UMRS 1127 UMR 7225

Développement du cerveau

Domaine de recherche principal: 

Neurogenetics / neurodevelopment

Mots clefs: 

Brain Development, Neuronal networks, Genetic regulation, Drosophila, Mouse

Labelisation ENP: 

2017

Centre de recherche / Institut: 

Institut du Cerveau et de la Moelle épinière

Code unité de recherche: 

UMRS 1127 UMR 7225

Notre laboratoire s’intéresse au développement du cerveau et à sa capacité à se protéger des désordres mentaux, telles que la déficience intellectuelle et la neuro-dégénérescence. Bien que les medias, mais aussi la littérature scientifique, mettent l’accent sur la maladie du cerveau, il est bon de rappeler que la vaste majorité des gens – et d’animaux – sont en bonne santé et ne souffrent pas de désordres mentaux. En réalité, la robustesse du cerveau est telle que même des individus ayant subi des mutations qui pourraient conduire à un désordre mental ne développent aucun symptôme.

Leader

Leader: 

Établissements

Établissement de rattachement: 

Inserm

Établissements affiliés: 

CNRS
Université Pierre et Marie Curie

École doctorale: 

ED 3C - 158
Laboratory

Initiatives d'Excellence: 

Allen Distinguished Investigator Award 2016
Publications

publications: 

Weinberger, S., M. Topping, J. Yan, A. Claeys, N. De Geest, D. Ozbay, T. Hassan, X. He, J. T. Albert, B. A. Hassan^ and A. Ramaekers^. 2017. “Evolutionary changes in transcription factor coding sequence quantitatively alter sensory organ development and function”. eLife pii: e26402.

Oliva C*, A. Soldano*, N. Mora, N. De Geest, A. Claeys, M-L Erfurth, J. Sierralta,, A. Ramaekers, D. Dascenco, R. Ejsmont, D. Schmucker, N. Sanchez-Soriano and B.A. Hassan. 2016. “Organization of Drosophila brain wiring by the mushroom body via a Slit-Robo-RPTP signaling complex”. Developmental Cell. 39:267-278.

Yuan L.*, S. Hu*, Z. Okray, X. Ren, N. De Geest, A. Claeys, J. Yan, E. Bellefroid, B.A. Hassan^ and X.J. Quan^. 2016. The Drosophila neurogenin Tap functionally interacts with the Wnt-PCP pathway to regulate neuronal extension and guidance. Development. 143:2760-6.

Quan, X-J, L. Yuan, L. Tiberi, A. Claeys, N. De Geest, J. Yan, W. R. Xie, T. J. Klisch, R. van der Kant, J. Shymkowitz, Frederic Rousseau, M. Bollen, M. Beullens, H. Y. Zoghbi, P. Vanderhaeghen, B. A. Hassan. 2016. “Post-translational control of the temporal dynamics of transcription factor activity regulates neurogenesis”. Cell 164:460-75.

Hassan, B. A. and P. Robin Hiesinger. 2015. "Beyond Molecular Codes: Simple Rules to Wire Complex Brains". Cell 163:285-91.

 

FRONTlab: the frontal systems, functions and dysfunctions

Domaine de recherche principal: 

Cognitive neurosciences / neuropsychology /neuroeconomy

Mots clefs: 

cognition
behavior
executive functions
neuroimaging
Prefrontal cortex

Labelisation ENP: 

2016

Centre de recherche / Institut: 

Institut du Cerveau et de la Moelle épinière

Code unité de recherche: 

UMRS 1127 UMR 7225

The prefrontal cortex (PFC) is a major challenge in Neurosciences. This brain region controls behavior adaptation and highercognitive functions that are needed for complex social interaction, abstract thinking, reasoning, planning or creativity.

