Dr. Patrick is Professor of Pediatrics at the University Paris-Descartes, Chief of Pediatric Neurology Department at the Hospital Saint-Vincent de Paul (Paris) and director of Inserm Research Unit UMR745 at the Faculty of Pharmaceutical and Biological Sciences of Paris Descartes. Dr. Patrick Aubourg is particularly involved, at the national and european levels, in several networks which have the aim to develop new therapeutic approaches in neurodegenerative diseases, in particular in the field of leukodystrophies.

Research director at the CNRS, Etienne Audinat is group leader of the team "Neurone-Glia Interactions" at Paris Descartes University (Inserm U603; CNRS UMR8154). He received an Inserm Avenir Award in 2001 and his current research focuses on the functional properties of the different glial cells of the central nervous system and on their interactions with neurons. He was member of the section "Physiology" of the CNRS national committee between 2004 and 2008 and he is member of the scientific advisory board of the French Foundation for Research on Epilepsy and of the French Society for Neuroscience.

Educational Background and Positions
• August 2011 – present: Senior Group Leader at the Institut du Cerveau et de la Moelle
épinière (ICM, Brain and Spine Institute) – Paris, France.
• December 2005 – July 2011: Group Leader at the European Brain Research Institute
(EBRI) – Roma, Italy.
• May 2003 – December 2005: Life Science Research Associate, Department of
Neurology and Neurological Sciences, Stanford University Medical Center, Stanford,
CA 94305, USA.
• November 1999 – April 2003: Postdoctoral Fellow in Drs David A. Prince and John R.
Huguenard laboratory, at the Department of Neurology and Neurological Sciences,
Stanford University Medical Center, Stanford, CA 94305, USA.
• January 2000: Ph.D. in Experimental Pharmacology and Therapeutics, Dept of
Medical Pharmacology, University of Milano, Italy.
• February 1994: Laurea (Master’s Degree) in Biological Sciences - Faculty of
Mathematical, Physical and Natural Sciences, University of Milano (grade: 110/110).

Awards
• 2011: Honorable Mention: Daniel X. Freedman Award for outstanding basic research
achievement by a Brain & Behavior Research Foundation Young Investigator (USA).
• 2010: Telethon, Italy: Coordinator of a multicenter grant.
• 2008: European Research Council (ERC): Starting Grant.
• 2007: National Alliance for Research on Schizophrenia and Depression – NARSAD
Young Investigator Award
• 2006: Member of the ENI-NET (European Neuroscience Institute Young Investigator
Network)
• 2006: European Commission: Marie Curie International Reintegration Grant (IRG).
• 2005: Giovanni Armenise-Harvard Foundation: Career Development Award.
• 1997: Howard Hughes Medical Institute Scholarship, USA.
• 1997: Neurobiology Course at the Marine Biological Laboratory, Woods Hole, MA,
USA.
• 1995: Ph.D. Program, University of Milano, Italy.

Our team is built at the interface between basic research in cognition and clinical research in brain therapies. We address two questions: 1) the bases of specifically human cognitive functions (language and social cognition), and the role of the striatum in such functions; 2) the relation between brain reconstruction and functional reconstruction (rehabilitation and grafting). Because Huntington's Disease is predominantly characterized by a neural degeneration targeting the striatum, we used it as a model both for striatal lesion and for cell therapy and neuroprotection. We combine large scale studies in cell therapy and basic research in cognition. This specificity enables us for the first time to use intracerebral grafting as a model of plasticity in human beings and to integrate therapeutics in basic research in cognition. In addition, we develop cognitive programs in language and social cognition within the Département d’Etudes Cognitives (ENS) and transfer them to brain pathology.

Education and Titles :
- 1985-91 : Bachelors and Masters education at Ecole Normale Supérieure and University Paris VI, Paris, France
- 1991-94 : Doctoral student, Salpêtrière Hosp. and University Paris VI
- 1994-96 : EMBO Postdoctoral fellow, Dept of Cell and Developmental Biology, Princeton University, NJ, USA
- 1996 : CNRS Research fellow
- 1997-2000 : Post-doctoral fellow, Helmholtz Zentrum München, Institute of Mammalian Genetics, Munich, Germany
- 2000-2006 : Junior group leader, Technical University of Munich and Helmholtz Zentrum München, Institute of Developmental Genetics
- 2006-2009 : Department leader, Helmholtz Zentrum München, Department of Zebrafish Neurogenetics
- since 2009 : CNRS Research Director, Institute of Neurobiology A. Fessard, Gif-sur-Yvette, France  

Current position :
CNRS Research Director, research group leader

Research interests :
Molecular control of neurogenesis, molecular and cellular mechanisms of neural stem cell maintenance and recruitment, genetics of emotional, motivational and cognitive behavior in zebrafish, zebrafish models of aggression, addiction and attention-deficit/hyperactivity disorders.

Awards and Prizes :
2006 : Heinz Maier-Leibnitz Prize for research excellence
2008 : Prize of the Schlumberger Foundation for Education and Research
2010-2013 : Prize of Scientific Excellence of the CNRS

Notre groupe de travail s’intéresse à l’histoire du mouvement international des neurosciences et de ses
composantes antérieures, telles que l’anatomie et la physiologie nerveuses, la neurophysiologie, le
behaviorisme etc. par l’étude des filiations entre écoles de recherche et des problématiques
concernant les interactions entre disciplines à l’échelle internationale. Nous sommes en
particulier responsables de l’animation du groupe d’histoire des neurosciences de la Société des
Neurosciences. Nos recherches ont concerné l’essor de ce domaine en France après la Seconde
Guerre mondiale, en collaboration avec Claude Debru, professeur de philosophie des sciences à l’ENS Ulm.
Un autre axe concerne les convergences disciplinaires à l’œuvre dans la différenciation du concept de neurone
au XXe siècle, notamment par les apports des techniques histochimiques, de la microscopie électronique,
la biophysique, et l’électrophysiologie. Une collaboration internationale est consacrée à l’étude des relations
 franco-russes dans les neurosciences, depuis la fin du XIXe siècle, jusqu’aux années 1960. Enfin, la recherche
 d’archives et leur sauvegarde sont développées grâce au soutien de l’unité mixte de recherche du CNRS,
CAPHES, ainsi que les Archives Nationales.

Head of research at INSERM, Anne Baron is coordinator of “Development, Glial pathology and Repair” research axe (Centre de Recherche de l’Institut du Cerveau et de la Moëlle épinière, Pitié-Salpêtrière Hospital) and group leader of the team “Molecular and cellular approaches of CNS myelin repair”. She studies the myelin repair of de- or dysmyelinating diseases in different animal models (rodent and primate) in order to develop therapeutical strategies  to promote the endogenous or exogenous repair of central myelin for patients suffering from multiple sclerosis, spinal trauma and some leucodystrophia. Awarded with the Charles Ketelear Prize, Belgian Society of Multiple Sclerosis in 1984, Prize of the Institut Electricité-Santé in 1996, she recently received the NRJ Prize from Institut de France. Knight of the Legion of Honour, Anne Baron is also teaching at Paris 6, Paris-Sud 11 and Paris 12 Universities.

With more than 200 publications in scientific reviews, about 90 lectures in Universities and Research Centers in more than 20 countries, and also many plenary lectures on physiology, physiopathology, sensori-motor function and in particular, on oculomotricity, vestibular system, equilibrium control and movement perception, spatial memory. He has been one of the pioneers of Microgravity physiology experiments. Alain Berthoz, author of seven books, is an outright figure of worldwide Neuroscience and cognitive sciences. Since 1993, Professor and holder of the chair of Physiology at the Collège de France, he leads the laboratory of Physiology of Perception and Action (Collège de France/CNRS). Member of the Académie des Sciences, Paris, he has obtained many prizes like the La Caze Prize and the CEA Prize of the Académie des Sciences, the Prize of the Académie de Médecine de Paris, Dax Award for Neuroscience (USA), International Prize of Neurology, Pavie University. Alain Berthoz is moreover member of the American Academy of Arts & Sciences, of the Academia Europae and other international academies (Belgium, Bulgaria). He is Knight of the Legion of Honour, Officier of Ordre National du Mérite and Commandeur de l’ordre du mérite de la République Italienne.

Positions :
1991:     PhD at Cerebrovascular Laboratory (UPR646 CNRS), Paris
1993:         Tenure position as INSERM Research Scientist at Cerebrovascular Laboratory (UPR646 CNRS), Paris, France
2002:         Head of group: Neuron-Glia interactions, Neurodegenerative Laboratory (URA2210 CEA CNRS), Orsay, France
2006:     Tenure Position as INSERM Research Director
2009:     3 months as invited professor at University of New Mexico, USA
2009:         Head of group: Neuron-Glia interactions, Neurodegenerative Laboratory (URA2210 CEA CNRS), MIRCen, Fontenay-aux-Roses, France

Conference and Workshop Service (selected) :
2006  :   Session co-Chair, FENS 2006 "Role of astrocyte networks in brain energy metabolism"
2007  :   Session co-Chair, French Neuroscience Society 2007 "Neuroglial interactions in the barrel field cortex"

Editorial Service :
Associate Editor for Frontiers in Neuroenergetics

Field of expertise :
Neuron-glia interactions – energy metabolism – in vivo rodent models of neurodegenerative diseases

Technical approaches :
In vitro and in vivo gene transfer
In vivo measurement of energy metabolism
Primary cell culture, time-lapse microscopy
Biochemistry, RT-PCR, immunofluorescence
Electrophysiological recordings in slices

Current position:

Since 2008: Director of the unit “Human Genetics and Cognitive Functions” at the Neuroscience Department of the Pasteur Institute. Member of the CNRS Unit “Genes, Synapses and Cognition” (URA 2182) directed by Pierre Marie Lledo.

Referee/editors:

Reviewer for Nature, Science, Cell, Nature Genetics, Am J Hum Genet, Molecular Psychiatry, Hum Mol Genet, Eur J Hum Genet, J Med Genet, Am J Med Genet

Field of expertise:

Genetics, autism, chronobiology, psychiatry, molecular biology

Technical approaches:

Molecular Genetics

Biochemistry

Cellular Neurobiology

Mouse behavior

Award & Prizes

Elected Member of the European Molecular Biology Organisation (EMBO), 2008

Vallery Radot award from the Pasteur Institute and the French Academy of Sciences, 2008

Lacassagne award from the Collège de France, 2007

Jean Bernard award of the victories of medicine 2007

French Academy of Sciences award 2007 (Biological discoveries of 2007)

Awarded ENI (European Neuroscience Institutes) Young Investigator (2005)

Alexis Brice is professor and hospital doctor at the Pitié-Salpêtrière Hospital. Formely head of the service at the Cytogenetic and Genetic Department, he leads the “Neurogenetic” team (U975 INSERM) and the DNA & Cell Bank. Between 1992 and 2006, he was also co-leader of the training of Medical Genetic in PCEM1, DCEM2 at the Pitié-Salpêtrière Hospital and since 2004, in charge of the training unit Articles analysis of the second year of the Master Genetic, Pierre and Marie Curie University. Member of several councils and scientific committees, he was, moreover, member of the Scientific Advisory Panel for neurological diseases, European College of Neuropsychopharmacology (ECNP) and member of the Scientific council of the European Society of Human Genetics.
Awarded in 2005 with the Prize of the Fondation pour la recherche médicale PCL (Parkinson Disease), Académie des Sciences (Institut de France), he is since 2007 corresponding member at the Biology section French National Academy of Medicine. In charge of the call for proposals “Longevity and aging” from the French National Research Agency (ANR) in 2007, Alexis Brice was in charge of the calls for proposals “Neuroscience, Neurology and psychiatry” then “Neurological and psychiatric diseases” from the French National Research Agency from 2005 to 2008. He is today co-director of the thematic Institute “Neuroscience, Cognitive Sciences, Neurology and Psychiatry”.

Education
Habilitation, Université Pierre et Marie Curie (2001)
PhD, Universit´e Pierre et Marie Curie (1993)
Student at Ecole Normale Sup´erieure (1986-1990)

Employment
DR2 CNRS, Laboratory of Neurophysics and Physiology, Université Paris Descartes (since 2005)
Senior research scientist, ISI, Torino (since (2005)
CR1 CNRS, Laboratory of Neurophysics and Physiology (2001-2005)
CR CNRS, Laboratory of Statistical Physics, ENS, Paris (1995-2001)
Visiting scientist, Biology Department, Brandeis University (1998-1999)
Post-doc, Physics Department, Universit`a “La Sapienza”, Rome (1993-1995).

Publications
Author of 67 articles: 46 primary research articles in journals, 6 review articles in journals, 4 book chapters, 8 conference proceedings, 3 other articles.

Invited talks
Invited speaker/lecturer at 59 international conferences/schools/workshops.

Supervision of students and post-docs
Supervised 5 PhD students and 5 post-docs.

Teaching
Teaches since 2004 in both Cognitive Science Master (DEC, ENS) and Neuroscience Master (Biology Department, Ecole Normale Sup´erieure: Neuroscience Master)

Organization of schools/workshops
Co-organizer of the Advanced Course in Computational Neuroscience, in Arcachon (four weeks in August, 2006-2007) then Freiburg (2008-2009). Co-organized a ‘Neurosciences et Computation’ program, IHP, Paris (2002). Co-organized 6 other workshops and schools.

Refereeing
Referee for 8 research organizations (France, Germany, UK, Switzerland, USA, Israel) and 28 journals (Science, Nature, PNAS, main Neuroscience, Computational Neuroscience and Physics journals).

Program committee
Served in the program committee of the two main computational neuroscience conferences: CNS (2003-2006) and Cosyne (2009)

Editorial boards
Currently in the editorial board of 4 journals: Frontiers in Computational Neuroscience; Biological Cybernetics; Network; Journal of Computational Neuroscience

Jocelyne Caboche est directrice de recherches au CNRS. Responsable de l’équipe « Signalisation neuronale et régulations géniques » au sein du Laboratoire de Neurobiologie des processus adaptatif (CNRS – UPMC), elle dirige depuis 2007 l’Institut de biologie intégrative de l’université de Pierre et Marie Curie qui regroupe onze formations de recherche. Les recherches menées par ces laboratoires ont pour objectif l'étude intégrée des mécanismes moléculaires et cellulaires qui président au développement, à la reproduction, aux grandes fonctions physiologiques des organismes animaux et végétaux, et à leur évolution.
Co-Responsable du Groupe de Réflexion Stratégique (GRS) de l’IFR de Biologie Intégrative de l’Université Pierre et Marie Curie de 2005 à 2007, elle a été membre nommée du conseil d’administration de l’UFR des Sciences de la Vie de 2001 à 2005.
Jocelyne CABOCHE est auteur d’un nombre important de publications scientifiques. Elle est aussi impliquée dans l’enseignement, la formation et la diffusion de la culture scientifique.

