Chronic high-density electrophysiology and optogenetics in the freely moving animal to investigate hippocampo-prefrontal network dynamics of emotional memories.
Dates:1 September 2016 - 31 December 2016
Date limite de candidature:1 September 2016
~ Sep-Dec 2016 ~ Jan-March 2017 ~ Apr-June 2017
The aim of this project is to characterize the network dynamics of the hippocampal-prefrontal network during the different stages of emotional learning (encoding, consolidation, extinction, and recall) looking for electrophysiological signatures of its contextual modulation. By recording simultaneously in the hippocampus and the prefrontal cortex with arrays of tetrodes, we will be able to isolate the activity of many neurons and dissect the reciprocal dynamics of these two structures’ cells assemblies and local field potential oscillations. We will also selectively modulate the activity of the hippocampal-prefrontal pathway with optogenetics to find the anatomical underpinnings of these functional relationships.
Address: Centre de Psychiatrie et Neurosciences Centre Hospitalier Sainte Anne - 1 Rue Cabanis 75014 Paris
Phone number: +33 1 40 78 86 68 or 31 ; Email: firstname.lastname@example.org