Leader

Leader: 

Personnel

Membres de l'équipe: 

Bruno DUBOIS Chef d'équipe
Antoni VALERO-CABRE
Benedicte BATRANCOURT
Emmanuelle VOLLE
Harald HAMPEL
Raffaella Lara MIGLIACCIO
Marc TEICHMAN
Michel THIEBAUT DE SCHOTTEN
Établissements

Établissement de rattachement: 

Inserm

Établissements affiliés: 

CNRS
UPMC
Publications

publications: 

Azuar C, Reyes P, Slachevsky A, Volle E, Kinkingnehun S, Kouneiher F, Bravo E, Dubois B, Koechlin E, Levy R. Testing the model of caudo-rostral organization of cognitive control in the human with frontal lesions. Neuroimage. 2014 Jan 1;84:1053-60. doi: 10.1016/j.neuroimage.2013.09.031.

Aichelburg C, Urbanski M, Thiebaut de Schotten M, Humbert F, Levy R, Volle E. Morphometry of Left Frontal and Temporal Poles Predicts Analogical Reasoning Abilities. Cereb Cortex. 2014 Oct 19. pii: bhu254. 

Lagarde J, Valabrègue R, Corvol JC, Garcin B, Volle E, Le Ber I, Vidailhet M, Dubois B, Levy R. Why do patients with neurodegenerative frontal syndrome fail to answer: ‘In what way are an orange and a banana alike?’. Brain. 2015 Feb;138(Pt 2):456-71. doi: 10.1093/brain/awu359. 

Gil Gonen-Yaacovi Leonardo Cruz de Souza Richard Levy Marika Urbanski Goulven Josse Emmanuelle Volle. Rostral and caudal prefrontal contribution to creativity: A meta-analysis of functional imaging data. Front. Hum. Neurosci. Published on 14 Aug 2013, doi:10.3389/fnhum.2013.00465. 

Thiebaut de Schotten M., Dell’Acqua F., Forkel S.J., Simmons A., Vergani F., Murphy D.G.M., Catani M. (2011) A lateralized brain network for visuospatial attentionNat Neurosci 14:1245-1246.(IF 14.191).

Causes de la SLA et mécanismes de la dégénérescence motoneuronale

Domaine de recherche principal: 

Neurological and psychiatric diseases

Mots clefs: 

Amyotrophic Lateral Sclerosis (ALS)
genetics
motor neurons degeneration
neuroimmunology
iPSc

Labelisation ENP: 

2016

Centre de recherche / Institut: 

Institut du Cerveau et de la Moelle épinière

Code unité de recherche: 

UMRS 1127 UMR 7225

Amyotrophic Lateral Sclerosis (ALS) is the most common adult-onset motor neuron disease. Although mostly sporadic, major geneticcauses are nucleotide expansions in C9ORF72 and mutations in SOD1, TARDBP and FUS. We have shown that motor neuron deathis non-cell autonomous and that reducing mutant SOD1 in CNS microglia/peripheral macrophages slows disease progression. This suggests that in ALS, mutant gene expression in microglia/macrophages as well as the natural activation response of these cellsbecome deleterious.

Leader

Leader: 

Établissements

École doctorale: 

ED 158 3C
Laboratory

Initiatives d'Excellence: 

IHU-A-ICM, Labex revive
Publications

publications: 

Phenotype difference between ALS patients with expanded repeats in C9ORF72 and patients with mutations in other ALS-related genes. Millecamps S, Boillée S, Le Ber I, Seilhean D, Teyssou E, Giraudeau M, Moigneu C, Vandenberghe N, Danel-Brunaud V, Corcia P, Pradat PF, Le Forestier N, Lacomblez L, Bruneteau G, Camu W, Brice A, Cazeneuve C, Leguern E, Meininger V, Salachas F. J Med Genet. 2012 Apr;49(4):258-63.

Novel UBQLN2 mutations linked to amyotrophic lateral sclerosis and atypical hereditary spastic paraplegia phenotype through defective HSP70-mediated proteolysis. Teyssou E, Chartier L, Amador MD, Lam R, Lautrette G, Nicol M, Machat S, Da Barroca S, Moigneu C, Mairey M, Larmonier T, Saker S, Dussert C, Forlani S, Fontaine B, Seilhean D, Bohl D, Boillée S, Meininger V, Couratier P, Salachas F, Stevanin G, Millecamps S. Neurobiol Aging. 2017 Oct;58:239.e11-239.e20

System xC- is a mediator of microglial function and its deletion slows symptoms in amyotrophic lateral sclerosis mice. Mesci P, Zaïdi S, Lobsiger CS, Millecamps S, Escartin C, Seilhean D, Sato H, Mallat M, Boillée S. Brain. 2015 Jan;138(Pt 1):53-68.

