Neurological and psychiatric diseases

Neurogénétique du Poisson Zébré

Domaine de recherche principal: 

Neurogenetics / neurodevelopment

Mots clefs: 

zebrafish
behavior
motivation
neurogenesis
stem cell
telencephalon
quiescence

Labelisation ENP: 

2009

Centre de recherche / Institut: 

Institut Pasteur

Code unité de recherche: 

UMR3738

Le système nerveux central des vertébrés est un assemblage complexe de neurones et de cellules gliales, mis en place en nombres et positions précis, principalement au cours du développement. Le maintien de progéniteurs neuraux jusqu’à des stades plus avancés et même jusqu’à l’âge adulte est cependant crucial, puisque ces progéniteurs pourront être utilisés dans des événements adaptatifs tardifs.

Leader

Leader: 

Personnel

Membres de l'équipe: 

Alessandro Alunni
Marion Coolen
Établissements

Établissement de rattachement: 

CNRS

Université: 

Université Pierre et Marie Curie

École doctorale: 

ED 515 Complexité du Vivant
Laboratory

Nom: 

Department of Developmental and stem cell Biology

Initiatives d'Excellence: 

Labex Revive
Publications

publications: 

G. FurlanV. Cuccioli, N. Vuillemin, L. Dirian, A. Janue Muntasell, M. CoolenN. DrayS. Bedu, C. Houart, E. Beaurepaire, I. Foucher*and L. Bally-Cuif*. Life-long neurogenic activity of individual neural stem cells and continuous growth establish an outside-in architecture in the teleost pallium. Curr. Biol., in press (2017). * co-senior authorship. 

 

S. KatzD. Cussigh, N. Urban, F. Guillemot, L. Bally-Cuif* and M. Coolen*. A non-canonical nuclear role for microRNA-9 and Argonaute proteins in balancing the quiescent and activated adult neural stem cell state. Cell Reports 17: 1383-1398 (2016).    

S. GalantG. FurlanM. CoolenL. DirianI. Foucher and L. Bally-CuifEmbryonic origin and lineage hierarchies of the neural progenitor subtypes building the zebrafish adult midbrain. Dev Biol. pii: S0012-1606(16)30424-9 (2016).

N. DrayS. Bedu, N. Vuillemin, A. AlunniM. CoolenM. Krecsmarik, W. Supatto, E. Beaurepaire and L. Bally-Cuif. Large-scale live imaging of adult neuro stem cells in their endogenous niche. Development 142: 3592-3600 (2015).

L. Dirian, S. Galant, M. Coolen, J. Livet, W. Chen, S. Bedu, C. Houart, L. Bally-Cuif* and I. Foucher*. Spatial regionalization and heterochrony in the formation of adult pallial neural stem cells. Dev. Cell 30:123-136 (2014).

Imagerie dynamique du neurone

Domaine de recherche principal: 

Neuropharmacology / cell signaling

Mots clefs: 

Cerebellum
Synapses
Dendrites
Superresolution Microscospy
Optophysiology

Labelisation ENP: 

2007

Centre de recherche / Institut: 

Institut Pasteur

Code unité de recherche: 

UMR 3571

 Understanding how information is processed within neuronal networks requires knowledge of how neurons use cellular and molecular mechanisms to transform information communicated by synapses. Defects in the communication between synapses are thought to be at the heart of the memory deficits associated with neuropathological disorders such as Alzheimer’s disease and autism.

Leader

Leader: 

Personnel

Membres de l'équipe: 

REBOLA Nelson
MONERON Gael
SAINT-CLOMENT Cecile
TRAN-VAN-MINH Alexandra
NAKAMURA Yukihiro
REPAK Emilienne
BRANDT Maryse
CHABROL François
Établissements

Établissement de rattachement: 

CNRS

Université: 

Université Pierre et Marie Curie

École doctorale: 

ED3C
Laboratory

Nom: 

Genes, Synapses, Cognition
Publications

publications: 

DiGregorio D. Confocal spot detection of presynaptic Ca²⁺ domains. PLoS Biol. 2014 Jul 8;12(7):e1001903. doi: 10.1371/journal.pbio.1001903. eCollection 2014 Jul.

