Traitement sensoriel, neuromodulation et plasticité neuronale

Leader

Research center

1 avenue de la Terrasse1 avenue de la Terrasse
91190 Gif-sur-Yvette
Yves Frégnac

Institution

CNRS
Université Paris Sud
ED158 - 3C ED FDV
Université Pierre et Marie Curie

Laboratory

Phone: 01 69 82 34 00
UPR3293
Idex NeuroSaclay - Equipe FRM
Available to host a PhD student

publications

Estebanez, L.#, Bertherat, J.#, Shulz, D.E.#, Bourdieu, L. and Léger, J. F. (2016) A radial map of multi-whisker correlation selectivity in the rat barrel cortex. Nature Communications DOI: 10.1038/ncomms13528

Perronnet L#, Vilarchao ME#, Hucher G, Shulz DE#, Peyré G, Ferezou I.#(2015) An automated workflow for the anatomo-functional mapping of the barrel cortex J Neurosci Methods doi:10.1016/j.jneumeth.2015.09.008.

Boubenec, Y.#, Claverie, N., Shulz, D.E.# and Debregeas, G. (2014) An amplitude modulation/demodulation scheme for whisker-based texture perception. J. Neuroscience, 34:10832–10843.

Arduin P-J.#, Frégnac Y., Shulz D.E.# & Ego-Stengel V.# (2014) Bidirectional control of a one-dimensional robotic actuator by operant conditioning of a single unit in rat motor cortex. Frontiers in Neuroscience (Neuroprosthetics) Vol. 8/206 : 1-15.

Arduin, P.J.#, Frégnac, Y., Shulz, D.E.# and Ego-Stengel, V.#, (2013). "Master" neurons induced by operant conditioning in rat motor cortex during a brain-machine interface task. J. Neuroscience. 33:8308–8320.

Fields of research

Neurophysiology / systems neuroscience

Research Theme

The Team is specialized in integrative neuroscience. Using the barrel cortex of rodents as a system model, our research is centered on the study of neuronal processes responsible for the coding of tactile sensory information and perception, as well as their regulation through the interaction of the animal with the environment. We are interested in the propagation and integration of neuronal information in the primary somatosensory cortex and subcortical somatosensory relays, and the emergence of collective properties in response to spatially distributed stimuli on the receptor surface. In addition, we study the functional and synaptic adaptation within the framework of Hebbian and non-Hebbian plasticity algorithms. We include in this research the study of permissive factors linked to the attentional and behavioral state of the animal which are mediated by ascending neuromodulatory systems. Our research involves a combination of cutting edge techniques (multi-electrode electrophysiology, functional imaging (VSD), optogenetics, multiple-whisker stimulation, behaviour) in acute and chronically implanted preparations.

Lab rotation

Reactivation of spatiotemporal patterns of activity induced by complex tactile stimuli, investigation by voltage sensitive dye imaging in mice

Chercheur responsable: 

SHULZ Daniel

Dates: 

1 September 2016 - 30 June 2017

Date limite de candidature: 

1 September 2016

Lab rotation proposal

~ Sep-Dec 2016 ~ Jan-March 2017 ~ Apr-June 2017

Project:

The Team is specialized in integrative neuroscience. Using the tactile somatosensory pathway from whiskers to cortex in rodents as a system model, our research is centered on the study of neuronal processes responsible for the coding of tactile sensory information and perception, as well as their regulation through the interaction of the animal with the environment. The proposed project aims to study the integrative properties of the primary somatosensory cortex (S1) involved in the association of sensory information to a specific behavioral context. We will specially focus on the assumption that they could predict the occurrence of future events based on the spatio-temporal structure of recent sensory experience. Upon repeated presentation of structured tactile stimuli, the evoked neural activity could generate a waiting signal linked to a high spatiotemporal predictability of input signals. Such "predictive" activity would anticipate the near future, be it motor commands, or the most likely evolution of the surrounding "variables". We will use voltage sensitive dye imaging to monitor in real time the activity of S1 in mice, combined with a multi-vibrissal stimulation matrix, in a paradigm of truncation of repeated spatiotemporal sequences of tactile stimuli to study the genesis of such predictive signals.

AddressNeuroscience Paris-Saclay Institute Neuropsi - Bâtiment 145, Centre D'études De Saclay 91191 Gif Sur Yvette

Phone number: 01 69 82 34 02 ; Emailferezou@unic.cnrs-gif.fr

Website

Superviseur: 

Isabelle FEREZOU

Development of a Brain-Machine Interface based on operant conditioning of neural activity in the head-fixed mouse

Chercheur responsable: 

SHULZ Daniel

Dates: 

1 September 2016 - 30 June 2017

Date limite de candidature: 

1 September 2016

Lab rotation proposal:

~ Sep-Dec 2016 ~ Jan-March 2017 ~ Apr-June 2017

Project:

Our team is interested in neuronal mechanisms of sensory processing and learning in the sensorimotor whisker system of the rodent. This project focuses on the impact of somatosensory feedback in learning a motor task, using a Brain Machine Interface set-up. Recently, we have demonstrated that operant conditioning of the firing rate of a single cortical neuron is a successful strategy to control an actuator bringing a reward to the rat mouth (Arduin et al, 2013, J Neurosci). We will now incorporate a sensory feedback in the control loop of the neuroprosthesis, by stimulating optogenetically neurons in the barrel cortex of the head-fixed mouse. We will investigate whether the performance of the animals is improved when somatosensory feedback is provided to the brain-machine interface, in particular when we apply biomimetic patterns similar to natural spatio-temporal sequences of whisker movements.

Address: Neuroscience Paris-Saclay Institute Neuropsi - Bâtiment 145, Centre D'études De Saclay 91191 Gif Sur Yvette

Phone number: +33 1 69 82 34 46 ; EmailValerie.Stengel@unic.cnrs-gif.fr

Website

Superviseur: 

Valerie EGO-STENGEL