electrophysiology

Synapses gabaergiques du cervelet

Domaine de recherche principal: 

Neuropharmacology / cell signaling

Mots clefs: 

Patch clamp
imagerie cellulaire
electrophysiologie

Labelisation ENP: 

2007

Centre de recherche / Institut: 

INCC - UMR 8002 - Paris Descartes University

Code unité de recherche: 

UMR 8118

L’équipe pratique une approche pluridisciplinaire incorporant des techniques physiques (optique), mathématiques (statistiques, modélisation) et chimiques (synthèse de composés). Elle développe des méthodes nouvelles pour étudier les mécanismes de communication cellulaire dans le tissu cérébral.

Leader

Leader: 

Personnel

Membres de l'équipe: 

David Ogden
Isabel Llano
Établissements

Établissement de rattachement: 

CNRS

Établissements affiliés: 

Université Paris Descartes

Université: 

Université Paris Descartes / Université Paris Diderot
Laboratory

Nom: 

Laboratoire de physiologie cérébrale
Publications

publications: 

Miki T, Malagon G, Pulido C, Llano I, Neher E, Marty A. Actin- and Myosin-Dependent Vesicle Loading of Presynaptic Docking Sites Prior to Exocytosis. Neuron. 2016 Aug 17;91(4):808-23. doi: 10.1016/j.neuron.2016.07.033.

Pulido C, Trigo FF, Llano I, Marty A. Vesicular release statistics and unitary postsynaptic current at single GABAergic synapses. Neuron. 2015 Jan 7;85(1):159-72. doi: 10.1016/j.neuron.2014.12.006. Epub 2014 Dec 24.

Alcami P, Marty A. Estimating functional connectivity in an electrically coupled interneuron network. Proc Natl Acad Sci U S A. 2013 Dec 3;110(49):E4798-807. doi: 10.1073/pnas.1310983110. Epub 2013 Nov 18.

Lamotte d'Incamps B, Krejci E, Ascher P (2012) Mechanisms shaping the slow nicotinic synaptic current at the motoneuron-renshaw cell synapse. J. Neurosci 32:8413-8423

Mejia-Gervacio, S. V. (2012). Muscarinic control of AMPA receptor responsiveness in mouse spinal cord motoneurons. J. Physiol. in press.

Palma-Cerda F, Auger C, Crawford DJ, Hodgson ACC, Reynolds SJ, Cowell JK, Swift KAD, Cais O, Vyklicky L, Corrie JET, Ogden D (2012) New caged neurotransmitter analogs selective for glutamate receptor sub-types based on methoxynitroindoline and nitrophenylethoxycarbonyl caging groups. Neuropharmacology 63:624-634

Pessac B, Nimmagadda VK, Makar T, Fishman PS, Bever CT, Trisler D (2012) Adult hematopoietic progenitors are multipotent in chimeric mice. C. R. Biol 335:454-462

Rossi B, Ogden D, Llano I, Tan YP, Marty A, Collin T (2012) Current and Calcium Responses to Local Activation of Axonal NMDA  Receptors in Developing Cerebellar Molecular Layer Interneurons. PLoS One 7 7(6): e39983



Genetics and physiopathology of epilepsy

Domaine de recherche principal: 

Neurogenetics / neurodevelopment

Mots clefs: 

Epilepsie
Physiopathologie
electrophysiology

Labelisation ENP: 

2009

Centre de recherche / Institut: 

Institut du Cerveau et de la Moelle épinière

Code unité de recherche: 

UMRS 1127 UMR 7225

Notre équipe s’intéresse aux aspects génétiques et physiopathologiques des épilepsies familiales. Notre objectif est d’élucider les bases moléculaires de certaines formes d’épilepsie et de clarifier les mécanismes pathogéniques sous-jacents grâce à l’étude de modèles cellulaires et animaux. Les formes familiales d’épilepsies constituent des modèles pertinents pour les formes communes d’épilepsie en identifiant des protéines clefs impliquées dans l’épileptogénèse et l’ictogénèse.

