Neurophysiology / systems neuroscience

CONTRÔLE MOTEUR NORMAL ET ANORMAL: DÉSORDRES MOTEURS ET THÉRAPEUTIQUES EXPÉRIMENTALES: MOV’IT

Domaine de recherche principal: 

Neurophysiology / systems neuroscience

Mots clefs: 

Parkinson
syndrome Gilles de la Tourette
dystonie
thérapeutique
ganglions de la base

Labelisation ENP: 

2007

Centre de recherche / Institut: 

Institut du Cerveau et de la Moelle épinière

Code unité de recherche: 

UMRS 1127 UMR 7225

Our main research topic is the physiological analysis of both subcortical and cortical brain structures involved in the control of normal and abnormal movements. Dystonia, Gilles de la Tourette syndrome (GTS) and Parkinson’s disease (PD) will be taken as models of basal ganglia dysfunction. The implication of basal ganglia in movement disorders will be analysed by a multimodal approaches in relation with basic science groups and access to platforms (CENIR-imaging; neurophysiology laboratory, functional neurosurgery team and sleep lab).

Leader

Leader: 

Co leader: 

Établissements

Établissement de rattachement: 

Inserm

Établissements affiliés: 

CNRS
Université Pierre et Marie Curie

Université: 

Université Pierre et Marie Curie

École doctorale: 

ED158
Laboratory

Initiatives d'Excellence: 

IHU A-ICM, Institut Carnot ICM Hôpital Pitié Salpêtrière
Publications

publications: 

Welter ML, Grabli D, Karachi C, Jodoin N, Fernandez-Vidal S, Brun Y, Navarro S, Rogers A, Cornu P, Pidoux B, Yelnik J, Roze E, Bardinet E, Vidailhet M. Pallidal activity in myoclonus dystonia correlates with motor signs. Mov Disord. 2015 Apr 16. doi: 10.1002/mds.26244. 

Nalls MA, et al. Large-scale meta-analysis of genome-wide association data identifies six new risk loci for Parkinson's disease. Nat Genet. 2014 Sep;46(9):989-93. doi: 10.1038/ng.3043. Epub 2014 Jul 27.

García-Lorenzo D, Longo-Dos Santos C, Ewenczyk C, Leu-Semenescu S, Gallea C, Quattrocchi G, Pita Lobo P, Poupon C, Benali H, Arnulf I, Vidailhet M, Lehericy S. (2013) The coeruleus/subcoeruleus complex in rapid eye movement sleep behaviour disorders inParkinson's disease. Brain. 136:2120-9

Nelson M, Bosch C, Venance L, Pouget P. (2013) Microscale inhomogeneity of brain tissue distorts electrical signal propagation. J.Neuroscience 33:2821-7. (IF=7.12)

Corvol JC, Bonnet C, Charbonnier-Beaupel F, Bonnet AM , Roze E, Melyksekian G, Ben Djebara M, Hartmann A, Lacomblez L, Vrignaud C, Zahr N, Agid Y, Costentin J, Hulot JB, Vidailhet M. The non synonymous Val258Met polymorphism in COMT gene impacts entacapone response to L-DOPA in Parkinson’s disease: a randomized cross-over clinical trial. Ann Neurol. 2011;;69:111-8. (IF=10.74)

Lehéricy S, Hartmann A, Lannuzel A, Galanaud D, Delmaire C, Bienaimée MJ, Jodoin N, Roze E, Gaymard B, Vidailhet M. Magnetic resonance imaging lesion pattern in Guadeloupean parkinsonism is distinct from progressive supranuclear palsy Source: Brain. 2010 Mar;133: 2410-2425    (IF=9.5)

