Research Highlight: White matter lesional predictors of chronic visual neglect: a longitudinal study
Left visual neglect is a frequent and dramatic consequence of right hemisphere lesions. Neglect patients are unaware of the left half of their environment, and have a poor functional outcome. The functional mechanisms and anatomical bases of neglect still remain controversial. In a functional and anatomical follow-up study of patients with unilateral right-hemisphere stroke, thanks to MRI/DTI (Diffusion tensor imaging, a technique capable of tracking white matter fibres), ENP team leader Bartolomeo and colleagues now confirm the role of disconnection between the frontal and the parietal lobes of the brain in the emergence and persistence of left visual neglect. In addition, their findings indicate that disconnection between the posterior parts of the two hemispheres can contribute to persistent unbalanced activity between left and right parietal regions, thus leading to chronic neglect.
White matter lesional predictors of chronic visual neglect: a longitudinal study. Marine Lunven , Michel Thiebaut De Schotten , Clémence Bourlon , Christophe Duret , Raffaella Migliaccio , Gilles Rode , Paolo Bartolomeo. Brain (2015) 138 (3): 746-760 DOI: http://dx.doi.org.gate1.inist.fr/10.1093/brain/awu389