Our research program is focused on the role of dopamine in behaviour control and neurodegenerative mechanisms in the fruit fly Drosophila melanogaster. Our approach combines Drosophila genetics, molecular biology, brain imaging and behavioral assays. We recently generated and characterized brain dopamine-deficient mutants and developed new models to study pathogenic mechanisms related to genetic and environmental factors of Parkinson disease.
Memory is a dynamical phenomenon, from the moment of encoding to retrieval. As shown in the mammalian brain, after encoding labile memories undergo consolidation, that is, they stabilize over time first in the hippocampus before being transferred to the neocortex for long-term storage (Battaglia et al., 2011, Frankland and Bontempi, 2005). In 1989, Gyorgy Buzsaki proposed the twostage model of memory consolidation, where each sequential phase of memory (encoding and consolidation) is related to different internal brain states (Buzsaki, 1989).