Synapses et physiopathologie de la récompense

Institution

Inserm
Université Pierre et Marie Curie
ED158
Université Pierre et Marie Curie

Laboratory

Marianne Coutures
Phone: 01 45 87 61 35
UMRS 839
Biopsy

Mots clefs

Synaptic plasticity
dopamine
reward
addiction
receptor trafficking
Available to host a PhD student

publications

Mameli M., Bellone C., Brown T.C., Lüscher C. Cocaine inverts rules for synaptic plasticity of glutamate transmission in the VTA. Nature Neuroscience. 2011 In press

Brown T.C., Bellone C., Mameli M., Balland B., Dahan L., Lujan R., Deisseroth K., Lüscher C. Drug-driven AMPA receptor redistribution mimicked by selective dopamine neuron stimulation. PLoSOne. 2010 5(12):e15870.

Mameli M., Halbout B., Creton C., Engblom D., Parkitna J. R., Spanagel R., Lüscher C.. Cocaine-evoked synaptic plasticity: persistence in the VTA triggers adaptations in the NAc. Nat Neurosci. 2009 12:1036-41.

Engblom D., Bilbao A., Sanchis-Segura C., Dahan L., Pereau-lenz S., Balland B., Parkitna J.R., Lujan R., Halbout B., Mameli M., Parlato R., Sprengel R., Lüscher C., Schütz G., Spanagel R.. Glutamate receptors on dopamine neurons control the persistence of cocaine-seeking. Neuron 2008 59:497-508.

Mameli M., Balland B., Lujan R., Lüscher C.. Rapid synthesis and synaptic insertion of GluR2 for mGluR-LTD in the ventral tegmental area. Science. 2007 317:530-3.

Fields of research

Neurophysiology / systems neuroscience

Research Theme

The general interest of the lab is to dissect the neuronal circuits implicated in reward learning and to understand how drugs co-opt these connections.

Goal directed actions, aimed to obtain a reward, motivate our behaviors and influence our decisions.

Midbrain dopamine neurons activity and therefore dopamine release are enhanced by external cues predicting a reward. Lateral habenula (LHb) neurons play a central role in this regulation since they instruct dopamine neurons during reward learning.A dysfunction in the output signal from the lateral habenula can be therefore at the basis of dysregulated dopamine signal and underly neuropsychiatric disorders characterized by an abnormal reward signal (i.e. drug addiction).