 Vidailhet M, Yelnik J, Lagrange C, Fraix V, Grabli D, Thobois S, Burbaud P, Welter ML, Xie-Brustolin J, Braga MC, Ardouin C, Czernecki V, Klinger H, Chabardes S, Seigneuret E, Mertens P, Cuny E, Navarro S, Cornu P, Benabid AL, Lebas JF, Dormont D, Hermier M, Dujardin K, Blond S, Krystkowiak P, Destée A, Bardinet E, Agid Y, Krack P, Broussolle E, Pollak P; for the French SPIDY-2 Study Group Bilateral pallidal deep brain stimulation for the treatment of patients with dystonia-choreoathetosis cerebral palsy: a prospective pilot study Lancet Neurol 8 (8): 709-17, 2009. (IF=18.12)

Génétique Moléculaire des Rythmes Circadiens

Domaine de recherche principal: 

Neurogenetics / neurodevelopment

Mots clefs: 

génétique de la drosophile
biologie moléculaire

Labelisation ENP: 

2005

Centre de recherche / Institut: 

Institut des Neurosciences Paris-Saclay NeuroPSI

Code unité de recherche: 

UMR9197

Notre équipe travaille sur l’horloge circadienne qui contrôle les rythmes activité-repos dans le cerveau de la drosophile, selon trois axes de recherche :- Bases neurales de l’horloge cérébrale : rôle des différents oscillateurs neuronaux et organisation du réseau, voies de synchronisation par la lumière et la température (entrées), transmission de l’information circadienne dans le cerveau (sorties)- Différenciation des neurones d’horloge et mise en place de la fonction circadienne au cours du développement cérébral- Bases moléculaires de l’oscillateur circadien : contrôle post-traductionne

Leader

Leader: 

Établissements

Établissement de rattachement: 

CNRS

Établissements affiliés: 

Université Paris Sud

Université: 

Université Paris Saclay

École doctorale: 

ED577
Laboratory

Nom: 

Département Molécules & Circuits

Initiatives d'Excellence: 

Idex NeuroSaclay
Publications

publications: 

Saint-Charles A, Michard-Vanhée C, Alejevski F, Chélot E, Boivin A, Rouyer F. Four of the six Drosophila rhodopsin-expressing photoreceptors can mediate circadian entrainment in low light. J Comp Neurol. 2016 Oct 1;524(14):2828-44. doi: 10.1002/cne.23994. Epub 2016 Mar 28.

Szabo, A., Papin, C., Zorn, D., Ponien, P., Weber, F., Raabe, T., and Rouyer, F. (2013). The CK2 kinase stabilizes CLOCK and represses its activity in the Drosophila circadian oscillator. PLoS Biol 11, e1001645.

Vieira, J., Jones, A. R., Danon, A., Sakuma, M., Hoang, N., Robles, D., Tait, S., Heyes, D. J., Picot, M., Yoshii, T., Helfrich-Forster, C., Soubigou, G., Coppee, J. Y., Klarsfeld, A., Rouyer, F., Scrutton, N. S., and Ahmad, M. (2012). Human cryptochrome-1 confers light independent biological activity in transgenic Drosophila correlated with flavin radical stability. PLoS One 7, e31867.

Grima, B., Dognon, A., Lamouroux, A., Chelot, E., and Rouyer, F. (2012). CULLIN-3 Controls TIMELESS Oscillations in the Drosophila Circadian Clock. PLoS Biol 10, e1001367.

Lamaze, A., Lamouroux, A., Vias, C., Hung, H. C., Weber, F., and Rouyer, F. (2011). The E3 ubiquitin ligase CTRIP controls CLOCK levels and PERIOD oscillations in Drosophila. EMBO Rep 12, 549-557.

Klarsfeld, A., Picot, M., Vias, C., Chelot, E., and Rouyer, F. (2011). Identifying specific light inputs for each subgroup of brain clock neurons in Drosophila larvae. J Neurosci 31, 17406-17415.

Métabolisme, Imagerie et Olfaction

Domaine de recherche principal: 

Neurophysiology / systems neuroscience

Mots clefs: 

Olfactory system
neuroglial activity
Multisensory integration
food intake/obesity
imaging
electrophy/oscillations/behavior

Labelisation ENP: 

2010

Code unité de recherche: 

UMR 8165

Notre recherche porte sur l’étude de la plasticité sensorielle dans le système olfactif chez le rongeur adulte. Dans ce cadre, nous étudions la représentation spatiale et temporelle des odeurs dans le la première structure qui est chargée de coder l’information olfactive dans le cerveau, le bulbe olfactif (BO).

