Neurophysiology / systems neuroscience

Cerveau et conscience

Domaine de recherche principal: 

Cognitive neurosciences / neuropsychology /neuroeconomy

Mots clefs: 

consciousness
perception
neuroimaging
Psychophysics
Brain function

Labelisation ENP: 

2014

Centre de recherche / Institut: 

ENS Ecole Normale Supérieure

Code unité de recherche: 

UMR 8554

Our team is composed of cognitive scientists working on the neurobiological and psychological foundations of consciousness. We are especially interested in how conscious and unconscious processes differ at both the psychological and neural level. We use various behavioral methods (e.g., priming, psychophysics) and brain imaging techniques (e.g., fMRI, EEG) to study how humans process things unconsciously (e.g., as in situations of subliminal perception, sleep or hypnosis) and compare it to situations of conscious processing.

Leader

Leader: 

Établissements

Établissement de rattachement: 

ENS

Établissements affiliés: 

CNRS
EHESS

Université: 

Université Paris Descartes - Université Pierre et Marie Curie

École doctorale: 

ED158 ED 474
Laboratory

Nom: 

Laboratoire de Sciences Cognitives et Psycholinguistique

Initiatives d'Excellence: 

Institut d'Etudes Cognitives
Publications

publications: 

Goupil L, Romand-Monnier M, Kouider S. Infants ask for help when they know they don't know. Proc Natl Acad Sci U S A. 2016 Mar 29;113(13):3492-6. doi: 10.1073/pnas.1515129113. Epub 2016 Mar 7.

#Bastian, M., #Sackur, J. (2013). Mind-Wandering at the fingertips: automatic parsing of subjective states based on response time variability. Frontiers in Psychology, 4, 1 -- 11.

#Kouider, S., Stahlhut, C., Gelskov, S., #Barbosa, L, de Gardelle, V., Dutat, M., Dehaene, S., & Dehaene-Lambertz, G. (2013).A neural marker of perceptual consciousness in infants. Science, 50(14), 3736?3744.

#Sackur, J.(2013). Two dimensions of visibility revealed by multidimensional scaling of metacontrast, Cognition, (in press).

Faivre, N., Charron, S., Roux, P., Lehericy, S., & #Kouider, S. (2012). Nonconscious Emotional Processing Involves Distinct Neural Pathways for Pictures and Videos. Neuropsychologia, 50(14), 3736?3744.

Faivre, N., Berthet, V. & #Kouider, S. (2012). Nonconscious influences from emotional faces: a comparison of visual crowding, masking, and continuous flash suppression. Frontiers in Consciousness Research, 3, 1?13.

Memory Oscillations and Brain states (MOBs)

Domaine de recherche principal: 

Neurophysiology / systems neuroscience

Labelisation ENP: 

2014

Centre de recherche / Institut: 

ESPCI Paris Tech -Ecole Supérieure de Physique et de Chimie Industrielles

Code unité de recherche: 

UMR 8249

Memory is a dynamical phenomenon, from the moment of encoding to retrieval. As shown in the mammalian brain, after encoding labile memories undergo consolidation, that is, they stabilize over time first in the hippocampus before being transferred to the neocortex for long-term storage (Battaglia et al., 2011, Frankland and Bontempi, 2005). In 1989, Gyorgy Buzsaki proposed the twostage model of memory consolidation, where each sequential phase of memory (encoding and consolidation) is related to different internal brain states (Buzsaki, 1989).

Leader

Leader: 

Personnel

Etudiants ENP: 

Membres de l'équipe: 

Thierry GALLOPIN
Établissements

Établissement de rattachement: 

CNRS

Établissements affiliés: 

ESPCI

École doctorale: 

ED 3C - 158
Laboratory

Nom: 

Laboratoire de Neurobiologie

Initiatives d'Excellence: 

Labex Memolife
Publications

publications: 

Roux L, Benchenane K#, Rothstein J, Bonvento G, Giaume G. (2011) Plasticity of astroglial networks in the olfactory glomeruli.PNAS. 108(45):18442-6.

Martinet LM, Sheynikhovich D, Benchenane K#, Arleo A (2011) Spatial learning and action planning in a prefrontal cortical network model. Plos Comp Biol. 7(5):e1002045.