Tran-Van-Minh A, Abrahamsson T, Cathala L, DiGregorio DA. Differential Dendritic Integration of Synaptic Potentials and Calcium in Cerebellar Interneurons. Neuron. 2016 Aug 17;91(4):837-50. doi: 10.1016/j.neuron.2016.07.029.

Fink AE., Bender, KJ., Trussell, LO., Otis, TS. and DiGregorio, DA. Two-photon compatibility and single-voxel, single-trial detection of subthreshold neuronal activity by a two-component optical voltage sensor. PLoS One, in press (2012).

Abrahamsson, T.,  Cathala,  L., Matsui, K., Shigemoto, R., and DiGregorio, DA. Thin dendrites of cerebellar interneurons confer sublinear synaptic integration and a gradient of short-term plasticity. Neuron, 73: 1159-1172 (2012).

DiGregorio DA. 2011. Confocal spot detection of presynaptic Ca2+ domains. In: Imaging in neuroscience: A laboratory manual (ed. Helmchen F, Konnerth A, Yuste R), pp. 141-150. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.

Bradley, J., Luo, R., Otis, T.S. and DiGregorio, D.A., Submillisecond optical reporting of membrane potential in situ using a neuronal tracer dye. Journal of Neuroscience, 29(29):9197–9209 (2009).

Lutz, C, Otis, T, DeSars, V., Charpak S., DiGregorio, D. A., and Emiliani, V. Holographic photolysis of caged neurotransmitters. Nature Methods, 5(9):821-827 (2008).

Thérapeutique Expérimentale de la maladie de Parkinson

Domaine de recherche principal: 

Neurological and psychiatric diseases

Mots clefs: 

Neuroinflammation
Parkinson
neuronal death
physiopathology
experimental models
therapy
Cellular and Molecular Biology

Labelisation ENP: 

2007

Centre de recherche / Institut: 

Institut du Cerveau et de la Moelle épinière

Code unité de recherche: 

UMRS 1127 UMR 7225

Notre projet vise deux objectifs complémentaires : 

1) Caractériser les mécanismes impliqués dans la progression de la mort neuronale dans les maladies neurodégénératives et en particulier la maladie de Parkinson ; 

Leader

Leader: 

Co leader: 

Établissements

Établissement de rattachement: 

Inserm

Établissements affiliés: 

CNRS
Université Pierre et Marie Curie

Université: 

Université Pierre et Marie Curie

École doctorale: 

ED158
Laboratory

Initiatives d'Excellence: 

IHU AICM
Publications

publications: 

Rousseau E, Michel PP, Hirsch EC. The iron-binding protein lactoferrin protects vulnerable dopamine neurons from degeneration by preserving mitochondrial calcium homeostasis. Mol Pharmacol. 2013 Dec;84(6):888-98. doi: 10.1124/mol.113.087965. Epub 2013 Sep 27.

Karachi C, André A, Bertasi E, Bardinet E, Lehéricy S and Bernard F (2012) Functional parcellation of the lateral mesencephalus.JNeurosci. 32(27):9396-9401. (IF 7.27)ACL

Huynh MB, Villares J, Sepúlveda Díaz JE, Christiaans S, Carpentier G, Ouidja MO, Sissoeff L, Raisman-Vozari R, Papy-Garcia D (2012) Glycosaminoglycans from aged human hippocampus have altered capacities to regulate trophic factors activities but not A?42 peptide toxicity. Neurobiol Aging 33 (5), 1005.e11-22 (IF : 6.63)ACL

Dumurgier J, Crivello F, Mazoyer B, Tavernier B, Grabli D, François C, Tzourio-Mazoyer N, Tzourio C, Elbaz A (2012) Mri Atrophy Of The Caudate Nucleus And Slower Walking Speed In The Elderly: A Population-Based Study. Neuroimage 60 (2), 871-878(IF:5.94) ACL

Torres-Bugeau CM, Avila Cl, Raisman-Vozari R, Papy-Garcia D, Itri R, Barbosa Lr, Cortez Lm, Sim Vl, Chehin Rn (2012) Characterization of heparin-induced glyceraldehyde-3-phosphate dehydrogenase early amyloid-like oligomers and their implication on ?-synuclein aggregation. J Biol Chem 287: 2398-2409. (IF 5.33)ACL