C1q induction and global complement pathway activation do not contribute to ALS toxicity in mutant SOD1 mice. Lobsiger CS, Boillée S, Pozniak C, Khan AM, McAlonis-Downes M, Lewcock JW, Cleveland DW. Proc Natl Acad Sci U S A. 2013 Nov 12;110(46):E4385-92.

The NADPH oxidase Nox2 regulates VEGFR1/CSF-1R-mediated microglial chemotaxis and promotes early postnatal infiltration of phagocytes in the subventricular zone of the mouse cerebral cortex. Lelli A, Gervais A, Colin C, Chéret C, Ruiz de Almodovar C, Carmeliet P, Krause KH, Boillée S, Mallat M. Glia. 2013 Sep;61(9):1542-55.

 

PICNIC Lab Physiological Investigations of Clinically Normal & Impaired Cognition

Domaine de recherche principal: 

Cognitive neurosciences / neuropsychology /neuroeconomy

Labelisation ENP: 

2014

Centre de recherche / Institut: 

Institut du Cerveau et de la Moelle épinière

Code unité de recherche: 

UMRS 1127 UMR 7225

The PICNIC lab is devoted to the study of cognitive functions with an exclusive or prevalent development in humans, namely language and conscious cognition. The study of brain-damaged patients occupies a central position in our methodological approach. For the study of both language and consciousness, and with both patients and healthy subjects, we resort to state-of-the-art behavioural methods and multimodal brain imaging (MRI, high-density surface EEG and intracerebral implanted electrodes).

Leader

Leader: 

Co leader: 

Personnel

Etudiants ENP: 

Membres de l'équipe: 

Paolo BARTOLOMEO
Établissements

Établissement de rattachement: 

Inserm

Établissements affiliés: 

Université Pierre et Marie Curie
CNRS
Université Paris 6

Université: 

Université Pierre et Marie Curie

École doctorale: 

ED158
Laboratory

Initiatives d'Excellence: 

Contrat ANR, ICM Big Brain Theory Program, Idex Sorbonne université
Publications

publications: 

 

Mongelli, V., Dehaene, S., Vinckier, F., Peretz, I., Bartolomeo, P., & Cohen, L. (2016). Music and words in the visual cortex: The impact of musical expertise. Cortex. doi: 10.1016/j.cortex.2016.05.016

Lunven, M., Thiebaut de Schotten, M., Bourlon, C., Duret, C., Migliaccio, R., Rode, G., & Bartolomeo, P. (2015). White matter lesional predictors of chronic visual neglect: a longitudinal study. Brain, 138, 746-760.

Sitt*, J., King*, J. R., El Karoui, I., Rohaut, B., Faugeras, F., Gramfort, A., Cohen, L., Sigman, M., Dehaene, S., & Naccache, L. (2014). Large scale screening of neural signatures of consciousness in patients in a vegetative or minimally conscious state. Brain, 137, 2258-2270.

Bouhali, F., Thiebaut de Schotten, M., Pinel, P., Poupon, C., Mangin, J. F., Dehaene, S., & Cohen, L. (2014). Anatomical Connections of the Visual Word Form Area. Journal of Neuroscience, 34(46), 15402-15414.  

King*, J. R., Sitt*, J., Faugeras, F., Rohaut, B., El Karoui, I., Cohen, L., Naccache, L., & Dehaene, S. (2013). Information Sharing in the Brain Indexes Consciousness in Noncommunicative Patients. Current Biology, 23(19), 1914-1919.