Battaglia FP, Benchenane K#, Sirota A, Pennartz CM, Wiener SI (2011) The hippocampus: hub of brain network communication for memory. Trends Cogn Sci. 15(7):310-8. (Review)

Benchenane K#, Tiesinga PH, Battaglia FP (2011) Oscillations in the prefrontal cortex: a gateway to memory and attention. Curr Op Neurobiol. 21(3):475-85. (Review)

Benchenane K#, Peyrache A, Khamassi M, Tierney PL, Gioanni Y, Battaglia FP, Wiener SI (2010) Coherent theta oscillations and reorganization of spike timing in the hippocampal-prefrontal network upon learning. Neuron. 66(6):921-36.

Dynamiques corticales et intégration multisensorielle

Domaine de recherche principal: 

Neurophysiology / systems neuroscience

Mots clefs: 

Optogenetics
multisensory processing
two photon calcium imaging
theoretical neuroscience
quantitative behavior

Labelisation ENP: 

2014

Centre de recherche / Institut: 

Unité de Neuroscience, Information et Complexité

Code unité de recherche: 

UPR 3293



Leader

Leader: 

Personnel

Etudiants ENP: 

Établissements

Établissement de rattachement: 

CNRS

Établissements affiliés: 

Université Paris Sud

Université: 

Université Pierre et Marie Curie

École doctorale: 

ED158
Laboratory

Nom: 

Unité Neuroscience Information Complexité (UNIC)

Initiatives d'Excellence: 

Idex NeuroSaclay
Publications

publications: 

Thomas Deneux, Alexandre Kempf, Aurélie Daret, Emmanuel Ponsot and Brice Bathellier, Temporal asymmetries in auditory coding and perception reflect multi-layered nonlinearities, Nature Communications 7: 12682, (2016)

Yves Frégnac and Brice Bathellier, Cortical Correlates of Low-Level Perception: From Neural Circuits to Percepts, Neuron 88(1): 110-126, (2015)

Bathellier B,  Tee SP, Hrovat C, Rumpel S, A multiplicative reinforcement learning model capturing learning dynamics and inter-individual variability in mice. Proc. Natl. Acad. Sci. USA, 2013, 110(49):19950-5.

Bathellier B, Ushakova L, and Rumpel S, Spontaneous association of sounds by discrete neuronal activity patterns in the neocortex. Neuron, 2012, 76(2):435-49

Cybernétique des microcircuits thalamiques et corticaux

Domaine de recherche principal: 

Neurophysiology / systems neuroscience

Mots clefs: 

Cell-machine interface
thalamo-cortical
synaptic homeostasy
neuronal magnetic field

Labelisation ENP: 

2014

Centre de recherche / Institut: 

Unité de Neuroscience, Information et Complexité

Code unité de recherche: 

NeuroPSI

Our team is specialized in electrophysiology in vitro. One of our main technological achievements is the development of a neuron-machine interface based on dynamic-clamp that allows the reconstruction of “hybrid circuits”, made of living neurons synaptically interacting with computer models. Current research interests include the modulation of sensory information processing in the thalamus and cortex by top-down background synaptic activity (in intra-UNIC collaboration with Alain Destexhe and Yves Frégnac’s teams).

Leader

Leader: 

Établissements

Établissement de rattachement: 

CNRS

Établissements affiliés: 

Université Paris Sud

Université: 

Université Pierre et Marie Curie

École doctorale: 

ED 158
Laboratory

Nom: 

UNIC CNRS

Initiatives d'Excellence: 

Idex NeuroSaclay
Publications

publications: 

See publications in Chercheurs/T. BAL 

Gomes, J.-M., bedard, C., Valtcheva, S., Nelson, M., Khokhlova, V., Pouget, P., Venance, L., Bal, T., & Destexhe, A. (2016) Intracellular Impedance Measurements Reveal Non-ohmic Properties of the Extracellular Medium around Neurons. Biophysj, 110, 234–246.