Ribeiro N, Thuaud F, Bernard Y, Gaiddon C, Cresteil T, Hild A, Hirsch EC, Michel PP, Nebigil CG,Desaubry L (2012) Flavaglines as Potent Anticancer and Cytoprotective Agents. J Med Chem (IF 5.25) ACL

Développement cortical et pathologie

Domaine de recherche principal: 

Neurogenetics / neurodevelopment

Mots clefs: 

genetic mouse model
neuropsychiatric disorders
cortical development
molecular and cellular mechanisms
epilepsy and intellectual disability

Labelisation ENP: 

2007

Centre de recherche / Institut: 

IFM - Institut du Fer à Moulin

Code unité de recherche: 

UMRS839

Nos projets de recherche se concentrent sur l’étude de trois protéines affectées par des mutations dans le cadre de malformations cérébrales ou d’anomalies corticales plus subtiles chez l’homme. Les malformations corticales ou des anomalies plus subtiles constituent une cause fréquente d’épilepsie résistante aux traitements, de déficience intellectuelle et de troubles neuropsychiatriques. Les défauts corticaux peuvent résulter d’anomalies de prolifération, de migration et/ou de connectivité neuronale.

Leader

Leader: 

Co leader: 

Personnel

Etudiants ENP: 

Établissements

Établissement de rattachement: 

Inserm

Établissements affiliés: 

Université Pierre et Marie Curie

Université: 

Université Pierre et Marie Curie

École doctorale: 

ED515
Publications

publications: 

*Kielar M, *Phan Dinh Tuy F, *Bizzotto S, *Lebrand C, de Juan C, Poirier K, Oegema R, Mancini GM, Bahi-Buisson N, Olaso R, Le Moing AG, Boutourlinsky K, Boucher D, Carpentier W, Berquin P, Deleuze JF, Belvindrah R, Borrell V, Welker E, Chelly J, Croquelois A#, Francis F#. (2014) Mutations in Eml1 lead to ectopic progenitors and neuronal heterotopia in mouse and human. Nat Neurosci. 17: 923–933. 

Bahi-Buisson N, Souville I, Fourniol F, Toussaint A, Moores C, Houdusse A, Lemaitre J-Y, Poirier K, Khalaf-Nazzal R, Hully M, Leger PL, Elie C, Boddaert N, Beldjord C, Chelly, J, Francis, F. (2013) SBH-LIS European consortium  New insights into genotype-phenotype correlations for the DCX-related lissencephaly spectrum. Brain 136:223-244.

Belvindrah R, Natarajan K, Shabajee P, Bruel-Jungerman E, Bernard J, Goutierre M, Moutkine I, Jaglin XH, Savariradjane M, Irinopoulou T, Poncer J-C, Janke C, Francis F. (2017) Mutation of the α-tubulin Tuba1a leads to straighter microtubules and perturbs neuronal migration. J Cell Biol. 216:2443-2461. 

*Khalaf-Nazzal R, *Stouffer MA, Olaso R, Muresan L, Roumegous A, Lavilla V, Carpentier W, Moutkine I, Dumont S, Albaud B, Cagnard N, Roest Crollius H, Francis F. (2017) Early born neurons are abnormally positioned in the doublecortin knockout hippocampus. Hum Mol Genet. 26:90-108. 

Klingler E, Martin P-M*, Garcia M*, Moreau-Fauvarque C, Falk J, Chareyre K, Giovannini M, Chédotal A, Girault J-A, Goutebroze L. (2015) The cytoskeleton-associated protein SCHIP-1 is involved in axon guidance and required for piriform cortex and anterior commissure development. Development 142:2026-2036. 

Réseau Cortical et Couplage Neurovasculaire

Domaine de recherche principal: 

Neurophysiology / systems neuroscience

Mots clefs: 

cerebral cortex
electrophysiology
Optogenetics
neuronal circuits
blood perfusion and metabolism

Labelisation ENP: 

2007

Code unité de recherche: 

U1130 UMR8246 UMCR18

The team “Cortical network and Neurovascular Coupling” studies neuronal circuits and their relationships with the glio-vascular network in the cerebral cortex. Our previous work has advanced our knowledge of neocortical neuronal types, of their sensitivity to afferent signals, of their places in the functional architecture of intracortical peptidergic transmission, and of their differential roles in neurovascular coupling.