Social and Affective Neuroscience Team (SAN)

Domaine de recherche principal: 

Cognitive neurosciences / neuropsychology /neuroeconomy

Mots clefs: 

Affective processes
social processes
neuroimaging
Depressive disorders
Self Processing
Emotional Vision
Social contact

Labelisation ENP: 

2014

Centre de recherche / Institut: 

Institut du Cerveau et de la Moelle épinière

Code unité de recherche: 

UMRS 1127 UMR 7225

The SAN team gathers together three PIs with complementary expertise in affective neuroscience, social neuroscience, and psychiatry. Our project focuses on the functional neuroanatomy of the emotional brain. We study the brain systems of emotion detection, evaluation, and regulation, with an emphasis on how social processes (eg social inclusion) activate and regulate the emotional brain. Dysfunction of the emotional brain is central to many mental disorders and in particular to major depressive disorder (MDD).

Leader

Leader: 

Co leader: 

Personnel

Membres de l'équipe: 

MILLET Bruno
Établissements

Établissement de rattachement: 

Inserm

Établissements affiliés: 

CNRS
Université Pierre et Marie Curie

Université: 

Université Pierre et Marie Curie

École doctorale: 

ED 158
Laboratory

Initiatives d'Excellence: 

Institute for Translational Neuroscience (IHU-A-ICM), Paris
Publications

publications: 

Mauras, T., Masson, M., Fossati, P*., & Pessiglione, M*. (2016). Incentive Sensitivity as a Behavioral Marker of Clinical Remission From Major Depressive Episode. Journal of Clinical Psychiatry, 77(6), E697-+. * equal contribution

Rotge, J. Y., Poitou, C., Fossati, P., Aron-Wisnewsky, J., & Oppert, J. M. (2017). Decision-making in obesity without eating disorders: a systematic review and meta-analysis of Iowa gambling task performances. Obes Rev.

Resibois, M., Verduyn, P., Delaveau, P., Rotge, J. Y., Kuppens, P., Van Mechelen, I., & Fossati, P. (2017). The neural basis of emotions varies over time: Different regions go with onset- and offset-bound processes underlying emotion intensity. Soc Cogn Affect Neurosci. doi: 10.1093/scan/nsx051. [Epub ahead of print]

Delaveau, P., Arruda Sanchez, T., Steffen, R., Deschet, K., Jabourian, M., Perlbarg, V., Gasparetto, E. L., Dubal, S., Costa, E. S. J., & Fossati, P. (2017). Default mode and task-positive networks connectivity during the N-Back task in remitted depressed patients with or without emotional residual symptoms. Hum Brain Mapp.

Burra, N., Baker, S., & George, N. (2017). Processing of gaze direction within the N170 / M170 time window: A combined EEG / MEG study. Neuropsychologia.

 

Sclérose latérale amyotrophique (SLA): de la génétique au traitement en utilisant le poisson zèbre

Domaine de recherche principal: 

Neurological and psychiatric diseases

Mots clefs: 

zebrafish
Amyotrophic Lateral Sclerosis
motor neuron
multigenic interaction
chemical screening

Labelisation ENP: 

2011

Code unité de recherche: 

UMRS 1127 UMR 7225

Our research team recently appointed at the Brain and Spinal Cord Institute will serve to close the gap between clinical and basic research in neuroscience. We will functionally characterize genetic variants for neurodegenerative diseases and develop models using these mutations. Further, we will use these models to identify and validate compounds with neuroprotective properties. Thus, our research will serve as a ring between clinical and basic research and we hope it will advance both these fields of neuroscience.

Établissements

Établissement de rattachement: 

Université Pierre et Marie Curie

Établissements affiliés: 

Inserm
CNRS

Université: 

Université Pierre et Marie Curie

École doctorale: 

ED158
Publications

publications: 

TARDBP mutations in individuals with sporadic and familial amyotrophic lateral sclerosis, Kabashi E, Valdmanis PN, Dion P, Spiegelman D, McConkey BJ, Vande Velde C, Bouchard JP, Lacomblez L, Pochigaeva K, Salachas F, Pradat PF, Camu W, Meininger V, Dupre N, Rouleau GA. Nat Genet. 2008 May;40(5):572-4. (Citations 318; IF 36.4)