Leader

Leader: 

Co leader: 

Personnel

Membres de l'équipe: 

Elise Marsan
Christel Depienne
Virginie Lambrecq
Eric Noé
Théo Ribierre
GIuseppe Muraca
Manon Quiquand
Établissements

Établissement de rattachement: 

Inserm

Établissements affiliés: 

CNRS
Université Pierre et Marie Curie

École doctorale: 

ED3C - n°158
Laboratory

Initiatives d'Excellence: 

IHU-A-ICM; ERC Consolidator Grant
Publications

publications: 

Boillot M, Lee CY, Allene C, Leguern E, Baulac S*, Rouach N* (2016). LGI1 acts presynaptically to regulate excitatory synaptic transmission during early postnatal development. Scientific Reports. Feb 16;6:21769. *co-last

Marsan E, Ishida S, Schramm A, Weckhuysen S, Muraca G, Lecas S, Liang N, Treins C, Pende M, Roussel D, Le Van Quyen M, Mashimo T, Kaneko T, Yamamoto T, Sakuma T, Mahon S, Miles R, Leguern E, Charpier S, Baulac S. (2016) Depdc5 knockout rat: A novel model of mTORopathy. Neurobiol Dis 89:180-189.

Weckhuysen S, Marsan E, Lambrecq V, Marchal C, Morin-Brureau M, An-Gourfinkel I, Baulac M, Fohlen M, Kallay Zetchi C, Seeck M, de la Grange P, Dermaut B, Meurs A, Thomas P, Chassoux F, Leguern E, Picard F, Baulac S. (2016) Involvement of GATOR complex genes in familial focal epilepsies and focal cortical dysplasia. Epilepsia 57:994-1003. Article awarded the 2017 Clinical Epilepsia Prize.

Baulac S, Ishida S, Marsan E, Miquel C, Biraben A, Nguyen DK, Nordli D, Cossette P, Nguyen S, Lambrecq V, Vlaicu M, Daniau M, Bielle F, Andermann E, Andermann F, Leguern E, Chassoux F, Picard F (2015). Familial focal epilepsy with focal cortical dysplasia due to DEPDC5 mutations. Ann Neurol. Apr;77(4):675-83. Article highlighted as Best Advances of 2015: Picks from the Neurology Today Editorial Advisory Board

Ishida S, Picard F, Rudolf G, Noé E, Achaz G, Thomas P, Genton P, Mundwiller E, Wolff M, Marescaux C, Miles R, Baulac M, Hirsch E, Leguern E and Baulac S (2013). Mutations of DEPDC5 cause autosomal dominant focal epilepsies. Nature Genetics, Apr 26;45(5):552-5. Highlighted in Nature Review Neurology 

Génétique et physiologie de l'audition

Domaine de recherche principal: 

Neurogenetics / neurodevelopment

Mots clefs: 

human genetics
electrophysiology
Biophysics
Biochemistry
Hearing molecular physiology
Sensorineural deafness
Retinal defects (Usher syndrome)
Cell biology

Labelisation ENP: 

2007

Centre de recherche / Institut: 

Institut Pasteur

Code unité de recherche: 

UMRS 1120

Nos projets de recherche ont deux buts liés étroitement :

Leader

Leader: 

Établissements

Établissement de rattachement: 

Inserm

Établissements affiliés: 

Collège de France

Université: 

Université Pierre et Marie Curie
Laboratory

Initiatives d'Excellence: 

Labex Lifesenses
Publications

publications: 

Delmaghani S, Aghaie A, Bouyacoub Y, El Hachmi H, Bonnet C, Riahi Z, Chardenoux S, Perfettini I, Hardelin JP, Houmeida A, Herbomel P, Petit C. J Cell Biol. 2016 Jan 18;212(2):231-44. doi: 10.1083/jcb.201509017. Epub 2016 Jan 11.

Michalski N, Petit C. Genetics of auditory mechano-electrical transduction. Pflugers Arch. 2015 Jan;467(1):49-72. doi: 10.1007/s00424-014-1552-9. Epub 2014 Jun 25.

Michalski N, Petit C. Genetics of auditory mechano-electrical transduction. Pflugers Arch. 2015 Jan;467(1):49-72. doi: 10.1007/s00424-014-1552-9. Epub 2014 Jun 25.

Kamiya K, Michel V, Giraudet F, Riederer B, Foucher I, Papal S, Perfettini I, Le Gal S, Verpy E, Xia W, Seidler U, Georgescu MM, Avan P, El-Amraoui A, Petit C. An unusually powerful mode of low-frequency sound interference due to defective hair bundles of the auditory outer hair cells. Proc Natl Acad Sci U S A. 2014 Jun 24;111(25):9307-12. doi: 10.1073/pnas.1405322111. Epub 2014 Jun 11.

Avan P, Büki B, Petit C (2013) Auditory distortions: origins and functions. Physiol Rev 93, 1563?1619.

Bonnet C, ? Petit C, Marlin S (2013) Biallelic nonsense mutations in the otogelin-like gene (OTOGL) in a child affected by mild to moderate hearing impairment. Gene 527, 537-40.

Boulay A-C, ? Petit C, Avan P, Cohen-Salmon M (2013) Hearing is normal without connexin30. J Neurosci 33, 430-34.