Établissements

Établissement de rattachement: 

Inserm

Établissements affiliés: 

CNRS
Université Pierre et Marie Curie

Université: 

Université Pierre et Marie Curie

École doctorale: 

ED158
Laboratory

Nom: 

Neuroscience Paris Seine

Initiatives d'Excellence: 

IHU Institut de Neurosciences Translationnelles de Paris
Publications

publications: 

Lecrux C, Toussay X, Kocharyan A, Fernandes P, Neupane S, Lévesque M, Plaisier F, Shmuel A, Cauli B, Hamel E. Pyramidal neurons are "neurogenic hubs" in the neurovascular coupling response to whisker stimulation. J Neurosci. 2011 Jul 6;31(27):9836-47.

Hu E, Demmou L, Cauli B, Gallopin T, Geoffroy H, Harris-Warrick RM, Paupardin-Tritsch D, Lambolez B, Vincent P, Hepp R. VIP, CRF, and PACAP act at distinct receptors to elicit different cAMP/PKA dynamics in the neocortex. Cereb  Cortex. 2011 Mar;21(3):708-18.

Tricoire L, Pelkey KA, Daw MI, Sousa VH, Miyoshi G, Jeffries B, Cauli B, Fishell G, McBain CJ. Common origins of hippocampal Ivy and nitric oxide synthase expressing neurogliaform cells. J Neurosci. 2010 Feb 10;30(6):2165-76.

Karagiannis A, Gallopin T, Dávid C, Battaglia D, Geoffroy H, Rossier J, Hillman EM, Staiger JF, Cauli B. Classification of NPY-expressing neocortical interneurons. J Neurosci. 2009 Mar 18;29(11):3642-59.

Petilla Interneuron Nomenclature Group, Ascoli GA, Alonso-Nanclares L, Anderson SA, Barrionuevo G, Benavides-Piccione R, Burkhalter A, Buzsáki G, Cauli  B, Defelipe J, Fairén A, Feldmeyer D, Fishell G, Fregnac Y, Freund TF, Gardner D, Gardner EP, Goldberg JH, Helmstaedter M, Hestrin S, Karube F, Kisvárday ZF, Lambolez B, Lewis DA, Marin O, Markram H, Muñoz A, Packer A, Petersen CC, Rockland KS, Rossier J, Rudy B, Somogyi P, Staiger JF, Tamas G, Thomson AM, Toledo-Rodriguez M, Wang Y, West DC, Yuste R. Petilla terminology: nomenclature of features of GABAergic interneurons of the cerebral cortex. Nat Rev Neurosci. 2008 Jul;9(7):557-68.

Laboratoire de neuro-imagerie cognitive

Domaine de recherche principal: 

Cognitive neurosciences / neuropsychology /neuroeconomy

Mots clefs: 

language
Functional imaging
cognition
calculation
consciousness

Labelisation ENP: 

2007

Centre de recherche / Institut: 

Neurospin

Code unité de recherche: 

U992

La mission de ce laboratoire est d'analyser les bases cérébrales des fonctions cognitives, chez l'homme normal et chez certains patients neurologiques, en développant et en exploitant les méthodes modernes de la neuro-imagerie conjointement à l'utilisation de paradigmes expérimentaux issus de la psychologie cognitive.

Nos principaux axes de recherche:

Leader

Leader: 

Personnel

Membres de l'équipe: 

Philippe Pinel
SCHURGER Aaron
MEYNIEL Florent
MARTI Sébastien
NELSON Matthew
HANNAGHAN Thomas
MOUTARD Clement
AMALRIC Marie
PINHEIRO CHAGAS Pedro
MAHEU Maxime
TROVO Bianca
POTIER WATKINS Cassandra
SANTORO Giovanna
LABRUNA Laurence
Établissements

Établissement de rattachement: 

Inserm

Établissements affiliés: 

Collège de France
CEA

Université: 

Université Paris Sud 11

École doctorale: 