The objective of the team is to investigate several aspects of glomerular neurophysiology in the rodent, combining electrophysiological recording and two-photon imaging, both in vivo and in vitro. We investigate functional hyperaemia by addressing the differential roles of neurones and astrocytes during odor stimulation. Because we are convinced that blood flow regulation cannot be understood without determining precisely which neuronal networks are mobilised, we also study intrinsic and synaptic properties of glomerular neurones. Finally, we maintain an activity in technological developments, by constructing improved two-photon microscopes and testing new optical probes reporting neuronal activity and oxygen consumption.

Positions Held:

• Chargé de Recherche INSERM, INSERM U106,
• Hôpital de la Salpêtrière, 75005 Paris, France 1997-2001
• Directeur de Recherche INSERM (DR2), group leader, INSERM U106,
• Hôpital de la Salpêtrière, Paris, France 09/2001-12/2002
• Directeur de Recherche INSERM (DR2), group leader, CNRS UMR7102,

• UMPC-Paris6, Paris, France 2003-2006
• Directeur de Recherche INSERM (DR1), group leader, CNRS UMR7102,
• UMPC-Paris6, Paris, France 2007-2008
• Directeur de Recherche INSERM (DR1), coordinator of the Department of Development
• Group leader, Vision Institute, Paris, France 2008

Education:

• Student Ecole Normale Supérieure de Lyon 1988-1993
• Licence in Animal Biology, Lyon 1 University 1988-1989
• M1 in Physiology and Neuroscience (B, rank 1st), Lyon 1 University 1989-1990
• M2 in Neuroscience, UMPC-Paris 6 (TB, rank 1st; adv.. Constantino Sotelo) 1990-1991
• Research fellow, Montreal Neurological Institute (resp. Edith Hamel) 1991-1992
• Ph.D in Neuroscience, UMPC-Paris 6 (adv..Constantino Sotelo) 1992-1995
• Post-doc, UC Berkeley (adv.. Corey S. Goodman) 1995-1997

Other activities:

• Elected Member at the scientific board of the Société Française de Biologie du Développement (1999-2003)
• Elected Member, Development, board of the Société Française des Neurosciences (2005-2009).
• Member of the scientific council of the Federation pour la Recherche sur le Cerveau (FRC) (2007-)
• Editorial Board of Development Growth and Differentiation (2007-) ; Plos One (2008-)

Jamel Chelly obtained his medical degree from the Medical School of Sfax, Tunisia in 1983. Between then and 1991, he acquired certificates in general biochemistry and cytogenetics, bachelor and master's degrees in genetics, and a PhD in human genetics from Paris Descartes University. In 1987 he was appointed as junior scientist by CNRS (Centre National de Recherche Scientifique, France) and reached the level of research director. During his post-doctoral studies in the Institute of Molecular Medicine, Oxford, UK, (1991–1994), he contributed to the identification of several disease-related genes. On his return to France in 1995 he set up the Laboratory of Genetics and Pathophysiology of Mental Retardation at the Cochin Institute. In September 2003, he was appointed as professor at Paris Descartes University and the medical centre of Cochin Hospital. He is also a founding member of the European XLMR Consortium. His achievemnts include the implication of genes such as Doublecortin/DCX, tubulins, OPHN1, IL1RAPL, TM4SF2 in lissencephaly/pachygyria spectrum and mental retardation disorders. Over the last years he received several prestigious awards, including a CNRS Silver Medal. He has numerous publications in many leading journals. His main current research interests are the genetics and pathophysiology of neurodevelopmental disorders.

Directeur de Recherche au CNRS, DR1
Praticien Hospitalier Attaché (Neuro-Oncology Hosp Salpétrière)
Team leader Glial Plasticity U894 Inserm/University Paris Descartes
Elected Head of the Neuroscience dpt Institut de Biologie du Quai St Bernard UPMC (2011- )
Chief Editor Médecine/Sciences

MD : 2002-now: Cerebral tumors and gliomas, Neuro-Oncology (La Salpetrière Pr JY Delattre).
PhD : Glial Plasticity team (Collège de France 1991-2006; CPN 2007-2012, Inst. Quai St Bernard 2012-),
phosphoproteins enriched in astrocytes. We characterized PEA-15, a substrate of PKC and CaMKII, protecting
astrocytes from apoptosis and inhibits entry into the cell cycle. This led us to investigate more properly gliomas. We
demonstrated that long-term exposure to TGFalpha, a growth factor overexpressed in gliomas, dedifferenciate
astrocytes into functional progenitors and makes them permissive to transformation. We characterized tumoral stem
cells in adult and pediatric gliomas and now use these cells to understand their difference with normal human neural
stem cells and to develop new therapeutic strategies against these devastating cancers.
Bioethic. Contribution in the fields of neurosciences, human stem cells, human genetic.

Professional experience and education :
2010 – present : Director of the Laboratoire de Sciences Cognitives et Psycholinguistique in Paris
2008 – present : CNRS senior researcher at the LSCP
2006 :“Habilitation à Diriger des Recherches”, Université Paris VI
"Bootstrapping lexical and syntactic acquisition".
2004-2009 : Deputy director of the LSCP
1995-2008 : CNRS junior researcher at the LSCP
1994-1995 : Post-doc at the Cognitive Development Unit, MRC, in London. Director: Pr John Morton. “Human Capital and Mobility“ programme
1993 : PhD in Cognitive Psychology, EHESS, Paris. Director : Dr Jacques Mehler. “The role of prosody in segmenting speech into words“
1989 : Diploma at Ecole Polytechnique (Paris)

Awards :
1998 : “Bronze Medal” from the CNRS
1993 : Award of the best PhD thesis defended at the EHESS this year

Editorial activities :
Associate Editor
-    Developmental Science, since 2009
-    Language & Speech, 2002-2009
Member of the Editorial Board
-    Language Learning and Development, since 2003
-    Cognition, 2000-2004

Invited expert for : Cerebral Cortex, Cognitive Psychology, Cognition, Development Psychology, Development Science, Early Development and Parenting, Infancy, Journal of Cognitive Neuroscience, Journal of Experimental Psychology : Human Perception and Performance, Journal of Memory and Language, Language and Cognitive Processes.

Pierre-Jean Corringer

Phone : +33-140-613-102 — Fax: +33-145-688-836 — E-mail: pjcorrin@pasteur.fr
Date of Birth : March 7, 1965. French citizen. one child.

Education / Training :
1988 - E.S.C.I.L: Ecole Supérieure de Chimie Industrielle de Lyon.
1992 - Ph.D. molecular pharmacology (Paris V University).
2003 - Habilitation (Paris V University).

Current Positions :
Head of the G5 group "Channel-Receptors" at the Institut Pasteur
Co-director of the Laboratory "Genes, Synapses and Cognition" at the (CNRS)

Research positions held :
1992-1993    -    Post-doctoral fellow (Wellcome trust) at Brighton University (U.K.).
1993-1997    -    Assistant Scientist (tenured position, CR2 at the CNRS) at the Institut Pasteur, Receptor and Cognition unit.
1997-2006    -    Associate Scientist (tenured position, CR1 at the CNRS) at the Institut Pasteur, Receptor and Cognition unit.
2006-2007    -    Senior Scientist at the CNRS (DR2) at the Institut Pasteur. Head of an autonomous research group.
Since 2008    -    Senior Scientist at the CNRS (DR2) at the Institut Pasteur, head of a Research G5 Group.

Honors and Awards :
2001 -            National academy of medicine “lutte contre la tabagie” award
2009 -             Pasteur Vallery-Radot award
Number of publications: 52 — Number of citations: 2440 — h-index: 24

Stanislas Dehaene, normalien, a intégré l’Inserm en 1989 comme chargé de recherche. Directeur de recherche Inserm de 1997 à 2005, il est aujourd’hui titulaire de la chaire de psychologie cognitive expérimentale au Collège de France. Stanislas Dehaene est par ailleurs, depuis 2002, directeur de l’unité de Neuroimagerie Cognitive (Inserm-Cea) au Service Hospitalier Frédéric Joliot à Orsay.

Membre de l’Académie des sciences depuis 2005 il est également conseiller éditorial de plusieurs revues et notamment de la revue PLOS Biology et de la revue Neuroimage, membre du Comité de pilotage du programme Neurosciences de l’ANR et du Conseil de l’International Association For The Study Of Attention And Performance.

1988 MD Thesis in Pediatrics University of Angers awarded by the Mustela Fundation
1988 to 1991: CCA Hopitaux de Paris
1995 PhD Thesis University Paris 6 awarded by the Société de Neuropsychologie de Langue Française
2001 HDR EHESS, Paris

1999 CR1 CNRS
2006 DR2 CNRS

Professor and attending neurologist since 1992, Jean-Yves Delattre, leads the Mazarin neurology service at Pitié-Salpêtrière Hospital since 1998. In charge of the neuroscience training at the Necker-Enfants Malades Medicine Faculty from 1992 to 2000, he is since 1998, group leader of the experimental neuro-oncology team, INSERM. Member of several societies such as Société Française de Neurologie, Association Française des Neuro-Oncologues d’Expression Française, European Neurological Society, European Association of Neuro-Oncology, American Academy of Neurology and the American Association for Cancer Research. Jean-Yves Delattre belongs otherwise to editorial committees of several reviews including Revue Neurologique, Neuro-Oncology, The Oncologist or the Journal of Clinical Oncology. General secretary of Neurology Teachers College from 1993 to 1999, he has been president of the ANOCEF (Association des Neuro-Oncologues d’Expression Française) from 1995 to 2002, Vice-chairman of Brain tumour group, EORTC (European Organization for Research and Treatment of Cancer) from 1996 to 2002 and president EANO (European association of neuro-oncology) from 2000 to 2002. He is author of more than 249 articles identified by PubMed including 186 in English.

Alain Destexhe, research director CNRS and CNRS Silver Medal 2008 is today member of the Integrative and computational neuroscience unit (UNIC) of the CNRS at Gif-sur-Yvette. In 2000, he got an ATIP young researcher startup from CNRS and participated to the creation of this unit of research which associates experimentation and theory.

During his PhD in the laboratory of Ilya Prigogine, Nobel prize of Chemistry 1977, he has described the electroencephalographic activity of human brain with dynamical systems and chaos theory before joining the Salk Institute of San Diego where he has set up during three years an international collaboration between biologists and physicists, which gave rise to a record number of scientific publications.

In the next five years, Alain Destexhe created a computational neuroscience laboratory at the faculty of medicine of Laval University (Québec, Canada) in order to continue his theoretical research in close relation with experiments. He is editor in chief of the "Journal of Computational Neuroscience".

Function: Charge de recherche CNRS (URA 2182)

Laboratory: Unit of Dynamic Neuronal Imaging (Intitut Pasteur)
CNRS researcher who was awarded an ATIP in 2005 and and an ATIP-Plus in 2008. David Di Gregorio is group leader of the laboratory « Dynamic Neuronal Imaging » in the department of Neuroscience at the Pasteur Institute. He has benefited from ANR grants (2008, 2010). He is currently a co-director of the Cold Spring Harbor course: Imaging structure and function in the nervous system. He is also a member of the European Neuroscience Institute and the American society for Neuroscience.

Website reference: http://www.pasteur.fr/ip/easysite/go/03b-000040-007/unites-et-groupes/imagerie-dynamique-du-neurone

Contact: david.digregorio[at]pasteur.fr

Mathematical and engineer training (Ecole Polytechnique, Paris)
Masters of Molecular Biology (Paris VI) and Organic Chemistry (Paris VII)
Medical training and thesis (Lariboisière St Louis)
 Fellowship from the Centre National d’Etudes Spatiales (78-82)
Researcher at the CNRS (82-92)
Habilitiation to supervise research (1992)
Research Director at the CNRS and Head of a research team since 1992
Medical Officer for experiments on human subjects in the LPPA since 1996
Author or co-author of about 90 papers in international journals, including one paper in PNAS on a model of sensori-motor integration and one paper in Nature on the object perception during self-motion

Bruno Dubois is currently Professor of Neurology at the Neurological Institute of the Salpetriere University Hospital in Paris. He is Director of the Cognitive and Behavioural Unit of this hospital and in charge of the National Center for Rare Dementias and for Young Onset Alzheimer’s Disease. He is also Director of the Research Inserm Laboratory “Cognition, Neuroimaging and Brain Diseases” of the Research Center of ICM. He has published on anatomical and biochemical studies on the central cholinergic systems in rodents and humans; on cognitive neuropharmacology; and on neuropsychology in patients with dementia, with special reference to memory and executive functions. He recently organized an Expert Consensus on the new criteria for Alzheimer’s disease and a Task Force on the new criteria for Parkinson’s disease dementia. He is principal or co-investigator of a number of research programmes focusing on AD, MCI and dementia in Parkinson’s disease.

Charles Duyckaerts, university professor and hospital practitioner, head of neuropathology’s laboratory at the Pitié-Salpêtrière. His has been interested for many years in neuropathology of neurodegenerative diseases, particularly Alzheimer's disease. He is co-directing since 2009 a team that focuses on Alzheimer’s and prion diseases at the Salpêtrière, and is responsible for the CRB, GIE Neuro-CEB (Brain Bank).

Professional activities :
- 1995    Directeur de recherche 2                
- 2008    Professeur, McGill University      

         
Research Experience in Neuroscience :
Years    Laboratory    Director

1979-1985    INSERM U114, Paris    J. Glowinski
1985-1990    INSERM U288, Paris    M. Hamon
1992-1992    Duke Univiversity, Durham, USA    MG. Caron
1992-1998    INSERM U288, Paris    M. Hamon
1996    CHUL Laval, Québec    P. Falardeau
1992-1998    INSERM U288, Paris    M. Hamon
1998-2008    INSERM U513, Paris    B. Giros
2008 to date    INSERM U952, CNRS UMR7224, UPMC, Paris    B. Giros
2008 to date    McGill University, Montreal    El Mestikawy

Main Research activity :
- 1978-1985    Regulation of dopamine and serotonin biosynthesis in the rodent brain.
- 1985-1990    Study of the 5HT1A serotonin receptor in the rodent brain.
- 1990-1992     Cloning and characterization of neurotransmitter transporters.
- 1992-1998    Study of the orphan transporter in the rodent and human brain.
- 1998-        Characterization of glutamatergic neurons in the normal and pathological brain.

