Metabolic manipulation of the neurovascular unit
Dates:2 April 2018 - 29 June 2018
Date limite de candidature:29 June 2018
~ April-June 2018
Metabolic therapies are emergent and promising approaches for the treatment of neurodegenerative diseases in human patients. This project aims at characterizing the impact of several diets mimicking those therapeutical approaches (ketogenic diet, caloric restriction, intermittent fasting) on the blood-brain barrier and neurovascular unit in the brain of WT mice and in a murine model of Alzheimer’s disease. Technics employed include magnetic cell sorting of brain cells, RNASeq, confocal imaging, in situ brain perfusion, primary culture of endothelial cells.