March 2008
25 June 2013

Years 2-4

2 November 2009 - 25 June 2013
ED 158
Université Pierre et Marie Curie

Integration of Dopamine and Glutamate signalling by D1R/NMDAR heteromers in the striatum in response to cocaine.


Recruited as PostDoc at University of Cambridge - Department of Psychology - Barry Everitt's lab .

Year 1

Biographie / Publications

ENP alumna Emma Cahill, now a postdoc at Cambridge University, studied the interactions of dopamine and glutamate signaling in response to cocaine during her PhD. She also contributed to an insightful publication on Huntington’s disease and signaling in the striatum. The neurodegeneration in Huntington’s disease is characterized by accumulation of mutated Huntingtin protein, impaired mitochondria function, axonal transport and transcription, among other deficits. Find more information about these mechanisms in the article:

Roze E, Cahill E, Martin E, Bonnet C, Vanhoutte P, Betuing S, Caboche J. Huntington’s disease and striatal signaling. Front Neuroanat. 23 August 2011.    

Key words: Polyglutamine, Huntingtin, Excitotoxicity, Mitochondrial dysfunctions, Transcriptional deregulation

Figure 1 from Roze et al., Front Neuroanat, 2011. Afferent projections onto the striatum, whose signaling is impaired in Huntington's disease.


 Nos principaux intérêts de recherche concernent l’étude des événements intracellulaires qui gouvernent la plasticité neuronale et les adaptations comportementales à long terme. Nous étudions le...