Développement et Neuropharmacologie


Research center

11 place Marcelin Berthelot
75231 Paris
Serge Haroche


Collège de France
Université Pierre et Marie Curie


Center for Interdisciplinary Research in Biology
Phone: +33 1 44 27 15 56
UMR 7241 - U 1050
Available to host a PhD student


Bernard C, Vincent C, Testa D, Bertini E, Ribot J, Di Nardo AA, Volovitch M, Prochiantz A. A Mouse Model for Conditional Secretion of Specific Single-Chain Antibodies Provides Genetic Evidence for Regulation of Cortical Plasticity by a Non-cell Autonomous Homeoprotein Transcription Factor. PLoS Genet. 2016 May 12;12(5):e1006035. doi: 10.1371/journal.pgen.1006035. eCollection 2016 May.

Spatazza J, Lee HH, Di Nardo AA, Tibaldi L, Joliot A, Hensch TK, Prochiantz A. Choroid-plexus-derived Otx2 homeoprotein constrains adult cortical plasticity. Cell Rep. 2013 Jun 27;3(6):1815-23. doi: 10.1016/j.celrep.2013.05.014. Epub 2013 Jun 13.

Beurdeley M., Spatazza J., Lee H., Sugiyama S., Bernard C., Di Nardo A., Hensch T. & Prochiantz A. (2012), Otx2 Binding to Perineuronal Nets Persistently Regulates Plasticity in the Mature Visual Cortex, The Journal of Neuroscience, July4, 2012-32(27): 9429-9437.

Stettler O., Joshi R.L., Wizenmann A., Reingruber J., Holcman D., Bouillot C., Castagner F., Prochiantz A. & Moya K.L. (2012), Engrailed homeoprotein recruits the adenosine A1 receptor to potentiate ephrin A5 function in retinal growth cones. Development. Jan; 139(1):215-24.

Layalle S., Volovitch M., Mugat B., Bonneaud N., Parmentier M.L., Prochiantz A., Joliot A. & Maschat F. (2011), Engrailed homeoprotein acts as a signaling molecule in the developing fly. Development, Jun; 138(11): 2315-23.

Di Lullo E., Haton C., Le Poupon C., Volovitch M., Joliot A., Thomas J.-L. & Prochiantz A. (2011), Paracrine Pax6 activity regulates oligodendrocyte precursor cell migration in the chick embryonic neural tube. Development 138, 4991-5001.

Torero Ibad R., Rheey J., Mrejen S., Forster V., Picaud S., Prochiantz A. & Moya K.L. (2011), Otx2 promotes the survival of damaged adult retinal ganglion cells and protects against excitotoxic loss of visual acuity in vivo. J. Neurosci., Apr 6;31(14):5495-503. 

Research Theme

Our research is centered on the physiological function of homeoprotein intercellular transfer, a novel signaling mechanism discovered by our group and that of Alain Joliot, also a CIRB member. This research has basic and translational aspects.