Neurological and psychiatric diseases

Développement, réparation et vieillissement cérébral

Domaine de recherche principal: 

Neurogenetics / neurodevelopment

Mots clefs: 

Alzheimer's disease
synaptic development
post-lesion repair
non-invasive brain stimulation

Labelisation ENP: 

2015

Centre de recherche / Institut: 

Institut de Biologie Paris Seine

Code unité de recherche: 

UMR8256

DRVC étudie les mécanismes impliquées dans le développement, la réparation, et le vieillissement du cerveau, avec comme modèles l'hippocampe et le cervelet, in vivo et in vitro.

Leader

Leader: 

Co leader: 

Établissements

Établissement de rattachement: 

UPMC

Établissements affiliés: 

CNRS

Université: 

Université Pierre et Marie Curie

École doctorale: 

ED3C 158
Laboratory

Nom: 

Biological Adaptation and Ageing

Initiatives d'Excellence: 

LabEx Biopsy, Udex Super de l'UPMC, DHU FAST
Publications

publications: 

Grehl S, Martina D, Goyenvalle C, Deng ZD, Rodger J, Sherrard RM. In vitro Magnetic Stimulation: A Simple Stimulation Device to Deliver Defined Low Intensity Electromagnetic Fields. Front Neural Circuits. 2016 Nov 3;10:85. 

Vernet-der Garabedian B#, Derer P#, Bailly Y, Mariani J# (2013) Innate immunity in the Grid2Lc/+ mouse model of cerebellar neurodegeneration: glial CD95/CD95L plays a non-apoptotic role in persistent neuron loss-associated inflammatory reactions in the cerebellum J Neuroinflamm.;10:65.

Chen XR Heck N Lohof AM# Rochefort C Morel MP Wehrle R Doulazmi M# Marty S Cannaya V Avci HX# Mariani J# Rondi-Reig L Vodjdani G Sherrard RM# Sotelo C Dusart I (2013) Mature Purkinje cells require RORalpha to maintain climbing fiber mono-innervation and other adult characteristics. J Neurosci. 33(22):9546-62.

Makowiecki K, Harvey AR, Sherrard RM#, Rodger J (2014) Low-Intensity Repetitive Transcranial Magnetic Stimulation Improves Abnormal Visual Cortical Circuit Topography and Upregulates BDNF in Mice. J Neurosci 34:10780-10792

Grehl S#, Viola H, Fuller-Carter PI, Carter KW, Dunlop SA, Hool L, Sherrard RM*#, Rodger J*# (2015) Cellular and molecular changes to cortical neurons following low intensity repetitive magnetic stimulation at different frequencies. Brain Stim in press *=co-senior

Cifuentes D, Poittevin M, Dere E#, Broqueres-You, D, Bonnin P, Benessiano J, Pocard M, Mariani J#, Kubis N, Merkulova-Rainon T, Lévy B (2014) Hypertension accelerates the progression of Alzheimer-Like pathology in a mouse model of the disease. Hypertension, (Oct 20)

Cervelet, Navigation et mémoire

Domaine de recherche principal: 

Neurophysiology / systems neuroscience

Mots clefs: 

spatial memory
spatial navigation
cervelet

Labelisation ENP: 

2008

Centre de recherche / Institut: 

Institut de Biologie Paris Seine

Code unité de recherche: 

U1130 UMR8246 UMCR18

Nous étudions les bases neurales de la mémoire spatiale grâce à des tests de navigation. La navigation est la capacité à se localiser dans un environnement et à trouver son chemin vers un but. La mémoire spatiale est une fonction centrale à cette capacité et son altération peut perturber la navigation. C’est par exemple le cas dans certaines pathologies de la mémoire telle que la maladie d'Alzheimer. 

