Computational neurosciences / neural theory

Equipe Audition

Domaine de recherche principal: 

Neurophysiology / systems neuroscience

Mots clefs: 

memory, learning, plasticity, human psychophysics, physiology in behaving ferrets

Labelisation ENP: 

2017

Centre de recherche / Institut: 

ENS Ecole Normale Supérieure

Code unité de recherche: 

UMR 8248

The Audition team is investigating the mechanisms of auditory perception, at the interface between low-level processing of acoustic features and high-level cognitive processes. We use a wide range of tools in order to address this research topic, from single unit recordings in behaving animals to advanced psychophysics and EEG in human subjects. Current projects in the lab revolve around three major threads:

Leader

Leader: 

Établissements

Établissement de rattachement: 

CNRS

Établissements affiliés: 

Ecole Normale Supérieure

Université: 

Université Pierre et Marie Curie

École doctorale: 

ED 3C - 158
Laboratory

Nom: 

Laboratoire des Systèmes Perceptifs

Initiatives d'Excellence: 

LabEx Institut d’Etude de la Cognition, IdEx Paris Sciences et Lettres
Publications

publications: 

Agus, T.R., Thorpe, S.J., & Pressnitzer, D. (2010). Rapid formation of auditory memories: Insights from noise. Neuron. 66, 610-618.

Andrillon, T., Pressnitzer, D., Léger, D., & Kouider, S. (2017).Formation and suppression of acoustic memories in human sleep. NatureCommunications, 8: 179.

Boubenec Y, Lawlor J, Górska U, Shamma S & Englitz B (2017). Detecting changes in dynamic and complex acoustic scenes. eLife 2017;10.7554/eLife.24910.

Chambers, C., Akram, S. Adam, V., Pelofi, C., Sahani, M., Shamma, S., & Pressnitzer, D. (2017). Prior context in audition informs binding and shapes simple features. Nature Communications, 8:15027.

Andrillon, T., Kouider, S., Agus, T., & Pressnitzer, D. (2015).Perceptual learning of acoustic noise generates memory-evoked potentials. Current Biology, 25: 2823-2829.

 

Multisensory signal processing: From whole-brain activity to behavior

Domaine de recherche principal: 

Neurophysiology / systems neuroscience

Labelisation ENP: 

2016

Centre de recherche / Institut: 

Laboratoire Jean Perrin

Code unité de recherche: 

UMR 8237

Our brain needs to constantly fuse sensory information detected by our multiple senses in order to produce a seamless coherent representation of the world. Rather than being the exception, this binding process is ubiquitous to sensory-motor integration and is implicated in most cognitive functions. Its impairment is a cause of various pathologies, such as schizophrenia or autism. Multisensory processing operates on all brain levels from primary cortices over subcortical structures up to higher associative centers, while the smallest operational units are single multisensory neurons.

Leader

Leader: 

Personnel

Membres de l'équipe: 

Thomas Panier (PostDoc)
Kris Severi (PostDoc)
Geoffrey Migault (PhD)
Hugo Trentenseaux (PhD)
Matthieu Dujany (Master)
Louis Chevalier (Master)
Établissements

Établissement de rattachement: 

Sorbonne Université

Établissements affiliés: 

CNRS

Université: 

UPMC

École doctorale: 

ED 564
Publications

publications: 

Bormuth, V., Barral, J., Joanny, J.F., Jülicher, F. & Martin, P.    Transduction channels gating controls friction on vibrating hair-cell bundles in the ear.

PNAS 111, 7185-90 (2014) 

Gardner, M.K.*, Zanic, M.*, Gell, C., Bormuth, V., & Howard J.    Depolymerizing Kinesins Kip3 and MCAK Shape
Cellular Microtubule Architecture by Differential Control of Catastrophe.

CELL 147, 1092-1103 (2011)

Bormuth, V., Varga, V., Howard, J., & Schäffer, E.    Protein friction limits diffusive and directed movements of kinesin motors on microtubules.