Financial support :
- 2004-2005     Fédération de la Recherche sur le Cerveau
- 2005         Material Transfert Agreement Johnson&Johnson
- 2007-2009     Agence Nationale pour la Recherche
- 2008-2010     Starting fund Douglas Mental Health Institute
- 2008-2009     Canadian fund for innovation
- 2010-2013     Agence Nationale pour la Recherche
- 2010-2013     CIHR/FRSQ/ANR

Valentina Emiliani: obtained her PhD in Physics at the University ‘La Sapienza’, Rome Italy in 1996 working on the investigation of tunneling effect in asymmetric double quantum wells by ultrafast spectroscopy. From 1997 to 2000 she joined the group of Prof. Thomas Elsaesser at the Max Born Institute of Berlin as a post doc, working on the investigation of carrier transport in single quantum wire by low temperature scanning near field optical microscopy (SNOM). From 2000 to 2002 she was in the laboratory directed by Prof. Marcello Colocci at the European laboratory for nonlinear spectroscopy, Florence Italy. There she worked on the investigation of light propagation in disordered structure by SNOM. From 2002 to 2004 she was at the Institute Jacques Monod, where she was working on the investigating of the role of mechanical forces on the establishment of cell polarity by the use of the optical tweezers technique. In the year 2005 she obtained the price EURYI 2005 and she moved in the Neurophysiology and New Microscopies Laboratory to lead a research team of physicists dedicated to the development of advanced optical technique for neuroscience.

V. E is coauthor of 40 publications in international journals.

Head of research at the CNRS and ATIP awarded in 2008, Philippe Faure is group leader of the team Neurophysiology and behaviour in the laboratory "Neurobiology of adaptative processes”. He is involved in different training courses at Pierre and Marie Curie University, École normale supérieure and at AgroParisTech.

2011: Group leader, CIRB, College de France, Paris
2006-10: Associate Research Scientist, Department of Neuroscience,
        Laboratory of Dr. R. Axel, Columbia University, New York
2001-06: Postdoctoral Fellow, Department of Neuroscience,
        Laboratory of Dr. R. Axel, Columbia University, New York
2001: Postdoctoral Fellow, Laboratory of Dr. E. Wagner, IMP Vienna
12/2000: PhD in Biochemistry and Genetics, University of Vienna
        Laboratory of Dr. E. Wagner, IMP Vienna
3/1997: Diploma in Biochemistry, University of Vienna,
        Laboratory of Dr. E. Wagner, IMP Vienna
1992-97: Studies of Biochemistry at the University of Vienna, Austria
1990-91: Studies of Music at the University of the Pacific, CA, USA

Neurologist, professor and hospital doctor at Pierre and Marie Curie Medecine Faculty, Bertrand Fontaine is group leader of the team « Genetics of multiple sclerosis and muscle excitability disorders » at the Centre de Recherche de l’Institut du Cerveau et de la Moëlle. In charge of the training at the Departement of Neurology, he is also coordinator of the Reference Center for Muscular Channelopathies, two national networks Résocanaux and REFGENSEP and of the center for biological ressources « Genetic of multiple sclerosis ».

Gilles Fortin received his Ph.D. in Neuroscience from the University Pierre et Marie Curie, Paris-6, France. He held a postdoctoral position at the MRC Center for Developmental Neurobiology at Guy’s Hospital in the laboratory of Professor Andrew Lumsden. His work on the chick embryo revealed a striking relationship between early rhombomeric pattern and the ontogeny of basal rhythmogenic circuitry in the brainstem, extending the significance of hindbrain segmentation beyond modular anatomical organization to the level of network assembly and function. He has been working since at the Centre National de la Recherche Scientifique where he is leading the group Hindbrain Integrative Neurobiology at the Institut de Neurobiologie Alfred Fessard in Gif-sur-Yvette. His present work focuses on the biological bases of the breathing behaviour.  His group investigates in the mouse, using developmental genetics tools, electrophysiology and calcium imaging, the ontogeny of distinct vital neural oscillator networks that couple at embryonic stages to establish the respiratory rhythm generator.

 Fiona Francis is group leader of the AVENIR team "Cytosquelette et  pathologie de la migration neuronale" at the /Fer à Moulin/ Institute.  She is member of the /Société Française de Neurosciences/, the Federation  of European Neuroscience societies, the European Society of Human Genetics and the EMBO Fellows Society. She reviews articles for several scientific journals such as Molecular and Cellular Neuroscience, the European Journal of Neuroscience, and the Journal of Neuroscience. Awarded with a grant from the ACI program Biology of development and integrative  physiology in 2002-2004, FRC grants in 2002, 2004 and 2005, and an INSERM Avenir 2008-2011 award, she also has a  grant for 2009-2010 from the French National Research Agency. The Bettencourt-Schueller Foundation awarded her a /"Coup d'élan"/ Prize in 2008.

Thierry Galli, directeur de recherche Inserm, est responsable de l’équipe de recherche labellisée INSERM U950 « Trafic membranaire et morphogenèse neuronale & épithéliale » de l’Institut Jacques Monod (CNRS – Paris VII).

Médaille de la Ville de Paris (échelon Argent), lauréat de la Subvention de la Ville de Paris en Recherche médicale et Santé, en 2006, il est éditeur en chef de Biology of the Cell depuis 2009, et a édité, en 2007, avec Peter Mc Pherson, le N° de Current Opinion in Cell Biology consacré à « Membranes ».

Membre élu de la CSS1 de l’Inserm (2008-2011), il est depuis 2001 membre du Conseil de la Société de Biologie Cellulaire de France, depuis 2006 membre du Comité de Réflexion Stratégique du PRES de l’Université Paris Centre (P1-P5-P7) et depuis 2008 Représentant de l’Université P7 au Conseil de l’école doctorale Frontières du Vivant (ENS-P5-P7).

Il a déposé trois brevets :

T. Galli, S. Martinez-Arca, et D. Louvard. « Control of Membrane Traffic », Demande Brevet Européen en 2000 (Institut Curie – CNRS) ;

JC Mazié, T. Galli. Dépôt de l’anticorps monoclonal Cl158.2 dirigé contre la protéine TI-VAMP(Institut Pasteur) en 2000 également ;

Dépôt de trois lignées de souris génétiquement modifiées (tetOmin-GFP, GFP-TIVAMP, GFP-Longin) au centre d’archivage européen des mutants de souris (EMMA), en 2007.

Present position :
Research Director (DR1) at Inserm - Co-director of the Institut du Fer à Moulin, Research-Neuroscience Center, ENP Director

Education.
. 1971-1979; Medical School Paris VI University, St Antoine,
. 1983 Masters (M2) in Molecular and Cellular Pharmacology (Paris VI),
. 1985 PhD in Molecular Pharmacology, Paris VI University,
Position held
1977-83 : Medical resident, Paris Hospitals (psychiatry, neurology, neuropathology)
1979-80    : Medical resident in the Centre for Neurology of Tunis, Tunisia.
1980-83: Graduate student, Laboratory of B Berger (Hôpital Salpêtrière Paris)
1986-95 : INSERM Research Associate -(Constantino Sotelo laboratory)
1990-1991  : Assistant Professor University of Vanderbilt – USA (Jon Kaas laboratory)
1995-    present: INSERM Research Director (DR)-, group leader,
2003-2006 : Unit Director, INSERM U616, Hôpital Pitié Salpêtirère
2007-present : Board of Directors, Institut du Fer à Moulin, INSERM/UPMC U839
Teaching activities
UPMC-Paris 6: Master M2 BIP – Neurosciences, co-organizer of a 2-week course: « Developmental Neuroscience »
Training students and post-docs (8 phD)
2007-10 :Director of studies of the ENP-PhD progam-

Scientific Boards-Organization of research
1999-03- Board of the Fondation de la Recherche Médicale (Funding Agency)
2000-04- Board on the Scientific Committee of the French Society of Neuroscience
2000-04- Representative of the French Neuroscience Society at the IBRO
2001-05- Board of the Fondation France -Parkinson, Fondation de France (Funding Agency)
2003-07- Member of advisory board at the University Paris 6 (section 69)
2003-09- Board of the INSERM Avenir study programme.
2003-09- Founder and presidency of the “Club Développement des Réseaux Neuronaux”,
2005-09 – Board of “Ecole Doctorale Cerveau Cognition Comportement “ Paris 6
2008-present : INSERM scientific board for Neuroscience (Specialized commisson 1).
2010- Director of Ecole de Neurosciences de Paris (ENP)
 
Editorial boards, reviews
Associate editor fof the European Journal of Neuroscience
Reviewing for :PLOS; J . Neuroscience, Nature signaling, Neuron,
Eur. J. Neuroscience, J. Comparative Neurology, Neuroscience, Neuropsychopharmacology,, J. Neurochemistry, FEBS.
Review  Grants : ANR, INSERM (France), Welcome Trust, Israel Science Foundation, Fond National Suisse, Fond National de Belgique,

Invited Lectures-Awards : Invited speaker in several international symposia.and in major research centers in France, Europe, Japan, America.

Christian Giaume, Directeur de Recherche CNRS, is head of the laboratory INSERM U840 «Junctional communication and interaction between neuronal and glial networks». As an invited speaker he has participed to more than 50 international meetings and has organized several national and international meetings. He is member of the Scientific Committee of Glia (since 2001), Biology of the Cell (2002-2005) and the Journal of Neurochemistry (since 2009). He is also member of the Scientific Comittee of the Fédération de la Recherche sur le Cerveau (2003-2009), of the Commission ANR CSS8 (since 2007) and of the "Peer Review Process" du German Research Council (Deutsche Forschungsgemeinschaft, DFG) Priority Program "The Significance of Neuroglia for the Formation, Function and Plasticity of Synapses" (2004-2009). Finally, he is responsible of a teaching unit on “Neuroglial interactions” at the University Pierre et Marie Curie and teaches in several universities (Orléans, Chatenay-Malabry, ENS Paris, Paris 6).

Anne-Lise Giraud is research director at CNRS, and heads the “Auditory Language Group”, one of the four Inserm U960 teams of the Cognitive Neuroscience Laboratory of the DEC at ENS – Paris. We study the neurophysiological mechanisms of speech perception and production, and their dysfunction in communication disorders, as deafness, autism, dyslexia and stuttering.

Jean-Antoine Girault, MD, PhD, holds an Inserm research director position. He is currently head of the Institut du Fer à Moulin, an Inserm-UPMC center of research, with about ten teams working on the development and plasticity of the nervous system. His research is mainly on the signalling mechanisms involved in the plasticity of the nervous system, in normal and pathological conditions. The fields of application concern drug addiction and Parkinson disease, as well as axoglial interactions in myelinated fibers. The approaches used include molecular and cellular biology, functional neuroanatomy, and behavioural studies, etc. Member of various professional committees and the French and American societies for Neurosciences, Jean-Antoine Girault has actively participated in the creation of the Neuropôle de recherche francilien (NeRF). Very involved in teaching and training of young researchers and doctors, he has been the director of the Paris School of Neuroscience (ENP) between 2007 and 2009.

From 1983, when I enter for the first time in a research laboratory, to 2007 where I am at the head of an INSERM laboratory, and Professor in the department of Psychiatry of McGill University, my interests evolved from biochemical and molecular aspects of the synaptic transmission to more integrated approaches involving behavioral studies and clinical research. However, I always tried to stay connected to human pathologies, either from direct genetic studies that are now performed in my laboratory or by studying neurotransmitter systems that are targeted by psychotropes of clinical or social use.

1983-1987 : Enkephalin metabolism in the brain.

During my thesis work, I completed the first characterization of the Aminopeptidase M (APM) involvement in the endogenous degradation of cerebral enkephalins.. Production of specific anti-catalytic antibodies. Rational design of specific inhibitors for APM and enkephalinase. Molecular cloning of APM.

1988-1991 : Study of dopamine receptors.

After a 4 month stay at Genentech Inc, in San Francisco, I had to setup Molecular Biology in the Jean-Charles Schwartz’s laboratory. Thereafter, together with P. Sokoloff, our research was extremely fertile with the molecular cloning of two isoforms for the dopamine D2 receptor, and specially the molecular cloning and characterization of a novel dopamine receptor, the D3 receptor. The discovery of this novel dopamine receptor with high affinity for antipsychotics, was very provocative at this time, where everybody thought that only two dopamine receptors existed. We were also able to unravel the brain localization, functional, pharmacological and genetic characteristics of the D3 dopamine receptor.

1992- 1998: Miscellaneous.

Gene characterization and knockout of the ß-Adrenergic Receptor Kinase-1. Involvement of the glycine receptor ß subunit in the neurological mutation spastic in mice. Molecular and functional characterization of the vesicular transporter for GABA and Glycine.

1991-       : Study of Na+/Cl--dependent neuronal transporters.

Molecular cloning and pharmacological characterization of the rat and human dopamine transporters. Structure-activity relationships study using chimera’s transporters and site-directed mutagenesis. Molecular cloning of the glycine transporter, the creatine transporter, and two orphan transporters RxT-1 and -2. Knockout of the dopamine transporter in mice. Biochemical, functional and behavioral study of KO mice.

1999-2008: Director of the INSERM U-513 laboratory “Neurobiology  and Psychiatry”
2007-        : Canada Research Chair "Neurobiology of Mental Disorders"
In addition to the above projects which are still ongoing:

Molecular and functional characterization of the first lysosomial amino-acid transporter. Study of the Organic Cation Transporters. Study of glutamate vesicular transporters. Yeast 2-hybrids screening of proteins interacting with 15 different transporters.
Development of animal models to study the role and function of dopamine in drug addiction. Study of the relationships between dopamine, noradrenaline and serotonine in drug addiction. Molecular study of dependence and tolerance mechanisms. Study of the role of memory in drug addiction. Development of animal models to search genes involved in the pathophysiology of psychiatric disorders, with focus on depression and schizophrenia.
Genetic studies of psychiatric disorders., with focus on autistic, schizophrenia and bipolar disorders. Investigation of candidate genes, mainly on genes involved in brain development and neurotransmission.