Leader

Leader: 

Personnel

Etudiants ENP: 

Établissements

Établissement de rattachement: 

UPMC

Établissements affiliés: 

CNRS
Inserm

Université: 

Université Pierre et Marie Curie

École doctorale: 

ED158
Laboratory

Nom: 

Neuroscience Paris Seine
Publications

publications: 

Traut N., Beggiato A., Bourgeron T., Delorme R., Rondi-Reig L., Paradis AL, Toro R. (accepted) Cerebellar volume in autism: Meta-analysis and analysis of the ABIDE cohort, Biological psychiatry [IF: 11.4]

Bellassen V., Igloi K., de Souza LC., Dubois B., Rondi-Reig L. Spatio-temporal navigation as behavioral cognitive marker J. Neuroscience, 32(6):19421952, 2012 [IF: 6.9]

de Lavilléon G, Lacroix MM, Rondi-Reig L*, Benchenane K*. Explicit memory creation during sleep demonstrates a causal role of place cells in navigation. Nat Neurosci. 18(4):493-5. 2015 [IF: 16.7]

Iglói K., Doeller C.F., Paradis A.L., Benchenane K., Berthoz A., Burgess N. and Rondi-Reig L. Interaction between hippocampus and cerebellum Crus I in sequence-based but not place-based navigation. Cerebral cortex, 25(11):4146-54, 2015  [IF: 8.28]

Cabral H.O., Vinck M., Fouquet C., Pennartz C.M.A., Rondi-Reig L., and Battaglia F.P. Oscillatory dynamics and place field maps reflect sequence and place memory processing in hippocampal ensembles under NMDA receptor control. Neuron, 81(2):402-15, 2014 [IF: 15.05]

Liens vidéos:

- « les-chemins-de-l-orientation »

UNIVERSCIENCE - Cité des sciences - Sens de l’orientation ? Où ça ? 

Bibliothèque Médicis  « sciences-bibliotheque-medicis_news »

http://videotheque.cnrs.fr/index.php?urlaction=doc&id_doc=2914

Science à Coeur: http://video.upmc.fr/differe.php?collec=CS_C_sac4&video=10 

 

MÉCANISMES CELLULAIRES DE LA NEUROTRANSMISSION

Domaine de recherche principal: 

Neuropharmacology / cell signaling

Mots clefs: 

Depression
Schizophrénie
psychiatrie

Labelisation ENP: 

2014

Code unité de recherche: 

UMR 894

Le projet de l'équipe est d’identifier de nouvelles protéines et de nouveaux mécanismes impliqués dans le trafic neuronal de récepteurs, dans le but de caractériser de nouvelles cibles thérapeutiques dans le domaine de la dépression, la schizophrénie et d’autres pathologies neuronales et psychiatriques.

Établissements

Établissement de rattachement: 

Inserm

Établissements affiliés: 

Université Paris Descartes

Université: 

Université Pierre et Marie Curie

École doctorale: 

ED158
Publications

publications: 

Al Awabdh Sana , ? Masson J., Hamon M., Emerit M.B., Darmon M. J Neurosci. 2012 32(41):14227-14241.

Sokoloff P, Leriche L, Diaz J, Louvel J, Pumain R. Naunyn Schmiedebergs Arch Pharmacol. 2013 Feb;386(2):107-24

M. Humbert-Claude, E. Davenas, F. Gbahou, L. Vincent and J. M. Arrang: Psychopharmacology (Berl). 2012;220(1):225-41.

F. Gbahou, A. Rouleau and J. M. Arrang: Br J Pharmacol. 2012 166(6):1860-71.

M. El Hage, J. Masson, A. Conjard-Duplany, B. Ferrier, G. Baverel and G. Martin: J Cereb Blood Flow Metab. 2012.

PICNIC Lab Physiological Investigations of Clinically Normal & Impaired Cognition

Domaine de recherche principal: 

Cognitive neurosciences / neuropsychology /neuroeconomy

Labelisation ENP: 

2014

Centre de recherche / Institut: 

Institut du Cerveau et de la Moelle épinière

Code unité de recherche: 

UMRS 1127 UMR 7225

The PICNIC lab is devoted to the study of cognitive functions with an exclusive or prevalent development in humans, namely language and conscious cognition. The study of brain-damaged patients occupies a central position in our methodological approach. For the study of both language and consciousness, and with both patients and healthy subjects, we resort to state-of-the-art behavioural methods and multimodal brain imaging (MRI, high-density surface EEG and intracerebral implanted electrodes).