Personnel

Membres de l'équipe: 

MARTIN
PAIN
Établissements

Établissement de rattachement: 

Université Paris Diderot

Établissements affiliés: 

Université Paris Sud 11
CNRS

Université: 

Université Paris Sud 11

École doctorale: 

ED 419
Publications

publications: 

Martin C, Ravel N. (2014) Beta and gamma oscillatory activities associated with olfactory memory tasks: different rhythms for different functional networks? Front Behav Neurosci. 8:218. Free on line.

Osmanski BF, Martin C, Montaldo G, Lanièce P, Pain F, Tanter M, Gurden H. (2014) Functional ultrasound imaging reveals different odor-evoked patterns of vascular activity in the olfactory bulb and the anterior piriform cortex. Neuroimage. 95:176-84.

Soria-Gómez E., Bellocchio L., Reguero L., Lepousez G., Martin M., Bendahmane M., Ruehle S, Remmers F, Desprez T, Matias I, Wiesner T, Cannich A, Nissant A, Wadleigh A, Pape HC, Chiarlone AP, Quarta C, Verrier D, Vincent P, Massa F, Lutz B., Guzmán M, Gurden H., Ferreira G., Lledo PM, Grandes P., Marsicano G. (2014) The endocannabinoid system controls food intake via olfactory processes. Nature Neuroscience. 17(3):407-15. 

Martin C, Houitte D, Guillermier M, Petit F, Bonvento G, Gurden H. (2012) Alteration of sensory-evoked metabolic and oscillatory activities in the olfactory bulb of GLAST-deficient mice. Front Neural Circuits. 6:1. Free on line.



Synapses gabaergiques du cervelet

Domaine de recherche principal: 

Neuropharmacology / cell signaling

Mots clefs: 

Patch clamp
imagerie cellulaire
electrophysiologie

Labelisation ENP: 

2007

Centre de recherche / Institut: 

INCC - UMR 8002 - Paris Descartes University

Code unité de recherche: 

UMR 8118

L’équipe pratique une approche pluridisciplinaire incorporant des techniques physiques (optique), mathématiques (statistiques, modélisation) et chimiques (synthèse de composés). Elle développe des méthodes nouvelles pour étudier les mécanismes de communication cellulaire dans le tissu cérébral.

Leader

Leader: 

Personnel

Membres de l'équipe: 

David Ogden
Isabel Llano
Établissements

Établissement de rattachement: 

CNRS

Établissements affiliés: 

Université Paris Descartes

Université: 

Université Paris Descartes / Université Paris Diderot
Laboratory

Nom: 

Laboratoire de physiologie cérébrale
Publications

publications: 

Miki T, Malagon G, Pulido C, Llano I, Neher E, Marty A. Actin- and Myosin-Dependent Vesicle Loading of Presynaptic Docking Sites Prior to Exocytosis. Neuron. 2016 Aug 17;91(4):808-23. doi: 10.1016/j.neuron.2016.07.033.

Pulido C, Trigo FF, Llano I, Marty A. Vesicular release statistics and unitary postsynaptic current at single GABAergic synapses. Neuron. 2015 Jan 7;85(1):159-72. doi: 10.1016/j.neuron.2014.12.006. Epub 2014 Dec 24.

Alcami P, Marty A. Estimating functional connectivity in an electrically coupled interneuron network. Proc Natl Acad Sci U S A. 2013 Dec 3;110(49):E4798-807. doi: 10.1073/pnas.1310983110. Epub 2013 Nov 18.