Ouanounou, G., Baux, G., & Bal, T. (2016) A novel synaptic plasticity rule explains homeostasis of neuromuscular transmission.eLife, 5 : e12190

Behuret, S., Deleuze, C., & Bal, T. (2015). Corticothalamic Synaptic Noise as a Mechanism for Selective Attention in Thalamic Neurons. Front Neural Circuits, 9, 11633

Casale, A.E., Foust, A.J., Bal, T., & McCormick, D.A. (2015). Cortical Interneuron Subtypes Vary in Their Axonal Action Potential Properties. Journal of Neuroscience, 35, 15555–15567

INTERACTIONS ENTRE NEURONES ET OLIGODENDROGLIES DANS LA MYÉLINISATION ET LA RÉPARATION DE LA MYÉLINE

Domaine de recherche principal: 

Neurophysiology / systems neuroscience

Mots clefs: 

Patch clamp
Optogenetics

Labelisation ENP: 

2014

Centre de recherche / Institut: 

Institut de Psychiatrie et Neurosciences de Paris, IPNP (ex-CPN) - Centre Hospitalier Sainte Anne

Code unité de recherche: 

UMRS 894

Oligodendrocyte precursor cells expressing the chondroitin sulfate proteoglycan NG2, also called NG2 cells, have the ability to proliferate in the postnatal brain to generate oligodendrocytes in grey and white matters. NG2 cells play a critical role in myelination during postnatal brain development, but a pool of these progenitors is maintained in the adult and recruited to lesions in demyelinating diseases. Recent discoveries have demonstrated that NG2 cells are contacted by functional glutamatergic and GABAergic synapses from neurons in grey and white matters.

Leader

Leader: 

Établissements

Établissement de rattachement: 

Inserm

Établissements affiliés: 

Université Paris Descartes

École doctorale: 

GC2IDED BioSPC ED572
Publications

publications: 

Balia M*, Vélez-Fort M*, Passlick S, Schäfer C, Audinat E, Steinhäuser C, Seifert G, Angulo MC (2015) Postnatal down-regulation of the GABAA receptor 2 subunit in neocortical NG2 cells accompanies synaptic-to-extrasynaptic switch in GABAergic transmission mode. Cereb Cortex, 25(4):1114-23

Balia M, Benamer N, Angulo MC (2017) A specific GABAergic synapse onto oligodendrocyte precursors does not regulate cortical oligodendrogenesis. Glia. 65(11):1821-1832.

Ledonne F, Orduz D, Mercier J, Vigier L, Grove EA, Tissir F, Angulo MC, Pierani A*, Coppola E*. (2016) Targeted inactivation of Bax reveals subtype-specific mechanism of Cajal-Retzius neuron death in the postnatal cerebral cortex. Cell Rep. 17(12) 3133

Wake H*, Ortiz FC*, Woo DH, Lee P, Angulo MC, Fields D (2015) Non-synaptic junctions on myelinating glia promote preferential myelination of electrically-active axons. Nat Commun 6:7844

Orduz D*, Maldonado PP*, Balia M, Vélez-Fort M, de Sars V, Yanagawa Y, Emiliani V, Angulo MC (2015) Interneurons and oligodendrocyte progenitors form a structured synaptic network in the developing neocortex. eLife 4:e06953

 

Transmission inhibitrice dans le cerveau

Domaine de recherche principal: 

Neurophysiology / systems neuroscience

Mots clefs: 

Inhibitory transmission
Multiphoton imaging
Glycine
Vesicular loading
Optogenetics
Cerebellum

Labelisation ENP: 

2012

Centre de recherche / Institut: 

ENS Ecole Normale Supérieure

Code unité de recherche: 

U1024 - UMR8197

. La transmission synaptique inhibitrice joue un rôle central dans le fonctionnement du cerveau. Preuve en est que le blocage de l’inhibition engendre des situations pathologiques comme l’épilepsie et l’hyperekplexie, une affection rare caractérisée par des sursauts exagérés en réponse à des stimuli auditifs, visuels ou tactiles. A l’inverse, une potentialisation de l’inhibition provoque des états modifiés du cerveau comme ceux résultant de l’action de psychotropes, anxiolytiques, somnifères ou encore analgésiques.

