Nuclear Function of microRNAs in Neural Stem Cell Quiescence
Dates:2 January 2018 - 29 June 2018
Date limite de candidature:29 June 2018
~ Jan-March 2018
~ April-June 2018
Adult neurogenesis is the generation of new neurons and glial cells from neural stem cells (NSCs) present in the adult brain. Fundamentally, this process requires a fine balance between maintaining a quiescent NSC reserve and recruiting them into the neurogenesis cascade. However our knowledge the safeguarding molecular pathways involved is far from comprehensive. Exploiting an emerging model system, the zebrafish, we recently identified an unexpected nuclear activity of microRNAs in maintaining a sub-state of NSC quiescence that emerges only at adult stages. Using these findings as an entry point, the research project aims at uncovering the molecular mechanism of action of nuclear microRNAs, and better understand the diversity of quiescent states in NSCs and their establishment during post-embryonic development.