Lamotte d'Incamps B, Krejci E, Ascher P (2012) Mechanisms shaping the slow nicotinic synaptic current at the motoneuron-renshaw cell synapse. J. Neurosci 32:8413-8423

Mejia-Gervacio, S. V. (2012). Muscarinic control of AMPA receptor responsiveness in mouse spinal cord motoneurons. J. Physiol. in press.

Palma-Cerda F, Auger C, Crawford DJ, Hodgson ACC, Reynolds SJ, Cowell JK, Swift KAD, Cais O, Vyklicky L, Corrie JET, Ogden D (2012) New caged neurotransmitter analogs selective for glutamate receptor sub-types based on methoxynitroindoline and nitrophenylethoxycarbonyl caging groups. Neuropharmacology 63:624-634

Pessac B, Nimmagadda VK, Makar T, Fishman PS, Bever CT, Trisler D (2012) Adult hematopoietic progenitors are multipotent in chimeric mice. C. R. Biol 335:454-462

Rossi B, Ogden D, Llano I, Tan YP, Marty A, Collin T (2012) Current and Calcium Responses to Local Activation of Axonal NMDA  Receptors in Developing Cerebellar Molecular Layer Interneurons. PLoS One 7 7(6): e39983



De la stimulation sensorielle à l'hyperémie fonctionnelle

Domaine de recherche principal: 

Neurophysiology / systems neuroscience

Mots clefs: 

Olfaction
Microscopy of the living brain

Labelisation ENP: 

2007

Centre de recherche / Institut: 

Institut de la Vision

Code unité de recherche: 

U1128

Our goal is to understand how a sensory stimulus such as an odor generates a population activity in a small cellular network, the olfactory bulb glomerulus. We investigate this question by using or developing optical tools that can be combined with electrophysiological recordings and allow the observation of neuron and astrocyte activities in vitro and in vivo. During the last 5 years, our research aimed in three directions:

1. The improvement of optical methods to image cellular activity, blood flow and brain metabolism

Leader

Leader: 

Établissements

Établissement de rattachement: 

Inserm

Établissements affiliés: 

CNRS
Université Paris Descartes

Université: 

Université Paris Descartes / Université Pierre et Marie Curie

École doctorale: 

ED 157 GC2ID / ED158
Laboratory

Nom: 

Neurophysiology & New Microscopies Laboratory

Initiatives d'Excellence: 

Idex Sorbonne Paris Cité
Publications

publications: 

Lyons DG, Parpaleix A, Roche M, Charpak S.Mapping oxygen concentration in the awake mouse brain.Elife. 2016 Feb 2;5. pii: e12024. doi: 10.7554/eLife.12024.

Ducros M, Houssen YG, Bradley J, de S, V, Charpak S (2013) Encoded multisite two-photon microscopy. Proc Natl Acad Sci U S A.110 13138-13143.

Parpaleix A, Houssen YG, Charpak S. (2013) Imaging local neuronal activity by monitoring Po2 transients in capillaries. Nature med,19:241-246.

Charpak S, Stefanovic B (2012) Shedding light on the BOLD fMRI response. Nat Methods 9:547-549. (News and Views)

Lecoq, J, Parpaleix, A, Roussakis, E, Ducros, M., Goulam, Y, Vinogradov, S, Charpak, S (2011) Simultaneous two-photon imaging of oxygen and blood flow in deep cerebral vessels. Nature Med. 17:893-898.

Najac M., De Saintjan D,Reguero L,Grandes P,Charpak S (2011) Mono- and polysynaptic feed-forward inputs to mitral cells from olfactory sensory neurons, J Neurosci. 31:8722-8729.

Plasticité Gliale et Neuro-Oncologie

Domaine de recherche principal: 

Neurophysiology / systems neuroscience

Mots clefs: 

Neural stem cells
Glial cells
Brain tumors
cellular biology
Therapeutics

Labelisation ENP: 

2009

Centre de recherche / Institut: 

Institut de Biologie Paris Seine

Code unité de recherche: 

U1130 UMR8246 UMCR18

The main focus of our research is the plasticity and development of human brain tumors
We are interested in understanding how interactions between cell intrinsic and extrinsic signaling pathways control the stem and tumor-initiating properties of glioma stem cells.