Leader

Leader: 

Co leader: 

Personnel

Etudiants ENP: 

Membres de l'équipe: 

Paolo BARTOLOMEO
Établissements

Établissement de rattachement: 

Inserm

Établissements affiliés: 

Université Pierre et Marie Curie
CNRS
Université Paris 6

Université: 

Université Pierre et Marie Curie

École doctorale: 

ED158
Laboratory

Initiatives d'Excellence: 

Contrat ANR, ICM Big Brain Theory Program, Idex Sorbonne université
Publications

publications: 

 

Mongelli, V., Dehaene, S., Vinckier, F., Peretz, I., Bartolomeo, P., & Cohen, L. (2016). Music and words in the visual cortex: The impact of musical expertise. Cortex. doi: 10.1016/j.cortex.2016.05.016

Lunven, M., Thiebaut de Schotten, M., Bourlon, C., Duret, C., Migliaccio, R., Rode, G., & Bartolomeo, P. (2015). White matter lesional predictors of chronic visual neglect: a longitudinal study. Brain, 138, 746-760.

Sitt*, J., King*, J. R., El Karoui, I., Rohaut, B., Faugeras, F., Gramfort, A., Cohen, L., Sigman, M., Dehaene, S., & Naccache, L. (2014). Large scale screening of neural signatures of consciousness in patients in a vegetative or minimally conscious state. Brain, 137, 2258-2270.

Bouhali, F., Thiebaut de Schotten, M., Pinel, P., Poupon, C., Mangin, J. F., Dehaene, S., & Cohen, L. (2014). Anatomical Connections of the Visual Word Form Area. Journal of Neuroscience, 34(46), 15402-15414.  

King*, J. R., Sitt*, J., Faugeras, F., Rohaut, B., El Karoui, I., Cohen, L., Naccache, L., & Dehaene, S. (2013). Information Sharing in the Brain Indexes Consciousness in Noncommunicative Patients. Current Biology, 23(19), 1914-1919.

Physiopathologie des troubles de l'humeur : dépression et addiction

Domaine de recherche principal: 

Neurological and psychiatric diseases

Mots clefs: 

plasticity
Stress
Depression
serotonine/
alcohol

Labelisation ENP: 

2014

Code unité de recherche: 

UMRS 894

The goal of the research team is to analyze the roles played by environmental and genetic factors, as well as the interactions between these components, in the etiology and treatment of psychiatric disorders such as depression, anxiety and addiction. The main objective of the team is to identify cellular and molecular mechanisms underlying these pathologies which are associated with major dysfunctions of the monoamine and HPA systems and characterized by cellular plasticity alterations of different brain areas and in particular the hippocampus.

Établissements

Établissement de rattachement: 

Inserm
Publications

publications: 

Stragier E, Massart R, Salery M, Hamon M, Geny D, Martin V, Boulle F, Lanfumey L. Ethanol-induced epigenetic regulations at the Bdnf gene in C57BL/6J mice. Neuroscience. 2014 Jun 20;271:56-63. doi: 10.1016/j.neuroscience.2014.04.027. Epub 2014 Apr 26.

Doucet EL, Lanfumey L, et al. (2013) Sustained impairment of alpha2A-adrenergic autoreceptor signaling mediates neurochemical and behavioral sensitization to amphetamine. Biol Psychiatry. 74:90-98

Garcia Garcia Al, Lanfumey L, et al. (2013) Regulation of serotonin (5-HT) function by a VGLUT1 dependent glutamate pathway. Neuropharmacology. 70:190-199

Lanfumey L, et al (2012) Biological rhythms and melatonin in mood disorders and their treatments Pharmacol Ther. 138:176-184 Review

Lanteri C, ?, Lanfumey L, et al.. (2013) Repeated exposure to MDMA triggers long-term plasticity of noradrenergic and serotonergic neurons Mol Psychiatry. 2013 Aug 20.

Martin CBP, .. Lanfumey L, .. et al. (2012) RNA splicing and editing modulation of 5-HT2C receptor function: relevance to anxiety and aggression in VGV mice. Mol Psychiatry. 18:656-665

Molet J,  Lanfumey L. Juvenile ethanol exposure increases rewarding properties of cocaine and morphine in adult DBA/2J mice. Eur Neuropsychopharmacol. 2013 Apr 22.