ED419 - ED158
Laboratory

Nom: 

Cognitive Neuroimaging Unit

Initiatives d'Excellence: 

Idex Neuro Saclay, ERC Advanced "NeuroSyntax"
Publications

publications: 

Amalric, M., & Dehaene, S. (2016). Origins of the brain networks for advanced mathematics in expert mathematicians. Proceedings of the National Academy of Sciences, 201603205. https://doi.org/10.1073/pnas.1603205113

 

Meyniel, F., & Dehaene, S. (2017). Brain networks for confidence weighting and hierarchical inference during probabilistic learning. Proceedings of the National Academy of Sciences of the United States of America, 114(19), E3859–E3868. https://doi.org/10.1073/pnas.1615773114

Meyniel, F., Maheu, M., & Dehaene, S. (2016). Human Inferences about Sequences: A Minimal Transition Probability Model. PLoS Computational Biology, 12(12), e1005260. https://doi.org/10.1371/journal.pcbi.1005260

Nelson, M. J., El Karoui, I., Giber, K., Yang, X., Cohen, L., Koopman, H., … Dehaene, S. (2017). Neurophysiological dynamics of phrase-structure building during sentence processing. Proceedings of the National Academy of Sciences of the United States of America, 114(18), E3669–E3678. https://doi.org/10.1073/pnas.1701590114

Trübutschek, D., Marti, S., Ojeda, A., King, J.-R., Mi, Y., Tsodyks, M., & Dehaene, S. (2017). A theory of working memory without consciousness or sustained activity. eLife, 6. https://doi.org/10.7554/eLife.23871

Groupe Récepteurs Canaux

Domaine de recherche principal: 

Neuropharmacology / cell signaling

Mots clefs: 

Receptors
ionic channels
drugs
anesthetics
anxiolytics

Labelisation ENP: 

2007

Code unité de recherche: 

UMR 3571

Nicotinic acetylcholine, GABAA and glycine receptors from the pentameric ligand-gated ion channel (pLGIC) superfamily are key players of the neuronal communication in the brain and are the target of important classes of therapeutic (anti-smoking, anti-Parkinson, anti-Alzheimer compounds, anxiolytics, general anesthetics) and addictive (nicotine, alcohol) drugs.

Établissements

Établissement de rattachement: 

CNRS
Publications

publications: 

Prevost, M., Sauguet, L., Nury H., Van Renterghem, C., Huon, C., Poitevin, F., Baaden, M., Delarue, M.*, Corringer, P.J.* A locally-closed conformation of a bacterial pentameric proton-gated ion channel. Nat Struct Mol Biol. 19:642-9. 2012

Duret, C., Van Renterghem, C, Weng, Y, Prevost, M., Moraga, G., Huon, C., Sonner, J.M., Corringer P-J.*, A functional prokaryotic-eukaryotic chimera from the pentameric ligand-gated ion channel family, Proc Natl Acad Sci U S A. in press

Nury, H, Van Renterghem, C, Weng, Y, Tran, A, Baaden, M, Dufresne, V, Changeux, J.P., Sonner, J.M., Delarue, M*, Corringer, P-J.* (2011) X-ray structures of general anesthetics bound to a pentameric ligand-gated ion channel Nature, 469:428-31

Nury, H, Bocquet, N, Le Poupon, C, Raynal, B, Haouz, A, Corringer, P-J, Delarue, M.* (2010) Crystal Structure of the Extracellular Domain of a Bacterial Ligand-Gated Ion Channel. J. Mol. Biol. 395 : 1114–1127

Bocquet, N., Nury, H., Baaden, M., Le Poupon, C., Changeux, J.P., Delarue, M.*, Corringer, P-J.* (2009) X-ray structure of a pentameric ligand-gated ion channel in an apparently open conformation, Nature, 457 :111-4.

