Brain imaging

NEURO-MODULATION (UVSQ)

Domaine de recherche principal: 

Cognitive neurosciences / neuropsychology /neuroeconomy

Mots clefs: 

Brain imaging
consciousness
Neurological disability
Neuromodulation
Translational neuroscience

Labelisation ENP: 

2014

The long-term objective of this project is to apply high field MRI eventually combined with other neuroscience approaches, to develop physical (e.g. electric neurostimulation) and/or chemical (e.g. pharmacological delivery) devices of neuromodulation that target neuronal sites and manipulate specific aspects of cognition, motor behavior or consciousness, leading ultimately to the development of treatments for patients with related diseases (e.g. disorders of consciousness, Parkinson's disease...).

Établissements

Établissement de rattachement: 

Inserm

Université: 

Univ Pierre et Marie Curie

École doctorale: 

ED158
Laboratory

Nom: 

Unicog Cognitive Neuroimaging Unit

Initiatives d'Excellence: 

IDEX Paris-Saclay / NeuroSaclay, IHU Handimedex
Publications

publications: 

-Arsenault J, Nelissen K, Jarraya B#, Vanduffel W. Dopaminergic reward signals selectively decrease fMRI activity in primate visual cortex. Neuron. Mars 2013.

-D. Le Bihan, O. Joly#, T. Aso, L. Uhrig#, C. Poupon, N. Tani#, H. Iwamuro#, S-I. Urayama, B. Jarraya# Brain tissue water comes in two pools: Evidence from diffusion and R2? measurements with USPIOs in non human primates. NeuroImage. 2012 May 11.

-K Nelissen*, B Jarraya* #, J Arsenault, B R. Rosen, L L. Wald, J B. Mandeville, J. J. Marota, W Vanduffel. Neural correlates of formation and retention of cocaine-induced stimulus-reward associations. Biological Psychiatry. 2012 Mar 20. * co-authoring

-L Ciobanu, O Reynaud, L Uhrig#, B Jarraya#, D Le Bihan. Effects of Anesthetic Agents on Brain Blood Oxygenation Level Revealed with Ultra-High Field MRI PlosONE. 2012;7(3):e32645.

- N Tani#, O Joly#, H Iwamuro#, L Uhrig#, C J. Wiggins, C Poupon, H Kolster, W Vanduffei, D Le Bihan, S Palfi#, B Jarraya# Direct visualization of non-human primate subcortical nuclei with contrast-enhanced high field MRI. NeuroImage 2011 Sep 1;58(1):60-8.

- Jarraya B#, Boulet S, Scott Ralph G, Jan C, Bonvento G, Azzouz M, E. Miskin J, Shin M, DelzescauxT, Drouot X, Hérard A.S, M. Day D, Brouillet E, M. Kingsman S, Hantraye P, A. Mitrophanous K, D. Mazarakis N, Palfi S#. Dopamine Gene Therapy for Parkinson?s Disease in a Nonhuman Primate Without Associated Dyskinesia. Science Translational Medicine Vol 1 2009.

Laboratoire de Psychologie du Développement et de l'Éducation de l'enfant (LaPsyDÉ)

Domaine de recherche principal: 

Cognitive neurosciences / neuropsychology /neuroeconomy

Mots clefs: 

Learning
Brain imaging
neurocognitive developpment
executive functions
inhibitory control
education

Labelisation ENP: 

2014

Centre de recherche / Institut: 

Institut de Psychologie Paris Descartes

Code unité de recherche: 

U8240

The LaPsyDÉ is one of the few lab in France conducting basic researches from childhood to adulthood that combine (1) integrated behavioral approaches of cognitive development in different domains (object perception, numerical cognition, categorization, reasoning, decision making and creativity) and (2) multimodal brain imaging (anatomical and functional MRI, high density EEG) of brain development, especially in normal preschoolers and school-age children. Our fundamental researches have also direct applications, in particular in education.

Leader

Leader: 

Personnel

Etudiants ENP: 

Établissements

Établissement de rattachement: 

CNRS

Établissements affiliés: 

Université Paris Descartes
Sorbonne Paris Cité
Université de Caen

Université: 

Université Paris Descartes

École doctorale: 

ED261
Laboratory

Initiatives d'Excellence: 

IDEX Sorbonne Paris Cité
Publications

publications: 

Krakowski CS, Poirel N, Vidal J, Roëll M, Pineau A, Borst G, Houdé O. The forest, the trees, and the leaves: Differences of processing across development. Dev Psychol. 2016 Aug;52(8):1262-72. doi: 10.1037/dev0000138.

Cachia A, Borst G, Vidal J, Fischer C, Pineau A, Mangin JF, Houdé O. The shape of the ACC contributes to cognitive control efficiency in preschoolers. J Cogn Neurosci. 2014 Jan;26(1):96-106. doi: 10.1162/jocn_a_00459. Epub 2013 Aug 5.

Borst G., Pineau A., Poirel N., Cassotti M., & Houdé O. (2013). Inhibitory control efficiency in a Piaget-like class-inclusion task in school-age children and adults: A developmental negative priming study. Developmental Psychology 49, 1366-1374.