Professional details
Centre de Neuroscience Paris Sud, Université d'Orsay, Bâtiment 446, 91405 Orsay

From october 2008
Leader of the team "Neurobiologie de la prise de décision", UMR CNRS-Université Paris Sud 8195, Centre de Neuroscience Paris Sud, head: Serge Laroche
1998-2008 : PI in Institut Pasteur, Paris, UMR 2182, head: Jean-Pierre Changeux (until 2007) and Pierre-Marie Lledo
1995-1997 : Post-doctoral fellow in Cambridge university (UK), head: Trevor Robbins

Main diplomas and titles
1995 PhD in Neurosciences, Aix-Marseille I University (supervisor: Bruno Poucet)
2005 Habilitation à diriger des recherches, Paris V University
2008 Elected Professor of Behavioral Neuroscience at the Orsay university

Teaching activities from 2008 (teaching duties are 192h /an)
Master 2 neuroscience: Neurobiology of memory (module supervisor), neurobiology of addiction, genetic of the mouse
Master 1 Neuroscience & Signalling: Behavioral Biology (supervisor), Technics in neuroscience
L3: Neural bases of behaviors
L2: Animal Physiology

Grants and prices
ANR (coordinator 2009-2012), Chaire d’excellence Orsay university (2008-2010), ANR (dec. 2005-dec. 2008), Cancéropôle (coordinator 2006-2007), Association pour la Recherche sur les Nicotianés (2004-2006), Letten F. Saugstad fundation (2002-2005)

Main invited conferences
21st ARN scientific conference, Paris, France
Merck-Serono, Lyon, France
32rd annual meeting of the Japanese Neuroscience Society, Nagoya, Japan
European College of NeuroPharmacology, Istanbul, Turkie

Since 2007,M.G has join "l'institut du Fer à Moulin."His research project : Neuropsychiatric disorders are often caused by perturbations during cortical development. Neurons of upper cortical layers particularly contribute to higher cognitive functions and are thought to arise mainly from intermediate progenitor cells in the cortical subventricular zone (SVZ). Here we propose to study the developmental trajectories from generation to specification of upper cortical layer neurons. As entry point we will explore the T-box transcription factor Tbr2 during cortical development in hypothesis-driven and hypothesis-generating experiments. Tbr2 is specifically and transiently expressed in intermediate progenitor cells during corticogenesis and Tbr2 deficiency in humans causes microcephaly and cognitive deficits.
We have generated a mouse model carrying a conditional, brain specific deletion of Tbr2.  These mice display a decreased pool of intermediate progenitor cells and disturbed generation and differentiation of upper cortical layer neurons. To further dissect underlying molecular and cell biological mechanisms in this animal model we will perform a series of in-vitro experiments. In genetic fate-mapping experiments we will dissect the specific contribution of Tbr2+ progenitors to cortical development. To identify new SVZ specific genes we will explore direct targets of Tbr2 transcriptional activity in a combined of approach using in-vivo chromatin-immunoprecipitation sequencing and expression profiling. Consecutively these genes will be analysed in morphological and functional studies. These experiments aim to advance our knowledge of upper cortical layer generation and specification and are therefore of fundamental importance for understanding complex neurodevelopmental disorders in humans.

Current team members:
3 permanent research scientists (2 in neuroscience, 1 in physics)
2 PhDs, 1 postdoc, ½ engineer

Current funding: Agence Nationale pour la Recherche (ANR)

Referee: Neuron, Frontiers / French Ministry of Research

Fields of expertise/Technical approaches:
>Imaging: skills in wide field optical imaging for sensory mapping in vivo (instrinsic optical imaging, autofluorescence of flavoproteins in mouse and rat) with instrumentation, acquisition & software interfacing. Standard autoradiographic imaging using 2DeoxyGlucose.
>Electrophysiology recording in behaving rodents and signal analysis: local field potentials in the olfactory bulb during behavioral task (go/no-go task in mouse and rat).
>Cellular biology: Immunohistochemistry, Western Blots, qRTPCR

Present Position
08-present: Team Leader, Group for Neural Theory, INSERM U960, DEC, ENS
05- 08: Senior Research Scientist, GNT, Department of Cognitive Studies, Ecole Normale Superior and College de France, 3 rue d’Ulm, Paris.
04- present: Senior Research Scientist, Departement de Neuroscience, Institut Pasteur, 25 rue Dr. Roux, 75015 Paris, France

Positions Previously Held
02-04: Senior Research Fellow, Gatsby Computational Neuroscience Unit, University College London, London, UK
09/99-09/02: NSF Biological Informatics Fellow,
-Coginition et Recepteurs, Department of Neuroscience, Institut Pasteur, Paris, France
- UNIC, Institut Alfred Fessard, CNRS, France.

Education
Ph.D. Theoretical Neuroscience, March 1999, University of Pittsburgh and Center for Neural Basis of Cognition, Pittsburgh, PA
M.A. Mathematics, May 1996, University of Pittsburgh, Pittsburgh, PA
M.S. Biomathematics, December 1993, North Carolina State University, Raleigh, NC
B.S. Physics/History (cum laude) May 1989, North Carolina State University, Raleigh, NC.

Former graduate of the École Normale Supérieure, Michel Hamon is director of research at INSERM and leader of the team “Pain, stress and neurovegetative correlates” at INSERM U894. He previously set up and directed the INSERM Unit (U288 than U677) of Neuropsychopharmacology from 1985 to 2008. President of the Société des Neurosciences from 1999 to 2001, member of the Bristol-Myers Squibb Scientific Committee in Neurosciences (US) from 1999 to 2003, member of the Scientific Advisory Board of the MILDT (French agency against drugs and addiction) from 1999 to 2005, member of the Scientific Advisory Board of the French Foundation for Medical Research from 2003 to 2007, Michel Hamon is, since 2004, member of the Executive Committee of the European College of Neuropsychopharmacology (ECNP), since 2007, Vice-president of the French Association for Biological Psychiatry, and since 2008, Vice-president of the scientific committee of the Institute for Scientific Studies on Alcohol (IREB). He is moreover, since 2005, associate member of the French National Academy of Medicine. Author of more than 500 papers in peer-reviewed journals and editor of five books, he teaches at universities Pierre & Marie Curie, Paris-Descartes and Paris-Sud 11 and at the ESPCI (Sup. School in Physics and Chemistry, Paris). He won several awards, notably the Paul Ehrlich Prize of the French Society for Medicinal Chemistry in 2002. He is also involved in editorial activities as member of the boards of Clin. Neuropharmacol., Eur. J. Pharmacol., Fundam. Clin. Pharmacol., Encéphale, J. Recept. Signal Transduct., NS Arch. Pharmacol., Neurochem. Int., Neuroscience, Synapse and World J. Biol. Psychiatry.

Physique statistique, systemes dynamiques, simulations numeriques, electrophysiologie in-vitro, morphologie, anatomie

Research director at the CNRS, Philippe Hantraye is since 2001, director of the laboratory “Neurodegenerative diseases: mechanisms, therapeutics and imaging” (CNRS-CEA) and since 2004, director of MIRCen (Molecular Imaging Research Center). Scientific adviser at the department of Life Sciences of CEA, since 2000, he is in charge of imaging thematic at the cluster MEDICEN Paris Region since 2006, member of the steering committee of the foundation for scientific cooperation Alzheimer for biomedical imaging since 2007, he represents the CEA in the steering committee of the Thematic Institute of Neuroscience since 2008. Awarded with the grant of the France-Parkinson association in 1987, he has been recipient of the Hoffman-La Roche Prize on anxiety in 1989. He is moreover member of the French association for Neuroscience since 1989 and, since 1991, of the European Neuroscience Association and the Society for Neuroscience (USA).

HIRSCH Etienne, Charles, Henri    
 Research Director (DRCE1) at CNRS,
1987    PhD in Neurobiology, University of Paris VI
1994    Habilitation à diriger les recherches, University of Paris VI
•    From Oct. 2009 Associate director of CRICM INSERM 975-UPMC CNRS UMR7225 (400 people)
•    From March 2010, Councilor for Neuroscience at the department of strategy of the French ministry of research

Awards :
Tourette Syndrome Association Award, USA, July 1986
Young researcher Award, European Society for Neurochemistry, July 1990
Prix de l’Académie de Sciences « Prix de la Fondation pour la recherche biomédicale, Prix François Lhermitte »,1999
Member of EDAB as an individual, 2006
Chevalier de l’ordre des palmes académiques (highest honoray university order in France), 2009

Editorial boards :
Neuroscience Associate editor
Journal of Neural transmission (Parkinson’s disease and related disorders section editor),
Journal of Neurochemistry (Handling editor and advisory board reviews),
Dementia and geriatric cognitive disorders,
Synapse,

Member of societies and boards :
INSERM section study for Neuroscience 2003-2008 President;
French Society for Neuroscience (Vice-President July 2005-2007, President 2007-2009);
SAB of INSERM 2008-2012
IEC of the Movement disorders Society, USA 2011-;

• CURRENT POSITION
Research Director at INSERM
Team Leader
Lab Physiopathologie des Maladies Psychiatriques, Centre de Psychiatrie Neurosciences,
INSERM U894 / Univ Paris Descartes, 2ter rue d'Alésia, 75014 Paris, France
Tel : 33 (0)1 40 78 86 31
Email : therese.jay[at]inserm.fr
Web : http://cpn.paris5.inserm.fr/site_cpn/equipes2.php?id_equipe=7

• ACADEMIC DEGREES AND AWARDS
Qualification for Supervising Research (1998) Univ Paris 11
PhD (1983) Dept Exp Neurophysiol, Univ C Bernard, Lyon1, France
Award 2000 : Visiting Scientist National Institute of Bioscience and Human-Technology, Tsukuba, Japan
Award 1987 : Visiting Scientist, National Institute of Health, Bethesda, USA

• RESEARCH GRANTS (PRIVATE AND PUBLIC LAST 5 YEARS)
- French National Agency for research (ANR) "Cannabinoids and neuronal remodeling in the adolescent brain; Association between structural abnormalities, chronic cannabinoid exposure and psychotic transition" PI : TM Jay (2010-12)
- ANR "Long-term consequences of peripubertal cannabinoid exposure: behavioural and transcriptional analyses in a rat model and in human" PI: TM Jay (2007-10).
- Servier Research Center. IMI (Innovative Medicine Initiative) program PI: TM Jay (2005-12).
- French Ministry of Research. Studies on heat shock proteins and inflammatory reactions following exposure to electromagnetic waves. PI: T Jay (2004 to 2007).
- French Ministry of Research. Integrative and Computational Neurosciences. "Dopaminergic modulation of intrinsic and extrinsic circuits of the prefrontal cortex: functional implication". PI: T Jay (2002 to 2006).

• 'AD HOC' REVIEWER FOR SCIENTIFIC JOURNALS AND GRANTS
Articles: Science, Biol Psychiatry, Cereb Cortex, Eur J Neurosci, Hippocampus, J Neurosci, NLM, Neuropsychopharmacol, Neuroscience …
'Grants': Swiss National Foundation,The Welcome Trust (England), National Science Foundation (USA), Grants from the Canadian government.

• EDITORIAL BOARD : Frontiers in Behavioral Neuroscience

• CONSULTING ACTIVITIES AND SELECTED COMMITTEES
2007: Coordinator of the evaluation of Health Sciences-Neurosciences panel in Lisbon (Portugal)
From 2006: French representative at the Eur Cooperation in the field of Scientific and Technical Research (COST) Action B30 : Neural Regeneration and Plasticity (NEREPLAS)
Executive Committee of Centre of Psychiatry and Neuroscience (from 2008)

• PROFESSIONAL SOCIETIES
Society for Neuroscience (SFN)
The Federation of European Neuroscience Societies (FENS)
International Brain Organization (IBRO)
European College of Neuropsychopharmacology (ECNP)
Collegium Internationale Neuro-Psychopharmacologicum (CINP)

KABASHI Edor Principal Investigator PhD, BSc (Honours) McGill University

CURRENT POSITIONS
2011 Principal Investigator, Institute of Brain and Spinal Cord (ICM), CHU Pitié-Salpêtrière, Paris, FRANCE
2011 Associate Professor, Department of Pathology and Cellular Biology, University of Montreal, Montreal, CANADA

PREVIOUS POSITIONS
2006 –2009 Post-doctoral Fellowship, Centre of Excellence in Neuromics and University of Montreal, Montreal, CANADA
2001–2006 PhD studentship, Montreal Neurological Institute and McGill University, Montreal, CANADA
2009 –2011 Research Associate, Department of Pathology and Cellular Biology, University of Montreal, Montreal, CANADA

AWARDS / DISTINCTIONS
2011 – 2014Equipe ATIP/AVENIR, INSERM/CNRS, Paris, France
2011 –2014 Contrat Jeune Chercheur de Durée Determinée, INSERM, Paris, France
2011 – 2014 Career Integration Grant, Marie Curie Action, European Research Council
2009 – 2012 Development Grant, Muscular Dystrophy Association, Tucson, AZ, USA
2009 – 2011 Herbert Jasper Fellowship, GRSNC/University of Montreal.
2006 –2009 Tim Noel Fellowship, CIHR/ALS Canada Partnership,
2008 Grand Prix d’Excellence, Jornees Genetiques, RGMA, Quebec City,
2007 Bernice Ramsay Travel Award, ALS Canada,
2004 – 2006 Doctoral Studentship, CIHR/ALS Canada Partnership
2004 – 2005 Studentship Research Award, Faculty of Medicine, McGill University
2001 Bachelor Degree with Distinction, McGill University, Major in Biology
1999 Dean List, McGill University
1999 Award of Exellence, Ministry Immigration Canada.
1998 Mention bien, Universite de Sorbonne (Paris V)
1997 – 1998 Dean Miles Honor Society, Mount Saint Mary’s College, USA
1996 – 1998 Academic Achievement Scholarship, Mount Saint Mary’s College, US
1996 Presidential Award, Rogers High School, Newport, USA

The cognitive neuroscience lab conducts researchs to understand the neural bases of Action and related cognitive processes along several dimensions: motor, linguistic, social and intentional. We especially study the brain functional architecture and neuronal computations underlying these processes using modern brain imaging techniques (IRMf, EEG-MEG), experimental psychology techniques and mathematical/ computational modeling.

