Role of the brain neurovascular unit in Vulnerability to addiction to the psychostimulant drugs
Dates:4 April 2016 - 30 June 2016
Date limite de candidature:4 April 2016
Addiction to psychostimulant drugs is a complex disorder lacking of effective treatments. Due to the sustained increase in cocaine use and to the alarming spread on the drug market of new psychoactive substances including synthetic cathinones, identification of the mechanisms responsible for vulnerability to stimulant drug dependence is becoming mandatory to better understand the complex mechanisms underlying addiction to these drugs. Investigating vulnerability and dependence in a rat model of addiction to stimulant drugs will enable us to determine possible molecular targets to improve management of dependence to these drugs. Clinical and preclinical studies have demonstrated the critical role of the rate of the drug delivery to the brain in the resulting neuronal plasticity, reward effects and addiction liability [1,2]. Slowing the brain delivery rate of the drug of abuse is known as the “pharmacokinetic (PK) strategy” using drug-specific blood trapping (e.g. vaccine/immune strategy) or increasing its metabolism . Recent studies of the team also illustrated the role of the blood-brain barrier (BBB) drug transporters and their critical rate-regulatory component in the brain uptake of psychoactive drugs [4,5].In this project we will study the role of the different endothelial and glial cells of the brain neurovascular unit and their plasticity with a multidisciplinary approach (behavior studies, pharmacokinetics, neurochemistry, and molecular biology).
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