Leader

Leader: 

Personnel

Membres de l'équipe: 

MARCAGGI Païkan
Établissements

Établissement de rattachement: 

Ecole Normale Supérieure

Établissements affiliés: 

Inserm
CNRS

Université: 

Université Pierre et Marie Curie

École doctorale: 

ED158
Laboratory

Nom: 

Institut de Biologie de l'ENS IBENS

Initiatives d'Excellence: 

Labex Memolife, IDEX PSL*, NIH Brain Initiative Grant
Publications

publications: 



Zampini V, Liu JK, Diana MA, Maldonado PP, Brunel N, Dieudonné S. (2016) Mechanisms and functional roles of glutamatergic synapse diversity in a cerebellar circuit. Elife. 2016 Sep 19;5. pii: e15872. doi: 10.7554/eLife.15872.

Akemann W, Léger JF, Ventalon C, Mathieu B, Dieudonné S, Bourdieu L. (2015) Fast spatial beam shaping by acousto-optic diffraction for 3D non-linear microscopy. Opt Express. 23: 28191-205.

Giber K, Diana MA*, M Plattner V*, Dugué GP, Bokor H, Rousseau CV, Maglóczky Z, Havas L, Hangya B, Wildner H, Zeilhofer HU, Dieudonné S§, Acsády L. (2015) A subcortical inhibitory signal for behavioral arrest in the thalamus. Nat Neurosci. 18:562-8.

Ankri L, Husson Z*, Pietrajtis K, Proville R, Léna C, Yarom Y, Dieudonné S§, Yoe Uusisaari M. (2015) A novel inhibitory nucleo-cortical circuit controls cerebellar Golgi cell activity. Elife. 4. doi: 10.7554/eLife.06262.

Otsu Y, Marcaggi P, Feltz A, Isope P, Kollo M, Nusser Z, Mathieu B, Kano M, Tsujita M, Sakimura K, Dieudonné S§. (2014) Activity-dependent gating of calcium spikes by A-type K+ channels controls climbing fiber signaling in Purkinje cell dendrites. Neuron. 84 : 137-51.

Groupe Développement des circuits neuronaux

Domaine de recherche principal: 

Neurogenetics / neurodevelopment

Mots clefs: 

neural circuits
zebrafish
Optogenetics
behavior
Vision

Labelisation ENP: 

2012

Centre de recherche / Institut: 

Institut Curie - Centre de Recherche - Paris/Orsay

Code unité de recherche: 

U934 - UMR3215

The optic tectum has emerged as a tractable visuomotor transformer, in which anatomical and functional studies can allow a better understanding of how behavior is controlled by neuronal circuits. We are examining the formation and function of the visual system in zebrafish larvae using in vivo time-lapse microscopy and state-of-the-art “connectomic” and “optogenetic” approaches to monitor and perturb neuronal activity. We apply complementary cellular and molecular analyses to dissect this circuit and identify the neuronal substrate of visual behaviors.

Leader

Leader: 

Personnel

Membres de l'équipe: 

Karine Duroure
Thomas Auer
Christoph Gebhardt
Vincenzo Di Donato
Flavia De Santis
Celine Revenu
Shahad Albadri
Noe Testa
Établissements

Établissement de rattachement: 

Institut Curie

Établissements affiliés: 

CNRS
Inserm

Université: 

Université Pierre et Marie Curie

École doctorale: 

ED158
Laboratory

Nom: 

Virginie Bourgeois

Initiatives d'Excellence: 

Labex DEEP
Publications

publications: 

Dunn, T. W., Gebhardt, C., Naumann, E. A., Riegler, C., Ahrens, M. B., Engert, F., and Del Bene, F. Neural Circuits Underlying Visually Evoked Escapes in Larval Zebrafish. Neuron (2016)

Di Donato, V., De Santis, F., Auer, T. O., Testa, N., Sanchez-Iranzo, H., Mercader, N., Concordet, J. P., and Del Bene, F.  2C-Cas9: a versatile tool for clonal analysis of gene function. Genome research (2016)

Auer, T. O., Xiao, T., Bercier, V., Gebhardt, C., Duroure, K., Concordet, J. P., Wyart, C., Suster, M., Kawakami, K., Wittbrodt, J., Baier, H., and Del Bene, F. Deletion of a kinesin I motor unmasks a mechanism of homeostatic branching control by neurotrophin-3. eLife (2015)

Auer, T. O., Duroure, K., Concordet, J. P., and Del Bene, F. CRISPR/Cas9-mediated conversion of eGFP- into Gal4-transgenic lines in zebrafish. Nature protocols (2014)