Bocquet, N., Prado de Carvalho, L., Cartaud, J., Neyton, J., Le Poupon, C., Taly, A., Grutter, T., Changeux, J.P., Corringer, P.J.* (2007) A prokaryotic proton-gated ion channel from the nicotinic acetylcholine receptor family, Nature, 445: 116-119

Dynamique cérébrale, Mémoire et Apprentissage

Domaine de recherche principal: 

Neurophysiology / systems neuroscience

Mots clefs: 

computational neuroscience
Cortex
Cerebellum
basal ganglia
Network mechanism

Labelisation ENP: 

2009

Centre de recherche / Institut: 

INCC - UMR 8002 - Paris Descartes University

Code unité de recherche: 

UMR 8002

Nos recherches portent sur la dynamique du cortex cérébral, du cervelet et des ganglions de la base. Les axes de recherche sont: 1- Etude de la Perception, de la Cognition & du Comportement, 2- Le Dévelopment & la Plasticité, 3- La Neurophysiologie & les Pathologies neuronales.

Leader

Leader: 

Établissements

Établissement de rattachement: 

CNRS

Établissements affiliés: 

Université Paris Descartes

Université: 

Université Pierre et Marie Curie

École doctorale: 

ED158
Laboratory

Nom: 

Centre de Neurophysique, Physiologie et Pathologie
Publications

publications: 

Arakaki T, Mahon S, Charpier S, Leblois A, Hansel D. The Role of Striatal Feedforward Inhibition in the Maintenance of Absence Seizures. J Neurosci. 2016 Sep 14;36(37):9618-32. doi: 10.1523/JNEUROSCI.0208-16.2016.

Arakaki T, Mahon S, Charpier S, Leblois A, Hansel D. The Role of Striatal Feedforward Inhibition in the Maintenance of Absence Seizures. J Neurosci. 2016 Sep 14;36(37):9618-32. doi: 10.1523/JNEUROSCI.0208-16.2016.

Gould M,# Leblois A, Cesa Bianchi F, Montenegro V. (2014) Convention on the rights of persons with disabilities, assistive technology and information and communication technology requirements: where do we stand on implementation? Disabil Rehabil Assist Technol. Nov 3:1-6.

#Mongillo G, Shteingart H, Loewenstein Y. 2014. The Misbehavior of Reinforcement Learning. Proceedings of the IEEE 102, 528–541.

#Ady V, Perroy J, Tricoire L, Piochon C, Dadak S, Chen X, Dusart I, Fagni L, Lambolez B,# Levenes C. 2014. Type 1 metabotropic glutamate receptors (mGlu1) trigger the gating of GluD2 delta  glutamate receptors. EMBO Reports 15(1), 103–109 

#Darshan R, #Leblois A, #Hansel D. 2014. Interference and Shaping in Sensorimotor Adaptations with rewards.PLOS Comput. Biol. 10:e1003377 

Goldin MA, Alonso LM, #Alliende JA, Goller F, Mindlin GB. 2013. Temperature Induced Syllable Breaking Unveils Nonlinearly Interacting Timescales in Birdsong Motor Pathway. PLOS ONE 8(6):e67814

CENIR Imagerie à Résonance Magnétique

Domaine de recherche principal: 

Neurophysiology / systems neuroscience

Mots clefs: 

MEG
EEG
IRM
Sciences Cognitives
Neurophysiologie
Pathologies cérébrales et médullaires

Labelisation ENP: 

2007

Centre de recherche / Institut: 

Institut du Cerveau et de la Moelle épinière

Code unité de recherche: 

UMRS 1127 UMR 7225

Le CENIR a pu commencer ses activités de recherche en neuro-imagerie grâce à la coopération financière de grandes institutions publiques et de prestigieux partenaires privés. L'ENP a cofinancé l'antenne tête 32 canaux et 100% de leur système EEG. 

Leader

Leader: 

Établissements

Établissement de rattachement: 

Inserm

Établissements affiliés: 

CNRS
Université Pierre et Marie Curie

Université: 

Université Pierre et Marie Curie

École doctorale: 

ED158
Laboratory

Nom: 

Institut du Cerveau et de la Moëlle

Initiatives d'Excellence: 

IHU-A-ICM, FLI, Neuratris
Publications

publications: 

Gargouri F, Messé A, Perlbarg V, Valabregue R, McColgan P, Yahia-Cherif L, Fernandez-Vidal S, Ben Hamida A, Benali H, Tabrizi S, Durr A, Lehéricy S. Longitudinal changes in functional connectivity of cortico-basal ganglia networks in manifests and premanifest huntington's disease. Hum Brain Mapp. 2016 Jul 12. doi: 10.1002/hbm.23299. 