FUS and TARDBP but not SOD1 interact in genetic models of ALS, Kabashi E, Bercier V, Lissouba A, Brustein E, Liao M, RouleauGA, Drapeau P PLoS Genetics 2011 Aug;7(8):e1002214. (IF 9.5)

In the swim of things: recent insights to neurogenetic disorders from zebrafish, Kabashi E, Champagne N, Brustein E, Drapeau P. Trends Genet. 2010 Aug;26:373-81. (Citations 3; IF 11.4

Gain and loss of function of ALS-related mutations of TARDBP (TDP-43) cause motor deficits in vivo, Kabashi E, Lin L, Tradewell M, Dion P, Bourgouin P, Rochefort D, Bel Hadj S, Durham H, Vande Velde C, Rouleau GA, Drapeau P. Hum Mol Genet 2010 Feb 15;19(4):671-83. (Citations 49; IF 8.1)

Oxidized/misfolded superoxide dismutase-1: the cause of all amyotrophic lateral sclerosis?, Kabashi E, Valdmanis PN, Dion P, Rouleau GA. Ann Neurol. 2007 Dec;62:553-9. (Citations 40; IF 10.8)

Spinal Sensory Signalling

Domaine de recherche principal: 

Computational neurosciences / neural theory

Mots clefs: 

behavior
Optogenetics
Locomotion
Circuit-breaking
Spinal cord

Labelisation ENP: 

2010

Centre de recherche / Institut: 

Institut du Cerveau et de la Moelle épinière

Code unité de recherche: 

UMRS 1127 UMR 7225

Les systèmes sensoriels transforment les fluctuations du monde physique en séquences de potentiels d'action qui sont intégrés pour contrôler les sorties motrices. La locomotion repose sur des circuits composés par des interneurones spinaux et capables de générer des oscillations. La physiologie moderne a permis d'établir la connectivité entre certaines cellules sensorielles et interneurones, mais la plupart des études se sont limitées à des préparations paralysées où les entrées locales ne peuvent être actives.

Leader

Leader: 

Personnel

Etudiants ENP: 

Établissements

Établissement de rattachement: 

Inserm

Établissements affiliés: 

CNRS
Université Pierre et Marie Curie

Université: 

Université Pierre et Marie Curie

École doctorale: 

ED158
Laboratory

Initiatives d'Excellence: 

IHU-A-ICM, ERC Grant 2013-18
Publications

publications: 

Knafo S#, Wyart C@ [2017]. Bioluminescence Monitoring of Neuronal Activity in Freely Moving Zebrafish Larvae. eLife, in press.

Knafo S#,%, Fidelin K#,%, Prendergast A+, Tseng PE, Parrin A, Dickey CW, Bohm UL#, Nunes Figueiredo S, Thouvenin O, Pascal-Moussellard H, Wyart C@ [2017]. Mechanosensory neurons control the timing of spinal microcircuit selection during locomotion. eLife 6:e25260 DOI: 10.7554/eLife.25260

 

Djenoune L#, Desban L#, Gomez J, Sternberg JR#, Prendergast A+, Langui D, Quan FB#, Marnas H#, Auer TO, Rio JP, Del Bene F, Bardet PL@, Wyart C@ [2017]. The dual developmental origin of spinal cerebrospinal fluid-contacting neurons gives rise to distinct functional subtypes, Scientific Reports 7:719.

Hubbard J+, Böhm U#, Prendergast A+, Tseng PE, Stokes C+, Newman M, Wyart C@ [2016]. GABAergic sensory neurons project onto key elements of the escape circuit, Current Biology 26: 2841-2853.

Sternberg J#,%, Severi K+,%, Fidelin K, Gomez J, Ihara H, Alcheikh Y, Hubbard J, Kawakami K, Suster M, Wyart C@[2016]. Optimization of Botulinum toxin to probe the role of specific interneurons in innate locomotion. Current Biology, 26: 2319-28.

