Gènes Circuits Rythmes et Neuropathologies

Leader

Institution

CNRS
ESPCI
ED 158 3C
Université Pierre et Marie Curie

Laboratory

Laboratoire Plasticité du Cerveau
UMR 8249
Labex MemoLife, Idex PSL

Mots clefs

dopamine
Neurodegeneration
Parkinson disease
Locomotor aging
Drosophila
oxidative stress
Available to host a PhD student

publications

Cassar M., Issa A.-R., Riemensperger T., Petitgas C., Rival T., Coulom H., Iché-Torres M., Han K.-A. & Birman S. (2015) A dopamine receptor contributes to paraquat-induced neurotoxicity in Drosophila. Hum. Mol. Genet. 24(1):197-212

Lavista-Llanos S., Svatoš A., Kai M., Riemensperger T., Birman S., Stensmyr M. C. & Hansson B. S. (2014) Dopamine drives Drosophila sechellia adaptation to its toxic host. eLife Dec 9;3

Riemensperger T., Issa A.-R., Pech U., Coulom H., Nguyen M.-V., Cassar M., Jacquet M., Fiala A. & Birman S. (2013) A single dopamine pathway underlies progressive locomotor deficits in a Drosophila model of Parkinson disease. Cell Rep. 5:952–960

Humphrey D. M., Parsons R. B., Ludlow Z. N., Riemensperger T., Esposito G., Verstreken P., Jacobs H. T., Birman S. & Hirth F. (2012) Alternative oxidase rescues mitochondria-mediated dopaminergic cell loss in Drosophila. Hum. Mol. Genet. 21(12): 2698-2712

Riemensperger T., Isabel G., Coulom H., Neuser K., Seugnet L., Kume K., Iché-Torres M., Cassar M., Strauß R., Préat T., Hirsh J. & Birman S. (2011) Behavioral consequences of dopamine deficiency in the Drosophila central nervous system. Proc. Natl. Acad. Sci. USA 108(2):834-39 



Fields of research

Neuropharmacology / cell signaling

Research Theme

Our research program is focused on the role of dopamine in behaviour control and neurodegenerative mechanisms in the fruit fly Drosophila melanogaster. Our approach combines Drosophila genetics, molecular biology, brain imaging and behavioral assays. We recently generated and characterized brain dopamine-deficient mutants and developed new models to study pathogenic mechanisms related to genetic and environmental factors of Parkinson disease. Our current goal is to identify genes and brain neuronal networks required to maintain locomotor activity and stress resistance during lifespan in healthy flies and Parkinson models. On-going studies address the role of specific mitochondrial and lysosomal proteins as well as the inluence of circadian genes in neuroprotection.

Membres de l'équipe

André Klarsfeld
Baya Chérif-Zahar
Ali Mteyrek
Abdul-Raouf Issa
Alexandra Vaccaro
Mathilde Lecompte
Jun Sun

Lab rotation

Study of neuroprotection mechanisms in Drosophila Parkinson’s disease models

Chercheur responsable: 

BIRMAN Serge

Dates: 

2 January 2018 - 29 June 2018

Date limite de candidature: 

29 June 2018

Period

~ Jan-March 2018

~ April-June 2018

Project

This project will address the implication of the autophagy-lysosome and mitochondrial biogenesis pathways and their interaction as endogenous mechanisms of neuroprotection in Parkinson’s disease using molecular, genetics and imaging methods in Drosophila.

Contact

ESPCI - 10 rue Vauquelin 75005 Paris - +33 1 40 79 58 35 - serge.birman@espci.fr

Superviseur: 

BIRMAN Serge or CHERIF-ZAHAR Baya