Period

~ Jan-March 2018

~ April-June 2018 (to be discussed)

Project

Non-invasive brain stimulation such as by repetitive magnetic stimulation (rMS) can modify neural circuit function and shows promise in treating a range of neurological disorders including injury and stroke. Our team has recently shown that a low intensity rMS, which is below depolarization threshold, can improve complex learned and reflex behaviors by removing abnormal ectopic neural connections, altering neuronal morphology (spines and dendritic branching) and modifying gene expression. We are interested in how this non-depolarizing rMS induces such profound effects: what intracellular signaling paths (eg calcium) are changed?  Does the brain contain magnetoreceptors?  The project will use an in vitro organotypic model of axonal injury to identify molecular mechanisms underlying different rMS protocols, including the requirement for potential magnetoreceptors. 

Contact

Institut de Biologie Paris Seine - Bat B 4th floor, 9 Quai St Bernard 75005 Paris - +33 1 44 27 33 78 ; +33 1 44 27 32 40 - Rachel.sherrard@upmc.fr

Period

~ Jan-March 2018

~ April-June 2018

Project

Since pharmaceutical treatments for AD provide little or no benefit, and non-invasive brain stimulation (NIBS) modifies neural circuit function and improves cognitive impairment, this project will use a mouse model of AD to identify NIBS parameters that improve learning and memory as well as reduce underlying cellular pathology.  The project will particularly focus on the expression of molecular markers associated with Alzheimer’s pathology and whether NIBS improves their abnormalities.

Contact

Institut de Biologie Paris Seine - Bat B 4th floor, 9 Quai St Bernard 75005 Paris - +33 1 44 27 33 78 ; +33 1 44 27 32 40 - kiyoka.kinugawa@aphp.fr 

Period

~ Jan-March 2018

Project

Understanding how a neuron transforms synaptic inputs into a neuronal output is fundamental to understand information processing in the brain since neuronal circuits that mediate brain functions are formed by synapses and dysfunctions in neuronal transfer function are associated with several neurodevelopmental disorders. In our lab we are studying how information is processed by interneurons within the cerebellar microcircuit, using a multidisciplinary approach combining electrophysiological recording in vitro, 3D morphological analysis and neuronal simulation. The lab project will focus on the cellular mechanisms allowing cerebellar molecular layer interneurons to acquire their mature phenotype by studying the development of excitatory synaptic transmission and integration and its impact on information transfer. 

Contact

Institut de Biologie Paris Seine - Bat B 4th floor, 9 Quai St Bernard 75005 Paris - +33 1 44 27 32 27 - Laurence.cathala@upmc.fr