Rosso C, Valabregue R, Arbizu C, Ferrieux S, Vargas P, Humbert F, Attal Y, Messé A, Zavanone C, Meunier S, Cohen L, Delmaire C, Thielscher A, Herz DM, Siebner HR, Samson Y, Lehéricy S. The eye of the self: precuneus volume and visual perspective during autobiographical memory retrieval. Brain Struct Funct. 2014 May;219(3):959-68. doi: 10.1007/s00429-013-0546-2. Epub 2013 Apr 4.

Dumas, T., Dubal, S., Attal, Y., Morel, S., Chupin, M., Jouvent, R., & George, N. (2013). MEG evidence for early amygdala responses to fearful faces in healthy adults. PloS ONE, 8(9): e74145. oi:10.1371/journal.pone.0074145.

Fasoula A, et al. Comparative performance evaluation of data-driven causality measures applied to brain networks. J Neurosci Methods (2013), http://dx.doi.org/10.1016/j.jneumeth.2013.02.021

Attal Y, Schwartz D Assessment of Subcortical Source Localization Using Deep Brain Activity Imaging Model with Minimum Norm Operators: A MEG Study. PLoS ONE (2013) 8(3): e59856. doi:10.1371/journal.pone.0059856

Dalal, SS., Jerbi, K., Bertrand, O., Adam, C., Ducorps, A., Schwartz, D., Garnero, L., Baillet, S., Martinerie, J., Lachaux, J-P. Evidence for MEG detection of hippocampus oscillations and cortical gamma-band activity from simultaneous intracranial EEG. Epilepsy & Behavior (2013) 28 (2), 310-311. Dio: 10.1016/j.yebeh.2012.04.032

Ulloa, J.L., Puce, A., Hugueville, L., & George, N. (2013). Sustained neural activity to gaze and emotion perception in dynamic social scenes. SCAN, in press. doi: 10.1093/scan/nss141

Inhibition synaptique et auto-régulation des microcircuits corticaux

Domaine de recherche principal: 

Neurophysiology / systems neuroscience

Mots clefs: 

Inhibition
cerebral cortex
interneurons
synaptic transmission
GABA

Labelisation ENP: 

2011

Centre de recherche / Institut: 

Institut du Cerveau et de la Moelle épinière

Code unité de recherche: 

UMRS 1127 UMR 7225

In the cerebral cortex the constant computation of incoming sensory information is dynamically integrated to provide a coherent representation of the world and generate highly sophisticated cognitive functions. Cortical circuits are made of different neuron types connecting one another through a staggering number of synaptic connections that are responsible for the propagation of information between neurons.

Leader

Leader: 

Personnel

Etudiants ENP: 

Établissements

Établissement de rattachement: 

Inserm

Établissements affiliés: 

CNRS
Université Pierre et Marie Curie

Université: 

Université Pierre et Marie Curie

École doctorale: 

ED158
Laboratory

Initiatives d'Excellence: 

LabEX BioPsy, ENI-Net
Publications

publications: 

Antonucci F, Corradini I, Morini R, Fossati G, Menna E, Pozzi D, Pacioni S, Verderio C, Bacci A, Matteoli M (2013) Reduced SNAP-25 alters short-term plasticity at developing glutamatergic synapses EMBO Rep. 14:645-51.

Baptista S, Lourenço J, Milhazes N, Borges F, Silva AP, Bacci A. Long-Term Treatment with Low Doses of Methamphetamine Promotes Neuronal Differentiation and Strengthens Long-Term Potentiation of Glutamatergic Synapses onto Dentate Granule Neurons. eNeuro. 2016 Jul 11;3(3). pii: ENEURO.0141-16.2016. doi: 10.1523/ENEURO.0141-16.2016. eCollection 2016 May-Jun.

Lourenço J, Pacioni S, Rebola N, van Woerden GM, Marinelli S, DiGregorio D, Bacci A (2014) Non-associative potentiation ofperisomatic inhibition alters the temporal coding of neocortical layer 5 pyramidal neurons PLoS Biology 12:e1001903