CONTRÔLE MOTEUR NORMAL ET ANORMAL: DÉSORDRES MOTEURS ET THÉRAPEUTIQUES EXPÉRIMENTALES: MOV’IT

Domaine de recherche principal: 

Neurophysiology / systems neuroscience

Mots clefs: 

Parkinson
syndrome Gilles de la Tourette
dystonie
thérapeutique
ganglions de la base

Labelisation ENP: 

2007

Centre de recherche / Institut: 

Institut du Cerveau et de la Moelle épinière

Code unité de recherche: 

UMRS 1127 UMR 7225

Our main research topic is the physiological analysis of both subcortical and cortical brain structures involved in the control of normal and abnormal movements. Dystonia, Gilles de la Tourette syndrome (GTS) and Parkinson’s disease (PD) will be taken as models of basal ganglia dysfunction. The implication of basal ganglia in movement disorders will be analysed by a multimodal approaches in relation with basic science groups and access to platforms (CENIR-imaging; neurophysiology laboratory, functional neurosurgery team and sleep lab).

Leader

Leader: 

Co leader: 

Personnel

Membres de l'équipe: 

MEUNIER Sabine
POUGET Pierre
ROZE Emmanuel
HARTMANN Andreas
RIVAUD-PECHOUX Sophie
WATTIEZ Nicolas
GAYMARD Bertrand
Établissements

Établissement de rattachement: 

Inserm

Établissements affiliés: 

CNRS
Université Pierre et Marie Curie

Université: 

Université Pierre et Marie Curie

École doctorale: 

ED158
Laboratory

Initiatives d'Excellence: 

IHU A-ICM, Institut Carnot ICM Hôpital Pitié Salpêtrière
Publications

publications: 

Welter ML, Grabli D, Karachi C, Jodoin N, Fernandez-Vidal S, Brun Y, Navarro S, Rogers A, Cornu P, Pidoux B, Yelnik J, Roze E, Bardinet E, Vidailhet M. Pallidal activity in myoclonus dystonia correlates with motor signs. Mov Disord. 2015 Apr 16. doi: 10.1002/mds.26244. 

Nalls MA, et al. Large-scale meta-analysis of genome-wide association data identifies six new risk loci for Parkinson's disease. Nat Genet. 2014 Sep;46(9):989-93. doi: 10.1038/ng.3043. Epub 2014 Jul 27.

García-Lorenzo D, Longo-Dos Santos C, Ewenczyk C, Leu-Semenescu S, Gallea C, Quattrocchi G, Pita Lobo P, Poupon C, Benali H, Arnulf I, Vidailhet M, Lehericy S. (2013) The coeruleus/subcoeruleus complex in rapid eye movement sleep behaviour disorders inParkinson's disease. Brain. 136:2120-9

Nelson M, Bosch C, Venance L, Pouget P. (2013) Microscale inhomogeneity of brain tissue distorts electrical signal propagation. J.Neuroscience 33:2821-7. (IF=7.12)

Corvol JC, Bonnet C, Charbonnier-Beaupel F, Bonnet AM , Roze E, Melyksekian G, Ben Djebara M, Hartmann A, Lacomblez L, Vrignaud C, Zahr N, Agid Y, Costentin J, Hulot JB, Vidailhet M. The non synonymous Val258Met polymorphism in COMT gene impacts entacapone response to L-DOPA in Parkinson’s disease: a randomized cross-over clinical trial. Ann Neurol. 2011;;69:111-8. (IF=10.74)

Lehéricy S, Hartmann A, Lannuzel A, Galanaud D, Delmaire C, Bienaimée MJ, Jodoin N, Roze E, Gaymard B, Vidailhet M. Magnetic resonance imaging lesion pattern in Guadeloupean parkinsonism is distinct from progressive supranuclear palsy Source: Brain. 2010 Mar;133: 2410-2425    (IF=9.5)