Leader

Leader: 

Co leader: 

Établissements

Établissement de rattachement: 

Inserm

Établissements affiliés: 

CNRS
Université Pierre et Marie Curie
Laboratory

Nom: 

Neuroscience Paris Seine
Publications

publications: 

El-Habr EA, Dubois LG, Burel-Vandenbos F, Bogeas A, Lipecka J, Turchi L, Lejeune FX, Coehlo PL, Yamaki T, Wittmann BM, Fareh M, Mahfoudhi E, Janin M, Narayanan A, Morvan-Dubois G, Schmitt C, Verreault M, Oliver L, Sharif A, Pallud J, Devaux B, Puget S, Korkolopoulou P, Varlet P, Ottolenghi C, Plo I, Moura-Neto V, Virolle T, Chneiweiss H*, Junier MP*. A driver role for GABA metabolism in controlling stem and proliferative cell state through GHB production in glioma. Acta Neuropathol. 2017 Apr;133(4):645-660. doi: 10.1007/s00401-016-1659-5. [IF: 12.21] 

Fareh M, Almairac F, Turchi L, Burel-Vandenbos F, Paquis P, Fontaine D, Lacas-Gervais S, Junier MP, Chneiweiss H, Virolle T. Cell-based therapy using miR-302-367 expressing cells represses glioblastoma growth. Cell Death Dis. 2017 ;8(3):e2713. doi: 10.1038/cddis.2017.117. [IF: 5.97]

 

Debruyne DN, Turchi L, Burel-Vandenbos F, Fareh M, Almairac F, Virolle V, Figarella-Branger D, Baeza-Kallee N, Lagadec P, Kubiniek V, Paquis P, Fontaine D, Junier MP, Chneiweiss H, Virolle T.DOCK4 promotes loss of proliferation in glioblastoma progenitor cells through nuclear beta-catenin accumulation and subsequent miR-302-367 cluster expression.Oncogene. 2017 Sep 18. doi: 10.1038/onc.2017.323

 Assad Kahn S, Costa SL, Gholamin S, Nitta RT, Dubois LG, F√®ve M, Zeniou M, Coelho PL, El-Habr E, Cadusseau J, Varlet P, Mitra SS, Devaux B, Kilhoffer MC, Cheshier SH, Moura-Neto V, Haiech J, Junier MP*, Chneiweiss H*. The anti-hypertensive drug prazosin inhibits glioblastoma growth via the PKCdelta-dependent inhibition of the AKT pathway. EMBO Mol Med. 2016 May 2;8(5):511-26. doi: 10.15252/emmm.201505421. [IF: 9.25]

Hirsch F, Lévy Y, Chneiweiss H. CRISPR-Cas9: A European position on genome editing. Nature. 2017 Jan 4;541(7635):30. doi: 10.1038/541030c.

Groupe Interactions cellules gliales/cellules gliales et cellules gliales/neurones

Domaine de recherche principal: 

Neurophysiology / systems neuroscience

Mots clefs: 

synaptic transmission
plasticity
astrocytes
GPCR signaling
neuron-glia interactions in physiology of the central nervous system
neuron-astrocyte interactions
glia in memory and sleep
glia in psychiatric and neurodegenerative diseases

Labelisation ENP: 

2012

Centre de recherche / Institut: 

INCC - UMR 8002 - Paris Descartes University

Code unité de recherche: 

FR3636

We are interested in understanding the role of glial cells in the mammalian central nervous system (CNS) and the mechanisms by which glial cells and neurons interact to support normal communication in the CNS.

Leader

Leader: 

Établissements

Établissement de rattachement: 

CNRS

Établissements affiliés: 

Université Paris Descartes

Université: 

Université Paris Descartes

École doctorale: 

ED3C
Laboratory

Nom: 

UFR Biomédicale

Initiatives d'Excellence: 

Institut Neuroscience et Cognition
Publications

publications: 

Agulhon C, Sun MY, Murphy T, Myers T, Lauderdale K, Fiacco TA. Calcium signaling and gliotransmission in normal versus reactive astrocytes, Frontiers in Neuropharmacology. In Press.

