Neurophysiology / systems neuroscience

Imagerie dynamique du neurone

Domaine de recherche principal: 

Neuropharmacology / cell signaling

Mots clefs: 

Cerebellum
Synapses
Dendrites
Superresolution Microscospy
Optophysiology

Labelisation ENP: 

2007

Centre de recherche / Institut: 

Institut Pasteur

Code unité de recherche: 

UMR 3571

 Understanding how information is processed within neuronal networks requires knowledge of how neurons use cellular and molecular mechanisms to transform information communicated by synapses. Defects in the communication between synapses are thought to be at the heart of the memory deficits associated with neuropathological disorders such as Alzheimer’s disease and autism.

Leader

Leader: 

Personnel

Membres de l'équipe: 

REBOLA Nelson
MONERON Gael
SAINT-CLOMENT Cecile
TRAN-VAN-MINH Alexandra
NAKAMURA Yukihiro
REPAK Emilienne
BRANDT Maryse
CHABROL François
Établissements

Établissement de rattachement: 

CNRS

Université: 

Université Pierre et Marie Curie

École doctorale: 

ED3C
Laboratory

Nom: 

Genes, Synapses, Cognition
Publications

publications: 

DiGregorio D. Confocal spot detection of presynaptic Ca²⁺ domains. PLoS Biol. 2014 Jul 8;12(7):e1001903. doi: 10.1371/journal.pbio.1001903. eCollection 2014 Jul.

Tran-Van-Minh A, Abrahamsson T, Cathala L, DiGregorio DA. Differential Dendritic Integration of Synaptic Potentials and Calcium in Cerebellar Interneurons. Neuron. 2016 Aug 17;91(4):837-50. doi: 10.1016/j.neuron.2016.07.029.

Fink AE., Bender, KJ., Trussell, LO., Otis, TS. and DiGregorio, DA. Two-photon compatibility and single-voxel, single-trial detection of subthreshold neuronal activity by a two-component optical voltage sensor. PLoS One, in press (2012).

Abrahamsson, T.,  Cathala,  L., Matsui, K., Shigemoto, R., and DiGregorio, DA. Thin dendrites of cerebellar interneurons confer sublinear synaptic integration and a gradient of short-term plasticity. Neuron, 73: 1159-1172 (2012).

DiGregorio DA. 2011. Confocal spot detection of presynaptic Ca2+ domains. In: Imaging in neuroscience: A laboratory manual (ed. Helmchen F, Konnerth A, Yuste R), pp. 141-150. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.

Bradley, J., Luo, R., Otis, T.S. and DiGregorio, D.A., Submillisecond optical reporting of membrane potential in situ using a neuronal tracer dye. Journal of Neuroscience, 29(29):9197–9209 (2009).

Lutz, C, Otis, T, DeSars, V., Charpak S., DiGregorio, D. A., and Emiliani, V. Holographic photolysis of caged neurotransmitters. Nature Methods, 5(9):821-827 (2008).

Dynamique et Physiopathologie des Réseaux Neuronaux

Domaine de recherche principal: 

Neurophysiology / systems neuroscience

Mots clefs: 

Synaptic plasticity
dopamine
Learning and Memory
Parkinson’s disease
neuronal networks
basal ganglia
GABAergic interneurons
endocannabinoids

Labelisation ENP: 

2007

Centre de recherche / Institut: 

Collège de France

Code unité de recherche: 

UMR 7241 - U1050

Nos projets de recherche concernent le codage de la mémoire et l’apprentissage dans les ganglions de la base, un ensemble de noyaux sous-corticaux impliqués dans le contrôle adaptif du comportement. Les ganglions de la base, connectés en retour au cortex cérébral et au système limbique, participent a la sélection d’actions en relation avec la motivation et la prédiction de récompense.

Leader

Leader: 

Établissements

Établissement de rattachement: 

Collège de France

Établissements affiliés: 

CNRS
Inserm

Université: 

Université Pierre et Marie Curie

École doctorale: 

ED158
Laboratory

Nom: 

Centre Interdisciplinaire Recherche Biologie

Initiatives d'Excellence: 

LabEx MemoLife
Publications

publications: 

Valtcheva S, Venance L. Astrocytes gate Hebbian synaptic plasticity in the striatum. Nat Commun. 2016 Dec 20;7:13845. doi: 10.1038/ncomms13845. 

