Research Highlight:Spatial Navigation

ENP team leader Laure Rondi-Reig continues to help us find our way: more advances in understanding how the brain navigates a space. Céline Fouquet and Bénédicte M. Babayan, members of Rondi-Reig’s team, found that the dorsal part of the hippocampus appears to be important to organize the sequence of one's own body movements along a route. The dorsomedial striatum also appears to play a significant role: lesioning this region completely prevented the mice from learning the navigation task!

"Experimental procedures in the starmaze." Figure 1A and 1B from Fouquet et al., PLoS One, 2013. Starmaze, training, and sampling of navigation strategy type used by the mouse in the Probe Trial (Allocentric or Sequential Egocentric)

For details on this fascinating study, see:

Fouquet C, Babayan B M, Watilliaux A, Bontempi B, Tobin C, Rondi-Reig L. Complementary roles of the hippocampus and the dorsomedial striatum during spatial and sequence-based navigation behavior. PLoS One. June 2013. 8(6): 1-11.

Check out the Rondi-Reig team's page.