SCIENCE 325, 870 - 873 (2009)

Varga, V.*, Leduc, C.*, Bormuth, V., Diez, S., & Howard, J.    inesin-8 motors act cooperatively to mediate length-dependent microtubule depolymerization.

CELL 138, 1174-83 (2009) 

Bormuth, V.*, Otsu, Y.*, et al.      Optical monitoring of neuronal activity at high frame rate with a digital random-access multiphoton (RAMP) microscope.

J. Neurosci. Methods 173(2), 259-270 (2008)   

Imagerie multimodale des maladies neurodégénératives et thérapies

Domaine de recherche principal: 

Neurological and psychiatric diseases

Mots clefs: 

Alzheimer
imagerie
Nucleation/propagation
Recherche translationnelle
Thérapies

Labelisation ENP: 

2016

Centre de recherche / Institut: 

MIRCen

Code unité de recherche: 

UMR 9199

La maladie d'Alzheimer (MA) est un problème de santé publique dans nos sociétés. Elle est associée à l'accumulation intracérébrale de plaques amyloïdes et de protéines tau anormales. Notre équipe aborde cette maladie en se concentrant sur trois points différents.

Leader

Leader: 

Personnel

Membres de l'équipe: 

Thierry Delzescaux
Fanny Petit
Jean-Luc Picq
Anne Sophie Herard
Nicolas Souedet
Nachiket Nadkarni
Cedric Clouchoux
Charlotte Gary
Yael Balbastre
Zhenzhen You
Clement Garin
Clemence Dudeffant
Clement Bouvier
Emmalaurie Baptiste
Lisa Ciaptacz
Établissements

Établissement de rattachement: 

Mircen

Établissements affiliés: 

CNRS
CEA
Université Paris Sud
Université Paris Saclay

École doctorale: 

ED568 - Biosigne
Laboratory

Nom: 

Laboratoire des Maladies Neurodégénératives

Initiatives d'Excellence: 

Neuratris
Publications

publications: 

Picq JL#, Villain N, Gary C#, Pifferi F, Dhenain M#, 2015. Jumping stand apparatus reveals rapidly specific age-related cognitive impairments in mouse lemur primates. PLoS ONE. 10, e0146238.

Djelti F, Braudeau J, Hudry E, Dhenain M #, Varin J, Bièche I, Marquer C, Chali F, Ayciriex S, Alves S, Langui D, Potier MC,Duyckaerts C, Miles R, Aubourg P, Cartier N. Excess of brain cholesterol triggers neuronal death and paves the way for Alzheimer’sdisease. Brain.2015.138,2383-2398.

Pifferi F, Dorieux O#, Castellano C A, Croteau E, Masson M, Guillermier M #, Van Camp N, Guesnet P, Alessandri JM, Cunnane S,Dhenain M#, Aujard F. Dietary omega3 polyunsaturated fatty acids enhance resting state brain glucose utilization and reduce anxietyin an adult non-human primate, the grey mouse lemur (Microcebus murinus). J Lipid Res.2015.56(8),1511-1518.

Ben Haim L, Ceyzeriat K, Carrillo de Sauvage MA, Aubry F, Auregan G, Guillermier M, Houitte D, Petit F #, Faivre E, VandesquilleM#, Dhenain M#, Déglon N, Hantraye P, Brouillet E, Bonvento G, Escartin C. The JAK/STAT3 pathway is a common mediator ofastrocyte reactivity in neurodegenerative disease models. J Neuroscience.2015.35(6):2817-2829.

Roy M#, Cardoso C#, Dorieux O#, Malgorn C#, Epelbaum S, Kraska A#, Brouillet E, Delatour B, Perret M, Aujard F, Dhenain M#.Age-associated evolution of plasmatic amyloid in mouse lemur primates: Relationship with neuronal accumulation of amyloid-ßprecursor protein, Neurobiol Aging.2015.36(1):149-156.