I obtained my PhD at the University of Rouen (France) in 1989, following a Masters in Biochemistry at the University Pierre and Marie Curie in Paris. I spent three years as a post-doctoral researcher in San Diego (UCSD and the Salk Institute) and moved back to Strasbourg where I worked at the IGBMC for four years.
My current project was initiated in Strasbourg where I was recruited as „Chargé de recherche Inserm" in 1998 and ultimately continued in Paris where I was promoted „Directeur de recherche‟ in 2006.
The diverse influences of these different geographic locations translate to a broad expertise in molecular biology.
I commenced my current medical project on signaling and the therapy of inherited retinal degeneration with José Sahel. It is ironic that within the field of neuroprotection, we try to promote the activity of the very same actors I was trying to inhibit in the field of cancer biology.  Examples include the growth factor GDNF, on which we published one paper in IOVS and two papers in Molecular Vision, and p53 shown to be activated in response to photoreceptor degeneration in a paper published in Molecular Neurosciences.
One novel scientific achievement, the yields of which have occupied most of my time over the last ten years, was based on the observations made by Saddek Mohand-Saïd and José Sahel in a mouse model of retinitis pigmentosa (RP). The transplantation of rod photoreceptors in the eye of this mouse was found to prevent the secondary loss of cones, the more vital class of photoreceptors necessary for vision. In the degenerative disease RP, most patients carry a mutation in a gene (among many) expressed selectively in rods, hence preventing secondary cone loss by means of mimicking the effects of transplantation could be an effective and broadly applicable therapy.
Two studies published respectively in PNAS and IOVS demonstrated that the molecules are proteins secreted by rods, but did not allow for their isolation. Using my broad expertise in molecular biology, I designed a protocol of systematic screening of a retinal library against primary cone cultures from chicken embryos. This strategy of expression cloning was inspired by the emerging concepts from the field of functional genomics. The identification of this novel member of the thioredoxin family, which we published in 2004 in Nature Genetics, resulted in our being honoured alongside José Sahel with the 2005 American foundation FFB award.
We more recently published in BMC molecular Biology, RdCVF2 the paralogue of the first factor.
We moved from Strasbourg to Paris in 2002, with the perspective of creating a new structure, the „Institut de la Vision" designed within the spirit of the idiom “from bench to the bedside”.
We also created the company Fovea-Pharmaceuticals in 2005 to valorise our high content screening expertise for the identification of novel molecules for the treatment of retinal diseases.

LAMBOLEZ Bertrand (08/09/1961)

INSERM Research Director

Education :
1991    PhD “Structure and Function of Glutamate Receptors”            UPMC
2001    Habilitation « Molecular and functional properties of neuronal types”    UPMC
Positions
2008-        Leader of team “Cortical Network and Neurovascular Coupling” UMR 7102
2005        Research Director INSERM (DR2)
2004-2008    Leader of team “Neuromodulation and dynamics of second messengers” UMR 7102
2000-2004    Leader of team “Cortical interneurons”, UMR 7637, ESPCI
1996        Associate scientist INSERM (CR1)
1995-2000    Associate scientist, UMR CNRS 7637, ESPCI
1992-1995    Associate scientist, CNRS UPR 2212, Gif/Yvette
1992        Associate scientist INSERM (CR2)

Commitments and awards :
•    International Society for Neurochemistry Young Scientist Award 1999
•    Member of ISN Conference Committee, 2001-2007
•    Associate Editor at J Neuroscience Research
•    Coordinator of the ENP “Network for Viral Transfer” (Ecole Neurosciences Paris)
•    Board of CNRS section 25, 2008-2012

Publications :
43 original articles, 3 review articles, 11 book chapters, 1 patent. h-index 24, number citations 2486, average citations 43.61 (ISI)

Director of research at CNRS (DR1)
Director of the Centre de Neurosciences Paris-Sud UMR 8195
Director of the GDR 2905 NeuroMem, Neuroscience of memory
CNRS Silver Medal, 1995.
Member Faculty of 1000.

1994-1998: Director of the Laboratory of the Neurobiology of Learning and Memory, CNRS URA 1491.
1998-2009: Director of the Laboratory of the neurobiology of Learning, memory and Communication, CNRS UMR 8620.
Editorial committee of Hippocampus, Neuroscience Research Comm, Gene Brain & Behaviour.
Associate Editor: Frontiers in Behavioral Neurosciences

Fields of expertise :
- Cellular and molecular mechanisms of synaptic plasticity and memory.
- Dysfunctional cellular and molecular mechanisms responsible for memory impairments in animals models of different types of brain pathologies.
- Neuronal signalling, transcriptional regulation, synaptic plasticity and memory.
- Adult hippocampal neurogenesis and memory

Denis Le Bihan has achieved international recognition for his outstanding contributions to the development of new imaging methods allowing, in particular to study human brain function. His work has combined extremely innovative methods, developed for Magnetic Resonance Imaging (MRI) with the application of these methods to questions of the utmost scientific and clinical importance. Dr. Le Bihan is especially credited with developing, refining, and introducing into research and clinical practice the concept of diffusion MRI, a new and powerful approach to study normal and diseased brain anatomy and function, as well as brain wiring, from the measurement of molecular motion, in particular water, in biological tissues. This method is today used worldwide both for basic research and clinical applications, especially in acute brain ischemia, white matter diseases and connectivity disorders. Dr. Le Bihan is a full member of the French Academy of Sciences and currently the Founding Director of NeuroSpin, a new Institute aimed at developing and using ultra high field Magnetic Resonance to understand the brain, from mouse to man. Dr. Le Bihan has authored or co-authored over 250 articles, book chapters and review articles in the fields of MRI, imaging, neuroscience and radiology. For his contributions, Dr. Le Bihan was awarded in 2001 the Gold Medal of the International Society for Magnetic Resonance in Medicine. He is also the 2002 recipient of the Lounsbery Award from the National Academy of Sciences (USA) and French Academy of Sciences and a 2003 corecipient (with S. Dehaene) of the prestigious Louis D. Award of the Institut de France. D. Le Bihan is Knight of the French National Order of Merit.

Our group is interested in the genetics and the physiopathology of epilepsy, peripheral neuropathies and motor neuropathies. These pathologies can affect the central as well as the peripheral nervous system and all affect the neuronal excitability and conduction. At the clinical level, electrophysiological studies (electroencephalography or electromyography) are essential to classify these pathologies. We have therefore established close collaborations with neurology but also neurophysiology departments. Our studies focus on the monogenetic forms of these diseases, which constitute useful models for discovering key proteins and pathways that play a role in the development, function or maintenance of the affected neurones and are involved in the physiopathology of the disease. Common pathways regulating ion homeostasis and cell excitability, involving ion channel and neurotransmitter receptors, might be implicated In both epilepsy and motor neuronopathies (ie, amyotrophy lateral sclerosis (ALS))
We will use the same strategy in all of our projects:
1- Identification and phenotyping of families;
2- Localisation and identification of genes using standard genetical approaches (exclusion of known loci and genes, genome wide screens, candidate gene analysis);
3- Analysis of mutational spectrum and phenotype-genotype correlations;
4- Studies of the functional consequences of mutations at cellular, tissue and animal levels.
Our group has extensive experience in linkage analysis, including the use of new genomic approaches such as SNPs microarrays. During the last 3 years, our group has developed molecular and cellular tools to study the functional consequences of the mutations (cell biology, proteomic, RNA interference ...).

Marion Leboyer, Professeur des Universités-Praticien Hospitalier depuis septembre 1998 (Université Paris XII) est responsable du Pôle de Psychiatrie (CHU Créteil) du Groupe Hospitalier Chenevier-Mondor, depuis janvier 2007. Ce pôle représente plus du quart de l’activité de psychiatrie de l’Assistance Publique des Hôpitaux de Paris et des missions hospitalo-universitaires comme les Urgences psychiatriques de l’hôpital Henri Mondor et la psychiatrie de liaison ou encore des missions innovantes comme la création de centres experts pour les troubles bipolaires, la schizophrénie ou l’autisme de haut niveau. Elle est également responsable de l’équipe « Psychiatrie Génétique » au sein de l’Institut Mondor de Recherches Biomédicales (Inserm U841).

Depuis Juillet 2007, elle dirige la Fondation FondaMental, fondation de coopération scientifique, dédiée à la recherche et aux soins en Santé Mentale (issue du RTRS Santé Mentale, labellisé par le ministère de la Recherche).

Lauréate du Prix Inserm de recherche en Santé Publique en 2002, la Fondation pour la Recherche Médicale lui a été décerné le Prix de la recherche en 2007 au cours des Victoires de la Médecine. Elle est par ailleurs Chevalier de la Légion d’Honneur.

Stéphane Lehericy, Professor neuroradiology, Director CENIR, Editorial board Movement Disorders, Reviewer : Brain, Cerebral Cortex. Field of Research : structural, diffusion and functional MRI, motor control and movement disorders, neurodegenerative dementias

Jean Livet is a researcher at INSERM, recipient of the 2007 AVENIR grant. He is a group leader of the team “Development of neuronal circuits” in the department biology of development at the Vision Institute in Paris. After his PhD with Christopher E. Henderson at IBDM (Marseille), he worked as a post-doc with Dr. Jeff W. Lichtman’s (Harvard University) on the generation of “Brainbow” multicolour fluorescent mices for visualizing neural circuits.

Education :
1991 - Ph.D. Neuroscience (Bordeaux University).
1986 -  Ecole Normale Superieure (Cachan, Life Science).

Current Positions :
Head of the Laboratory "Perception and Memory" at the Pasteur Institute
Director of the Unit "Genes, Synapses and Cognition" at the CNRS
Director of Graduate Program "Neuroscience" at the Pasteur Institute

Professional positions held :
Since 2009 - Chairman of the Scientific Council of the FNRS (Belgium).
Since 2009 - Member of the Scientific Council of "Biovision" (French National Academy of Science).
Since 2009 - Vice-president of the Scientific Council at the Institut Pasteur.
Since 2008 - Panel Expert at the European Commission (FP7 and ERA-Net program).
Since 2008 - Visiting Scientist at the Harvard University, Cambridge (Dept. of Mol & Cell Biol)
Since 2007 - Member of the PhD program committee (Ecole Doctorale 3C) at University Paris VI.

Referee : Nature, Science, Nature Neurosci., Neuron, Proc. Natl. Acad. Sci. (USA), TINS, Eur. J. Neurosci., J. Neurophysiol., Cerebral Cortex & Neuroscience.

Since 2007 : Review Editor for Frontiers in Neuroscience.
Since 2008 : Associate Editor for Frontiers in Neurogenesis.
Since 2009 : Associate Editor for Neural Systems & Circuits (BioMed Central).
Editor for Encyclopedia of Neuroscience, Springer Verlag (2009).
Editor for Textbook in Neurosciences, Springer Verlag (2011).

Professor of neurology (Pitié-Salpêtrière Hospital, Pierre and Marie Curie University), Catherine Lubetzki leads an INSERM research team. Her works aim at understanding neuroglial interactions in developmental myelinisation and demyelinating pathologies and opening new prospects on repair capacity. Her clinical studies are focused on the care of multiple sclerosis patients, and she coordinates the clinical research group on multiple sclerosis in Salpêtrière hospital. Catherine Lubetzki is also president of the scientific advisory board of the Association for Multiple Sclerosis Resarch (ARSEP) and involved in different international scientific committees. She is also member of the editorial committee of several journals as Multiple Sclerosis, Neuron /Glia Biology and Brain.

M MAIER :

Current position :
Prof Université Paris Diderot, Team leader at UMR 8194

Prior positions :
2005-2008 Prof, Dir UMR-S 742, UPMC
2001-2007 Prof, team leader UMR-S 483, UPMC
1993-2000 Post-Doc (USA, UK, F)

Expertise : Human and primate motor control, Computational neuroscience.
Specialties : Neurophysiology, Brain imaging.

Michel Mallat

Education
-1987: MD Paris 5 University
- 1984: PhD molecular and cellular Pharmacology (Paris 6 university).

Research Experience
1986-1994 :    assistant professor at  INSERM
since 1989    Direction of a team investigating functions and development of microglia
since 1994-    :Professor (research director) at lNSERM

Board of peer-reviewed scientific journals
Glia (Since 2003))

Fields of expertise
Neuroscience,  functions of microglia in physiology and pathologies

Technics
Neuronal and glial primary cell cultures, Protein biochemistry, Molecular biology, Immunohistology, in situ hybridization, Image analyses

Pascal Mamassian has a degree in engineering (Sup' Télécom, Paris), a masters in Cognitive Sciences (EHESS & Univ. Paris 6) and a PhD in Experimental and Biological Psychology (Univ. of Minnesota, USA). He has worked at the Max-Planck Institute for Biological Cybernetics (Tübingen, Germany) and New York University (USA). He was senior lecturer at the University of Glasgow (UK) before taking a researcher position at the CNRS. In 2004, he received a "chaire d'excellence" from the French Ministry of Research. He is the founding director of the GDR-vision, a CNRS structure that links together all the French laboratories interested in vision science. He is one of the directors of he Vision Sciences Society and leads the vision team in the Laboratoire Psychologie de la Perception. His research interests focus on mid-level vision, the link between the processing of elementary features in the image and the awareness of natural scenes. Current research topics include three-dimensional perception, cross-modal perception, temporal dynamics of bistable perception, and probabilistic (Bayesian) modelling of perception.

Manuel Mameli developed has a strong background in the neurobiology of addiction. He was trained as an in vitro electrophysiologist in the laboratory of Prof. C.F. Valenzuela in the Departement of Neurosciences at the University of New Mexico and in the laboratory of Prof. Christian Lüscher at the University of Geneva. He joined the "Institut du Fer à Moulin" in September 2010 as a recipient of the ENP “Chair of Excellence”.