Cui Y, Paille V, Xu H, Genet S, Delord B, Fino E, Berry H, Venance L. Endocannabinoids mediate bidirectional striatal spike-timing dependent plasticity. J Physiol. 2015 Apr 15. doi: 10.1113/JP270324.

Paille V#, Fino E#, Du K, Morera-Herreras T##, Perez S#, Hellgren Kotaleski J & Venance L# (2013) GABAergic circuits control spike-timing-dependent plasticity. J Neurosci. 33:9353-9363.

Nelson MJ, Bosch C#, Venance L# & Pouget P (2013) Microscale inhomogeneity of brain tissue distorts electrical signal propagation. J Neurosci. 33(7):2821-7.

Bosch C#, Mailly P, Degos B#, Deniau JM# & Venance L #(2012) Preservation of the hyperdirect pathway of basal ganglia in a rodent brain slice. Neuroscience 215, 31-41.

Evans RC, Morera-Herreras T#, Cui Y#, Du K, Sheehan T, Kotaleski JH, Venance L# & Blackwell KT (2012) The effects of NMDA subunit composition on calcium influx and spike timing-dependent plasticity in striatal medium spiny neurons. PLoS Comput Biol. 8, e1002493.

Puente N, Cui Y#, Lassalle O, Lafourcade M, Georges F, Venance L#*, Grandes P* & Manzoni OJ* (2011) Polymodal activation of the endocannabinoid system in the extended amygdala. Nature Neuroscience 14(12), 1542-7. *: co-senior authors Pandolfo, P, Silveirinha, V, dos Santos-Rodrigues, A, Venance, L#, Ledent, C, Takahashi, RN, Cunha, RA & Köfalvi, A 2011

Cannabinoids inhibit the synaptic uptake of adenosine and dopamine in the rat and mouse striatum?, Eur J Pharmacol. Vol.655(1-3), pp. 38-45.

Développement oligodendrocytaire et Interactions neurovasculaires

Domaine de recherche principal: 

Neurogenetics / neurodevelopment

Mots clefs: 

Neural stem cells
Neural development
Oligodendrocyte precursors
Vacsular growth factors and receptors
Neurovascular interactions
Multiple Sclerosis (MS) and gliomas
remyelinisation

Labelisation ENP: 

2007

Centre de recherche / Institut: 

Institut du Cerveau et de la Moelle épinière

Code unité de recherche: 

UMRS 1127 UMR 7225

One aspect of our research is the study of oligodendroglial cell development in the embryonic brain, especially the specification and migration of oligodendrocyte precursors (OPs). In addition, since the development of the central nervous system depends on constant interactions between neural cells and the cerebral vascular network, our studies extend to the neurovascular interactions occurring in the neurogenic niches and the white matter of the normal brain, as well as in the context of neural pathologies such as Multiple Sclerosis (MS) and gliomas.

Établissements

Établissement de rattachement: 

Inserm

Établissements affiliés: 

CNRS
Université Pierre et Marie Curie

Université: 

Université Pierre et Marie Curie

École doctorale: 

ED158
Laboratory

Initiatives d'Excellence: 

IHU-A-ICM
Publications

publications: 

He D, Marie C, Zhao C, Wang J, Deng Y, Kim B, Clavairoly A, Frah M, Wang H, He X, Hmidan H, Jones BV, Witte D, Zalc B, Zhou X, Choo DI, Martin DM, Parras C, Lu QR. (2016) Chd7 cooperates with Sox10 and regulates the onset of CNS myelination and remyelination. Nature Neurosci. 2016 May;19(5):678-89. doi: 10.1038/nn.4258. Epub 2016 Feb 29.

Bodini B, Veronese M, Garcia-Lorenzo D, Battaglini M, Poirion E, Chardain A, Freeman L, Louapre C, Tchikviladzé M, Papeix C, Dolle F, Zalc B, Lubetzki C, Bottlaender M, Turkheimer F, Stankoff B. (2016) Dynamic imaging of individual remyelination profiles in multiple sclerosis. Ann Neurol. 2016 Feb 18. doi: 10.1002/ana.24620. [Epub ahead of print]

Salzer JL & Zalc B. Myelination. Curr. Biol. 2016 Oct 24 ; vol. 26 (20) : R971‑R975. doi: 10.1016/j.cub.2016.07.074.