De Neys W., Rossi S., & Houdé O. (2013). Bats balls and substitution sensitivity: Cognitive misers are no happy fools. Psychonomic Bulletin & Review 20, 269-273.

Rossi S., Lubin A., Simon G., Lanoë C., Poirel N., Cachia A., Pineau A., & Houdé O. (2013). Structural brain correlates of
executive engagement in working memory: Children's inter individual differences are reflected in the anterior insular cortex. Neuropsychologia 51, 1145-1150.

Cassotti M., Habib M., Poirel N., Aïte A., Houdé O., & Moutier S. (2012). Positive emotional context eliminates the framing effect in decision-making. Emotion 12, 926-931.

Poirel N., Borst G., Simon G., Rossi S., Cassotti M., Pineau A., & Houdé O. (2012). Number conservation is related to children's prefrontal inhibitory control: An fMRI study of a Piagetian task. PLoS ONE 7(7): e40802.

Gènes et Dynamique des Systèmes de Mémoire

Domaine de recherche principal: 

Neurophysiology / systems neuroscience

Mots clefs: 

réseaux neuronaux
apprentissage olfactif
mémoire à long terme
mutants de Drosophile
métabolisme énergétique
Imagerie cérébrale
Maladie d'Alzheimer

Labelisation ENP: 

2012

Centre de recherche / Institut: 

ESPCI Paris Tech -Ecole Supérieure de Physique et de Chimie Industrielles

Code unité de recherche: 

UMR8249

Comment sont encodés les souvenirs dans le cerveau? Comment les différentes formes de mémoire interagissent-elles ? Le principal défi à relever par les neurobiologistes qui étudient la mémoire est de définir les liens entre les différents niveaux d'organisation du cerveau. Les puissants outils de génétique moléculaire disponibles chez la drosophile, combinés aux propriétés de son cerveau hautement organisé, en font un modèle de choix pour une telle analyse intégrée.

Leader

Leader: 

Personnel

Etudiants ENP: 

Membres de l'équipe: 

Valérie Goguel
Pierre-Yves Plaçais
Alice Pavlowsky
Laure Pasquer
Lisa Scheunemann
Eloïse de Tredern
Julia Minatchy
Johann Schor
Olivier Mantha
Établissements

Établissement de rattachement: 

CNRS

Établissements affiliés: 

ESPCI
Laboratory

Nom: 

Laboratoire Plasticité du cerveau

Initiatives d'Excellence: 

Labex MemoLife, Idex PSL, EMBO
Publications

publications: 

Dolan, M.-J., Belliart-Guérin, G., Bates, A.S., Frechter, S. , Lampin-Saint-Amaux, A. , Aso, Y. , Roberts, R.J.V. , Schlegel, P., Wong, A., , Hammad, A. , Bock, D., Rubin, G.M., Preat, T., Plaçais, P.-Y.* and Jefferis, G.S.X.E.* (2018). Communication from learned to innate olfactory processing centers is required for memory retrieval in Drosophila. Neuron, 100: 1-18.

Pavlowsky, A., Schor , J., Plaçais, P.-Y., and Preat, T. (2018). A GABAergic feedback shapes dopaminergic input  on the Drosophila mushroom body  to promote appetitive long-term memory. Curr Biol, 28: 1–11.

Scheunemann, L., Plaçais, P.-Y., Dromard, Y., Schwärzel, M., and Preat, T. (2018). Dunce phosphodiesterase acts as a checkpoint for Drosophila long-term memory in a pair of serotonergic neurons. Neuron, 98:350-365.

Turrel, O., Goguel, V.* and Preat, T.* (2017). Drosophila neprilysin 1 rescues memory deficits caused by amyloid-β peptide. J Neurosci, 37(43):10334-10345.

Plaçais, P.-Y., de Tredern, E., Scheunemann, L., Trannoy, S., Goguel, V., Han, K.-A., Isabel, G., and Preat, T. (2017). Upregulated energy metabolism in the Drosophila mushroom body is the trigger for long-term memory. Nat Commun, 8:15510.

Musso, P.-Y., Tchenio, P.* and Preat, T.* (2015). Delayed dopamine signaling of energy level builds appetitive long-term memory in Drosophila. Cell Rep, 10: 1-9.

Plaçais, P.-Y. and Preat, T. (2013). To favor survival under food shortage, the brain disables costly memory. Science, 339(6118): 440-442.

Plaçais, P.-Y., Trannoy, S., Isabel, G., Aso, Y., Siwanowicz, I., Belliart-Guérin, G., Vernier, P., Birman, S., Tanimoto, H. and Preat, T. (2012). Slow oscillations in two pairs of dopaminergic neurons gate long-term memory formation in Drosophila. Nat Neurosci, 15(4): 592-599.

Séjourné, J., Plaçais, P.-Y., Aso, Y., Siwanowicz, I., Trannoy, S., Vladimiros, T., Tedjakumala, S.R., Rubin, G.M., Tchénio, P., Ito, K., Isabel, G., Tanimoto, H.* and Preat, T.* (2011). Mushroom body efferent neurons responsible for aversive olfactory memory retrieval in Drosophila. Nat Neurosci, 14(7): 903-910.