 Vidailhet M, Yelnik J, Lagrange C, Fraix V, Grabli D, Thobois S, Burbaud P, Welter ML, Xie-Brustolin J, Braga MC, Ardouin C, Czernecki V, Klinger H, Chabardes S, Seigneuret E, Mertens P, Cuny E, Navarro S, Cornu P, Benabid AL, Lebas JF, Dormont D, Hermier M, Dujardin K, Blond S, Krystkowiak P, Destée A, Bardinet E, Agid Y, Krack P, Broussolle E, Pollak P; for the French SPIDY-2 Study Group Bilateral pallidal deep brain stimulation for the treatment of patients with dystonia-choreoathetosis cerebral palsy: a prospective pilot study Lancet Neurol 8 (8): 709-17, 2009. (IF=18.12)

Motivation, Cerveau & Comportement

Domaine de recherche principal: 

Cognitive neurosciences / neuropsychology /neuroeconomy

Mots clefs: 

decision-making
computational modeling
Neuropsychology
neuroimaging
elecrophysiology

Labelisation ENP: 

2007

Centre de recherche / Institut: 

Institut du Cerveau et de la Moelle épinière

Code unité de recherche: 

UMRS 1127 UMR 7225

Why do we do what we do? We are largely unaware of our own motives. Our team seeks to understand how motivation works, in both the normal and pathological brain. We define motivation as a set of processes that assign values to potential situations so as to drive behavior.

Our research is closely related to the emerging field of neuroeconomics, which is focused on understanding value-based decision-making and on explaining deviations to rationality. We wish to build a comprehensive account of motivational processes, investigating

Leader

Leader: 

Co leader: 

Personnel

Etudiants ENP: 

Établissements

Établissement de rattachement: 

Inserm

Établissements affiliés: 

CNRS
Université Pierre et Marie Curie

Université: 

Université Pierre et Marie Curie

École doctorale: 

ED158
Laboratory

Initiatives d'Excellence: 

Labex BioPsy
Publications

publications: 

Blain B, Hollard G, Pessiglione M. Incentive Sensitivity as a Behavioral Marker of Clinical Remission From Major Depressive Episode. J Clin Psychiatry. 2016 Jun;77(6):e697-703. doi: 10.4088/JCP.15m09995.

Automatic integration of confidence in the brain valuation signal. Lebreton M, Abitbol R, Daunizeau J, Pessiglione M. Nat Neurosci. 2015 Aug;18(8):1159-67. 

Skvortsova V, Palminteri S, Pessiglione M. Learning to minimize efforts versus maximizing rewards: computational principles and neural correlates. J Neurosci. 2014 Nov 19;34(47):15621-30. doi: 10.1523/JNEUROSCI.1350-14.2014.

Lebreton M, Bertoux M, Boutet C, Lehericy S, Dubois B, Fossati P, Pessiglione M. A critical role for the hippocampus in the valuation of imagined outcomes. PLoS Biol. 2013 Oct;11(10):e1001684. doi: 10.1371/journal.pbio.1001684. Epub 2013 Oct 22.

Similar improvement of reward and punishment learning by serotonin reuptake inhibitors in obsessive-compulsive disorder. Palminteri S, Clair AH, Mallet L, Pessiglione M.  Biological Psychiatry (2012).

Neural mechanisms underlying motivation of mental versus physical effort. 
Schmidt L, Lebreton M, Cléry-Melin ML, Daunizeau J, Pessiglione M
PLoS Biol. 2012 Feb;10(2):e1001266.

Complementary neural correlates of motivation in dopaminergic and noradrenergic neurons of monkeys, S. Bouret, S. Ravel, et B. J. Richmond, Frontiers in Behavioral Neuroscience, vol. 6, 201

Intersection of reward and memory in monkey rhinal cortex. Clark AM, Bouret S, Young AM, Richmond BJ.J Neurosci. 2012 May 16;32(20):6869-77

Bases moléculaires, physiopathologie et traitement des maladies neurodégénératives

Domaine de recherche principal: 

Neurological and psychiatric diseases

Mots clefs: 

bases moléculaires
Physiopathologie
Parkinson
Alzheimer
Démences fronto-temporales
Ataxies cérébelleuses
Paraplégies spastiques et dystonies

Labelisation ENP: 

2007

Centre de recherche / Institut: 

Institut du Cerveau et de la Moelle épinière

Code unité de recherche: 

UMRS 1127 UMR 7225

Notre recherche est centrée sur l’étude des bases moléculaires et de la physiopathologie de différentes affections neurodégénératives. Les approches génétiques visent à cartographier des gènes responsables ou des facteurs de susceptibilité génétique de ces maladies (maladies de Parkinson et d’Alzheimer, démences fronto-temporales, ataxies cérébelleuses, paraplégies spastiques et dystonies).