El-Amraoui A, Petit C (2013) Cadherin defects in inherited human diseases. Progr Mol Biol Transl Sci, Conn PM (ed.), Elsevier 116, 361-84.

Greenspan R, Petit C (2013) Neurogenetics. Curr Opin Neurobiol. 23, 1-2.

Lepelletier L, ? Petit C (2013) Auditory hair cell centrioles undergo confined brownian motion throughout the developmental migration of the kinocilium. Biophys J 105, 48-58.

Réseau Cortical et Couplage Neurovasculaire

Domaine de recherche principal: 

Neurophysiology / systems neuroscience

Mots clefs: 

cerebral cortex
electrophysiology
Optogenetics
neuronal circuits
blood perfusion and metabolism

Labelisation ENP: 

2007

Code unité de recherche: 

U1130 UMR8246 UMCR18

The team “Cortical network and Neurovascular Coupling” studies neuronal circuits and their relationships with the glio-vascular network in the cerebral cortex. Our previous work has advanced our knowledge of neocortical neuronal types, of their sensitivity to afferent signals, of their places in the functional architecture of intracortical peptidergic transmission, and of their differential roles in neurovascular coupling.

Établissements

Établissement de rattachement: 

Inserm

Établissements affiliés: 

CNRS
Université Pierre et Marie Curie

Université: 

Université Pierre et Marie Curie

École doctorale: 

ED158
Laboratory

Nom: 

Neuroscience Paris Seine

Initiatives d'Excellence: 

IHU Institut de Neurosciences Translationnelles de Paris
Publications

publications: 

Lecrux C, Toussay X, Kocharyan A, Fernandes P, Neupane S, Lévesque M, Plaisier F, Shmuel A, Cauli B, Hamel E. Pyramidal neurons are "neurogenic hubs" in the neurovascular coupling response to whisker stimulation. J Neurosci. 2011 Jul 6;31(27):9836-47.

Hu E, Demmou L, Cauli B, Gallopin T, Geoffroy H, Harris-Warrick RM, Paupardin-Tritsch D, Lambolez B, Vincent P, Hepp R. VIP, CRF, and PACAP act at distinct receptors to elicit different cAMP/PKA dynamics in the neocortex. Cereb  Cortex. 2011 Mar;21(3):708-18.

Tricoire L, Pelkey KA, Daw MI, Sousa VH, Miyoshi G, Jeffries B, Cauli B, Fishell G, McBain CJ. Common origins of hippocampal Ivy and nitric oxide synthase expressing neurogliaform cells. J Neurosci. 2010 Feb 10;30(6):2165-76.

Karagiannis A, Gallopin T, Dávid C, Battaglia D, Geoffroy H, Rossier J, Hillman EM, Staiger JF, Cauli B. Classification of NPY-expressing neocortical interneurons. J Neurosci. 2009 Mar 18;29(11):3642-59.

Petilla Interneuron Nomenclature Group, Ascoli GA, Alonso-Nanclares L, Anderson SA, Barrionuevo G, Benavides-Piccione R, Burkhalter A, Buzsáki G, Cauli  B, Defelipe J, Fairén A, Feldmeyer D, Fishell G, Fregnac Y, Freund TF, Gardner D, Gardner EP, Goldberg JH, Helmstaedter M, Hestrin S, Karube F, Kisvárday ZF, Lambolez B, Lewis DA, Marin O, Markram H, Muñoz A, Packer A, Petersen CC, Rockland KS, Rossier J, Rudy B, Somogyi P, Staiger JF, Tamas G, Thomson AM, Toledo-Rodriguez M, Wang Y, West DC, Yuste R. Petilla terminology: nomenclature of features of GABAergic interneurons of the cerebral cortex. Nat Rev Neurosci. 2008 Jul;9(7):557-68.

Cognisciences: Intégration et plasticité synaptique dans le cortex visuel

Domaine de recherche principal: 

Neurophysiology / systems neuroscience

Mots clefs: 

Vision
electrophysiology
imaging
Multiscale
Modeling

Labelisation ENP: 

2007

Centre de recherche / Institut: 

Unité de Neuroscience, Information et Complexité

Code unité de recherche: 

UPR 3293

An issue central to the theme of complexity in the dynamics and function of biological networks concerns the inferences that can be made from multiscale measurements ranging from microscopic to macroscopic levels of integration. Our research is based on interdisciplinary approaches ranging from electrophysiology (intracellular sharp and patch recordings, in vivo), network imaging (voltage sensitive dye), psychophysical measurements to functional databasing and phenomenological and computational modeling.