Since 2007, I am leading the LNAO. Prior to that, I was in the Service Hospitalier Frédéric Joliot, CEA, Orsay, France, as a PhD student (1992-1995), research scientist (1996-1999), group leader (2000-2006). In 2001, I enjoyed a sabbatical year in the Montreal Neurological Institute of McGill University.
I received the engineer degree from Ecole Centrale Paris in 1989, the M.Sc. degree in numerical analysis from Paris VI University in 1989, the PhD degree in signal and image processing from Ecole Nationale Supérieure des Télécommunications of Paris in 1995, and the "Habilitation à diriger des recherches" from Paris XI university in 2005.
A few papers introducing some of my research programs:
•    J. Régis et al. Sulcal root generic model: a hypothesis to overcome the variability of the human cortex folding patterns. Neurol Med Chir, 45:1-17, 2005
•    J.-F. Mangin et al. A framework to study the cortical folding patterns. Neuroimage, 23:S129-S138, 2004
•    J.-F. Mangin et al. Object-based morphometry of the cerebral cortex. IEEE Trans. Med. Imag., 23(8):968-982, 2004
•    J.-F. Mangin et al. Coordinate-based versus structural approaches to brain image analysis. Artificial Intelligence in Medicine, 30:177-197, 2004
•    J.-F. Mangin et al. A framework based on spin glass models for the inference of anatomical connectivity from diffusion-weighted MR data. NMR in Biomedicine, 15:481-492, 2002

Jean Mariani is Professor at Pierre & Marie Curie University, where he teaches neuroscience and aging biology, hospital practitioner at Charles Foix hospital where he leads the "Institut de la longévité" project. He leads the Neurobiology of adaptative processes laboratory (UMR CNRS-UPMC) since its creation in 2001. His works are focuses on the late stages of nervous system development, its aging and certain neurodegenerative pathologies. He was and is in different postions of responsibility at Pierre and Marie Curie University (member of he scientific advisory board of the University and of the UFR Life Sciences) and also at the Departement Life Sciences CNRS and many other fundations as well as the Foundation for Medical Research. Jean Mariani is also since 2002, the director of the Institut de la longévité et du vieillissement, created as an Scientific Interest Group and since 2007 head of the interdisciplinary program "Longévité et Vieillissement" CNRS.

I. SCIENTIFIC FUNCTIONS
Since 2006 :     Director (INSERM DR1) Research Unit INSERM-CEA U.1000 « Neuroimaging & Psychiatry ».
2002 – 06 :     Director of the research team ERM 0205 (methodology unit)
2000 :    Director of research INSERM (DR2)
1992 – 2000:    Researcher INSERM (CR1). Inserm U 334 ; in charge of the research group Brain imaging in Psychiatry at the Service Hospitalier Frtédéric Joliot, Orsay

II. OTHER ADMINISTRATIVE  & SCIENTIFIC FUNCTIONS
2004 -2011     Vice - president, European Psychiatric Association, Neuroimaging section.
2000 - 2011        Member of the MILDT scientific council (mission interministérielle contre la toxicomanie).
2006 – 2008     Member of the scientific committee of the National Research Program alcohol.
2003 - 2005      Member of the INSERM biomedical research comittee
2005 - 2008     Member of the COSSEC (Comité d’orientation stratégique et de suivi des essais cliniques de l’INSERM).
2004 :      Member of the scientific Comitee « action in  psychiatrie » of the Foundation for medical research.
2000 – 2003        Vice-president of the INSERM intercommission 2.
1999 - 2011     Expert activities : Expert for research projects or research teams submitted for evaluation at the : French research ministry, French health ministry, for a north american foundation, for the European Union (PCRD6), for the MRC (UK).

Alain Marty was born in 1949 in Montbéliard (eastern France). After studies at the Ecole Polytechnique he did his thesis work in Paris on biophysical properties of acetylcholine-gated channels in the marine mollusc Aplysia (thesis adviser, Philippe Ascher). He worked as a postdoc in Göttingen in the laboratory of Erwin Neher in 1980-1982, and participated then to the development of the patch-clamp technique. He led an independent group at the Ecole Normale Supérieure in Paris from 1982 to 1994, working on calcium homeostasis in acinar cells of exocrine glands (1982-1990) and then on patch-clamp studies in brain slices (1991-1994). He has kept this theme of research since then, first as head of a team at the Max Planck Institut für biophysikalische Chemie in Göttingen (1994 to 2000), and more recently as head of a CNRS Unit at the Université Paris 5 (2001-present).

Alain Marty’s contributions include the demonstration of a coupling between ion channel permeation and gating in acetylcholine-sensitive channels; a participation in the development of the patch-clamp method (in particular, measurement of cell capacitance; perforated patch recording); the discovery of BK channels in chromaffin cells, and of Ca-dependent Cl channels in acinar exocrine cells; the discovery of DSI and rebound potentiation (two novel forms of synaptic plasticity at central synapses); the demonstration of multivesicular release at central gabaergic synapses; the description of spontaneous calcium transients in axons and synaptic terminals of central gabaergic neurons.

Our research aims to investigate at multiple levels the molecular mechanisms and neuronal circuits
underlying executive function and nicotine re-inforcement in a simple animal model. The system chosen is the mouse that lends itself to a large variety of approaches, from genetic manipulations and molecular pharmacology to brain imaging and behaviour.
The ultimate goal is to develop a molecular neurobiology of cognitive functions using a novel molecular genetic strategy: the stereotaxic injection in defined brain regions of lentiviral vectors to stably express defined genes. The method has already been successfully used to restore executive functions and nicotine re-inforcement in the mouse (Maskos et al., Nature, 2005) following re-expression of functional nicotinic acetylcholine receptors (nAChRs) in the VTA of nAChR KO mice. It will be further exploited to differentially express genes in defined categories of neurons, e.g. dopaminergic vs. GABAergic, but also to inactivate genes using the expression of siRNAs. The lentiviral strategy will also be extended to the rat brain and to the construction of genetically modified mice and rats (GMMs and GMRs) by infection of early embryos with lentiviral vectors.
Indeed, many advanced behavioural tests cannot be applied to the mouse, but have given a wealth of information on rat behaviour. This approach can even be potentially applied to non-human primates.
nAChRs are known to regulate brain functions such as learning and memory, reward processes and addiction, together with anxiety, central processing of pain, selective attention, sleep and wakefulness. Moreover, nAChRs are implicated in a variety of pathologies, like ADHD, Alzheimer, Tourette, possibly autism, and also ageing. The program will aim at the understanding of the role of defined species of nAChR in the neuronal circuits underlying executive function and nicotine addiction in wild-type and genetically modified organisms. It will include the comparative evaluation of the role of the diverse brain areas and centers engaged in these functions in the mouse, including cortical areas like the prefrontal cortex, primary and secundary sensory areas, the nucleus accumbens, the VTA or the amygdala together with a detailed dissection of the neuromodulatory systems and signal transduction processes under nAChR control.
Combined with the latest developments in functional Magnetic Resonance Imaging (fMRI) and novel fibre-optic deep-brain imaging technology, the cellular and anatomical bases of the underlying brain circuits will be further explored. These data will motivate the development and test of theoretical models (such as the global neuronal wokspace) aimed to define the neural processes that underlie generation of cognitive behaviours and their executive control. In particular, a coherent computational network will be built that defines the pathways and processes by which nicotine modifies executive and motivational processes.

BSc Physics, MSc Physiol UCLondon, PhD UBristol (1981).
Postdoc RKSWong UTexas, Colombia NY.
En France : Inst Pasteur (1989-2000), Univ P5, CHU Pitié- Salpetrière (2002-prés). DR1, CNRS.
Unité-équipe INSERM739 Cortex&Epilepsie. CRICM.

Expertise: Synapses, circuits et pathologies.
CA3 dans l'hippocampe. Subiculum du tissu humain.

Reviewing editor: JPhysiol
Expert: Commission Européenne DGXII
Expert: Wellcome Trust, Neuroscience & Mental health comm..

Qualifications PhD in Physiology, University of London 1981. Supervisor Dr Rolf Niedergerke, Department of Biophysics , UCL

Career :
1968 Research Officer, Parke-Davis Research Labs, UK
1969 Research Technician, Department of Pharmacology University College London,. Dr David Colquhoun
Part- time study for first degree
1971 Research Assistant, Department of Biophysics, UCL. Dr Rolf Niedergerke. Part time PhD student.
1976 MRC Research Grant. Department of Pharmacology, St Georges Hospital Medical School, London
1978 Research Fellow, MRC Receptor Mechanisms Research Group, Department of Pharmacology , University College London. Prof David Colquhoun.
1986 Lecturer in Pharmacology, Kings College London.
1988 Group Leader, Division of Neurophysiology, MRC-National Institute for Medical Research, London.
2004 Team Leader Laboratoire Physiologie Cerebrale UMR 8118, Universite Paris Descartes

Editorial Board: Journal of Physiology 1990-1997.

Postgraduate Teaching:
1984-present Coordinator ‘Microelectrode Techniques for Cell Physiology: the Plymouth Workshop” Residential 2 week electrophysiological techniques workshop.
2003-present Similar residential Workshop for ‘Optical techniques in cell physiology’. The Plymouth Microscopy course.
2009,2010 Organiser of the ENP Paris Neuroscience School ‘Optical imaging and electrophysiological methods in Neuroscience’.

Martin OHEIM
Born June 18, 1970, Germany

Education :
1996-98 :   Physics PhD  Institut Max-Planck and Georg-August Universität (Göttingen)  Drs. W Stühmer & E. Neher.
1998-99  :  Post-doc. same lab
1999-2001 :   Post-doc (Alexander-von-Humboldt foundation) Dir J Mertz

Professional Experience :
1999-2001  :  Assistant Professor, ESPCI, Paris.
Since 2002  :  Resaerch Associate, CR1, CNRS, Paris Descartes
Since 2009  :  Director of Research, DR2, CNRS. Paris Descartes

Awards and Honours :
2004  :  Young Investigator Award, Soc Française Lasers Médicaux
2001  :  Young Investigator Award, French Ministry of Science and Technology
1998  :  Otto-Hahn Medal of the Max-Planck Society

Current grants :
2007-2012  :   FP6-STRP-2006-037897 « Autoscreen », Coord.: K. Palme (Freiburg)
2010-2012  :  ERA-NET NEURON “NANOSYN”, with Drs. W Parak and R. Fernandez-Charcon. Coord.: R. Fernandez-Charcon.
2010-2012  :  ANR P3N “nanoFRET²”, with Drs Feltz, Mallet, de Waard,. Coordinator: J-M. Mallet.

Selected Publication and Patents :
35 publications, 3 book chapters and reviews and 3 patents
Ducros, M. et al. 2011 J Neurosci Methods. 2011 198:172-80
van 't Hoff M, et al,  Opt Express. 2008 16:18495-504.
Nadrigny F,et al 2007 Biophys J 93:969-980.
Gaillard S, et al. 2007 Org Lett. 9: 2629−32.
Nadrigny F, et al 2006 Eur Biophys J 35:533-547.

CURRENT POSITION
Senior tenured research position at the CNRS (Directeur de Recherche, DR)

RESEARCH POSITIONS HELD
1999-2006 Junior tenured research position at the CNRS (Chargé de Recherche, CR)
1997-1999 Post-doctoral position, University of Cambridge, UK
1996-1997 Post-doctoral position, University of California San Diego, USA
1996 Ph.D. Thesis, University Paris-Sud, France

EDITORIAL ACTIVITIES
• Member of the editorial board of World Journal of Stem Cells (WJSC)
• Referee for >10 Research Organizations and >20 International Journals
• Jury member in 18 Thesis/HDR committees
• Member in hiring committees: Univ Paris-Sud (2000-03), Muséum (2006-07; 2011-13), Univ Paris VI (2009-12), Univ Toulouse (2011)
• Board of trustees in scientific societies (SFBD and CNSB: 2006-2012)

FIELD OF EXPERTISE
• signalling and retinal stem cell research
• retinal cell fate determination

TECHNICAL APPROACHES
• functional embryology: in vivo lipofection, microinjection, electroporation, transgenesis
• histology: immunohistochemistry, in situ hybridization (small and large scale)
• molecular biology and biochemistry: RT-QPCR, Western blot, co-IP, two-hybrid screen

PUBLICATIONS AND COMMUNICATIONS
• 31 publications in peer reviewed journals
• 3 book chapter
• 15 invitations to International Congress
• 23 invited seminars
• 3 popularization articles
• 5 popularization conferences/debate

Why do we do what we do? We are largely unaware of our own motives. Our team seeks to understand how motivation works, in both the normal and pathological brain. We define motivation as a set of processes that assign values to potential situations so as to drive behavior.

Our research is closely related to the emerging field of neuroeconomics, which is focused on understanding value-based decision-making and on explaining deviations to rationality. We wish to build a comprehensive account of motivational processes, investigating
- not only valuation but also belief attribution (assigning probabilities to potential situations)
- not only choice but also effort allocation (translating expected value into energy expenditure)

More specifically, our aims are to better describe
a) how the brain encodes values and beliefs
b) how values depend on parameters such as reward magnitude, probability, delay and cost
c) how values are affected by social contexts
d) how values are modified through learning
e) how values influence the brain systems (perceptual, cognitive, motor) that underpin behavioral performance

To investigate neural correlates of motivational processes, we combine three approaches:
1) human cognitive neuroscience, which is central as we ultimately wish to understand ourselves, in both healthy states and pathological conditions where motivation is either deficient (apathy) or out of control (impulsivity)
2) primate neurophysiology, which is essential to describe information processing at the single-unit level and to derive causality by observing behavioral consequences of brain manipulations
3) computational modeling, which is mandatory to quantitatively link the different description levels (single-unit recordings, local field potentials, regional hemodynamic response and motor outputs)

Our research projects have two tightly linked goals: (i) to decipher the cellular and molecular mechanisms that underlie the development of the auditory system and the way it processes acoustic signals; the lab is mainly focused on the mechanotransduction (MET) process and the fascinating synaptic properties of the auditory sensory cells as well as the way their auditory afferent neurons operate. A focus on the auditory central system is also developed; and (ii) to identify the genes causative for deafness in humans, early- and late-onset forms, as well as forms including retinal defects (Usher syndrome), to elucidate the corresponding pathogenic pathways as well as to search for therapeutic tools based on the gathered knowledge.

Genes causative for some twenty monogenic deafness forms have been identified in C. Petit’s laboratory. These proteins are key components of the auditory MET machinery, the sensory cell synapse and the auditory nerves. Puzzling out of the molecular physiology and pathophysiology of the peripheral auditory system through multidisciplinary analyses (morphological, biochemical, in vivo and ex vivo electrophysiology and behavior analyses) of mouse models for human deafness is a major focus of the lab. Because these models also allow unraveling new physiological properties of the hearing system, much effort is devoted to this research field.

