PICNIC Lab Physiological Investigations of Clinically Normal & Impaired Cognition

Research center

47 bld de l'Hôpital
75651 Paris
Alexis Brice

Institution

Inserm
Université Pierre et Marie Curie
CNRS
Université Paris 6
ED158
Université Pierre et Marie Curie

Laboratory

UMRS 1127 UMR 7225
 

publications

Martinaud O, Pouliquen D, Gerardin E, Loubeyre M, Hirsbein D, Hannequin D, Cohen L (2012) Visual agnosia and posterior cerebral artery infarcts: an anatomical-clinical study. ploS One 7:e30433.

Faugeras F, Rohaut B, Weiss N, Bekinschtein T, Galanaud D, Puybasset L, Bolgert F, Sergent C, Cohen L, Dehaene S, Naccache L (2012) Event related potentials elicited by violations of auditory regularities in patients with impaired consciousness. Neuropsychologia 50:403-418.

Bouvier G, Laviolette L, Kindler F, Naccache L, Mouraux A, Similowski T, Morelot-Panzini C (2012) Dyspnea-pain counter-irritation induced by inspiratory threshold loading: a laser evoked potentials study. J Appl Physiol. 2011

King JR, Bekinschtein T, Dehaene S (2011) Comment on "Preserved feedforward but impaired top-down processes in the vegetative state". Science 334:1203 5. Vinckier F, Qiao E, Pallier C, Dehaene S, Cohen L (2011) The impact of letter spacing on reading: A test of the bigram coding hypothesis. J Vis 11:1-21.

Fields of research

Cognitive neurosciences / neuropsychology /neuroeconomy

Research Theme

The PICNIC lab is devoted to the study of cognitive functions with an exclusive or prevalent development in humans, namely language and conscious cognition. The study of brain-damaged patients occupies a central position in our methodological approach. For the study of both language and consciousness, and with both patients and healthy subjects, we resort to state-of-the-art behavioural methods and multimodal brain imaging (MRI, high-density surface EEG and intracerebral implanted electrodes). In the field of language, we mostly address the brain mechanisms of reading a domain which gives an empirical grasp on the interplay of cultural phenomena and biological background. Our main project concerns the dynamics of word reading: functioning, origins, and impairments. We address questions such as: how are visual words encoded and recognized in adults? how do word recognition abilities emerge from the interaction of education and of the pre-existing biological background? what are the functional abnormalities underlying acquired reading impairments, and what are the compensation mechanisms that may develop in such conditions? In the field of consciousness, we aim at discovering the specific psychological and neural properties of conscious processing, by contrasting conscious and unconscious cognition, both in healthy subjects and in patients in comatose, vegetative or  inimally conscious states. Particularly we probe in such patients the depth of cognitive processing in the domain of semantics, short-term memory, and strategic elaboration. Beyond fundamental issues, we also derive tools for the assessment or rehabilitation of patients. Thus we recently demonstrated the value of ERPs for assessing the diagnosis and prognosis of comatose patients.

Etudiants ENP

Katarzyna SIUDA-KRZYWICKA

Membres de l'équipe

Paolo BARTOLOMEO

Lab rotation

Neurosciences of human attention

Chercheur responsable: 

NACCACHE Lionel

Dates: 

1 September 2016 - 31 December 2016

Date limite de candidature: 

1 September 2016

Lab rotation proposal: 3 months

~ Sep-Dec 2016 ~ Jan-March 2017 ~ Apr-June 2017

Project

Attention allows us to explore our environment. Many patients with a lesion in the right hemisphere of the brain find themselves living in a halved word, because they suffer from neglect (inattention) for the left side of space. Neglect patients are unaware of the left half of their environment, and have a poor functional outcome. To understand the brain mechanisms of attention and awareness, we study these patients as well as healthy participants. Our research employs several advanced methods, including neurophysiological (intracerebral recordings and MEG), neuroanatomical (high resolution MRI) and behavioral techniques (manual response times and eye-tracking).

AddressInstitut Du Cerveau et de la Moelle Épinière - 47 bld de l'Hôpital 75651 Paris

Phone number+33 1 57 27 41 40 ; Emailpaolo.bartolomeo@icm-institute.org

Website

Superviseur: 

Paolo BARTOLOMEO