Agulhon C, Fiacco TA, McCarthy KD , Hippocampal short- and long-term plasticity are not modulated by astrocyte Ca2+ signaling, Science.327:1250-4, 2010.

Fiacco TA, Agulhon C, McCarthy KD. Sorting out astrocyte physiology from pharmacology, Annu Rev Pharmacol Toxicol. 49:151-174 2009.

Agulhon C, Petravicz J, McMullen AB, Sweger EJ, Minton SK, Taves SR, Casper KB, Fiacco TA, McCarthy KD. What is the role of astrocyte calcium in neurophysiology?, Neuron. 59:932-946, 2008.

Fiacco TA, Agulhon C, Taves S, Petravicz J, Casper K, Dong Xinzhong, Chen J, McCarthy KD. Selective stimulation of astrocyte calcium in situ does not affect neuronal excitatory synaptic activity, Neuron. 54:611-626, 2007.

Genetics and physiopathology of epilepsy

Domaine de recherche principal: 

Neurogenetics / neurodevelopment

Mots clefs: 

Epilepsie
Physiopathologie
electrophysiology

Labelisation ENP: 

2009

Centre de recherche / Institut: 

Institut du Cerveau et de la Moelle épinière

Code unité de recherche: 

UMRS 1127 UMR 7225

Notre équipe s’intéresse aux aspects génétiques et physiopathologiques des épilepsies familiales. Notre objectif est d’élucider les bases moléculaires de certaines formes d’épilepsie et de clarifier les mécanismes pathogéniques sous-jacents grâce à l’étude de modèles cellulaires et animaux. Les formes familiales d’épilepsies constituent des modèles pertinents pour les formes communes d’épilepsie en identifiant des protéines clefs impliquées dans l’épileptogénèse et l’ictogénèse.

Leader

Leader: 

Co leader: 

Personnel

Membres de l'équipe: 

Elise Marsan
Christel Depienne
Virginie Lambrecq
Eric Noé
Théo Ribierre
GIuseppe Muraca
Manon Quiquand
Établissements

Établissement de rattachement: 

Inserm

Établissements affiliés: 

CNRS
Université Pierre et Marie Curie

École doctorale: 

ED3C - n°158
Laboratory

Initiatives d'Excellence: 

IHU-A-ICM; ERC Consolidator Grant
Publications

publications: 

Boillot M, Lee CY, Allene C, Leguern E, Baulac S*, Rouach N* (2016). LGI1 acts presynaptically to regulate excitatory synaptic transmission during early postnatal development. Scientific Reports. Feb 16;6:21769. *co-last

Marsan E, Ishida S, Schramm A, Weckhuysen S, Muraca G, Lecas S, Liang N, Treins C, Pende M, Roussel D, Le Van Quyen M, Mashimo T, Kaneko T, Yamamoto T, Sakuma T, Mahon S, Miles R, Leguern E, Charpier S, Baulac S. (2016) Depdc5 knockout rat: A novel model of mTORopathy. Neurobiol Dis 89:180-189.

Weckhuysen S, Marsan E, Lambrecq V, Marchal C, Morin-Brureau M, An-Gourfinkel I, Baulac M, Fohlen M, Kallay Zetchi C, Seeck M, de la Grange P, Dermaut B, Meurs A, Thomas P, Chassoux F, Leguern E, Picard F, Baulac S. (2016) Involvement of GATOR complex genes in familial focal epilepsies and focal cortical dysplasia. Epilepsia 57:994-1003. Article awarded the 2017 Clinical Epilepsia Prize.

