Neurobiology of intellectual disability in Duchenne muscular dystrophy
Dates:1 September 2016 - 30 June 2017
Date limite de candidature:1 September 2016
Lab rotation proposal:
~ Sep-Dec 2016 ~ Jan-March 2017 ~ Apr-June 2017
The identification of the pathophysiological mechanisms leading to intellectual disability (mental retardation) in neurodevelopmental diseases such as muscular dystrophy is a major challenge, due to the variety of brain mechanisms involved, from synapse function to intercellular communication at the glial-vascular interface and blood-brain barrier function. We have developped a research program to decipher the molecular, cellular, neuroanatomical and cognitive defects in several mouse transgenic models and to evaluate novel pharmacological and gene-therapy approaches for this disease. We use a range of converging methodologies including behavioral testing, biochemistry, molecular biology, immunohistochemistry, confocal microscopy and gene-repair strategies, thus providing a strong multidisciplinary research environment with a variety of subprojects for student rotation.
Address: Département Cognition-Comportement - Neuroscience Paris-Saclay Institute NEUROPSI - Bâtiment 145, Centre d'études de Saclay 91191 Gif sur Yvette
Phone number: +33 1 69 15 49 85 ; Email: email@example.com