Imagerie et Psychiatrie

Research center

4, place du Général Leclerc
91401 Orsay

Institution

Inserm
CEA
ED158
Université Paris Saclay / Université Paris Descartes

Laboratory

Laboratoire Imagerie et Psychiatrie
U1000
IHU Necker

Mots clefs

Depression
autisme
Schizophrénie
Imagerie du cerveau
addictions
Available to host a PhD student

publications

Paillère-Martinot ML, Lemaitre H, Artiges E, Miranda R, Goodman R, Penttilä J, Struve M, Fadai T, Kappel V, Poustka L, Conrod P, Banaschewski T, Barbot A, Barker GJ, Büchel C, Flor H, Gallinat J, Garavan H, Heinz A, Ittermann B, Lawrence C, Loth E, Mann K, Paus T, Pausova Z, Rietschel M, Robbins TW, Smolka MN, Schumann G, Martinot JL & IMAGEN Consortium. White-matter microstructure and gray-matter volumes in adolescents with subthreshold bipolar symptoms. Molecular Psychiatry. 2013, doi: 10.1038/mp.2013.44. [Epub ahead of print]

 Müller KU, Mennigen E, Ripke S, Banaschewski T, Barker GJ, Büchel C, Conrod PJ, Fauth-Bühler M, Flor H, Garavan H, Heinz A, Lawrence C, Loth E, Mann K, Martinot JL, Pausova Z, Rietschel M, Ströhle A, Struve M, Walaszek B, Schumann G, Paus T, Smolka MN & the IMAGEN Consortium. Altered Reward Processing in Adolescents With Prenatal Exposure to Maternal Cigarette Smoking. JAMA Psychiatry. 2013, Jun 19:1-10. doi: 10.1001/jamapsychiatry.2013.44. [Epub ahead of print]

Schilling C, Kühn S, Paus T, Romanowski A, Banaschewski T, Barbot A, Barker GJ, Brühl R, Büchel C, Conrod PJ, Dalley JW,Flor H, Ittermann B, Ivanov N, Mann K, Martinot JL, Nees F, Rietschel M, Robbins TW, Smolka MN, Ströhle A, Kathmann N, Garavan H, Heinz A, Schumann G, Gallinat J; IMAGEN consortium (www.imagen-europe.com). Cortical thickness of superior frontal cortex predicts impulsiveness and perceptual reasoning in adolescence.Mol Psychiatry. 2013 May;18(5):624-30

Loth E, Poline JB,Thyreau B, Jia T, Tao C, Lourdusamy A, Stacey D, Cattrell A, Desrivieres S, Ruggeri B, Fritsch V, Banaschewski T, Barker GJ, Bokde AL, Bruehl R, Büchel C, Carvalho F, Conrod PJ, Fauth-Buehler M, Flor H, Gallinat J,Garavan H, Heinz A, Lawrence C, Mann K, Martinot JL, Nees F, Paus T, Pausova Z, Poustka L, Rietschel M, Smolka MN, Struve M, Feng J, Schumann G & the IMAGEN Consortium. Oxytocin receptor genotype modulates ventral striatal activity to social cues and response to stressful life events. Biological Psychiatry. (In press)

Nees F, Witt SH, Lourdusamy A, Vollstädt-Klein S, Steiner S, Poustka L, Banaschewski T, Barker GJ, Büchel C, Conrod PJ, Frank J, Gallinat J, Garavan H, Heinz A, Ittermann B, Loth E, Mann K, Artiges E, Paus T, Pausova Z, Smolka MN, Struve M, Schumann G, Rietschel M, Flor H & the IMAGEN Consortium. Genetic Risk For Nicotine Dependence in the Cholinergic System and Activation of the Brain Reward System in Healthy Adolescents. Neuropsychopharmacology. 2013, May 21. doi:10.1038/npp.2013.131. [Epub ahead of print]

Fields of research

Neurological and psychiatric diseases

Research Theme

Cerebral development, imaging and psychopathology

The first axis of research is to characterize psychiatric disorders linked to brain development, using anatomical and functional neuroimaging. Patient groups with psychiatric disorders beginning in the early decades of life, are studied at complimentary periods: childhood, adolescence, adulthood.

Searching for anatomical and functional changes of the brain in a few selected psychiatric syndromes. Autism, schizophrenia and addiction are examples of psychiatric conditions for research in neuroimaging. The comparison with addiction disorders provides a thorough characterization of the detected variations.

Neuroimaging and psychiatrics treatments

The second research axis is to identify the brain sites of action of psychotropic drugs and monitoring treatment effects.

We search for relationship between response to treatment and anatomical or functional brain specificities.

Three imaging techniques were adapted to explore the brain of subjects with various mental disorders:
• 1 / MRI (Magnetic Resonance Imaging) for brain morphology,
• 2 / functional MRI (fMRI)for brain function,
• 3 / PET (Positron Emission Tomography) for neurochemistry.

The researches of the Unit 1000  INSERM-CEA are performed on CEA platforms, Service Hospitalier Frédéric Joliot and Neurospin. The unit includes two sub-sites, one in the department of Paediatric Radiology of theNeckerHospital, the other one in the Solenn House, adolescents' house,CochinHospital.