astrocytes

Junctional communication and neuro-glio-vascular interactions

Domaine de recherche principal: 

Neuropharmacology / cell signaling

Mots clefs: 

astrocytes
cellules gliales

Labelisation ENP: 

2007

Code unité de recherche: 

UMR7241-U1050

L’objet principal de nos recherches concerne l’étude des réseaux astrocytaires constitués entre cellules gliales, en particulier les astrocytes qui expriment un grand nombre de connexines, les constituants moléculaires des jonctions communicantes (gap junctions). Nos projets sont développés dans le cadre des interactions entre neurones et astrocytes ainsi qu’au niveau de l’unité gliovasculaire.

Personnel

Membres de l'équipe: 

Cohen-Salmon Martine
Koulakoff Annette
Établissements

Établissement de rattachement: 

Collège de France

Établissements affiliés: 

CNRS
Inserm

Université: 

Université Pierre et Marie Curie

École doctorale: 

ED158
Laboratory

Nom: 

Center for Interdisciplinary Research in Biology

Initiatives d'Excellence: 

Labex Memolife- PSL
Publications

publications: 

Koulakoff A., Mei X., Orellana J.A., Sáez J.C. & Giaume C. Glial connexin expression and function in the context of Alzheimer's disease. Biochimica Biophysica Acta, 1818:2048-57. (2012)

Ezan P., André P., Cisternino S., Saubaméa B., Boulay A.C., Doutremer S., Thomas M.A., Quenech'du N., Giaume C. & Cohen-Salmon M. Deletion of astroglial connexins weakens the blood-brain barrier. Journal of Cerebral Blood Flow and Metabolism, 32:1457-67.(2012)

Roux L., Benchenane K., Rothstein J.D., Bonvento G. & Giaume C. Plasticity of astroglial networks in olfactory glomeruli. Proceedings of theNational Academy of Sciences (USA),108:18442-6. (2011)

Orellana J.A., Shoji K.F., Abudara V., Ezan P., Amigou E., Sáez P.J., Jiang J.X., Naus C.C., Sáez J.C. & Giaume C. Amyloid β-induced death in neurons involves glial and neuronal hemichannels.Journal of Neuroscience, 31:4962-77.(2011),

Giaume C., Koulakoff A., Roux L., Holcman D. & Rouach N. Astroglial networks: a step further in neuroglial and gliovascular interactions. Nat Rev Neurosci, 11:87-99. (2010)

Groupe Interactions cellules gliales/cellules gliales et cellules gliales/neurones

Domaine de recherche principal: 

Neurophysiology / systems neuroscience

Mots clefs: 

synaptic transmission
plasticity
astrocytes
GPCR signaling
neuron-glia interactions in physiology of the central nervous system
neuron-astrocyte interactions
glia in memory and sleep
glia in psychiatric and neurodegenerative diseases

Labelisation ENP: 

2012

Centre de recherche / Institut: 

INCC - UMR 8002 - Paris Descartes University

Code unité de recherche: 

FR3636

We are interested in understanding the role of glial cells in the mammalian central nervous system (CNS) and the mechanisms by which glial cells and neurons interact to support normal communication in the CNS.

Leader

Leader: 

Établissements

Établissement de rattachement: 

CNRS

Établissements affiliés: 

Université Paris Descartes

Université: 

Université Paris Descartes

École doctorale: 

ED3C
Laboratory

Nom: 

UFR Biomédicale

Initiatives d'Excellence: 

Institut Neuroscience et Cognition
Publications

publications: 

Agulhon C, Sun MY, Murphy T, Myers T, Lauderdale K, Fiacco TA. Calcium signaling and gliotransmission in normal versus reactive astrocytes, Frontiers in Neuropharmacology. In Press.

Agulhon C, Fiacco TA, McCarthy KD , Hippocampal short- and long-term plasticity are not modulated by astrocyte Ca2+ signaling, Science.327:1250-4, 2010.

Fiacco TA, Agulhon C, McCarthy KD. Sorting out astrocyte physiology from pharmacology, Annu Rev Pharmacol Toxicol. 49:151-174 2009.

Agulhon C, Petravicz J, McMullen AB, Sweger EJ, Minton SK, Taves SR, Casper KB, Fiacco TA, McCarthy KD. What is the role of astrocyte calcium in neurophysiology?, Neuron. 59:932-946, 2008.

Fiacco TA, Agulhon C, Taves S, Petravicz J, Casper K, Dong Xinzhong, Chen J, McCarthy KD. Selective stimulation of astrocyte calcium in situ does not affect neuronal excitatory synaptic activity, Neuron. 54:611-626, 2007.