Research Highlight: Huntington's Disease

ENP leader Anne-Catherine Bachoud-Lévi has made several characterizations of Huntington’s disease, a neurodegenerative disorder caused by an inheritable genetic mutation. In a recent publication, Bachoud-Lévi and her team observed that Huntington’s patients are aware of their memory deficits in the early stages of the disease, similar to Parkinson’s patients. This finding counters previous assumptions that Huntington’s patients were not cognizant of their motor and cognitive deficits throughout the entire disease progression. The awareness of memory deficits in these patients does appear to fade with more advanced stages of the disease. Get more details about the finding in the article:

Cleret de Langavant L, Fénelon G, Benisty S, Boissé MF, Jacquemot C, Bachoud-Lévi AC. Awareness of memory deficits in early stage Huntington’s disease. PLoS One. 19 April 2013. 8(4): e61676.

Check out the Bachoud-Lévi team website.

Keywords: Huntington’s, Memory, Cognitive decline

Figure 1a from de Langavant et al., PLoS One, 2013. The figure shows the correlation between objective memory performance and patients' subjective memory ratings in Stage 1 Huntington's Disease patients.