Physiologie et physiopathologie de la moelle épinière

Domaine de recherche principal: 

Neurophysiology / systems neuroscience

Mots clefs: 

electrophysiology in vivo and in vitro
spinal cord circuitry
Renshaw cell

Labelisation ENP: 


Centre de recherche / Institut: 

INCC - UMR 8002 - Paris Descartes University

Code unité de recherche: 


Our team investigates the relationships between spinal motoneurons and the muscle fibers they are targeting, and how thisrelationship is altered in the context of a human degenerative disease of motoneurons (ALS). To do so, we have recently pioneeredtwo new preparations that allow studying the electrophysiological properties of identified spinal motoneurons.




Établissement de rattachement: 


Établissements affiliés: 

Université Paris Descartes

École doctorale: 



Leroy F, Lamotte d'Incamps B, Zytnicki D. Potassium currents dynamically set the recruitment and firing properties of F-type motoneurons in neonatal mice. J Neurophysiol. 2015 Sep;114(3):1963-73. doi: 10.1152/jn.00193.2015. Epub 2015 Aug 12.

Leroy F#, Lamotte d'Incamps B#, Imhoff-Manuel RD#, Zytnicki D#. (2014) Early intrinsic hyperexcitability does not contribute to motoneuron degeneration in amyotrophic lateral sclerosis. Elife Oct14;3. doi: 10.7554/eLife.04046.

Lamotte d’Incamps B#, Ascher P. (2014) High affinity and low affinity heteromeric nicotinic acetylcholine receptors at central synapses. J Physiol. Oct 1;592(Pt 19):4131-6

Delestrée N#, Manuel M#, Iglesias C, Elbasiouny SM, Heckman CJ, Zytnicki D#. (2014) Adult spinal motoneurones are not hyperexcitable in a mouse model of inherited amyotrophic lateral sclerosis. J. Physiol. Apr 1;592(Pt 7):1687-703

Ritter LK, Tresch MC, Heckman CJ, Manuel M#, Tysseling VM. (2014) Characterization of motor units in behaving adult mice shows a wide primary range. J Neurophysiol. Aug 1;112(3):543-51

Manuel M#, Zytnicki D#, Meunier C. (2014) The dendritic location of the L-type current and its deactivation by the somatic AHP current both contribute to firing bistability in motoneurons. Front Comput Neurosci. Jan 27;8:4.