Serotonin and microglia
Dates:1 January 2017 - 30 June 2017
Date limite de candidature:1 April 2016
Lab rotation proposal:
~ Jan-March 2017 ~ Apr-June 2017
Htr2b encodes the main serotonin receptor expressed by microglial cells. Microglia have been recently involved in several psychiatric disorders, and we observed that lack of Htr2b receptor leads to increased vulnerability to sickness behavior induced by peripheral inflammation, a state that shares some aspects with depression. Thus, unraveling the mechanisms sustaining this vulnerability may help understanding depression. To this aim, on one hand we are using conditional Knock-Out and pharmacogenetic approaches (DREADDs) to study the link between microglial activation, Htr2b, and behavioral changes, and on the other hand, we plan to specify, at the single cell level, the heterogeneity and plasticity of microglia/neuron interaction. Techniques used are cell biology, imaging, neuropharmacology, molecular biology and behavioral experiments.
Address: Institut du Fer à Moulin - 17, rue du Fer à Moulin 75005 PARIS
Phone number: +33 1 45 87 61 24 ;