Personnel

Etudiants ENP: 

Établissements

Établissement de rattachement: 

CNRS

Établissements affiliés: 

Université Paris Sud

Université: 

Université Pierre et Marie Curie

École doctorale: 

ED158 - 3C
Laboratory

Initiatives d'Excellence: 

Idex i-Code, Idex NeuroSaclay
Publications

publications: 

Gerard-Mercier F, Carelli PV, Pananceau M, Troncoso XG, Frégnac Y. Synaptic Correlates of Low-Level Perception in V1. J Neurosci. 2016 Apr 6;36(14):3925-42. doi: 10.1523/JNEUROSCI.4492-15.2016.

Fournier J, Monier C, Levy M, Marre O, Sári K, Kisvárday ZF, Frégnac Y. Hidden complexity of synaptic receptive fields in cat V1. J Neurosci. 2014 Apr 16;34(16):5515-28. doi: 10.1523/JNEUROSCI.0474-13.2014.

Arduin P.J. , Ego-Stengel V. , Frégnac Y. and Shulz D.E. (2013) Master neurons induced by operant conditioning in rat motor cortex during a brain-machine interface task. The Journal of Neuroscience. 33(19): 8308-20.

Levy M. , Fournier J. and Frégnac Y. (2013) The role of delayed suppression in slow and fast contrast adaptation in v1 simple cells. The Journal of Neuroscience. 33(15):6388-400.

El Boustani S. , Yger P. , Destexhe A. and Frégnac Y. (2012) A. Stable learning in stochastic network states. J. Neurosci. 32: 194-214.

Frégnac Y. (2012) Reading out the synaptic echoes of low level perception in V1. Lecture Notes in Computer Science. 7583: 486-495.

Chavane F. , Sharon D. , Jancke D. , Marre O. , Frégnac Y. and Grinvald A. (2011) Lateral spread of orientation selectivity in V1 is controlled by intracortical cooperativity. Frontiers in System Neuroscience, 5:4. 1-26.

Visual Cognition Group

Domaine de recherche principal: 

Cognitive neurosciences / neuropsychology /neuroeconomy

Mots clefs: 

electrophysiology
consciousness
human visual system
attention
brain-body interactions

Labelisation ENP: 

2007

Centre de recherche / Institut: 

ENS Ecole Normale Supérieure

Code unité de recherche: 

U960

The articulation between cognition and consciousness

We use MEG and behavior to understand how the neural processes performing perceptual (ie, figure/ground) or cognitive (ie, attentional selection) are articulated with those giving rise to visual subjective experience.

How brain-body loops may participate to the emergence of consciousness

Leader

Leader: 

Personnel

Etudiants ENP: 

Établissements

Établissement de rattachement: 

Ecole Normale Supérieure

Établissements affiliés: 

Inserm

Université: 

Université Pierre et Marie Curie

École doctorale: 

ED158
Laboratory

Nom: 

Laboratoire de Neurosciences Cognitives

Initiatives d'Excellence: 

Institut d'Etudes Cognitives
Publications

publications: 

Park HD, Tallon-Baudry C. The neural subjective frame: from bodily signals to perceptual consciousness. Philos Trans R Soc Lond B Biol Sci. 2014 Mar 17;369(1641):20130208. doi: 10.1098/rstb.2013.0208. Print 2014 May 5.

Sergent C., Wyart V., Babo-Rebelo M., Naccache L., Cohen L., Tallon-Baudry C. (2013) Cueing attention after the stimulus is gone can retrospectively trigger conscious perception. Current Biology 23, 150-155.

Rastelli, F., Tallon-Baudry, C., Migliaccio, R., Toba, M.N., Ducorps, A., Pradat-Diehl, P., Duret, C., Dubois, B., Valero-Cabre, A., and Bartolomeo, P. (2013) Neural dynamics of neglected targets in patients with right hemisphere damage, Cortex, 49(7), 1989-1996.

Campana, F. and Tallon-Baudry, C. (2013) Anchoring visual subjective experience in a neural model: The coarse vividness hypothesis. Neuropsychologia, 51(6), 1050-1060.

Chanes, L., Quentin, R., Tallon-Baudry, C., and Valero-Cabre, R. (2013) Causal frequency-specific contributions of frontal spatiotemporal patterns induced by non-invasive neurostimulation to human visual performance (2013), Journal of Neuroscience, 33, 5000-5005.

Gamond L, Tallon-Baudry C, Guyon N, Lemaréchal JD, Hugueville L, George N. (2012) Behavioral evidence for differences in social and non-social category learning. Frontiers in Psychology 3:291.