Dopaminergic modulation of striatal electrical synapses
Dates:1 September 2016 - 30 June 2017
Date limite de candidature:1 September 2016
~ Sep-Dec 2016 ~ Jan-March 2017 ~ Apr-June 2017
In Parkinson’s disease, caused by a deficit of dopamine, deleterious synchronous activities (beta-band) are recorded throughout basal ganglia. Synchronous activities can arise from electrically-coupled GABAergic interneuron networks. Gap junctions between neurons underlie electrical synapses. The project consists in recording electrical synapses between striatal GABAergic interneurons with double patch-clamp and evaluating their modulation by dopamine in physiological conditions and a rodent model of Parkinson’s disease. The state of electrical coupling will be put in relation with synchronous activities to determine the role of neuronal gap junctions onto deleterious synchronous activities (beta-band) in Parkinson’s disease. Techniques: electrophysiology (double patch-clamp in vitro), optognetics, two-photon calcium imaging, multi-channel recordings in vivo, Parkinson’s disease rodent model, computational modeling (in coll).
Address: Collège de France - 11, Place Marcelin Berthelot 75231 Paris Cedex 05
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