UMR7241 - U1050

Rythmes cérébraux et codage neural de la mémoire

Domaine de recherche principal: 

Neurophysiology / systems neuroscience

Mots clefs: 

Neurophysiology
Neuromodulation
neural oscillation
decision
visual handicap

Labelisation ENP: 

2012

Centre de recherche / Institut: 

Collège de France

Code unité de recherche: 

UMR7241 - U1050

Our research targets the neurophysiological basis of spatial navigation and memory, in particular the network processes that integrate internal signals (representations, expectations, emotions) and multisensory information from the environment to store and update memories, and guide behavior. We record large neuronal ensembles and local field potential oscillations in freely moving animals performing learning and memory tasks. We focus on the hippocampal system (affected in epilepsy and Alzheimer's disease), where neurons code for the position and direction of the head in space.

Leader

Leader: 

Personnel

Etudiants ENP: 

Membres de l'équipe: 

Sidney WIENER
Susan SARA
Chantal MILLERET
Établissements

Établissement de rattachement: 

Collège de France

Établissements affiliés: 

CNRS
Inserm

École doctorale: 

ED 158 - 474
Laboratory

Nom: 

Centre Interdisciplinaire Recherche Biologie

Initiatives d'Excellence: 

LabEx Memolife - ANR 2017
Publications

publications: 

Maingret N, Girardeau G, Todorova R, Goutierre M1,2,3,4, Zugaro M. Hippocampo-cortical coupling mediates memory consolidation during sleep. Nat Neurosci. 2016 Jul;19(7):959-64. doi: 10.1038/nn.4304. Epub 2016 May 16.

Catanese J, Viggiano A, Cerasti E, Zugaro MB, Wiener SI. (2014) Retrospectively and prospectively modulated hippocampal place responses are differentially distributed along a common path in a continuous T-maze. J Neurosci. 34(39):13163-9

Cei A, Girardeau G, Drieu C, Kanbi KE, Zugaro M. Reversed theta sequences of hippocampal cell assemblies during backward travel. Nat Neurosci. 2014 May;17(5):719-24.

Girardeau G, Cei A, Zugaro M. Learning-induced plasticity regulates hippocampal sharp wave-ripple drive. J Neurosci. 2014 Apr 9;34(15):5176-83.

Arleo A, Déjean C, Allegraud P, Khamassi M, Zugaro M, Wiener SI (2013) Optic flow stimuli update anterodorsal thalamus head direction neuronal activity in rats. J. Neuroscience 33(42):16790-5.

Catanese J, Cerasti E, Zugaro M, Viggiano A, Wiener S.I. (2012) Dynamics of decision-related activity in prospective hippocampal place cells. Hippocampus 22(9):1901-11 

Neuroglial Interactions in Cerebral Physiopathology

Domaine de recherche principal: 

Neurophysiology / systems neuroscience

Mots clefs: 

Epilepsie
Interactions neurone-glie
transmission synaptique
plasticité synaptique

Labelisation ENP: 

2011

Centre de recherche / Institut: 

Collège de France

Code unité de recherche: 

UMR7241 - U1050

Notre objectif est de déterminer si et comment les astrocytes jouent un rôle actif et direct dans le traitement de l'information. Nous souhaitons comprendre les modalités moléculaires et les conséquences fonctionnelles des interactions neurogliales dans des conditions physiologiques et pathologiques.

Leader

Leader: 

Établissements

Établissement de rattachement: 

Collège de France

Établissements affiliés: 

CNRS
Inserm

Université: 

Université Pierre et Marie Curie

École doctorale: 

ED158
Laboratory

Nom: 

Centre Interdisciplinaire Recherche Biologie

Initiatives d'Excellence: 

Labex Memolife, ERC 2016
Publications

publications: 

Chever, O., Lee, C.-Y., Rouach, N., 2014. Astroglial connexin43 hemichannels tune Basal excitatory synaptic transmission. J. Neurosci. 34, 11228–11232. 

Pannasch, U., Rouach, N., 2013. Emerging role for astroglial networks in information processing: from synapse to behavior. Trends Neurosci. Volume 36, Issue 7, July, 405–417.

Dallérac, G., Rouach, N., 2016. Astrocytes as new targets to improve cognitive functions. Prog. Neurobiol.

Chever, O., Dossi, E., Pannasch, U., Derangeon, M., Rouach, N., 2016. Astroglial networks promote neuronal coordination. Sci Signal 9, ra6.

Pannasch, U., Freche, D., Dallérac, G., Ghézali, G., Escartin, C., Ezan, P., Cohen-Salmon, M., Benchenane, K., Abudara, V., Dufour, A., Lübke, J.H.R., Déglon, N., Knott, G., Holcman, D., Rouach, N., 2014. Connexin 30 sets synaptic strength by controlling astroglial synapse invasion. Nat. Neurosci. 17, 549–558.