Axonal plasticity of thalamocortical inputs during early life
Dates:1 September 2016 - 31 December 2016
Date limite de candidature:1 September 2016
~ Sep-Dec 2016 ~ Jan-March 2017 ~ Apr-June 2017
Brain functioning relies on the formation of stereotyped axonal connections. In mammals, the neocortex is organized in different areas receiving specific sensory and motor information via subsets of thalamocortical axons (TCA) topographically organized. Two sequential and independent developmental processes are required for the formation of functional cortical maps: i) extracortical cues initially control TCA pathfinding en route to the neocortex while ii) intrinsic neocortical informations then governs specific matching between TCA and their target areas. Indeed, it is known that modification of cortical regionalization induces a rerouting of TCA in the neocortex and a subsequent displacement of the cortical maps. Conversely, we have shown that aberrant initial TCA pathfinding (Dlx5/6::cre; Ebf1fl/- mutants) leads to an axonal rerouting in the neocortex that recovers innervation with respective cortical targets. How is this remarkable plastic axonal remodelling is controlled and how it impacts on cortical function remain largely to be explored. By taking advantage of the Dlx5/6::cre; Ebf1fl/- mutants, we will characterize the impact of axonal rerouting on cortical regionalization using immunohistochemistry and in situ hybridization. Furthermore, we are currently assessing the factors that regulate and modulate TCA plasticity in this model. Our study thus provides novel mechanistic insights into axonal plasticity and cortical wiring.
Address: Ecole Normale Superieure, Institut de Biologie IBENS, Brain Development and Plasticity, 46, rue d’Ulm 75005 Paris
Phone: 01 44 32 37 25