Auer, T. O., Duroure, K., De Cian, A., Concordet, J. P., and Del Bene, F.  Highly efficient CRISPR/Cas9-mediated knock-in in zebrafish by homology-independent DNA repair. Genome research (2014)

Dynamique corticale et mécanismes de codage

Domaine de recherche principal: 

Neurophysiology / systems neuroscience

Mots clefs: 

Neurosciences intégratives Modalité sensorielle tactile Cortex à tonneaux Microscopie de fluorescence à deux photons Optique adaptative

Labelisation ENP: 

2012

Centre de recherche / Institut: 

ENS Ecole Normale Supérieure

Code unité de recherche: 

U1024 UMR8197

Nous étudions la représentation de l’information sensorielle dans une colonne corticale en enregistrant optiquement l’activité de centaines de neurones. Nous nous intéressons en particulier à la représentation de l’information tactile collectée par les vibrisses des rongeurs et représentée dans le cortex somato-sensoriel primaire à tonneaux.

Leader

Leader: 

Personnel

Membres de l'équipe: 

Wang Jinyu
Paresys Gérard
Léger Jean François
Ventalon Cathie
Établissements

Établissement de rattachement: 

Ecole Normale Supérieure

Établissements affiliés: 

Inserm
CNRS

Université: 

Université Pierre et Marie Curie

École doctorale: 

ED158
Laboratory

Nom: 

Institut de Biologie de l'ENS IBENS

Initiatives d'Excellence: 

Labex Memolife, Programme France Bio-Imaging, NIH Brain Initiative 2017
Publications

publications: 

L. Estebanez, J. Bertherat, D.E. Shulz, L. Bourdieu, J.-F. Léger, High order statistics of naturalistic stimuli are orderly mapped in the primary somatosensory cortex, (2016) Nature Comm. 7:13528.

J. Wang, J.-F. Leger, J. Binding, C. Boccara, S. Gigan and L. Bourdieu, Measuring aberrations in the rat brain by coherence-gated wavefront sensing using a Linnik interferometer, Biomed. Opt. Exp. (2012) 3(10) 2510-25.

V. Szabo*, C. Ventalon*, V. De Sars, J. Bradley, and V. Emiliani, “Spatially selective photoactivation with computer generated holography and functional fluorescence imaging in freely behaving mice with a fiberscope”, Neuron, 84 (6), 1157-1169. (2014) * Equal contribution.

S. Schott, J. Bertolotti, J.F. Léger, L. Bourdieu and S. Gigan, Characterization of the angular memory effect of scattered light in biological tissues. Opt. Exp. 23(10) (2015) 13505-16, arXiv:1502.00270.

W. Akemann, J.-F. Léger, C. Ventalon, B. Mathieu, S. Dieudonné and L. Bourdieu, Fast spatial beam shaping by acousto-optic diffraction for 3D non-linear microscopy, Opt. Express 23(22), 28191-28205 (2015).

 

Plasticité synaptique et réseaux neuronaux

Domaine de recherche principal: 

Neurophysiology / systems neuroscience

Mots clefs: 

Hippocampe, mémoire, interneurones, pasticité synaptique, émotions

Labelisation ENP: 

2012

Centre de recherche / Institut: 

Institut de Psychiatrie et Neurosciences de Paris, IPNP (ex-CPN) - Centre Hospitalier Sainte Anne

Code unité de recherche: 

UMRS 894

Notre équipe s’intéresse aux mécanismes impliqués dans la formation de la mémoire. L’hippocampe est une structure importante pour l’apprentissage et la formation de nouvelles mémoires. Le réseau d’interneurones inhibiteurs joue un rôle important dans le contrôle de l’activité hippocampique. Notre recherche est focalisée sur la région CA2, une région qui contient une très forte densité d’interneurones et qui est spécifiquement connectée par des afférences extra-hippocampiques venant notamment du cortex ou de l’hypothalamus.

