Cerebellum

Transmission inhibitrice dans le cerveau

Domaine de recherche principal: 

Neurophysiology / systems neuroscience

Mots clefs: 

Inhibitory transmission
Multiphoton imaging
Glycine
Vesicular loading
Optogenetics
Cerebellum

Labelisation ENP: 

2012

Centre de recherche / Institut: 

ENS Ecole Normale Supérieure

Code unité de recherche: 

U1024 - UMR8197

. La transmission synaptique inhibitrice joue un rôle central dans le fonctionnement du cerveau. Preuve en est que le blocage de l’inhibition engendre des situations pathologiques comme l’épilepsie et l’hyperekplexie, une affection rare caractérisée par des sursauts exagérés en réponse à des stimuli auditifs, visuels ou tactiles. A l’inverse, une potentialisation de l’inhibition provoque des états modifiés du cerveau comme ceux résultant de l’action de psychotropes, anxiolytiques, somnifères ou encore analgésiques.

Leader

Leader: 

Personnel

Membres de l'équipe: 

MARCAGGI Païkan
Établissements

Établissement de rattachement: 

Ecole Normale Supérieure

Établissements affiliés: 

Inserm
CNRS

Université: 

Université Pierre et Marie Curie

École doctorale: 

ED158
Laboratory

Nom: 

Institut de Biologie de l'ENS IBENS

Initiatives d'Excellence: 

Labex Memolife, IDEX PSL*, NIH Brain Initiative Grant
Publications

publications: 



Zampini V, Liu JK, Diana MA, Maldonado PP, Brunel N, Dieudonné S. (2016) Mechanisms and functional roles of glutamatergic synapse diversity in a cerebellar circuit. Elife. 2016 Sep 19;5. pii: e15872. doi: 10.7554/eLife.15872.

Akemann W, Léger JF, Ventalon C, Mathieu B, Dieudonné S, Bourdieu L. (2015) Fast spatial beam shaping by acousto-optic diffraction for 3D non-linear microscopy. Opt Express. 23: 28191-205.

Giber K, Diana MA*, M Plattner V*, Dugué GP, Bokor H, Rousseau CV, Maglóczky Z, Havas L, Hangya B, Wildner H, Zeilhofer HU, Dieudonné S§, Acsády L. (2015) A subcortical inhibitory signal for behavioral arrest in the thalamus. Nat Neurosci. 18:562-8.

Ankri L, Husson Z*, Pietrajtis K, Proville R, Léna C, Yarom Y, Dieudonné S§, Yoe Uusisaari M. (2015) A novel inhibitory nucleo-cortical circuit controls cerebellar Golgi cell activity. Elife. 4. doi: 10.7554/eLife.06262.

Otsu Y, Marcaggi P, Feltz A, Isope P, Kollo M, Nusser Z, Mathieu B, Kano M, Tsujita M, Sakimura K, Dieudonné S§. (2014) Activity-dependent gating of calcium spikes by A-type K+ channels controls climbing fiber signaling in Purkinje cell dendrites. Neuron. 84 : 137-51.

Cerebellum, Navigation and Memory

Domaine de recherche principal: 

Neurophysiology / systems neuroscience

Mots clefs: 

Learning, Memory, Brain Plasticity, Behaviour, Neuropathology
spatial navigation
Cerebellum
hippocampus

Labelisation ENP: 

2012

Code unité de recherche: 

U1130 UMR8246 UMCR18



Leader

Leader: 

Établissements

Établissement de rattachement: 

UPMC

Établissements affiliés: 

CNRS
Inserm

Université: 

Université Pierre et Marie Curie

École doctorale: 

ED158
Publications

publications: 

Spatio-temporal navigation as behavioral cognitive marker. Bellassen V., Igloi K., de Souza LC., Dubois B., Rondi-Reig L. J. Neuroscience, 32(6):19421952

Cerebellum Shapes Hippocampal Spatial Code. Rochefort C., Arnaud Arabo A., André M., Poucet B.,  Save E. and Rondi-Reig L. Science 2011     334, 385-389 Faculty of 1000: F1000.com/13357388 http://www.newscientist.com/article/dn21075-mouse-manoeuvres-in-the-  dark-reveal-brains-map-links.html 2011.

Early individual detection of age-related memory Neurobiology of Aging, Fouquet C, Petit GH; Auffret, Gaillard, Rovira, Mariani J., Rondi-Reig L. 2011 Oct;32(10):1881-95. 

Role of the Cerebellar Cortex in Conditioned Goal-directed Behavior. Burguière E., Arabo A., Jarlier F. , De Zeeuw C.I, Rondi-Reig L. J. Neuroscience, 30(40):13265-13271, Highlighted by J. Neuroscience editor: http://www.jneurosci.org.gate1.inist.fr/content/30/40/i.full 2010 

Lateralized Human Hippocampal Activity Predicts Navigation Based on Sequence or Place Memory V Igloi K., Doellers C., Berthoz A., Rondi-Reig L.*, Burgess N.* (*co-last authors)  Proc. Natnl. Acad. Sci. (USA) , 107(32):14466-71, 2010

 

Liens vidéos:

http://videotheque.cnrs.fr/index.php?urlaction=doc&id_doc=2914

http://www.rts.ch/emissions/36-9/3981100-quand-la-memoire-se-trouble.html



 



Imagerie dynamique du neurone

Domaine de recherche principal: 

Neuropharmacology / cell signaling

Mots clefs: 

Cerebellum
Synapses
Dendrites
Superresolution Microscospy
Optophysiology

Labelisation ENP: 

2007

Centre de recherche / Institut: 

Institut Pasteur

Code unité de recherche: 

UMR 3571

 Understanding how information is processed within neuronal networks requires knowledge of how neurons use cellular and molecular mechanisms to transform information communicated by synapses. Defects in the communication between synapses are thought to be at the heart of the memory deficits associated with neuropathological disorders such as Alzheimer’s disease and autism.

