Monsieur
Cyrille VAILLEND
Chargé de recherche
Chercheur
ED419 BioSigne Université Paris-Sud

Neurobiology of intellectual disability

09-04-2015
08-11-2017
05-10-2017
Available to host a PhD student

Team

Serge LAROCHE
Le thème central des recherches de l’équipe concerne les mécanismes cellulaires et moléculaires de l’apprentissage et de la mémoire et l’identification des mécanismes responsables de pathologies...

Biographie / Publications

CR1 CNRS, HDR

EDUCATION

Cyrille Vaillend obtained a PhD in Behavioral Neuroscience with ADRERUS PhD award at the Strasbourg University in 1998. He was then enrolled in a postdoc program focused on the neurophysiological mechanisms of epilepsy at University of Maryland at Baltimore (School of Medicine) and in a second postdoc in the team of Serge Laroche in Orsay, during which he developed a program of research focused on the neurobiology of mental retardation. He obtained a permanent position at CNRS in 2004 and is currently Research Associate (CR1, CNRS, HDR), co-leader with Serge Laroche of the team « Cellular and molecular mechanisms of plasticity and memory » in the Neuroscience Paris-Saclay Institute (Neuro-PSI) and delegate President of the Ethical Committee Paris-Centre Sud.

RESEARCH & PROFESSIONAL EXPERIENCE

Cyrille Vaillend has long been involved in the investigation of the cellular and molecular mechanisms underlying altered synaptic and structural plasticity in mouse genetic models of mental retardation (intellectual disability or ID). He has a pioneer history in the study of the role of dystrophins, the proteins responsible for Duchenne muscular dystrophy, in cognitive function and neurophysiology, with original evaluations of new gene-therapy and pharmacological rescue strategies. His research programs extend to the study of several other proteins involved in mental retardation, such as the Pak3 (non syndromic ID) and rsk2 (Coffin-Lowry syndrome) kinases, of other forms of brain plasticity such as adult neurogenesis and of modulatory mechanisms involving non-neuronal factors (e.g., glial or vascular factors). C. Vaillend has a long-standing expertise and main know-how in mouse behavioral studies, and he developed a variety of methodological approaches to achieve multidisciplinary studies from the molecular to the behavioral levels. His current reasearch is supported by grants from the AFM-Telethon (Association Fra,çaise contre les Myopathies), the ANR (Agence Nationale de la Recherche), the FRC (Fondation pour la Recherche sur le Cerveau) and the Jerome Lejeune Foundation. He teaches the neurobiology of learning and memory in the module “From gene to normal and pathological behavior” of the Master 2 at University Paris-Sud (Cell Signaling and Neuroscience) and Agrégation SV-STU Ecole Normale Supérieure. He supervised 4 postdocs and 2 PhD students, as well as several students enrolled in Master and Bachelor programs.

PUBLICATIONS

Goyenvalle A, Griffith G, Babbs A, EL Andaloussi S, Ezzat K, Avril A, Dugovic B, Chaussenot R, Ferry A, Voit T, Amthor H, Bühr C, Schürch S, Wood MJA, Davies KE, Vaillend C, Leumann C, Garcia L. Functional correction in muscular dystrophic mice using spliceswitching tricyclo-DNA oligomers. Nature Medicine. 21(3):270-5, 2015.

Morice E, Farley S, Poirier R, Dallerac G, Chagneau C, Pannetier S, Hanauer A, Davis S, Vaillend C, Laroche S. Defective synaptic transmission and structure in the dentate gyrus and selective fear memory impairment in the Rsk2 mutant mouse model of Coffin-Lowry syndrome. Neurobiology of Disease. 58C:156-168, 2013.

 Perronnet C, Chagneau C, Samson-Desvignes N, Leblanc-Veyrac P, Mornet D, Laroche S, De La Porte S, Vaillend C. Upregulation of brain utrophin does not overcome behavioral alterations in dystrophin-deficient mice. Human Molecular Genetics, 21(10):2263-76, 2012. 

Daoud F, Candelario-Martínez A, Billard J-M, Avital A, Khelfaoui M, Rozenvald Y, Guegan M, Mornet D, Jaillard D, Nudel U, Chelly J, Martínez-Rojas D, Laroche S, Yaffe D, Vaillend C. The role of the dystrophin-gene product Dp71 in excitatory synapse organization, glutamatergic transmission, synaptic plasticity, and selective behavioral functions. PLoS ONE, 4(8) :e6574, 2009.

Miranda R, Sébrié C, Degrouard J, Gillet B, Jaillard D,  Laroche S, & Vaillend C. Reorganization of inhibitory synapses and increased PSD length of perforated-excitatory synapses in hippocampal area CA1 of dystrophin-deficient mdx mice. Cerebral Cortex 19(4):876-88, 2009.

Vaillend C, Poirier R, & Laroche S. Genes, Plasticity and Mental Retardation. Behavioural Brain Research 192(1):88-105, 2008.