Sawiak SJ, Picq JL#, Dhenain M#, Voxel-based morphometry analyses of in-vivo MRI in the aging mouse lemur primate. FrontiersAging Neurosc.2014.6:82.doi:10.3389/fnagi.2014.00082

Neurosciences computationnelles des systèmes sensoriels

Domaine de recherche principal: 

Computational neurosciences / neural theory

Mots clefs: 

computational neuroscience
sensory systems
spike initiation
neural simulation
spike timing

Labelisation ENP: 

2015

Centre de recherche / Institut: 

Institut de la Vision

Code unité de recherche: 

UMRS968 UMR7210 UM80

Nous tentons de comprendre les mécanismes neuronaux de la perception à l'aide de modèles théoriques et informatiques des systèmes sensoriels. Ces modèles permettent de relier le niveau physiologique (les propriétés des neurones) et le niveau comportemental. Les théories sont ainsi testées à la fois par des expériences physiologiques (en particulier électrophysiologie) et comportementales (psychophysique). Elles sont également testées sous l'angle computationnel, en évaluant la performance fonctionnelle des modèles dans des tâches perceptives complexes.

Leader

Leader: 

Personnel

Etudiants ENP: 

Établissements

Établissement de rattachement: 

Inserm

Établissements affiliés: 

CNRS

Université: 

Université Pierre et Marie Curie

École doctorale: 

ED3C
Laboratory

Initiatives d'Excellence: 

Labex LIFESENSES, Label "Institut Carnot", Label CTRS / RTRS "Fondation Voir & Entendre", Qualification de « Projet Structurant » par Medicen Paris Région, Labellisation par la Foundation Fighting blindness
Publications

publications: 

Fontaine B, Peña JL, Brette R (2014). Spike-threshold adaptation predicted by membrane potential dynamics in vivo. PLoS Comp Biol, 10(4): e1003560.

Hamada M, Goethals S, de Vries S, Brette R, Kole M (2016). Covariation of axon initial segment location and dendritic tree normalizes the somatic action potential. PNAS 113(51): 14841–14846.

Yger P, Stimberg M, Brette R (2015). Fast learning with weak synaptic plasticity. J Neurosci 35(39): 13351-13362.

Bénichoux V, Fontaine B, Karino S, Franken TP, Joris PX*, Brette R* (2015). Neural tuning matches frequency-dependent time differences between the ears. eLife 10.7554/eLife.06072.

Brette R (2015). What Is the Most Realistic Single-Compartment Model of Spike Initiation? PLoS Comput Biol. 2015 Apr 9;11(4):e1004114.

 

Ageing in Vision and Action

Domaine de recherche principal: 

Cognitive neurosciences / neuropsychology /neuroeconomy

Mots clefs: 

Spatial Cognition
Healthy visual aging
Visual perception
Autonomy loss, visual aids & rehabilitation
Psychophysics & mathematical modelling

Labelisation ENP: 

2015

Centre de recherche / Institut: 

Institut de la Vision

Code unité de recherche: 

U968 UMR7210 UMRS968

The Ageing in Vision and Action team is a new research group created in 2014 at the Institute of Vision, Paris. It aims at gaining a better understanding of the perceptive and cognitive disturbances occurring with natural visual ageing in humans. Natural ageing of the visual system induces a complex pattern of perceptual, cognitive, and executive disturbances. The natural progressive degradation of visual functions in the elderly is the core subject of the Ageing in Vision and Action team.

Leader

Leader: 

Personnel

Membres de l'équipe: 

SHEYNIKHOVICH Denis
MASQUELIER Tim
BOLOGNA Luca L.
William H. SEIPLE
Angelo ARLEO
Remy ALLARD
Guillaume TATUR
Elisa TARTAGLIA
Laureline LOGIACO
Marcia BECU
JEHENNE Béryl
BARHOMI Youssef
HUTH Jacob
SILVESTRE Daphné
FARZMAHDI Amir
Établissements

Établissement de rattachement: 

Inserm

Établissements affiliés: 

CNRS

Université: 

Université Pierre et Marie Curie

École doctorale: 

ED3C
Laboratory

Initiatives d'Excellence: 

IDEX : SUPER, LABEX : LIFESENSES, DHU : VISION ET HANDICAPS ("VIEWMAINTAIN"), INSTITUT CARNOT : VOIR ET ENTENDRE, CARNOT INTERNATIONAL : GLOBALCARE
Publications

publications: 

#Tartaglia et al (2015) PLoS Comput Biol, 11(2):e1004059.

