Developmental role of protocadherins in migration of cortical neurons
Dates:1 September 2016 - 30 June 2017
Date limite de candidature:1 September 2016
Lab rotation proposal:
~ Sep-Dec 2016 ~ Jan-March 2017 ~ Apr-June 2017
Extensive migration serves during development to direct neurons to their final location and the construction of functional circuits. Altered migration processes at embryonic stages lead to the construction of pathological neural circuits in adults. The project aims at testing how members of the protocadherin family control migration in the developing cerebral cortex. Variants associated with pathological conditions will be used in gain- and loss-of function approaches by in utero electroporation, mouse genetics, in vitro primary cell culture and timelapse microscopy.
Address: Institut Jacques Monod - Bât. Buffon - 15 rue Hélène Brion 75205 Paris cedex 13
Phone number: +33 1 57 27 81 25 ;