Mannioui A, Vauzanges Q,Fini JB, Henriet E, Sekizar S, Azoyan L, Thomas JL, Du Pasquier D, Giovannangeli C, Demeneix B, Lubetzki C, Zalc B. The Xenopus tadpole: an in vivo model to screen drugs favoring remyelination. Mult Scler. 2017 Jul 1:1352458517721355. doi: 10.1177/1352458517721355.

Remaud S, Ortiz FC, Perret-Jeanneret M, Aigrot MS, Gothié JD, Fekete C, Kvárta-Papp Z, Gereben B, Langui D, Lubetzki C, Angulo MC, Zalc B, Demeneix B. Transient hypothyroidism favors oligodendrocyte generation providing functional remyelination in the adult mouse brain.Elife. 2017 Sep 6;6. pii: e29996. doi: 10.7554/eLife.29996. [Epub ahead of print]

 

Développement et Evolution de la Neurotransmission

Domaine de recherche principal: 

Neurogenetics / neurodevelopment

Mots clefs: 

Dopamine, hypothalamus, forebrain, neuronal plasticity, neurogenesis

Labelisation ENP: 

2007

Centre de recherche / Institut: 

Institut des Neurosciences Paris-Saclay NeuroPSI

Code unité de recherche: 

UMR9197

Les recherches menées dans le laboratoire ont pour objet de comprendre les mécanismes de la mise en place, de l'organisation et de la différenciation du système nerveux des prochordés et des vertébrés. Nous analysons de façon comparative le développement du système nerveux d'organismes modèles (ascidies, amphioxus, lamproies, poissons téléostéens, xénope, poulet, souris), en utilisant une grande diversité de techniques moléculaires, cellulaires et embryologiques.

Leader

Leader: 

Établissements

Établissement de rattachement: 

CNRS

Établissements affiliés: 

Université Paris Sud

Université: 

Université Paris Sud 11

École doctorale: 

ED 568 BioSigNe
Laboratory

Nom: 

Département Développement & Évolution du cerveau

Initiatives d'Excellence: 

Idex NeuroSaclay
Publications

publications: 

Affaticati P, Yamamoto K, Rizzi B, Bureau C, Peyriéras N, Pasqualini C, Demarque M, Vernier P. Identification of the optic recess region as a morphogenetic entity in the zebrafish forebrain. Sci Rep. 2015 Mar 4;5:8738. doi: 10.1038/srep08738.  

Yamamoto, K, Mirabeau, O., Bureau, C., Blin, M., Coudouel, S. and Vernier, P. (2013) Evolution of the dopamine receptor genes of the D1 class in Vertebrates. Mol. Biol. Evol. 30: 833-843

 Fontaine, R., Affaticati, P., Yamamoto, K, Jolly, C., Bureau, C, Baloche, S., Gonnet, F., Vernier, P., Dufour, S. and Pasqualini, C. (2013) Dopamine inhibits reproduction in zebrafish (Danio rerio) via three pituitary D2 receptor subtypes. Endocrinology 54: 807-18. doi: 10.1210/en.2012-1759.

Bosco A, Bureau C, Affaticati P, Gaspar P, Bally-Cuif L, Lillesaar C. (2013) Development of hypothalamic serotoninergic neurons requires Fgf signalling via the ETS-domain transcription factor Etv5b. Development. 140: 372-84. doi: 10.1242/dev.089094.

Kalueff, AV, Stewart, AM, Kyzar, EJ, Cachat, J, Gebhardt, M., Landsman, S., Robinson, K, Maximino, C., Herculano, AM, Jesuthasan, S., Wisenden, B., Bally-Cuif, L., Lange, M., Vernier, P., Norton, W., Tierney, K., Tropepe, V., Neuhauss, SCF and the International Zebrafish Neuroscience Research Consortium. (2012) Time to recognize zebrafish ?affective? behaviour. Behaviour,149: 11019-1036

Razy-Krajka F, Brown, E., Horie, T., Callebert, J., Sasakura, Y, Joly, JS, Kusakabe, T and Vernier, P. (2012) Monoaminergic modulation of photoreception in ascidia: Evidence for a proto-hypothalamo-retinal territory. BMC Biol., 10: 45 doi:10.1186/1741-7007-10-45