Leader

Leader: 

Personnel

Membres de l'équipe: 

REBOLA Nelson
MONERON Gael
SAINT-CLOMENT Cecile
TRAN-VAN-MINH Alexandra
NAKAMURA Yukihiro
REPAK Emilienne
BRANDT Maryse
CHABROL François
Établissements

Établissement de rattachement: 

CNRS

Université: 

Université Pierre et Marie Curie

École doctorale: 

ED3C
Laboratory

Nom: 

Genes, Synapses, Cognition
Publications

publications: 

DiGregorio D. Confocal spot detection of presynaptic Ca²⁺ domains. PLoS Biol. 2014 Jul 8;12(7):e1001903. doi: 10.1371/journal.pbio.1001903. eCollection 2014 Jul.

Tran-Van-Minh A, Abrahamsson T, Cathala L, DiGregorio DA. Differential Dendritic Integration of Synaptic Potentials and Calcium in Cerebellar Interneurons. Neuron. 2016 Aug 17;91(4):837-50. doi: 10.1016/j.neuron.2016.07.029.

Fink AE., Bender, KJ., Trussell, LO., Otis, TS. and DiGregorio, DA. Two-photon compatibility and single-voxel, single-trial detection of subthreshold neuronal activity by a two-component optical voltage sensor. PLoS One, in press (2012).

Abrahamsson, T.,  Cathala,  L., Matsui, K., Shigemoto, R., and DiGregorio, DA. Thin dendrites of cerebellar interneurons confer sublinear synaptic integration and a gradient of short-term plasticity. Neuron, 73: 1159-1172 (2012).

DiGregorio DA. 2011. Confocal spot detection of presynaptic Ca2+ domains. In: Imaging in neuroscience: A laboratory manual (ed. Helmchen F, Konnerth A, Yuste R), pp. 141-150. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.

Bradley, J., Luo, R., Otis, T.S. and DiGregorio, D.A., Submillisecond optical reporting of membrane potential in situ using a neuronal tracer dye. Journal of Neuroscience, 29(29):9197–9209 (2009).

Lutz, C, Otis, T, DeSars, V., Charpak S., DiGregorio, D. A., and Emiliani, V. Holographic photolysis of caged neurotransmitters. Nature Methods, 5(9):821-827 (2008).

Dynamique cérébrale, Mémoire et Apprentissage

Domaine de recherche principal: 

Neurophysiology / systems neuroscience

Mots clefs: 

computational neuroscience
Cortex
Cerebellum
basal ganglia
Network mechanism

Labelisation ENP: 

2009

Centre de recherche / Institut: 

INCC - UMR 8002 - Paris Descartes University

Code unité de recherche: 

UMR 8002

Nos recherches portent sur la dynamique du cortex cérébral, du cervelet et des ganglions de la base. Les axes de recherche sont: 1- Etude de la Perception, de la Cognition & du Comportement, 2- Le Dévelopment & la Plasticité, 3- La Neurophysiologie & les Pathologies neuronales.

Leader

Leader: 

Établissements

Établissement de rattachement: 

CNRS

Établissements affiliés: 

Université Paris Descartes

Université: 

Université Pierre et Marie Curie

École doctorale: 

ED158
Laboratory

Nom: 

Centre de Neurophysique, Physiologie et Pathologie
Publications

publications: 

Arakaki T, Mahon S, Charpier S, Leblois A, Hansel D. The Role of Striatal Feedforward Inhibition in the Maintenance of Absence Seizures. J Neurosci. 2016 Sep 14;36(37):9618-32. doi: 10.1523/JNEUROSCI.0208-16.2016.

Arakaki T, Mahon S, Charpier S, Leblois A, Hansel D. The Role of Striatal Feedforward Inhibition in the Maintenance of Absence Seizures. J Neurosci. 2016 Sep 14;36(37):9618-32. doi: 10.1523/JNEUROSCI.0208-16.2016.

Gould M,# Leblois A, Cesa Bianchi F, Montenegro V. (2014) Convention on the rights of persons with disabilities, assistive technology and information and communication technology requirements: where do we stand on implementation? Disabil Rehabil Assist Technol. Nov 3:1-6.

#Mongillo G, Shteingart H, Loewenstein Y. 2014. The Misbehavior of Reinforcement Learning. Proceedings of the IEEE 102, 528–541.

#Ady V, Perroy J, Tricoire L, Piochon C, Dadak S, Chen X, Dusart I, Fagni L, Lambolez B,# Levenes C. 2014. Type 1 metabotropic glutamate receptors (mGlu1) trigger the gating of GluD2 delta  glutamate receptors. EMBO Reports 15(1), 103–109 

#Darshan R, #Leblois A, #Hansel D. 2014. Interference and Shaping in Sensorimotor Adaptations with rewards.PLOS Comput. Biol. 10:e1003377 

Goldin MA, Alonso LM, #Alliende JA, Goller F, Mindlin GB. 2013. Temperature Induced Syllable Breaking Unveils Nonlinearly Interacting Timescales in Birdsong Motor Pathway. PLOS ONE 8(6):e67814