#Logiaco et al. (2015) PLoS Biology, 13(8):e1002222.

#Allard R, Faubert J (2014) J Vision, 14(8):2.

#Allard R, Faubert J (2014) Front Psychol, 5:426.

#Masquelier T (2014) Network, 25:85–96.

#Allard R, Faubert J (2014) Front Psychol, 5:749.
Korotchenko S, Cingolani L A, Kuznetsova T, #Bologna LL, et al. (2014) Philos Trans R Soc Lond B Biol Sci, 369(1654):20140134.

#Arleo A, et al. (2013) J Neurosci, 33(42):16790-5.

#Sheynikhovich D, Otani S, #Arleo A (2013) J Neurosci, 33(34):13914-26.

Dynamique des circuits neuronaux & comportement

Domaine de recherche principal: 

Neurophysiology / systems neuroscience

Mots clefs: 

zebrafish
neural circuits
Optogenetics
Two-photon calcium imaging
motor behaviour
cognitive functions
light-sheet microscopy
ongoing spontaneous activity

Labelisation ENP: 

2014

Centre de recherche / Institut: 

ENS Ecole Normale Supérieure

Code unité de recherche: 

U1024 UMR 8197

Using the zebrafish larva as the experimental model and a multidisciplinary approach, including twophoton calcium imaging to monitor activity of neural networks, motor behaviours, genetic engineering techniques to label, monitor and manipulate activity of specific neurons or entire circuits and mathematical methods for data analysis, we are studying the following subjects:

1) Multimodal sensory perception:

Leader

Leader: 

Établissements

Établissement de rattachement: 

ENS

Établissements affiliés: 

CNRS
Inserm

Université: 

Université Pierre et Marie Curie

École doctorale: 

ED158
Laboratory

Nom: 

Institut de Biologie de l'ENS IBENS

Initiatives d'Excellence: 

Labex Memolife, Idex PSL, ERC Cog 2016
Publications

publications: 

Romano SA, Pérez-Schuster V, Jouary A, Boulanger-Weill J, Candeo A, Pietri T, Sumbre G. (2017) An integrated calcium imaging processing toolbox for the analysis of neuronal population dynamics PLOS Computational Biology. 13, e1005526.

Boulanger-Weill J, Candat V, Jouary A, Romano S, Pérez-Schuster V, Sumbre G. (2017) Functional Interactions between Newborn and Mature Neurons Leading to Integration into Established Neuronal Circuits. Current Biology. 27, 1–14.

Pietri, T., Romano, S.A., Pérez-Schuster, V., Boulanger-Weill, J., Candat, V., and Sumbre G. (2017). The Emergence of the Spatial Structure of Tectal Spontaneous Activity Is Independent of Visual Inputs. Cell Reports. 19, 939–948.

Pérez-Schuster V, Kulkarni A, Nouvian M, Romano SA, Lygdas K, Jouary A, Dipoppa M, Pietri T, Haudrechy M, Candat V, Boulanger-Weill J, Hakim V, Sumbre G.  (2016) Sustained Rhythmic Brain Activity Underlies Visual Motion Perception in Zebrafish. Cell Reports. 17, 4:1098-1112.

Romano SA, Pietri T, Pérez-Schuster V, Jouary A, Haudrechy M and Sumbre G. (2015) Spontaneous neuronal network dynamics reveal circuit's functional adaptations for behavior. Neuron. 85(5):1070–1085.