Réseau Cortical et Couplage Neurovasculaire

Domaine de recherche principal: 

Neurophysiology / systems neuroscience

Mots clefs: 

cerebral cortex
electrophysiology
Optogenetics
neuronal circuits
blood perfusion and metabolism

Labelisation ENP: 

2007

Code unité de recherche: 

U1130 UMR8246 UMCR18

The team “Cortical network and Neurovascular Coupling” studies neuronal circuits and their relationships with the glio-vascular network in the cerebral cortex. Our previous work has advanced our knowledge of neocortical neuronal types, of their sensitivity to afferent signals, of their places in the functional architecture of intracortical peptidergic transmission, and of their differential roles in neurovascular coupling.

Établissements

Établissement de rattachement: 

Inserm

Établissements affiliés: 

CNRS
Université Pierre et Marie Curie

Université: 

Université Pierre et Marie Curie

École doctorale: 

ED158
Laboratory

Nom: 

Neuroscience Paris Seine

Initiatives d'Excellence: 

IHU Institut de Neurosciences Translationnelles de Paris
Publications

publications: 

Lecrux C, Toussay X, Kocharyan A, Fernandes P, Neupane S, Lévesque M, Plaisier F, Shmuel A, Cauli B, Hamel E. Pyramidal neurons are "neurogenic hubs" in the neurovascular coupling response to whisker stimulation. J Neurosci. 2011 Jul 6;31(27):9836-47.

Hu E, Demmou L, Cauli B, Gallopin T, Geoffroy H, Harris-Warrick RM, Paupardin-Tritsch D, Lambolez B, Vincent P, Hepp R. VIP, CRF, and PACAP act at distinct receptors to elicit different cAMP/PKA dynamics in the neocortex. Cereb  Cortex. 2011 Mar;21(3):708-18.

Tricoire L, Pelkey KA, Daw MI, Sousa VH, Miyoshi G, Jeffries B, Cauli B, Fishell G, McBain CJ. Common origins of hippocampal Ivy and nitric oxide synthase expressing neurogliaform cells. J Neurosci. 2010 Feb 10;30(6):2165-76.

Karagiannis A, Gallopin T, Dávid C, Battaglia D, Geoffroy H, Rossier J, Hillman EM, Staiger JF, Cauli B. Classification of NPY-expressing neocortical interneurons. J Neurosci. 2009 Mar 18;29(11):3642-59.

Petilla Interneuron Nomenclature Group, Ascoli GA, Alonso-Nanclares L, Anderson SA, Barrionuevo G, Benavides-Piccione R, Burkhalter A, Buzsáki G, Cauli  B, Defelipe J, Fairén A, Feldmeyer D, Fishell G, Fregnac Y, Freund TF, Gardner D, Gardner EP, Goldberg JH, Helmstaedter M, Hestrin S, Karube F, Kisvárday ZF, Lambolez B, Lewis DA, Marin O, Markram H, Muñoz A, Packer A, Petersen CC, Rockland KS, Rossier J, Rudy B, Somogyi P, Staiger JF, Tamas G, Thomson AM, Toledo-Rodriguez M, Wang Y, West DC, Yuste R. Petilla terminology: nomenclature of features of GABAergic interneurons of the cerebral cortex. Nat Rev Neurosci. 2008 Jul;9(7):557-68.

Dynamique oscillante et stochastique des réseaux thalamocorticaux

Domaine de recherche principal: 

Computational neurosciences / neural theory

Labelisation ENP: 

2007

Centre de recherche / Institut: 

Unité de Neuroscience, Information et Complexité

Code unité de recherche: 

UPR 3293

Propriétés intégratives des neurones du neocortex dans les états de haute conductance.

