Directeur de recherche
ED 158


The main focus of our research is the plasticity and development of human brain tumorsWe are interested in understanding how interactions between cell intrinsic and extrinsic signaling pathways...

Biographie / Publications

Position (present)
Directeur de Recherche au CNRS, DR1(research scientist)
Praticien Hospitalier Attaché (Neuro-Oncology HospSalpétrière)(neurologist)
Team leader Glial Plasticity
Head Centre de Recherche Neuroscience Paris Seine Cnrs U77xx/Inserm U1130/ Univ Pierre et Marie
Chief Editor Médecine/Sciences
University Training and main topics
MD : 1984 at UPMC, Paris, France, specialized in Neurology : 1988 (CES of neurology). After 2-year in the French governement
(ministry of 1Research, Adviser to the minister for Life sciences, Health, Bioethics and Biotechnologies), I turned my clinical practice toward cerebral tumors and gliomas, Neuro- Oncology (Pr JY Delattre).
PhD : 1986, PhD in Neurosciences at UPMC; Pr J. Glowinski, Collège de France, ?Functionality and diversity of adenylatecyclase coupled neurotransmitter receptors on astrocytes?
Post-doctoral fellow ,Pr André Sobel, Inst. Fer à Moulin, Paris, ?Phosphoproteins involved in neuronal signaling?
HDR 1993.
Bioethics. Contributions in the fields of neuroscience, stem cell and regenerative medicine, genetics, assisted procreation in articles,books and national or international symposia.
Scientific mentoring and Teaching (last 5 years) :
Three students Master 2, Five students in PhD thesis , Two post-docs Teaching M2 Neurosciences UPMC (4h), M2 Neurosciences UPD(4h), M2 Bioethics Paris 11 and Sciences-Po Paris (8h), M2 Biotherapies Paris 12 (2h)

Evaluation and administration (since 2007)
2003-present Ethic Committee of Inserm (President since 2013)
2004- present Scientific council Office Parlementaired Evaluation des ChoixScientifiques et Techniques
2008-present Expert biologie/santé COST (Bruxelles, Commission Européennne)
2008-present Administration council ED 3C UPMC/UPD/ENS/EHESS
2008-2012 Comité de pilotage du réseau Cellules SouchesCancéreuses d Ile de France
2011-present SC Institut National des Sciences Biologiques (CNRS)
2012-2016 SC Fondation pour la RechercheMédical (Charity)
2013-present CCNE (National Avisory Board for Bioethics)

Valorisation (recent):
3 patents 2012 and 1 pending (2013).
Main grants (as PI, recent)
Equipe labelisée La Ligue 2007-2009 (210k?), La Ligue 2013-15 (210k?), ARC 2007/2008 (40 k?), 2013_14 (50k?); CSC idF (40k?/2008, 90k? 2009/2011), INCa PLBIO 2013-15 (210k?)

Editorial boards (recent)
2004- International Journal of Ethics
2005- Progress in Neurobiology
2006- Medecine/Sciences (editor in chief)
Miscellaneous : Co-founder and past-president of the French Glial Cell Club. Co-founder of the biennal european meetings Euroglia and co-organizer of the 2th (Arcachon 1994) and 9th(Paris 2009) editions. 1992-now collaboration with Pr. V. Moura-Neto UFRJ Rio
Brazil (several CAPES/COFECUB contracts)

Prize/honors :

Best biomedical article of broad interest « Grand Prix Editorial de la Presse Médicale » 2006 Corresponding Member of the Brazilian Academy of Sciences (Elected dec 2009)

Publications : 107 Pubmed entries, h-index :30 ; 12 book chapters, 4 reviews upon invitation. 3 books for the lay public.

Selected 5 recent publications:

Turchi L, Debruyne DN, Almairac F, Virolle V, Fareh M, Neirijnck Y, Burel-Vandenbos F, Paquis P, Junier MP, Van
Obberghen-Schilling E, Chneiweiss H,Virolle T. Tumorigenic Potential of miR-18A* in Glioma Initiating Cells Requires NOTCH-1 Signaling. Stem Cells. 2013 31:1252-65.

Thirant C, Galan-Moya EM, Dubois LG, Pinte S, Chafey P, Broussard C, Varlet P, Devaux B,Soncin F, Gavard J, Junier MP, Chneiweiss H. Differential proteomic analysis of human glioblastoma and neural stem cells reveals HDGF as a novel angiogenic secreted factor.Stem Cells. 2012 May;30(5):845-53.

Fareh M, Turchi L, Virolle V, Debruyne D, Almairac F, de-la-Forest Divonne S, Paquis P, Preynat-Seauve O, Krause KH, Chneiweiss H, Virolle T The. miR 302-367 cluster drastically affects self-renewal and infiltration properties of glioma-initiating cells through CXCR4 repression and consequent disruption of the SHH-GLI-NANOG network.Cell Death Differ. 2012 Feb;19(2):232-44.

Galan-Moya EM, Le Guelte A, Lima-Fernandes E, Thirant C, Dwyer J, Bidere N, Couraud PO, Scott M, Junier MP Chneiweiss H, Gavard J.?Brain endothelial cells maintain glioblastoma stem-like cell expansion through the mTOR pathway. EMBO Report 2011, 12: 470-6.

Silvestre DC, Pineda Marti JR, Hoffschir F, Studler JM,Mouthon MA, Pflumio F, Junier MP, Chneiweiss H,Boussin FD. Alternative Lengthening of Telomeres in Human Glioma Stem Cells. Stem Cells. 2011 Mar;29(3):440-