Neurobiologie intégrative du cerveau postérieur

Leader

Research center

Bâtiment 145, Centre d'études de Saclay
91191 Gif sur Yvette
Philippe Vernier

Institution

CNRS
Université Paris Sud
ED 568 BioSigNe
Université Paris Sud 11

Laboratory

Département Molécules & Circuits
Phone: 06 18 35 80 54
UMR9197
Idex NeuroSaclay, EQUIPE X "MORPHOSCOPE 2"

Mots clefs

Behaviour
Development
Breathing
Neural circuit
Rhythm generation
Mouse embryo
Available to host a PhD student

publications

Talpalar AE, Bouvier J, Borgius L, Fortin G, Pierani A, Kiehn O. Nature. 2013;500:85-88.

Ramanantsoa N, Hirsch MR, Thoby-Brisson M, Dubreuil V, Bouvier J, Ruffault PL, Matrot B, Fortin G, Brunet JF, Gallego J, Goridis C. Journal of Neuroscience. 2011;31:12880-8.

Bouvier J, Thoby-Brisson M, Renier N, Dubreuil V, Ericson J, Champagnat J, Pierani A, Chédotal A, Fortin G. Nature Neuroscience. 2010;13:1066-74.

Thoby-Brisson M KM, Wu N, Charnay P, Champagnat J, Fortin G. Nature Neuroscience. 2009;12(8):1028-1035.

Thoby-Brisson M, Trinh JB, Champagnat J, Fortin G. Journal of Neuroscience. 2005;25:4307-4318.

Fields of research

Neurophysiology / systems neuroscience

Research Theme

The intrinsic logic of neural networks controlling defined circuit functions and behaviours in the central nervous system is a fundamental issue of neuroscience. We study the central control of breathing, a classical model system to (i) perform integrative neurobiology and (ii) extend the significance of developmental biology, beyond anatomical organization to the level of network assembly and function.

Focusing on the inception of this circuit, we are identifying in the mouse embryo, the progenitor domains that give rise to distinct components of the network that have a vital fate. We are using developmental genetics tools, to fate map, follow the migration, impair the connectivity, invalidate and actuate selective neuronal populations in the circuit, to derive the operating principles, provide constituent cells with molecular identities and reveal early pre-disposition to dysfunctions. We intend to make sense of cellular identities now investigating cells’ functional and anatomical connectivities respectively, by optogenetics combined to phase modulation of optical wave-fronts, and by monosynaptic viral tracing.

Etudiants ENP

Jinjin WU

Lab rotation

Study of a novel putative respiratory center

Chercheur responsable: 

FORTIN Gilles

Dates: 

1 September 2016 - 31 December 2016

Date limite de candidature: 

1 September 2016

Lab rotation proposal

~ Sep-Dec 2016 ~ Jan-March 2017 ~ Apr-June 2017

Project:

We have recently identified a molecular signature for neurons forming a respiratory nucleus obligatory for the control of breathing by CO2. As it turns out, this signature is shared by only one other group of neurons in the CNS whose function is presently unknown. We want to characterize these neurons anatomically and functionally using conditional expression of viral tracers, calcium imaging and optogenetics. This project is funded by a 2015 ANR grant to Jean-François Brunet & Gilles Fortin.

AddressNeuroscience Paris-Saclay Institute Neuropsi - Bâtiment 145, Centre D'études De Saclay 91191 Gif Sur Yvette

Phone number: +33 1 69 82 34 33 ; Emailgilles.fortin@inaf.cnrs-gif.fr

Website

Superviseur: 

Gilles FORTIN