ganglions de la base

CONTRÔLE MOTEUR NORMAL ET ANORMAL: DÉSORDRES MOTEURS ET THÉRAPEUTIQUES EXPÉRIMENTALES: MOV’IT

Domaine de recherche principal: 

Neurophysiology / systems neuroscience

Mots clefs: 

Parkinson
syndrome Gilles de la Tourette
dystonie
thérapeutique
ganglions de la base

Labelisation ENP: 

2007

Centre de recherche / Institut: 

Institut du Cerveau et de la Moelle épinière

Code unité de recherche: 

UMRS 1127 UMR 7225

Our main research topic is the physiological analysis of both subcortical and cortical brain structures involved in the control of normal and abnormal movements. Dystonia, Gilles de la Tourette syndrome (GTS) and Parkinson’s disease (PD) will be taken as models of basal ganglia dysfunction. The implication of basal ganglia in movement disorders will be analysed by a multimodal approaches in relation with basic science groups and access to platforms (CENIR-imaging; neurophysiology laboratory, functional neurosurgery team and sleep lab).

Leader

Leader: 

Co leader: 

Établissements

Établissement de rattachement: 

Inserm

Établissements affiliés: 

CNRS
Université Pierre et Marie Curie

Université: 

Université Pierre et Marie Curie

École doctorale: 

ED158
Laboratory

Initiatives d'Excellence: 

IHU A-ICM, Institut Carnot ICM Hôpital Pitié Salpêtrière
Publications

publications: 

Welter ML, Grabli D, Karachi C, Jodoin N, Fernandez-Vidal S, Brun Y, Navarro S, Rogers A, Cornu P, Pidoux B, Yelnik J, Roze E, Bardinet E, Vidailhet M. Pallidal activity in myoclonus dystonia correlates with motor signs. Mov Disord. 2015 Apr 16. doi: 10.1002/mds.26244. 

Nalls MA, et al. Large-scale meta-analysis of genome-wide association data identifies six new risk loci for Parkinson's disease. Nat Genet. 2014 Sep;46(9):989-93. doi: 10.1038/ng.3043. Epub 2014 Jul 27.

García-Lorenzo D, Longo-Dos Santos C, Ewenczyk C, Leu-Semenescu S, Gallea C, Quattrocchi G, Pita Lobo P, Poupon C, Benali H, Arnulf I, Vidailhet M, Lehericy S. (2013) The coeruleus/subcoeruleus complex in rapid eye movement sleep behaviour disorders inParkinson's disease. Brain. 136:2120-9

Nelson M, Bosch C, Venance L, Pouget P. (2013) Microscale inhomogeneity of brain tissue distorts electrical signal propagation. J.Neuroscience 33:2821-7. (IF=7.12)

Corvol JC, Bonnet C, Charbonnier-Beaupel F, Bonnet AM , Roze E, Melyksekian G, Ben Djebara M, Hartmann A, Lacomblez L, Vrignaud C, Zahr N, Agid Y, Costentin J, Hulot JB, Vidailhet M. The non synonymous Val258Met polymorphism in COMT gene impacts entacapone response to L-DOPA in Parkinson’s disease: a randomized cross-over clinical trial. Ann Neurol. 2011;;69:111-8. (IF=10.74)

Lehéricy S, Hartmann A, Lannuzel A, Galanaud D, Delmaire C, Bienaimée MJ, Jodoin N, Roze E, Gaymard B, Vidailhet M. Magnetic resonance imaging lesion pattern in Guadeloupean parkinsonism is distinct from progressive supranuclear palsy Source: Brain. 2010 Mar;133: 2410-2425    (IF=9.5)

 Vidailhet M, Yelnik J, Lagrange C, Fraix V, Grabli D, Thobois S, Burbaud P, Welter ML, Xie-Brustolin J, Braga MC, Ardouin C, Czernecki V, Klinger H, Chabardes S, Seigneuret E, Mertens P, Cuny E, Navarro S, Cornu P, Benabid AL, Lebas JF, Dormont D, Hermier M, Dujardin K, Blond S, Krystkowiak P, Destée A, Bardinet E, Agid Y, Krack P, Broussolle E, Pollak P; for the French SPIDY-2 Study Group Bilateral pallidal deep brain stimulation for the treatment of patients with dystonia-choreoathetosis cerebral palsy: a prospective pilot study Lancet Neurol 8 (8): 709-17, 2009. (IF=18.12)