Role of striatal interneurons in goal directed behavior
Chercheur responsable:
VENANCE LaurentDates:
2 April 2018 - 29 June 2018Date limite de candidature:
29 June 2018Period
~ April-June 2018
Project
Basal ganglia are involved in goal-directed behavior and procedural learning. Striatum, the main input nucleus of basal ganglia, is composed of a majority of striatal projection neurons, but also of a variety of GABAergic interneurons which, and exert a strong feedforward inhibition. As we recently showed, GABAergic interneurons efficiently control synaptic hebbian plasticity (Paille et al., 2013, J Neurosci; Valtcheva et al., 2017, Neuropharmacol; Valtcheva and Venance, 2017, Nat Comm).
In this project we aim at optogenetically activating or inhibiting specifically each GABAergic subpopulation in dorsal striatum and observe the impact on a goal directed task and the associated procedural learning and recall. Neuronal activity in the behaving mice will be concomitantly examined with multi-channels recordings.
Techniques: in vivo optogenetics, behavioral tasks, in vivo multi-channel recordings, immunohistochemistry.
Contact
Collège de France - CIRB - 11, Place Marcelin Berthelot 75005 Paris - +33 1 44 27 12 26 - laurent.venance@college-de-france.fr