Leader

Leader: 

Personnel

Etudiants ENP: 

Établissements

Établissement de rattachement: 

CNRS

Établissements affiliés: 

Université Paris Sud

Université: 

Université Pierre et Marie Curie

École doctorale: 

ED158 - 3C
Laboratory

Initiatives d'Excellence: 

IDEX NeuroSaclay
Publications

publications: 

Dehghani, N., Peyrache, A., Telenczuk, B., Le Van Quyen, M., Halgren, E., Cash, S.S., Hatsopoulos, N.G. and Destexhe, A. Dynamic balance of excitation and inhibition in human and monkey neocortex.  Nature Scientific Reports 6: 23176, 2016.  DOI: 10.1038/srep23176

Zerlaut, Y. and Destexhe, A. Enhanced responsiveness and low-level awareness in stochastic network states.  Neuron 7: 1002-1009, 2017. DOI: 10.1016/j.neuron.2017.04.001

Telenczuk, B., Dehghani, N., Le Van Quyen, M., Cash, S., Halgren, E., Hatsopoulos, N.G. and Destexhe, A. Local field potentials primarily reflect inhibitory neuron activity in human and monkey cortex.  Nature Scientific Reports 7: 40211, 2017.  DOI: 10.1038/srep40211

Barbieri, F., Trauchessec, V.. Caruso, L., Trejo Rosillo, J., Telenczuk, B., Paul, E., Bal, T., Destexhe, A., Fermon, C., Pannetier-Lecoeur, M. and Ouanounou, G. Local recording of biological magnetic fields using Giant Magneto Resistance-based micro-probes.  Nature Scientific Reports 6: 39330, 2016.  DOI: 10.1038/srep39330

Le Van Quyen, M., Muller, L., Telenczuk, B., Cash, S.S., Halgren, E., Hatsopoulos, N.G., Dehghani, N. and Destexhe, A. High-frequency oscillations in human and monkey neocortex during the wake-sleep cycle.  Proc. Natl. Acad. Sci. USA 113: 9363-9368, 2016.  DOI: 10.1073/pnas.1523583113

Cognisciences: Intégration et plasticité synaptique dans le cortex visuel

Domaine de recherche principal: 

Neurophysiology / systems neuroscience

Mots clefs: 

Vision
electrophysiology
imaging
Multiscale
Modeling

Labelisation ENP: 

2007

Centre de recherche / Institut: 

Unité de Neuroscience, Information et Complexité

Code unité de recherche: 

UPR 3293

An issue central to the theme of complexity in the dynamics and function of biological networks concerns the inferences that can be made from multiscale measurements ranging from microscopic to macroscopic levels of integration. Our research is based on interdisciplinary approaches ranging from electrophysiology (intracellular sharp and patch recordings, in vivo), network imaging (voltage sensitive dye), psychophysical measurements to functional databasing and phenomenological and computational modeling.

Personnel

Etudiants ENP: 

Établissements

Établissement de rattachement: 

CNRS

Établissements affiliés: 

Université Paris Sud

Université: 

Université Pierre et Marie Curie

École doctorale: 

ED158 - 3C
Laboratory

Initiatives d'Excellence: 

Idex i-Code, Idex NeuroSaclay
Publications

publications: 

Gerard-Mercier F, Carelli PV, Pananceau M, Troncoso XG, Frégnac Y. Synaptic Correlates of Low-Level Perception in V1. J Neurosci. 2016 Apr 6;36(14):3925-42. doi: 10.1523/JNEUROSCI.4492-15.2016.

Fournier J, Monier C, Levy M, Marre O, Sári K, Kisvárday ZF, Frégnac Y. Hidden complexity of synaptic receptive fields in cat V1. J Neurosci. 2014 Apr 16;34(16):5515-28. doi: 10.1523/JNEUROSCI.0474-13.2014.

Arduin P.J. , Ego-Stengel V. , Frégnac Y. and Shulz D.E. (2013) Master neurons induced by operant conditioning in rat motor cortex during a brain-machine interface task. The Journal of Neuroscience. 33(19): 8308-20.

Levy M. , Fournier J. and Frégnac Y. (2013) The role of delayed suppression in slow and fast contrast adaptation in v1 simple cells. The Journal of Neuroscience. 33(15):6388-400.

El Boustani S. , Yger P. , Destexhe A. and Frégnac Y. (2012) A. Stable learning in stochastic network states. J. Neurosci. 32: 194-214.

Frégnac Y. (2012) Reading out the synaptic echoes of low level perception in V1. Lecture Notes in Computer Science. 7583: 486-495.

Chavane F. , Sharon D. , Jancke D. , Marre O. , Frégnac Y. and Grinvald A. (2011) Lateral spread of orientation selectivity in V1 is controlled by intracortical cooperativity. Frontiers in System Neuroscience, 5:4. 1-26.

