Major Depressive Episode. Journal of Clinical Psychiatry, 77(6), E697-+. * equal contribution

Rotge, J. Y., Poitou, C., Fossati, P., Aron-Wisnewsky, J., & Oppert, J. M. (2017). Decision-making in obesity without eating disorders: a systematic review and meta-analysis of Iowa gambling task performances. Obes Rev.

Resibois, M., Verduyn, P., Delaveau, P., Rotge, J. Y., Kuppens, P., Van Mechelen, I., & Fossati, P. (2017). The neural basis of emotions varies over time: Different regions go with onset- and offset-bound processes underlying emotion intensity. Soc Cogn Affect Neurosci. doi: 10.1093/scan/nsx051. [Epub ahead of print]

Delaveau, P., Arruda Sanchez, T., Steffen, R., Deschet, K., Jabourian, M., Perlbarg, V., Gasparetto, E. L., Dubal, S., Costa, E. S. J., & Fossati, P. (2017). Default mode and task-positive networks connectivity during the N-Back task in remitted depressed patients with or without emotional residual symptoms. Hum Brain Mapp.

Burra, N., Baker, S., & George, N. (2017). Processing of gaze direction within the N170 / M170 time window: A combined EEG / MEG study. Neuropsychologia.

 

Motivation, Cerveau & Comportement

Domaine de recherche principal: 

Cognitive neurosciences / neuropsychology /neuroeconomy

Mots clefs: 

decision-making
computational modeling
Neuropsychology
neuroimaging
elecrophysiology

Labelisation ENP: 

2007

Centre de recherche / Institut: 

Institut du Cerveau et de la Moelle épinière

Code unité de recherche: 

UMRS 1127 UMR 7225

Why do we do what we do? We are largely unaware of our own motives. Our team seeks to understand how motivation works, in both the normal and pathological brain. We define motivation as a set of processes that assign values to potential situations so as to drive behavior.

Our research is closely related to the emerging field of neuroeconomics, which is focused on understanding value-based decision-making and on explaining deviations to rationality. We wish to build a comprehensive account of motivational processes, investigating

Leader

Leader: 

Co leader: 

Personnel

Etudiants ENP: 

Établissements

Établissement de rattachement: 

Inserm

Établissements affiliés: 

CNRS
Université Pierre et Marie Curie

Université: 

Université Pierre et Marie Curie

École doctorale: 

ED158
Laboratory

Initiatives d'Excellence: 

Labex BioPsy
Publications

publications: 

Blain B, Hollard G, Pessiglione M. Incentive Sensitivity as a Behavioral Marker of Clinical Remission From Major Depressive Episode. J Clin Psychiatry. 2016 Jun;77(6):e697-703. doi: 10.4088/JCP.15m09995.

Automatic integration of confidence in the brain valuation signal. Lebreton M, Abitbol R, Daunizeau J, Pessiglione M. Nat Neurosci. 2015 Aug;18(8):1159-67. 

Skvortsova V, Palminteri S, Pessiglione M. Learning to minimize efforts versus maximizing rewards: computational principles and neural correlates. J Neurosci. 2014 Nov 19;34(47):15621-30. doi: 10.1523/JNEUROSCI.1350-14.2014.

Lebreton M, Bertoux M, Boutet C, Lehericy S, Dubois B, Fossati P, Pessiglione M. A critical role for the hippocampus in the valuation of imagined outcomes. PLoS Biol. 2013 Oct;11(10):e1001684. doi: 10.1371/journal.pbio.1001684. Epub 2013 Oct 22.

Similar improvement of reward and punishment learning by serotonin reuptake inhibitors in obsessive-compulsive disorder. Palminteri S, Clair AH, Mallet L, Pessiglione M.  Biological Psychiatry (2012).

Neural mechanisms underlying motivation of mental versus physical effort. 
Schmidt L, Lebreton M, Cléry-Melin ML, Daunizeau J, Pessiglione M
PLoS Biol. 2012 Feb;10(2):e1001266.

Complementary neural correlates of motivation in dopaminergic and noradrenergic neurons of monkeys, S. Bouret, S. Ravel, et B. J. Richmond, Frontiers in Behavioral Neuroscience, vol. 6, 201

Intersection of reward and memory in monkey rhinal cortex. Clark AM, Bouret S, Young AM, Richmond BJ.J Neurosci. 2012 May 16;32(20):6869-77