Reactivation of spatiotemporal patterns of activity induced by complex tactile stimuli, investigation by voltage sensitive dye imaging in mice
Dates:1 September 2016 - 30 June 2017
Date limite de candidature:1 September 2016
Lab rotation proposal:
~ Sep-Dec 2016 ~ Jan-March 2017 ~ Apr-June 2017
The Team is specialized in integrative neuroscience. Using the tactile somatosensory pathway from whiskers to cortex in rodents as a system model, our research is centered on the study of neuronal processes responsible for the coding of tactile sensory information and perception, as well as their regulation through the interaction of the animal with the environment. The proposed project aims to study the integrative properties of the primary somatosensory cortex (S1) involved in the association of sensory information to a specific behavioral context. We will specially focus on the assumption that they could predict the occurrence of future events based on the spatio-temporal structure of recent sensory experience. Upon repeated presentation of structured tactile stimuli, the evoked neural activity could generate a waiting signal linked to a high spatiotemporal predictability of input signals. Such "predictive" activity would anticipate the near future, be it motor commands, or the most likely evolution of the surrounding "variables". We will use voltage sensitive dye imaging to monitor in real time the activity of S1 in mice, combined with a multi-vibrissal stimulation matrix, in a paradigm of truncation of repeated spatiotemporal sequences of tactile stimuli to study the genesis of such predictive signals.
Address: Neuroscience Paris-Saclay Institute Neuropsi - Bâtiment 145, Centre D'études De Saclay 91191 Gif Sur Yvette
Phone number: 01 69 82 34 02 ; Email: firstname.lastname@example.org