Baulac S, Ishida S, Marsan E, Miquel C, Biraben A, Nguyen DK, Nordli D, Cossette P, Nguyen S, Lambrecq V, Vlaicu M, Daniau M, Bielle F, Andermann E, Andermann F, Leguern E, Chassoux F, Picard F (2015). Familial focal epilepsy with focal cortical dysplasia due to DEPDC5 mutations. Ann Neurol. Apr;77(4):675-83. Article highlighted as Best Advances of 2015: Picks from the Neurology Today Editorial Advisory Board

Ishida S, Picard F, Rudolf G, Noé E, Achaz G, Thomas P, Genton P, Mundwiller E, Wolff M, Marescaux C, Miles R, Baulac M, Hirsch E, Leguern E and Baulac S (2013). Mutations of DEPDC5 cause autosomal dominant focal epilepsies. Nature Genetics, Apr 26;45(5):552-5. Highlighted in Nature Review Neurology 

Génétique et physiologie de l'audition

Domaine de recherche principal: 

Neurogenetics / neurodevelopment

Mots clefs: 

human genetics
electrophysiology
Biophysics
Biochemistry
Hearing molecular physiology
Sensorineural deafness
Retinal defects (Usher syndrome)
Cell biology

Labelisation ENP: 

2007

Centre de recherche / Institut: 

Institut Pasteur

Code unité de recherche: 

UMRS 1120

Nos projets de recherche ont deux buts liés étroitement :

Leader

Leader: 

Établissements

Établissement de rattachement: 

Inserm

Établissements affiliés: 

Collège de France

Université: 

Université Pierre et Marie Curie
Laboratory

Initiatives d'Excellence: 

Labex Lifesenses
Publications

publications: 

Delmaghani S, Aghaie A, Bouyacoub Y, El Hachmi H, Bonnet C, Riahi Z, Chardenoux S, Perfettini I, Hardelin JP, Houmeida A, Herbomel P, Petit C. J Cell Biol. 2016 Jan 18;212(2):231-44. doi: 10.1083/jcb.201509017. Epub 2016 Jan 11.

Michalski N, Petit C. Genetics of auditory mechano-electrical transduction. Pflugers Arch. 2015 Jan;467(1):49-72. doi: 10.1007/s00424-014-1552-9. Epub 2014 Jun 25.

Michalski N, Petit C. Genetics of auditory mechano-electrical transduction. Pflugers Arch. 2015 Jan;467(1):49-72. doi: 10.1007/s00424-014-1552-9. Epub 2014 Jun 25.

Kamiya K, Michel V, Giraudet F, Riederer B, Foucher I, Papal S, Perfettini I, Le Gal S, Verpy E, Xia W, Seidler U, Georgescu MM, Avan P, El-Amraoui A, Petit C. An unusually powerful mode of low-frequency sound interference due to defective hair bundles of the auditory outer hair cells. Proc Natl Acad Sci U S A. 2014 Jun 24;111(25):9307-12. doi: 10.1073/pnas.1405322111. Epub 2014 Jun 11.

Avan P, Büki B, Petit C (2013) Auditory distortions: origins and functions. Physiol Rev 93, 1563?1619.

Bonnet C, ? Petit C, Marlin S (2013) Biallelic nonsense mutations in the otogelin-like gene (OTOGL) in a child affected by mild to moderate hearing impairment. Gene 527, 537-40.

Boulay A-C, ? Petit C, Avan P, Cohen-Salmon M (2013) Hearing is normal without connexin30. J Neurosci 33, 430-34.

El-Amraoui A, Petit C (2013) Cadherin defects in inherited human diseases. Progr Mol Biol Transl Sci, Conn PM (ed.), Elsevier 116, 361-84.

Greenspan R, Petit C (2013) Neurogenetics. Curr Opin Neurobiol. 23, 1-2.

Lepelletier L, ? Petit C (2013) Auditory hair cell centrioles undergo confined brownian motion throughout the developmental migration of the kinocilium. Biophys J 105, 48-58.