NEURO-MODULATION (UVSQ)

Domaine de recherche principal: 

Cognitive neurosciences / neuropsychology /neuroeconomy

Mots clefs: 

Brain imaging
consciousness
Neurological disability
Neuromodulation
Translational neuroscience

Labelisation ENP: 

2014

The long-term objective of this project is to apply high field MRI eventually combined with other neuroscience approaches, to develop physical (e.g. electric neurostimulation) and/or chemical (e.g. pharmacological delivery) devices of neuromodulation that target neuronal sites and manipulate specific aspects of cognition, motor behavior or consciousness, leading ultimately to the development of treatments for patients with related diseases (e.g. disorders of consciousness, Parkinson's disease...).

Établissements

Établissement de rattachement: 

Inserm

Université: 

Univ Pierre et Marie Curie

École doctorale: 

ED158
Laboratory

Nom: 

Unicog Cognitive Neuroimaging Unit

Initiatives d'Excellence: 

IDEX Paris-Saclay / NeuroSaclay, IHU Handimedex
Publications

publications: 

-Arsenault J, Nelissen K, Jarraya B#, Vanduffel W. Dopaminergic reward signals selectively decrease fMRI activity in primate visual cortex. Neuron. Mars 2013.

-D. Le Bihan, O. Joly#, T. Aso, L. Uhrig#, C. Poupon, N. Tani#, H. Iwamuro#, S-I. Urayama, B. Jarraya# Brain tissue water comes in two pools: Evidence from diffusion and R2? measurements with USPIOs in non human primates. NeuroImage. 2012 May 11.

-K Nelissen*, B Jarraya* #, J Arsenault, B R. Rosen, L L. Wald, J B. Mandeville, J. J. Marota, W Vanduffel. Neural correlates of formation and retention of cocaine-induced stimulus-reward associations. Biological Psychiatry. 2012 Mar 20. * co-authoring

-L Ciobanu, O Reynaud, L Uhrig#, B Jarraya#, D Le Bihan. Effects of Anesthetic Agents on Brain Blood Oxygenation Level Revealed with Ultra-High Field MRI PlosONE. 2012;7(3):e32645.

- N Tani#, O Joly#, H Iwamuro#, L Uhrig#, C J. Wiggins, C Poupon, H Kolster, W Vanduffei, D Le Bihan, S Palfi#, B Jarraya# Direct visualization of non-human primate subcortical nuclei with contrast-enhanced high field MRI. NeuroImage 2011 Sep 1;58(1):60-8.

- Jarraya B#, Boulet S, Scott Ralph G, Jan C, Bonvento G, Azzouz M, E. Miskin J, Shin M, DelzescauxT, Drouot X, Hérard A.S, M. Day D, Brouillet E, M. Kingsman S, Hantraye P, A. Mitrophanous K, D. Mazarakis N, Palfi S#. Dopamine Gene Therapy for Parkinson?s Disease in a Nonhuman Primate Without Associated Dyskinesia. Science Translational Medicine Vol 1 2009.

Social Cognition Group

Domaine de recherche principal: 

Cognitive neurosciences / neuropsychology /neuroeconomy

Mots clefs: 

social cognition
neuroimaging
Social Behaviour
Affective processes
Non verbal Communication

Labelisation ENP: 

2014

Centre de recherche / Institut: 

ENS Ecole Normale Supérieure

Code unité de recherche: 

U960

Our primary interest is to study the neural time course and correlates underpinning the processing of the early stages of social interactions. We have now set out to address several key issues important to our understanding of the processing of social interactions, for example (i) what is the biological function of spontaneous and involuntary facial reactions when facing emotional events; (ii) how and when do we perceive / decide that we are the target of a communicative intention (iii) how we (decide to) prepare an adapted motor response.

Leader

Leader: 

Établissements

Établissement de rattachement: 

Inserm

Université: 

Université Pierre et Marie Curie

École doctorale: 

ED158
Laboratory

Nom: 

Laboratoire de Neurosciences Cognitives

Initiatives d'Excellence: 

Paris-Science Lettre (ANR-11-0001-02 PSL), Laboratoire d’excellence : Institut des Sciences Cognitives (IEC) – Ecole Normale (ANR-10-LABX-0087)
Publications

publications: 

Dezecache G, Grèzes J and Dahl C. The nature and distribution of affiliative behaviour during exposure to mild threat. Royal Society Open Science (in press)

Ioannou C., El Zein M., Wyatt V., Scheid I., Amsellem F., Delorme R., Chevallier C. & Grèzes J. Shared mechanism for emotion processing in adolescents with and without autism. Scientific Reports 7:42696 (2017).