 

Neural Inference Group

Domaine de recherche principal: 

Computational neurosciences / neural theory

Labelisation ENP: 

2017

Centre de recherche / Institut: 

ENS Ecole Normale Supérieure

Code unité de recherche: 

U 960

Currently developping several research topics

1- Spike-based predictive coding:

Leader

Leader: 

Établissements

Établissement de rattachement: 

CNRS

Établissements affiliés: 

Inserm

Université: 

Université Pierre et Marie Curie

École doctorale: 

ED 3C - 158
Laboratory

Nom: 

Laboratoire de Neurosciences Cognitives

Initiatives d'Excellence: 

PSL, Labex de l’institut d’Etudes cognitives de l’ENS
Publications

publications: 

Constructing precisely computing networks with biophysical spiking neurons. MA Schwemmer#, AL Fairhall, S Denéve, ETShea-Brown. J Neurosci 2014

What visual illusions teach us about schizophrenia. CE Notredame#, D Pins, S Deneve, R Jardri Frontiers in integrative neuroscience 8 2014

Neural oscillations as a signature of efficient coding in the presence of synaptic delays. Chalk M#, Gutkin B, Denève S. Elife. 2016 Jul 7;5. pii: e13824. doi: 10.7554/eLife.13824.

Are Hallucinations Due to an Imbalance Between Excitatory and Inhibitory Influences on the Brain? Jardri R#, Hugdahl K, Hughes M, Brunelin J, Waters F, Alderson-Day B, Smailes D, Sterzer P, Corlett PR, Leptourgos P, Debbané M, Cachia A, Denève S. Schizophr Bull. 2016 Sep;42(5):1124-34. doi:10.1093/schbul/sbw075.

Efficiency turns the table on neural encoding, decoding and noise. Deneve S, Chalk M#. Curr Opin Neurobiol. 2016 Apr;37:141-8. doi: 10.1016/j.conb.2016.03.002. Review.

Efficient codes and balanced networks. Denève S, Machens CK. Nat Neurosci. 2016 Mar;19(3):375-82. doi: 10.1038/nn.4243. Review.

Traitement sensoriel, neuromodulation et plasticité neuronale

Domaine de recherche principal: 

Neurophysiology / systems neuroscience

Labelisation ENP: 

2010

Centre de recherche / Institut: 

Unité de Neuroscience, Information et Complexité

The Team is specialized in integrative neuroscience. Using the barrel cortex of rodents as a system model, our research is centered on the study of neuronal processes responsible for the coding of tactile sensory information and perception, as well as their regulation through the interaction of the animal with the environment. We are interested in the propagation and integration of neuronal information in the primary somatosensory cortex and subcortical somatosensory relays, and the emergence of collective properties in response to spatially distributed stimuli on the receptor surface.

Leader

Leader: 

Établissements

Établissement de rattachement: 

CNRS

Établissements affiliés: 

Université Paris Sud

Université: 

Université Pierre et Marie Curie

École doctorale: 

ED158 - 3C ED FDV
Laboratory

Initiatives d'Excellence: 

Idex NeuroSaclay - Equipe FRM
Publications

publications: 

Kerekes, P. et al.(2017) Bilateral discrimination of tactile patterns without whisking in freely-running rats.*Journal of Neuroscience* 37:7567-7579

Estebanez, L. et al. (2012) Correlated input reveals coexisting coding schemes in a sensory cortex. *Nature Neuroscience* 15:1691-1699.

Arduin, P.J. et al. (2013). "Master" neurons induced by operant conditioning in rat motor cortex during a brain-machine interface task. *Journal of Neuroscience* 33:8308–8320.

Arduin P-J. et al. (2014) Bidirectional control of a one-dimensional robotic actuator by operant conditioning of a single unit in rat motor cortex. *Frontiers in Neuroscience* (Neuroprosthetics) Vol. 8/206 : 1-15.

Estebanez, L., et al. (2016) A radial map of multi-whisker correlation selectivity in the rat barrel cortex. *Nature Communications.* 7, 13528 doi: 10.1038/ncomms13528.