Leader

Leader: 

Co leader: 

Personnel

Etudiants ENP: 

Établissements

Établissement de rattachement: 

Inserm

Établissements affiliés: 

Sainte Anne

Université: 

Université Paris Descartes
Publications

publications: 

Piskorowski RA, Nasrallah K, Diamantopoulou A, Mukai J, Hassan SI, Siegelbaum SA, Gogos JA, Chevaleyre V.Age-Dependent Specific Changes in Area CA2 of the Hippocampus and Social Memory Deficit in a Mouse Model of the 22q11.2 Deletion Syndrome.Neuron. 2016 Jan 6;89(1):163-76. doi: 10.1016/j.neuron.2015.11.036.

Piskorowski R.A. and Chevaleyre V. (2012) Synaptic integration by different dendritic compartments of hippocampal CA1 and CA2 pyramidal neurons. Cellular and Molecular Life Science 69(1); 75-88.

Pavlopoulos E; Trifilieff P; Chevaleyre V; Zairis S; Fioriti L; Malleret G; Kandel E.R. (2011) Non-Proteolytic Ubiquitination by Neuralized1 Leads to Activation of CPEB3: A Novel Function of the Ubiquitin System in Synaptic Plasticity and Memory Storage. Cell 147(6); 1369-83.

Piskorowski R, Santoro B, Siegelbaum SA. (2011) TRIP8b splice forms act in concert to regulate the localization and expression of HCN1 channels in CA1 pyramidal neurons. Neuron. 70(3):495-509

Chevaleyre V. and Siegelbaum S.A. (2010) Strong CA2 pyramidal neuron synapses define a powerful disynaptic cortico-hippocampal loop. Neuron 66(4):560-72

Chevaleyre V., Heifets B.D., Kaeser P., Südhof T.C., Castillo P.E. (2007) Endocannabinoid-mediated long-term plasticity requires cAMP/PKA signalling and RIM1. Neuron.  54 (5): 801-12.

Algorithmes neuronaux

Domaine de recherche principal: 

Neurophysiology / systems neuroscience

Labelisation ENP: 

2012

Centre de recherche / Institut: 

ENS Ecole Normale Supérieure

Code unité de recherche: 

U1024 UMR 8197

Le cervelet constitue une région quasi idéale pour aborder ces questions à différents niveaux. Il a une architecture cellulaire et un réseau de connexions simples et décrits en détail. Le cervelet joue un rôle essentiel dans l’apprentissage et la coordination de l’activité motrice. Son rôle dans l’apprentissage de réflexes conditionnés comme le réflexe vestibulooculaire (qui permet de maintenir la stabilité de l’image sur la rétine lorsque la tête tourne) a été démontré.

Leader

Leader: 

Établissements

Établissement de rattachement: 

Ecole Normale Supérieure

Établissements affiliés: 

Inserm
CNRS
Laboratory

Nom: 

Institut de Biologie de l'ENS IBENS

Initiatives d'Excellence: 

Labex : "mémolife" (IBENS, CdF, ESPCI), Idex : PSL*
Publications

publications: 

Bouvier, G., Clopath, C., Bimbard, C., Nadal, J.-P., Brunel, N., Hakim, V. and Barbour, B. Cerebellar learning using perturbations. bioRxiv 053785; doi: https://doi.org/10.1101/053785

Blot, A. and Barbour, B. Ultra-rapid axon-axon ephaptic inhibition of cerebellar Purkinje cells by the pinceau. Nature neuroscience, 2014, Vol. 17, pp. 289-295

Ostojic, S., Szapiro, G., Schwartz, E., Barbour, B., Brunel, N. and Hakim, V. Neuronal morphology generates high-frequency firing resonance. The Journal of neuroscience, 2015, Vol. 35, pp. 7056-7068

Ly, R., Bouvier, G., Szapiro, G., Prosser, H. M., Randall, A. D., Kano, M., Sakimura, K., Isope, P., Barbour, B. and Feltz, A.  Contribution of postsynaptic T-type calcium channels to parallel fibre-Purkinje cell synaptic responses. The Journal of physiology, 2016, Vol. 594, pp. 915-936

Bouvier, G., Higgins, D., Spolidoro, M., Carrel, D., Mathieu, B., Léna, C., Dieudonné, S., Barbour, B., Brunel, N. and Casado, M. Burst-Dependent Bidirectional Plasticity in the Cerebellum Is Driven by Presynaptic NMDA Receptors. Cell reports, 2016, Vol. 15, pp. 104-116