El Zein M., Wyart V., Grèzes J.  Anxiety dissociates the adaptive functions of sensory and motor response enhancements to social threats. Elife, 4:e10274 (2015).

Grèzes J., Valabregue R., Gholipour B., Chevallier C.A direct amygdala-motor pathway for emotional displays to influence action: a Diffusion Weighted Imaging study. Human Brain Mapping. 35(12):5974-83 (2014).

Conty L., Dezecache G., Hugueville L., Grèzes J. Early binding of gaze, gesture and emotion: neural time course and correlates. Journal of Neuroscience, 32(13):4531-9 (2012).

Social and Affective Neuroscience Team (SAN)

Domaine de recherche principal: 

Cognitive neurosciences / neuropsychology /neuroeconomy

Mots clefs: 

Affective processes
social processes
neuroimaging
Depressive disorders
Self Processing
Emotional Vision
Social contact

Labelisation ENP: 

2014

Centre de recherche / Institut: 

Institut du Cerveau et de la Moelle épinière

Code unité de recherche: 

UMRS 1127 UMR 7225

The SAN team gathers together three PIs with complementary expertise in affective neuroscience, social neuroscience, and psychiatry. Our project focuses on the functional neuroanatomy of the emotional brain. We study the brain systems of emotion detection, evaluation, and regulation, with an emphasis on how social processes (eg social inclusion) activate and regulate the emotional brain. Dysfunction of the emotional brain is central to many mental disorders and in particular to major depressive disorder (MDD).

Leader

Leader: 

Personnel

Membres de l'équipe: 

MILLET Bruno
Établissements

Établissement de rattachement: 

Inserm

Établissements affiliés: 

CNRS
Université Pierre et Marie Curie

Université: 

Université Pierre et Marie Curie

École doctorale: 

ED 158
Laboratory

Initiatives d'Excellence: 

Institute for Translational Neuroscience (IHU-A-ICM), Paris
Publications

publications: 

Mauras, T., Masson, M., Fossati, P*., & Pessiglione, M*. (2016). Incentive Sensitivity as a Behavioral Marker of Clinical Remission From Major Depressive Episode. Journal of Clinical Psychiatry, 77(6), E697-+. * equal contribution

Rotge, J. Y., Poitou, C., Fossati, P., Aron-Wisnewsky, J., & Oppert, J. M. (2017). Decision-making in obesity without eating disorders: a systematic review and meta-analysis of Iowa gambling task performances. Obes Rev.

Resibois, M., Verduyn, P., Delaveau, P., Rotge, J. Y., Kuppens, P., Van Mechelen, I., & Fossati, P. (2017). The neural basis of emotions varies over time: Different regions go with onset- and offset-bound processes underlying emotion intensity. Soc Cogn Affect Neurosci. doi: 10.1093/scan/nsx051. [Epub ahead of print]

Delaveau, P., Arruda Sanchez, T., Steffen, R., Deschet, K., Jabourian, M., Perlbarg, V., Gasparetto, E. L., Dubal, S., Costa, E. S. J., & Fossati, P. (2017). Default mode and task-positive networks connectivity during the N-Back task in remitted depressed patients with or without emotional residual symptoms. Hum Brain Mapp.

Burra, N., Baker, S., & George, N. (2017). Processing of gaze direction within the N170 / M170 time window: A combined EEG / MEG study. Neuropsychologia.