Leader

Leader: 

Co leader: 

Établissements

Établissement de rattachement: 

Inserm

Établissements affiliés: 

CNRS
Université Pierre et Marie Curie

Université: 

Université Pierre et Marie Curie

École doctorale: 

ED158
Publications

publications: 

Depienne, C, et al. Sporadic infantile epileptic encephalopathy caused by mutations in PCDH19 resembles Dravet syndrome but mainly affects females. PLoS Genet, 5:e1000381, 2009.

Mochel, F, et al. Cerebellar ataxia with elevated cerebrospinal free sialic acid (CAFSA). Brain, 132:801-9, 2009.

Benajiba, L, et al. TARDBP mutations in motoneuron disease with frontotemporal lobar degeneration. Ann Neurol, 65:470-3, 2009.

Lesage, S, et al. Parkinson?s disease-related LRRK2 G2019S mutation results for independent mutational events in humans. HMG,19:1998-2004, 2010.

Slabicki, M, et al. A genome-scale DNA repair RNAi screen identifies SPG48 as a novel gene associated with hereditary spastic
paraplegia. PLOS-Biol, 8:e1000408, 2010.

Nalls, MA, et al. Imputation of sequence variants for identification of genetic risks for Parkinson's disease: a meta-analysis of genome-wide association studies. Lancet, 377:641-9, 2011.

Corvol, JC, et al. The COMT Val158Met polymorphism affects the response to entacapone in Parkinson's disease: a randomized crossover clinical trial. Ann Neurol, 69:111-8, 2011.

Depienne, C, et al. RAD51 haploisufficiency causes congenital mirror movements in humans. AJHG, 90:301-7, 2012.

Mochel, F, et al. Adult polyglucosan body disease: natural history and key MRI findings. Ann Neurol, 72:433-41, 2012.

Tesson, C, et al. Alteration of fatty-acid-metabolizing enzymes affects mitochondrial form and function in hereditary spasticparaplegia. AJHG, 91:1051-64, 2012.

Lee, Y-C, Dürr, A, et al. Mutations in KCND3 cause spinocerebellar ataxia type 22. Ann Neurol, 72:859-69, 2012.

Palminteri S, et al. Critical roles for anterior insula and dorsal striatum in punishment-based avoidance learning. Neuron, 76:998-1009,2012.

Martin, E, et al. Loss of function of glucocerebrosidase GBA2 is responsible for motor neuron defects in hereditary spastic paraplegia.AJHG, 92:238-44, 2013.

Chort, A, et al. Interferon-beta induces clearance of mutant ataxin-7 and improves locomotion in SCA7 knock-in mice. Brain,136:1732-45, 2013.

Depienne, C, et al. Brain white matter oedema due to ClC-2 chloride channel defi ciency: an observational analytical study. Lancet Neurol, 12:659-68, 2013.

Boukhris, A, et al. Alteration of ganglioside biosynthesis responsible for complex hereditary spastic paraplegia. AJHG. 93:118-23,2013.

Lesage, S, et al. G51D alpha-synuclein mutation causes a novel parkinsonian-pyramidal syndrome. Ann Neurol, 73(4):459-71,2013.

Bertolin, G, et al. Parkin interacts with the TOM machinery to modulate mitochondrial protein import. Autophagy, 9(11):1-17,2013.

Esteves, T, et al. Loss of association of REEP2 with membranes leads to hereditary spastic paraplegia. AJGH, 94(2):268-77,2014.

van Rheenen W, et al. Genome-wide association analyses identify new risk variants and the genetic architecture of amyotrophic lateral sclerosis. Nat Genet. 2016 Sep;48(9):1043-8. doi: 10.1038/ng.3622. Epub 2016 Jul 25.