Unravelling the role of perivascular macrophages in Parkinson’s disease pathophysiology
Dates:1 September 2016 - 31 December 2016
Date limite de candidature:1 September 2016
~ Sep-Dec 2016
Our central hypothesis is that perivascular macrophages (PVMs), an immune cell population strategically positioned within the perivascular space, may play a key role in PD pathophysiology by modulating neuro-immune responses and the fate/clearance of -Synuclein (-SYN) assemblies. This hypothesis is inspired by our pilot studies which indicate that PVM population is increased in postmortem tissue from PD patients. To address this question, we will first determine how PVMs dynamically respond to fully characterized α-SYN fibrils resulting in prion-like propagation of α-SYN aggregates and nigral dopaminergic (DN) degeneration. In a second task, we will evaluate the impact of cell-specific PVM depletion by brain delivery of clodronate liposomes, on neuropathological parameters including DN cell death, immune responses (local and leukocyte infiltration) and the spreading/clearance of α-SYN assemblies. We anticipate that PVM alteration in response to neurodegeneration will be associated with key mechanisms involved in disease progression.
Address: ICM 47 bd de l’Hôpital, Paris 13
Email : Stephane.firstname.lastname@example.org Phone: 0157274556