UMR 8249

Gènes Circuits Rythmes et Neuropathologies

Domaine de recherche principal: 

Neuropharmacology / cell signaling

Mots clefs: 

dopamine
Neurodegeneration
Parkinson disease
Locomotor aging
Drosophila
oxidative stress

Labelisation ENP: 

2016

Centre de recherche / Institut: 

ESPCI Paris Tech -Ecole Supérieure de Physique et de Chimie Industrielles

Code unité de recherche: 

UMR 8249

Our research program is focused on the role of dopamine in behaviour control and neurodegenerative mechanisms in the fruit fly Drosophila melanogaster. Our approach combines Drosophila genetics, molecular biology, brain imaging and behavioral assays. We recently generated and characterized brain dopamine-deficient mutants and developed new models to study pathogenic mechanisms related to genetic and environmental factors of Parkinson disease.

Leader

Leader: 

Personnel

Membres de l'équipe: 

André Klarsfeld
Baya Chérif-Zahar
Ali Mteyrek
Abdul-Raouf Issa
Alexandra Vaccaro
Mathilde Lecompte
Jun Sun
Établissements

Établissement de rattachement: 

CNRS

Établissements affiliés: 

ESPCI

Université: 

Université Pierre et Marie Curie

École doctorale: 

ED 158 3C
Laboratory

Nom: 

Laboratoire Plasticité du Cerveau

Initiatives d'Excellence: 

Labex MemoLife, Idex PSL
Publications

publications: 

Cassar M., Issa A.-R., Riemensperger T., Petitgas C., Rival T., Coulom H., Iché-Torres M., Han K.-A. & Birman S. (2015) A dopamine receptor contributes to paraquat-induced neurotoxicity in Drosophila. Hum. Mol. Genet. 24(1):197-212

Lavista-Llanos S., Svatoš A., Kai M., Riemensperger T., Birman S., Stensmyr M. C. & Hansson B. S. (2014) Dopamine drives Drosophila sechellia adaptation to its toxic host. eLife Dec 9;3

Riemensperger T., Issa A.-R., Pech U., Coulom H., Nguyen M.-V., Cassar M., Jacquet M., Fiala A. & Birman S. (2013) A single dopamine pathway underlies progressive locomotor deficits in a Drosophila model of Parkinson disease. Cell Rep. 5:952–960

Humphrey D. M., Parsons R. B., Ludlow Z. N., Riemensperger T., Esposito G., Verstreken P., Jacobs H. T., Birman S. & Hirth F. (2012) Alternative oxidase rescues mitochondria-mediated dopaminergic cell loss in Drosophila. Hum. Mol. Genet. 21(12): 2698-2712

Riemensperger T., Isabel G., Coulom H., Neuser K., Seugnet L., Kume K., Iché-Torres M., Cassar M., Strauß R., Préat T., Hirsh J. & Birman S. (2011) Behavioral consequences of dopamine deficiency in the Drosophila central nervous system. Proc. Natl. Acad. Sci. USA 108(2):834-39 



Memory Oscillations and Brain states (MOBs)

Domaine de recherche principal: 

Neurophysiology / systems neuroscience

Labelisation ENP: 

2014

Centre de recherche / Institut: 

ESPCI Paris Tech -Ecole Supérieure de Physique et de Chimie Industrielles

Code unité de recherche: 

UMR 8249

Memory is a dynamical phenomenon, from the moment of encoding to retrieval. As shown in the mammalian brain, after encoding labile memories undergo consolidation, that is, they stabilize over time first in the hippocampus before being transferred to the neocortex for long-term storage (Battaglia et al., 2011, Frankland and Bontempi, 2005). In 1989, Gyorgy Buzsaki proposed the twostage model of memory consolidation, where each sequential phase of memory (encoding and consolidation) is related to different internal brain states (Buzsaki, 1989).

Leader

Leader: 

Personnel

Etudiants ENP: 

Membres de l'équipe: 

Thierry GALLOPIN
Établissements

Établissement de rattachement: 

CNRS

Établissements affiliés: 

ESPCI

École doctorale: 

ED 3C - 158
Laboratory

Nom: 

Laboratoire de Neurobiologie

Initiatives d'Excellence: 

Labex Memolife
Publications

publications: 

Roux L, Benchenane K#, Rothstein J, Bonvento G, Giaume G. (2011) Plasticity of astroglial networks in the olfactory glomeruli.PNAS. 108(45):18442-6.

Martinet LM, Sheynikhovich D, Benchenane K#, Arleo A (2011) Spatial learning and action planning in a prefrontal cortical network model. Plos Comp Biol. 7(5):e1002045.

Battaglia FP, Benchenane K#, Sirota A, Pennartz CM, Wiener SI (2011) The hippocampus: hub of brain network communication for memory. Trends Cogn Sci. 15(7):310-8. (Review)

Benchenane K#, Tiesinga PH, Battaglia FP (2011) Oscillations in the prefrontal cortex: a gateway to memory and attention. Curr Op Neurobiol. 21(3):475-85. (Review)

Benchenane K#, Peyrache A, Khamassi M, Tierney PL, Gioanni Y, Battaglia FP, Wiener SI (2010) Coherent theta oscillations and reorganization of spike timing in the hippocampal-prefrontal network upon learning. Neuron. 66(6):921-36.