 

Membrane Transport

Domaine de recherche principal: 

Neuropharmacology / cell signaling

Mots clefs: 

Optogenetics
Transporter
Synaptic vesicle
Lysosome
Neurodegeneration

Labelisation ENP: 

2014

Centre de recherche / Institut: 

INCC - UMR 8002 - Paris Descartes University

Code unité de recherche: 

UMR 8250

RESEARCH INTERESTS:

Leader

Leader: 

Établissements

Établissement de rattachement: 

CNRS

Établissements affiliés: 

Université Paris Descartes
Laboratory

Nom: 

Neurophotonics laboratory
Publications

publications: 

Chapel A, Kieffer-Jaquinod S, Sagné C#, Verdon Q#, Ivaldi C, Mellal M, Thirion J, Jadot M, Bruley C, Garin J, Gasnier B#, Journet  A (2013) An extended proteome map of the lysosomal membrane reveals novel potential transporters. Mol Cell Proteomics, 12:1572

M. Martineau, T. Shi, J. Puyal, A.M. Knolhoff, J. Dulong, B. Gasnier#, J. Klingauf, J. V. Sweedler, R. Jahn, and J-P Mothet (2013) Storage and uptake of D-serine into astrocytic synaptic-like vesicles specify gliotransmission. J Neurosci, 34:646.

A. Jezegou#, E. Llinares, C. Anne#, S. Kieffer-Jaquinod, S. O'Regan#, J. Aupetit , A. Chabli, C. Sagné#, C. Debacker#, B. Chadefaux-Vekemans, A. Journet, B. Andre, B. Gasnier# (2012) Heptahelical protein PQLC2 is a lysosomal cationic amino acid exporter underlying the action of cysteamine in cystinosis therapy. PNAS 109:E3434

R. Ruivo#, G.C. Bellenchi#, X. Chen#, G. Zifarelli, C. Sagné#, C. Debacker#, M. Pusch, S. Supplisson, B. Gasnier# (2012) Mechanism of proton/substrate coupling in the heptahelical lysosomal transporter cystinosin, PNAS 109:E210.

N. Pietrancosta*, C. Anne*#, H. Prescher, R. Ruivo#, C. Sagné#, C. Debacker#, H.O. Bertrand, R. Brossmer, F. Acher, B. Gasnier# (2012) Successful prediction of the substrate-binding pocket in the SLC17 transporter sialin, JBC 287:11489

Memory Oscillations and Brain states (MOBs)

Domaine de recherche principal: 

Neurophysiology / systems neuroscience

Labelisation ENP: 

2014

Centre de recherche / Institut: 

ESPCI Paris Tech -Ecole Supérieure de Physique et de Chimie Industrielles

Code unité de recherche: 

UMR 8249

Memory is a dynamical phenomenon, from the moment of encoding to retrieval. As shown in the mammalian brain, after encoding labile memories undergo consolidation, that is, they stabilize over time first in the hippocampus before being transferred to the neocortex for long-term storage (Battaglia et al., 2011, Frankland and Bontempi, 2005). In 1989, Gyorgy Buzsaki proposed the twostage model of memory consolidation, where each sequential phase of memory (encoding and consolidation) is related to different internal brain states (Buzsaki, 1989).

Leader

Leader: 

Personnel

Etudiants ENP: 

Membres de l'équipe: 

Thierry GALLOPIN
Établissements

Établissement de rattachement: 

CNRS

Établissements affiliés: 

ESPCI

École doctorale: 

ED 3C - 158
Laboratory

Nom: 

Laboratoire de Neurobiologie

Initiatives d'Excellence: 

Labex Memolife
Publications

publications: 

Roux L, Benchenane K#, Rothstein J, Bonvento G, Giaume G. (2011) Plasticity of astroglial networks in the olfactory glomeruli.PNAS. 108(45):18442-6.

Martinet LM, Sheynikhovich D, Benchenane K#, Arleo A (2011) Spatial learning and action planning in a prefrontal cortical network model. Plos Comp Biol. 7(5):e1002045.

Battaglia FP, Benchenane K#, Sirota A, Pennartz CM, Wiener SI (2011) The hippocampus: hub of brain network communication for memory. Trends Cogn Sci. 15(7):310-8. (Review)

Benchenane K#, Tiesinga PH, Battaglia FP (2011) Oscillations in the prefrontal cortex: a gateway to memory and attention. Curr Op Neurobiol. 21(3):475-85. (Review)

Benchenane K#, Peyrache A, Khamassi M, Tierney PL, Gioanni Y, Battaglia FP, Wiener SI (2010) Coherent theta oscillations and reorganization of spike timing in the hippocampal-prefrontal network upon learning. Neuron. 66(6):921-36.