 

Memory Oscillations and Brain states (MOBs)

Domaine de recherche principal: 

Neurophysiology / systems neuroscience

Labelisation ENP: 

2014

Centre de recherche / Institut: 

ESPCI Paris Tech -Ecole Supérieure de Physique et de Chimie Industrielles

Code unité de recherche: 

UMR 8249

Memory is a dynamical phenomenon, from the moment of encoding to retrieval. As shown in the mammalian brain, after encoding labile memories undergo consolidation, that is, they stabilize over time first in the hippocampus before being transferred to the neocortex for long-term storage (Battaglia et al., 2011, Frankland and Bontempi, 2005). In 1989, Gyorgy Buzsaki proposed the twostage model of memory consolidation, where each sequential phase of memory (encoding and consolidation) is related to different internal brain states (Buzsaki, 1989).

Leader

Leader: 

Personnel

Etudiants ENP: 

Membres de l'équipe: 

Thierry GALLOPIN
Établissements

Établissement de rattachement: 

CNRS

Établissements affiliés: 

ESPCI

École doctorale: 

ED 3C - 158
Laboratory

Nom: 

Laboratoire de Neurobiologie

Initiatives d'Excellence: 

Labex Memolife
Publications

publications: 

Roux L, Benchenane K#, Rothstein J, Bonvento G, Giaume G. (2011) Plasticity of astroglial networks in the olfactory glomeruli.PNAS. 108(45):18442-6.

Martinet LM, Sheynikhovich D, Benchenane K#, Arleo A (2011) Spatial learning and action planning in a prefrontal cortical network model. Plos Comp Biol. 7(5):e1002045.

Battaglia FP, Benchenane K#, Sirota A, Pennartz CM, Wiener SI (2011) The hippocampus: hub of brain network communication for memory. Trends Cogn Sci. 15(7):310-8. (Review)

Benchenane K#, Tiesinga PH, Battaglia FP (2011) Oscillations in the prefrontal cortex: a gateway to memory and attention. Curr Op Neurobiol. 21(3):475-85. (Review)

Benchenane K#, Peyrache A, Khamassi M, Tierney PL, Gioanni Y, Battaglia FP, Wiener SI (2010) Coherent theta oscillations and reorganization of spike timing in the hippocampal-prefrontal network upon learning. Neuron. 66(6):921-36.

Dynamiques corticales et intégration multisensorielle

Domaine de recherche principal: 

Neurophysiology / systems neuroscience

Mots clefs: 

Optogenetics
multisensory processing
two photon calcium imaging
theoretical neuroscience
quantitative behavior

Labelisation ENP: 

2014

Centre de recherche / Institut: 

Unité de Neuroscience, Information et Complexité

Code unité de recherche: 

UPR 3293



Leader

Leader: 

Personnel

Etudiants ENP: 

Établissements

Établissement de rattachement: 

CNRS

Établissements affiliés: 

Université Paris Sud

Université: 

Université Pierre et Marie Curie

École doctorale: 

ED158
Laboratory

Nom: 

Unité Neuroscience Information Complexité (UNIC)

Initiatives d'Excellence: 

Idex NeuroSaclay
Publications

publications: 

Thomas Deneux, Alexandre Kempf, Aurélie Daret, Emmanuel Ponsot and Brice Bathellier, Temporal asymmetries in auditory coding and perception reflect multi-layered nonlinearities, Nature Communications 7: 12682, (2016)

Yves Frégnac and Brice Bathellier, Cortical Correlates of Low-Level Perception: From Neural Circuits to Percepts, Neuron 88(1): 110-126, (2015)

Bathellier B,  Tee SP, Hrovat C, Rumpel S, A multiplicative reinforcement learning model capturing learning dynamics and inter-individual variability in mice. Proc. Natl. Acad. Sci. USA, 2013, 110(49):19950-5.

Bathellier B, Ushakova L, and Rumpel S, Spontaneous association of sounds by discrete neuronal activity patterns in the neocortex. Neuron, 2012, 76(2):435-49