Status and Education
2001 Authorization in animal research as principal investigator, University Louis Pasteur, France
2000 Promoted Director of research ( DR2) at INSERM, France
1999 Habilitation, Université Louis Pasteur, Strasbourg, France
1997 Permanent Research Position (CR1) at INSERM, France
1990 PhD in Neuroscience, University of Aix-Marseille, France
1984 Master in pharmacology, major in Neurobiology, University of Paris, France
1981-1985 Ecole Normale Supérieure de l'Enseignement Technique, major in Biochemistry

Fields of expertise
- Synaptic transmission
 - Pharmacology of transporters and receptors
 - Information processing in a neural network (retina)
- Retinal degeneration and neuroprotection
- Pharmacotoxicity of the retina
- Cell biology of endocytosis and exocytosis
- Photosensitization of cell membrane.

Technical approaches
- Electrophysiology (Patch-clamp, Multielectrode recording, electroretinogram)
- Histology (Electron microscopy, fluorescence microscopy, immunocytochemistry)
- Cell culture (mixed and purified cells, retinal explant)
- In vivo morphofunctional analysis of the retina (SLO, Endoscopy, optomotor response, ….)

Education

2006-present DR2, Institut Jacques Monod, Paris
2002-2006 CR1, Ecole Normale Supérieure, Paris
2002 HDR, Univ. Paris XI
1996-2001 Visiting Scientist, Columbia University, New York
1993-1996 CR1 CNRS, Institut Curie, Paris
1990-1994 Ph.D., Biology, Univ. Paris XI
1990-1993 Postdoctoral Fellow, Institut Curie, Paris
1987-1990 Postdoctoral Fellow, The Rockefeller University, New York
1981-86 Ph.D., Biology, Univ. of Florence, Italy

Awards

2006 Laureat Ville de Paris
1999 ATIPE-CNRS grant
1994 Graduated cum laude with Ph.D in Biology
1991-1993 EEC Research Fellowship
1990-1991 NATO-CNR Research Fellowship
1988-89 AIRC USA Fellowship
1987-88 WHO Fellowship
1986-87 AIRC Italian Fellowship
1986 Graduated cum laude with Ph.D in Biology

Research Experience

2006-present Principal Investigator, IJM. Molecular control of cerebral cortex development and evolution.
2002-2006 Principal Investigator, ENS, Dr. Wassef's laboratory. Molecular control of cell fate allocation and function in the embryonic and adult telencephalon.
1996-2001 Visiting Scientist, Columbia University, Dr. Jessell’s laboratory. Molecular control of interneurons generation and function during spinal cord development.
1995 Cold Spring Harbor Course on "Developmental Neurobiology" (New York).
1990-1996 Research Fellow, since 1993 CR1 CNRS, Institut Curie, Dr. Calothy's laboratory. Tissue specific and developmental regulation of transcription of the QR1 gene in the developing neural retina.
1987-1990 Postdoctoral Fellow, The Rockefeller University, Dr. Roeder, Advisor. Molecular and functional characterization of the ubiquitous octamer transcription factor OTF-1 and associated proteins.
1986-87 Postdoctoral Fellow, CNR, Dr. Righi, Advisor. Expression and rearrengements of oncogenes in Radiation Leukemia Virus induced murine T cell lymphomas.
1986 EMBO Practical Course "Genetic Engineering- Basic Techniques", (Galway).
1984-86 Graduate Thesis Research, CNR, Center of Cytopharmacology, Univ. of Milan, Dr. Ricciardi Castagnoli and Dr. Righi advisors.
1983 Graduate research in the Laboratory of Radiobiology, Univ. of Florence, Prof. Becciolini advisor.
Scientific Supervising activities

Post-doctoral fellows
2007-present M. Barber, Y. Arai, F. Causeret (INSERM CR2)

Hilke Plassmann is Assistant Professor at INSEAD, where she has been since September 2008. Since 2009 she is an affiliated PI at the Cognitive Neuroscience Laboratory INSERM U960.

Before that, she was a postdoctoral researcher in the Division of Humanities and Social Sciences of the California Institute of Technology and the Department of Economics of Stanford University. She received a Ph.D. from the University of Muenster’s School of Business and Economics in 2005 and a M.Sc. jointly from Muenster University and Montpellier Graduate School of Management in 2001.

Hilke’s primary research areas are decision-making in the intersection of neuroscience, psychology and economics. In recent and current research projects she investigates the influence of cognitive concepts on the consumption experience, satiation for different rewards, and the neural basis of different decision-making related value signals, and ways to alter/self-control/regulate these signals.

Jean-Christophe is principal investigator at INSERM and head of the AVENIR team “Plasticity in cortical networks and epilepsy” at the Institut du Fer à Moulin since 2007. After a PhD at the Pasteur Institute and the University of Zurich (Switzerland), he joined the Cold Spring Harbor Laboratory (New York, USA) as a postdoctoral fellow and was appointed associate investigator at INSERM in 1999. His work focuses on the basic mechanisms of synaptic plasticity in cortical networks and their involvement in epileptogenesis.

Jean Christophe Poncer teaches at the École Normale Supérieure de Cachan (Master in biology) and University Pierre & Marie Curie (Master of integrative biology and physiology) where he organizes a master course entirely devoted to the hippocampal cortex.He is also a member of the board of the ED3C PhD program at University Pierre & marie Curie and coordinator of a network of European PhD programs (European School of Neuroscience).

In 2008, his team received support from the ‘Biomedical and Health Research Program’ of the City of Paris, as well as the ‘Neurological and Psychiatric Diseases’ Program of the National Research Agency.

ALAIN PROCHIANTZ
Present position : Professor at Collège de France

Education/Training
Ecole normale supérieure 1969-1972 Pre-Doc 1969-1971
Faculty of sciences Paris VII, France and MIT Cambridge, USA PhD 1971-1976
Collège de France Post-Doc 1976-1980

Academic carrier
Years
1981-1984 Research Director at CNRS (Group leader INSERM U114, Collège de France)
1985-1986 Sabbatical, NYU School of Medicine, (Pr. Michael Shelanski)
1986-1989 Research Director at CNRS (Group leader INSERM U114, Collège de France)
1984-1987 Professor at Ecole Polytechnique, Paris
1990-2001 Research Director at CNRS, Head of CNRS Unit 8542: Development and Evolution of the Nervous System at Ecole Normale Supérieure
1996- 2004 Director of doctoral studies in Neuropharmacology
1987-1994 Member of the CNRS study section on cell interactions
1991-1994 Member of the Human Frontier Science Program Committee, Brain committee
2001-2004 Chairman of the Parkinson's Disease committee Fondation de France
2001-2005 Member of Italian Telethon scientific committee
2002-2005 Chairman of Department of Biology at Ecole normale supérieure
2002-2005 Research Director at CNRS, Deputy-Head of CNRS Unit 8542: Development and Evolution of the Nervous System at Ecole Normale Supérieure
2006-2009 Head of CNRS Unit 8542: Development and Evolution of the Nervous System at Ecole Normale Supérieure and Collège de France
2007- Professor at Collège de France
2010- Head of CNRS Unit 7233 at Collège de France and ENS
2010- Adjunct Professor. KAIST University, South Korea.

Honors and Awards
Years
2001 Athena award from the Academy of Sciences
2003 Member of the French Academy of Sciences

Editor
1990-1995 Associate Editor J. Neurochemistry
2007-2009 Associate Editor Molecular and Cellular Neuroscience
2005- Member of Faculty of 1000

Laure Rondi-Reig s’intéresse à la mémoire, à la navigation et au vieillissement à travers l’approche de la génétique comportementale chez la souris et à ses applications à l’homme. Chargée de recherche CNRS depuis 2002, elle est aujourd’hui responsable de l’équipe « Navigation Mémoire et Vieillissement » (ENMVI) au sein du laboratoire Neurobiologie des Processus Adaptatifs (CNRS – UPMC). Elle a obtenu en 2007 des subventions de l’ANR et de la FRM pour ses projets intitulés « Early detection of age-related memory disorders: parallel and combined approach in mice and human », et « Early detection of age-related memory disorders using behavioural genetic and molecular approaches ».

Responsable d’une unité d’enseignement dans le Master Biologie Intégrative et Physiologie de l’UPMC, elle est par ailleurs, depuis 2004, membre du comité d'organisation du plateau d'exploration fonctionnelle du centre de Recherche et développement de Charles Foix, membre du comité de phénotypage puis d’animalerie de l'IFR 83 de Biologie Intégrative et depuis 2009 membre nommé de la commission de spécialistes 29 du CNRS.

Elle est aussi referee dans différents journaux parmi lesquels European Journal of Neuroscience, Journal of Neuroscience methods, Hippocampus, Brain Research Review, EMBO report, Learning and Memory.

Current positions
Since 2011    DR2 Inserm, CIRB, CNRS UMR 7241/INSERM U1050, Collège de France
Group leader Team “Neuroglial Interactions in Cerebral Physiopathology”

Research positions held
2007-2011    
CR1, Inserm, Inserm U840, Collège de France
2004-2007    
CR2, CNRS, Inserm U114, U587 and U840, Collège de France
2002-2004    
Postdoc, University of California San Francisco, laboratory R. Nicoll

 Referee/editors
. Member of INSERM Specialized Scientific Committe 1 (2008-2012)
. Member of AERES committee  
Referee for scientific journals (Science, J Neurosci, Neurochem Intl, PLoS One, Vision Neurosci, Eur J Neurosci, Neuron Glia Biology…)
. Review editor of ‘Frontiers in Neuroenergetics’
. Referee for agencies (ANR, LFCE, ISF…)

Fields of expertise
Neuroglial interactions
 Synaptic transmission, plasticity and network activity
Brain disorders

Technical approaches
Electrophysiology, Calcium imaging, Molecular Biology,
Immunostaining, Immunoblotting     

Awards & prizes
2011-2015 ANR Programme Blanc Neurosciences (PI)  
2011-2012  Barrande Program, Hubert Curien Partnership (PI)
2011 CNRS PEPII project (PI)
2010-2013 Translational research contract, La Pitié Salpêtrière hospital
2010-2014 Scientific Excellence Award, Inserm
2010-2011 FRC grant (PI)
 2006-2010 Career Development Award, Human Frontier Science Program (PI)
2005-2008 ANR Jeune chercheur (PI)
2008 Interdisciplinary program in neurocomputation, CNRS
2002-2004 Postdoc Long-Term Fellowship, Human Frontier Science Program
1998-2001 PhD fellowship, French Ministry of Research

Research director at INSERM and group leader (Molecular genetics of circadian rhythms) at Institut de Neurobiologie Alfred Fessard, Gif-sur-Yvette, Francois Rouyer's fields of expertise are neurogenetics, circadian clock, sleep-wake cycles, photoreception and drosophila. He teaches at Université Paris-Sud, Orsay and École Normale Supérieure, Paris. François Rouyer is a member of the board of the European Society for Biological Rhythms and of the scientific advisory board of the École Doctorale “Genes, genomes, cells” of  Paris-Sud University.

Our team focuses on translational research, that is, the bidirectional transfert of models and techniques between humans and experimental models. We thus aim at establishing and validating experimental models of humans diseases, to apply in vivo examination techniques to the experimental retina, and in return to develop clinical application of experimental therapeutics. Our main interest concern photoreceptor degeneration and vascular diseases. We also developed techniques for in vivo examination ot the rodent retina.

CURRENT POSITION    
DR2 INSERM
Group leader . Group “Brain patterning and Morphogenesis in Vertebrates”, Equipe de recherche labellisée (ERL) INSERM U969, in CNRS UMR7622, Paris 6 University, Paris.

DIPLOMAS
•    PhD in microbiology, Paris VI University, 1989.
•    Habilitation à Diriger les recherches (HDR), Paris XI University, 1999.

RESEARCH EXPERIENCE
•    Since 2004: Group leader in the UMR CNRS 7622, "Biologie du Développement" (Dir. C. Jessus), Université Pierre et Marie Curie.
•    1996-2004: Unité de Biologie Moléculaire du Développement (Dir. P. Charnay), ENS, Paris.
•    1995-1996: Julian Lewis's laboratory, ICRF Developmental Biology Unit, University of Oxford, UK
•    1989-1995: Unité de Biologie Moléculaire du Développement (Dir. P. Charnay), ENS, Paris.
•    1983-1989: Unité des Papillomavirus (Dir. G. Orth), Institut Pasteur, Paris

SCIENTIFIC ANIMATION/ADMINISTRATION ACTIVITIES
•    Member of CNRS Section 26 since 2008
•    Member of AERES committees, 2009-2011
•    Reviewer for several journals in the field of developmental biology and genetics.
•    Expert for AVIESAN
•    Member of Scientific Advisory Boards
•    PhD/HDR reviewer/jury member: about 10 per year
•    Director of the Small Animal Phenotyping Network, UPMC, since 2009

Current : Principal Investigator, CR1 CNRS, AVENIR team “Mice, molecules and Synapse formation”, CIRB-Collège de France, Paris, France
2006-2010: Analyzing the composition of specific synapses in vivo to unravel synapse specificity, CNRS CR1

position : (UMR7102, Paris, France)
2004-2006: Analyzing the composition of specific synapses in vivo to unravel synapse specificity, CNRS CR2 position : (UMR7102, Paris, France); Research associate (Rockefeller Univ. USA).
2001 – 2004: Analyzing the composition of specific synapses in vivo to unravel synapse specificity, Post-doctoral fellow (HFSPO), Lab. of Dr. Nathaniel Heintz, The Rockefeller University, HHMI, New York, USA.
1996-2000:     Study of the mechanisms of cell death in Lurcher mice, PhD thesis (lab. of Dr. Jean Mariani, CNRS-Université Paris VI, France).

Fields of expertise/technical approaches: molecular and cellular neurobiology, mouse transgenesis
Awards : 2010 FENS Boehringer Ingelheim award, 2010 ATIP-AVENIR program

EDUCATION
• 1980 B.Sc. in Biology. Hebrew University, Jerusalem, Israel.
• 1983 M.Sc. in Basic Medical Sciences and Neurobiology. Hadassah Medicine School, Jerusalem, Israel. (with Distinctions).
• 1987 Ph.D. in Neurosciences. University of Paris XI. Laboratoire de Neurobiologie et Neuropharmacologie du Développement. (Très Honorable).
• 2002 Habilitation Diploma for Research Direction. Univ. Paris XI.