Dynamique cérébrale, Mémoire et Apprentissage

Domaine de recherche principal: 

Neurophysiology / systems neuroscience

Mots clefs: 

computational neuroscience
Cortex
Cerebellum
basal ganglia
Network mechanism

Labelisation ENP: 

2009

Centre de recherche / Institut: 

INCC - UMR 8002 - Paris Descartes University

Code unité de recherche: 

UMR 8002

Nos recherches portent sur la dynamique du cortex cérébral, du cervelet et des ganglions de la base. Les axes de recherche sont: 1- Etude de la Perception, de la Cognition & du Comportement, 2- Le Dévelopment & la Plasticité, 3- La Neurophysiologie & les Pathologies neuronales.

Leader

Leader: 

Établissements

Établissement de rattachement: 

CNRS

Établissements affiliés: 

Université Paris Descartes

Université: 

Université Pierre et Marie Curie

École doctorale: 

ED158
Laboratory

Nom: 

Centre de Neurophysique, Physiologie et Pathologie
Publications

publications: 

Arakaki T, Mahon S, Charpier S, Leblois A, Hansel D. The Role of Striatal Feedforward Inhibition in the Maintenance of Absence Seizures. J Neurosci. 2016 Sep 14;36(37):9618-32. doi: 10.1523/JNEUROSCI.0208-16.2016.

Arakaki T, Mahon S, Charpier S, Leblois A, Hansel D. The Role of Striatal Feedforward Inhibition in the Maintenance of Absence Seizures. J Neurosci. 2016 Sep 14;36(37):9618-32. doi: 10.1523/JNEUROSCI.0208-16.2016.

Gould M,# Leblois A, Cesa Bianchi F, Montenegro V. (2014) Convention on the rights of persons with disabilities, assistive technology and information and communication technology requirements: where do we stand on implementation? Disabil Rehabil Assist Technol. Nov 3:1-6.

#Mongillo G, Shteingart H, Loewenstein Y. 2014. The Misbehavior of Reinforcement Learning. Proceedings of the IEEE 102, 528–541.

#Ady V, Perroy J, Tricoire L, Piochon C, Dadak S, Chen X, Dusart I, Fagni L, Lambolez B,# Levenes C. 2014. Type 1 metabotropic glutamate receptors (mGlu1) trigger the gating of GluD2 delta  glutamate receptors. EMBO Reports 15(1), 103–109 

#Darshan R, #Leblois A, #Hansel D. 2014. Interference and Shaping in Sensorimotor Adaptations with rewards.PLOS Comput. Biol. 10:e1003377 

Goldin MA, Alonso LM, #Alliende JA, Goller F, Mindlin GB. 2013. Temperature Induced Syllable Breaking Unveils Nonlinearly Interacting Timescales in Birdsong Motor Pathway. PLOS ONE 8(6):e67814

CENIR Imagerie à Résonance Magnétique

Domaine de recherche principal: 

Neurophysiology / systems neuroscience

Mots clefs: 

MEG
EEG
IRM
Sciences Cognitives
Neurophysiologie
Pathologies cérébrales et médullaires

Labelisation ENP: 

2007

Centre de recherche / Institut: 

Institut du Cerveau et de la Moelle épinière

Code unité de recherche: 

UMRS 1127 UMR 7225

Le CENIR a pu commencer ses activités de recherche en neuro-imagerie grâce à la coopération financière de grandes institutions publiques et de prestigieux partenaires privés. L'ENP a cofinancé l'antenne tête 32 canaux et 100% de leur système EEG. 

Leader

Leader: 

Établissements

Établissement de rattachement: 

Inserm

Établissements affiliés: 

CNRS
Université Pierre et Marie Curie

Université: 

Université Pierre et Marie Curie

École doctorale: 

ED158
Laboratory

Nom: 

Institut du Cerveau et de la Moëlle

Initiatives d'Excellence: 

IHU-A-ICM, FLI, Neuratris
Publications

publications: 

Gargouri F, Messé A, Perlbarg V, Valabregue R, McColgan P, Yahia-Cherif L, Fernandez-Vidal S, Ben Hamida A, Benali H, Tabrizi S, Durr A, Lehéricy S. Longitudinal changes in functional connectivity of cortico-basal ganglia networks in manifests and premanifest huntington's disease. Hum Brain Mapp. 2016 Jul 12. doi: 10.1002/hbm.23299. 