Microscopie à modulation de front d'onde

Domaine de recherche principal: 

Neurophysiology / systems neuroscience

Labelisation ENP: 

2007

Centre de recherche / Institut: 

INCC - UMR 8002 - Paris Descartes University

Code unité de recherche: 

UMR 8250

Le travail de recherche de cette équipe est consacré au développement de techniques optiques reposant sur la microscopie à modulation de front d’onde. Les montages optiques traditionnels utilisent des lentilles, diaphragmes, miroirs, réseaux ainsi que des fibres. Ces optiques ne permettent cependant que d’obtenir des faisceaux de formes relativement simples et ne peuvent être aisément déplacés au cours d’une expérience.

Leader

Leader: 

Établissements

Établissement de rattachement: 

CNRS

Établissements affiliés: 

Université Paris Descartes

Université: 

Université Paris Descartes
Laboratory

Nom: 

Neurophotonics laboratory
Publications

publications: 

Szabo V, Ventalon C, De Sars V, Bradley J, Emiliani V. Spatially selective holographic photoactivation and functional fluorescence imaging in freely behaving mice with a fiberscope. Neuron. 2014 Dec 17;84(6):1157-69. doi: 10.1016/j.neuron.2014.11.005. Epub 2014 Nov 26.

Lauterbach MA, Guillon M, Soltani A, Emiliani V. STED microscope with spiral phase contrast. Sci Rep. 2013;3:2050. doi: 10.1038/srep02050.

E. Papagiakoumou, A. Bègue, B. Leshem, O. Schwartz, B. Stell, J. Bradley, D. Oron and V. Emiliani. Functional patterned multiphoton excitation deep inside scattering tissue, Nature Photonics , in press.


    K. Kam, J.W. Worrell1, C. Ventalon, V. Emiliani, and J. L. Feldman. Emergence of population bursts from simultaneous activation of small subsets of preBötzinger Complex inspiratory neurons , Journal of Neuroscience, 33: 3332-3338 (2013) 


    E. Ronzitti, M. Guillon, V. de Sars, and V. Emiliani. LCoS nematic SLM characterization and modeling for diffraction efficiency optimization, zero and ghost orders suppression, Optics Express vol. 20, pp. 2012 (2012)


    A. Vaziri, and V. Emiliani. Reshaping the optical dimension in optogenetics, Current Opinion in Neurobiology vol. 22, pp. 2012 (2012)


    D. Oron, E. Papagiakoumou, F. Anselmi and V. Emiliani. Two-photon Optogenetics, Progress in Brain Research vol. 194, pp. 2012 (2012)


    F. Anselmi, C. Ventalon, V. de Sars, D. Ogden and V. Emiliani. 3D imaging and photostimulation by remote focusing and holographic light patterning, PNAS vol. 108, pp. 2011 (2011)


    S. Yang, E. Papagiakoumou, M. Guillon, V. de Sars, C.-M Tang, and V. Emiliani. 3D Holographic Photostimulation of the Dendritic Arbor, Journal of Neural engineering , 8: 046002 (2011)

Scanless two-photon excitation of channelrhodopsin-2, E. Papagiakoumou, F. Anselmi, A. Begue, V. de Sars, J. Gluckstad, E. Y. Isacoff, and V. Emiliani, Nature Methods 7, 848-854 (2010).

Holographic photolysis for multiple cell stimulation in mouse hippocampal slices, M. Zahid, M. Velez-Fort, E. Papagiakoumou, C. Ventalon, M. C. Angulo, and V. Emiliani, PLoS One 5, e9431 (2010).

Temporal focusing with spatially modulated excitation.E. Papagiakoumou, V. de Sars, V. Emiliani, and D. Oron, Optics Express 17, 5391-5401 (2009).

Patterned two-photon illumination by spatiotemporal shaping of ultrashort pulses, E. Papagiakoumou, C. Lutz, V. De Sars, D. Oron, and V. Emiliani, Optics Express 16, 22039-22047 (2008).

Holographic photolysis of caged neurotransmittersC. Lutz, T. Otis, V. DeSars, S. Charpak, D. Digregorio, and V. Emiliani, Nature Methods 5, 821-827 (2008).