Rosso C, Valabregue R, Arbizu C, Ferrieux S, Vargas P, Humbert F, Attal Y, Messé A, Zavanone C, Meunier S, Cohen L, Delmaire C, Thielscher A, Herz DM, Siebner HR, Samson Y, Lehéricy S. The eye of the self: precuneus volume and visual perspective during autobiographical memory retrieval. Brain Struct Funct. 2014 May;219(3):959-68. doi: 10.1007/s00429-013-0546-2. Epub 2013 Apr 4.

Dumas, T., Dubal, S., Attal, Y., Morel, S., Chupin, M., Jouvent, R., & George, N. (2013). MEG evidence for early amygdala responses to fearful faces in healthy adults. PloS ONE, 8(9): e74145. oi:10.1371/journal.pone.0074145.

Fasoula A, et al. Comparative performance evaluation of data-driven causality measures applied to brain networks. J Neurosci Methods (2013), http://dx.doi.org/10.1016/j.jneumeth.2013.02.021

Attal Y, Schwartz D Assessment of Subcortical Source Localization Using Deep Brain Activity Imaging Model with Minimum Norm Operators: A MEG Study. PLoS ONE (2013) 8(3): e59856. doi:10.1371/journal.pone.0059856

Dalal, SS., Jerbi, K., Bertrand, O., Adam, C., Ducorps, A., Schwartz, D., Garnero, L., Baillet, S., Martinerie, J., Lachaux, J-P. Evidence for MEG detection of hippocampus oscillations and cortical gamma-band activity from simultaneous intracranial EEG. Epilepsy & Behavior (2013) 28 (2), 310-311. Dio: 10.1016/j.yebeh.2012.04.032

Ulloa, J.L., Puce, A., Hugueville, L., & George, N. (2013). Sustained neural activity to gaze and emotion perception in dynamic social scenes. SCAN, in press. doi: 10.1093/scan/nss141

Inhibition synaptique et auto-régulation des microcircuits corticaux

Domaine de recherche principal: 

Neurophysiology / systems neuroscience

Mots clefs: 

Inhibition
cerebral cortex
interneurons
synaptic transmission
GABA

Labelisation ENP: 

2011

Centre de recherche / Institut: 

Institut du Cerveau et de la Moelle épinière

Code unité de recherche: 

UMRS 1127 UMR 7225

In the cerebral cortex the constant computation of incoming sensory information is dynamically integrated to provide a coherent representation of the world and generate highly sophisticated cognitive functions. Cortical circuits are made of different neuron types connecting one another through a staggering number of synaptic connections that are responsible for the propagation of information between neurons.

Leader

Leader: 

Personnel

Etudiants ENP: 

Établissements

Établissement de rattachement: 

Inserm

Établissements affiliés: 

CNRS
Université Pierre et Marie Curie

Université: 

Université Pierre et Marie Curie

École doctorale: 

ED158
Laboratory

Initiatives d'Excellence: 

LabEX BioPsy, ENI-Net
Publications

publications: 

Antonucci F, Corradini I, Morini R, Fossati G, Menna E, Pozzi D, Pacioni S, Verderio C, Bacci A, Matteoli M (2013) Reduced SNAP-25 alters short-term plasticity at developing glutamatergic synapses EMBO Rep. 14:645-51.

Baptista S, Lourenço J, Milhazes N, Borges F, Silva AP, Bacci A. Long-Term Treatment with Low Doses of Methamphetamine Promotes Neuronal Differentiation and Strengthens Long-Term Potentiation of Glutamatergic Synapses onto Dentate Granule Neurons. eNeuro. 2016 Jul 11;3(3). pii: ENEURO.0141-16.2016. doi: 10.1523/ENEURO.0141-16.2016. eCollection 2016 May-Jun.

Lourenço J, Pacioni S, Rebola N, van Woerden GM, Marinelli S, DiGregorio D, Bacci A (2014) Non-associative potentiation ofperisomatic inhibition alters the temporal coding of neocortical layer 5 pyramidal neurons PLoS Biology 12:e1001903