PROFESSIONAL POSITIONS
• 1989/93 Scientist (tenured) at the CNRS (Chargé de Recherche).
• 1993/2002 Senior scientist at CNRS (Chargé de Recherche 1st class).
• since January 2000 Head of the "Sensory Processing, Neuromodulation and Plasticity" Lab at UNIC (Gif sur Yvette, France).
• since 2002 Research Director at CNRS

AWARDS AND FELLOWSHIPS
• Hadassah Faculty of Medicine award for outstanding MSc. Thesis (Israel).
• Fellowship of the Foundation Singer-Polignac (France).
• Fellowship of the Foundation Cino del Duca (France).
• Post-doc fellowship of the Foundation pour la Recherche Médicale (France).

TEACHING (selection)
• since 1989 Neurophysiology of the visual system. MSc degree Optometry, Univ. Paris XI.
• since 1989 Member. Master program committee in Optometry (Univ. Paris XI).
• since 1999 "Role of the behavioral context on learning and cortical plasticity" PhD in Cognitive Science (Univ. Paris XI).
• 2001/2007 "Temporal processing, neuromodulation and plasticity in the barrel cortex" Ph D program of Cognitive, Integrative and Molecular Biology (Lyon University).
• since 2004 "Biological Principles of organization of visual and somatosensory systems" MSc degree (ENS Paris).

STUDENT SUPERVISION
7 Master degrees, 8 Ph. D. degrees, 4 Postdoc

COUNCILS AND BOARDS
• 1999-2001 President of the Council of the Institut des Science Cognitives et de la Communication (Univ. Paris XI).
• 2007-2011 Elected member. Administration Council. French Society for Neuroscience. In charge of International relationships with Latin America Neuroscience Societies.
• since 2008 Founder and Member. Administration Council. France-Israel Society for Neurosciences, Neurology and Psychiatry (FINNePS).
• since 2009. Member of the Scientific Advisory panel of BIOTACT (EU Consortium, FP7, Coordinator: T Prescott).

EDITORIAL BOARD/ REFEREE
• since 2009. Review Editor in Frontiers in Integrative Neuroscience.
• from July 2011. Chief-Editor of Journal of Physiology Paris.
• Ad hoc reviewer (selection) : Nature, Nature Neuroscience, Neuron, J. Neuroscience, European J. Neuroscience, J. Neurophysiology, Learning and Memory and others.
• Ad hoc Grant reviewer (selection): National Science Foundation (USA), Medical Research Council (UK), Israeli Science Foundation (Israel), National Institut for Pyschobiology (Israel), Neuropole de Recherche francilien (Paris, France), French Society for Neuroscience.

Michel SIMONNEAU M.D., Ph.D.

1981 : Doctorat d’Etat, Université de Paris VI (Pharmacologie moléculaire)
1978 : Thèse de troisième cycle, Université de Paris VI (Pharmacologie moléculaire
1976 : Doctorat en médecine, Université de Bordeaux II

University position : Professeur des Universités, Première Classe

1993 : Professeur des Universités, Ecole Normale Supérieure, Cachan
1988 : Professeur des Universités, Universités de Bordeaux I
1979 : Chargé de recherche CNRS

Positions
2009- responsable Génomique fonctionnelle/Equipe 1 Unité INSERM U894
Centre Psychiatrie & Neurosciences INSERM
2005- responsable équipe Génomique Fonctionnelle Unité INSERM U675
(Directeur Pr. Philip Gorwood), Faculté Bichat
1996- responsable équipe Neurogénétique, EPI E9935 (Directeur P. Evrard)
1985-1996 : responsable équipe Développement, CNRS UPR Neurobiologie, Gif sur
Yvette (L. Tauc)
1983-1985 : Laboratoire de génétique cellulaire Institut Pasteur (Pr. F. Jacob),
1980-1983 : Laboratoire de Neurobiologie, Stanford Medical School (Pr. J. Nicholls)
1973-1973 : CNRS UPR Neurobiologie Gif sur Yvette (L. Tauc)

SERVICE NATIONAL
1974-1975 : Laboratoire de recherches (CRSSA), Hôpital Desgenettes, Lyon

GRANTS
CNRS [2010-2012], programme « interface physique-chimie-biologie », soutien à la prise de risque. Projet « INaDiaRM » : Imagerie de Nanoparticules de Diamant détectée optiquement. Application à la localisation super-résolue de nanoparticules dans les épines dendritiques de neurones en culture. Coordinateurs : TREUSSART/SIMONNEAU.

- ANR [2011-2115] MALZ Coordinateur Jacques EPELBAUM Interneurones somatostatine & Alzheimer [Titulaires : Epelbaum ; Simonneau, Bue]

- ANR [2011-2014] Programme Blanc international France-Taiwan. Projet « NeuroDiam » : Nanoparticules de diamant fluorescentes: une sonde innovante pour étudier l’organisation macromoléculaire et le trafic dans les neurones. Coordinateur : François TREUSSART [Titulaires : Treussart, Simonneau, Chang]

- Fondation Recherche ALZHEIMER [2010-2012] coordinateur M. SIMONNEAU
Nouveaux modèles de souris exprimant les gènes humanisés du GWAS : [Titulaires : M. Simonneau ; Y. Herault, M.C. Birling, IGBMC]

RESPONSABILITES COLLECTIVES
Membre Jury Concours 3ème année ENS Cachan

INTERNATIONAL DISTINCTIONS
International Fogarty NIH fellow (1980-1983)

TITULAIRE PRIME EXCELLENCE SCIENTIFIQUE

André Sobel is co-director of the Fer à Moulin Institute, where he leads the team “Intracellular signal relay and integration”. Member of the Société des Neurosciences, Société Française de Biochimie et Biologie Moléculaire, American Society for Cell Biology and the Society for Neurosciences, he is also president of the Committee for administration of the research, INSERM, and member of the ANR "non-thematic and young investigator" Committee. Since 2005, André Sobel is the regional scientific correspondent of INSERM and, since 2007, member of the committee of École Polytechnique for recruitments in biology. President of the CSCRI at UPMC from 2002 to 2005, he has been member of the Scientific Advisory Board of the Medicine Faculty Pierre and Marie Curie University in 2007. He has moreover been vice-president of the department of biology of the École Polytechnique from 1996 to 2001. Involved in graduate and pre-graduate teaching activities, he has also been professor at the École Polytechnique from 1989 to 2001 and 2002 to 2003.

Researcher at INSERM and group leader of the team “Functions of ventricular cilia during neurogenesis”, Nathalie Spassky has benefited from the Young Investigator Grant of the Human Frontier Science Program for 2007 – 2010 and awarded for the Young researchers competition of the Mairie de Paris for 2009-2012. She is also member of the editorial committee of the French Glial Cell Club.

C. Tallon-Baudry, Senior Researcher, Editorial Boards: J Neuroscience, NeuroImage; Reviewer for Neuron, PNAS, Current Biology, J Neuroscience… Fields of expertise: Visual Cognition, Oscillatory synchrony, MEG-EEG

Education/Training :

1981 : University of Nantes, France B.S/M.Sc. Biology and Geology
1992 : Institute of Embryology, Nogent/Marne, France Ph.D.
Development, Cell & Mol Biology, University Paris VII
1993-1997 : Postdoc & Habilitation (HDR) Developmental
Neurobiology Inserm U711 Hospital Salpetriere, University P.M. Curie, France

Positions and Employment:

1983-1992 : Professor of Biology in High School
1992-1997 : Senior Lecturer in Cell Biology, University Marne la Vallee
1997-2004 : Inserm U711, co-director of team “Origin of Oligodendrocytes”, Assistant Professor in Cell
Biology, Univ Marne la Vallee
2005-present : Research Director (DR2) (equivalent of associate professor) Inserm UMRS 975
2009-present : Inserm UMRS 975, Chief of team “Oligodendrocyte dev & Neurovascular interactions”
2011-present : Associate professor, Department of Neurology, Yale School of Medicine

Professor at Paris Diderot University from 2001 to 2005, Alain Trembleau is currently Professor at UPMC (Pierre and Marie Curie University) where he teaches neuroscience.
He is scientific director of the “Electronic microscopy service” (IFR83). Member of the Institut Universitaire de France, he is in charge of the Master of Neuroscience at Pierre and Marie Curie University and co-director of the “Pasteur Course” entitled ”Development and plasticity of the nervous system”. Alain Trembleau leads the AVENIR & FRM team ”Development and plasticity of neural systems”, within the CNRS UMR 7102 at UPMC. He obtained the “Young Investigator award” from the Société française de neuroendocrinologie in 1994, and he is currently reviewer for many foundations and scientific journals. He was member of the editorial committee of the Journal of Histochem. Cytochem. from 1997 to 2003.
Member of the American Society for Neuroscience, Société française des neurosciences and Histochemical Society, Alain Trembleau has participated in many international symposia and organized several scientific meetings including, in 2006 and 2007, two scientific meetings at the Fondation des Treilles and, in 2009, an international symposium in Paris.

Laurent VENANCE, DR2 INSERM,

Current Position       
Director of Research 2nd Class (DR2) at INSERM

Group leader of  "Dynamic and Pathophysiology of Neuronal Networks”,
Center for Interdisciplinary Research in Biology (CIRB), CNRS/ UMR 7241 - INSERM U1050,
College de France, 11 Place Marcelin Berthelot, 75005 Paris, France


Degree
1996     PhD in Neurosciences, University Pierre et Marie Curie (Paris VI).
2005     HDR in Neurosciences, University Pierre et Marie Curie (Paris VI).


Career   
1996-1998 Post-doctorat in Pr. Peter Seeburg lab (Pr Hannah Monyer team) at the Max-Planck Institut, Heidelberg (Germany).
1998    tenure position Chargé de Recherche CR2 INSERM
2003     promoted Chargé de Recherche CR1 INSERM
2009    promoted Director of Research DR2 INSERM
   
   
Direction appointments
2008-2010 Co-direction (L Venance & JM Deniau) of the INSERM U667 (College de France, Paris)
2011- Group leader of “Dynamic and Pathophysiology of Neuronal Networks” (CIRB, College de France, Paris)
   
   
Technical expertise
-    Electrophysiology (in vitro & in vivo)
-    Single-cell RT-PCR
-    Imaging


Consulting activity
CHDI-Inc (Los Angeles, USA) (2007-2010)
Neuroservice (Aix-en-Provence) (2008-2010)

Committee
Member of the scientific board of France Parkinson

Scientific societies
Society for Neurosciences
International Basal Ganglia Society
Société des Neurosciences françaises
Club des Ganglions de la Base

Philippe Vernier is neurologist, former Medical Resident at Grenoble University Hospital and head of research at CNRS in the “Development, evolution, plasticity of the nervous system” laboratory at Gif-sur-Yvette. Researches in his group concern fundamental aspects of brain development and evolution and aim at a better understanding of how brains of different species develop during embryogenesis, how they are structured and organized as functional systems. Philippe Vernier was in different positions of responsibility at the CNRS or other institutions (board of directors of the Muséum National d’Histoire Naturelle, scientific council of PHASE department, INRA and other foundations). He is currently president of the Neuropôle de Recherche Francilien (NeRF).

Marie VIDAILHET, Professor of Neurology, Salpétrière Hospital, University Pierre Marie Curie Paris, Head of the Movement Disorders section in the Department of Neurology, Salpêtrière Hospital..

Since 2009:  Director of the Research Team: Movement disorders and basal ganglia: Pathophysiology and experimental therapeutics, CRICM UPMC/INSERM UMR_S975 CNRS UMR7225, and ICM (Institut Cerveau Moelle) Salpêtrière,
H Index = 37, In the past 15 years, over 180 papers

Past positions:
Since I986: member of ISERM research unit (U289 then U679) Salpetriere Hospital.
1997-2007: Head of the Department of Neurology, St Antoine Hospital
1994-1997:Clinical Associate professor Neurology, Salpêtrière Hospital, Paris
1990-1991:Visiting Research Fellow, Institute of Neurology, Queen Square, London, UK.
1996:Accreditation to supervise research (HDR), Neuroscience, University Pierre Marie Curie Paris 6

Research grants
2009 : ANR Nucleipark Imagerie 3T et 7T dans la maladie de Parkinson :  PI Principal Investigator)
2007 : ANR Gilles de la Tourette (co-investigator)
Coordination of the French Dystonia Network (INSERM and GIS maladies rares) 2003-2009
Coordination of 3 national programs on deep brain stimulation in dystonia PHRC 1998 and 2002, 2005)
Poste Interface INSERM (renewed in 2009 for 3 years)
Reference Center for Movement Disorders (Dystonia) as part of the Neurogénétique Centre de Référence Maladies Rares

Education

09/1996 Researcher at CNRS

09/1994 PhD in Cellular and Molecular Pharmacology, UPMC

07/1990 Magistère Ecole Normale Supérieure de Lyon Research

01/1998 - now: UMR7102 CNRS UPMC. Integration of neuromodulatory signals controling neuronal excitability with approaches combining new optical methods and electrophysiology in vitro et in vivo.

Since january 2009: team leader «Cellular Integration of Neuromodulatory Processes»at UMR7102 "Neurobiology of Adaptative Processes".

10/1994 - 12/1997 Roger Y. Tsien's laboratory, University of California, San Diego. Cellular integration of the cAMP signal in the dendrites of lobster stomatogastric neurons.

09/1992 - 09/1993 Jean-Pierre Changeux's laboratory, Pasteur Institut, Paris. Electrophysiological characterization of nicotinic receptors in brain slices.

09/1989 - 09/1994: Alain Marty's team, Cellular Neurobiology, ENS, Paris. GABAergic transmission in the cerebellum.

Dr. Sidney Wiener (born in 1955 in Manhattan, USA) is a Research Director and Laboratory Director at the CNRS College de France LPPA. He joined the laboratory of Alain Berthoz in 1989, after a post-doctoral fellowship with Howard Eichenbaum in the Boston (USA) area. He holds a Ph.D. in Neuroscience and Biophysics (1983) and an M.S. in Biophysics (1980) from Michigan State Univ. USA.; B.S. in Chemistry, 1977, from College of William and Mary USA).
His team has active or past collaborations with F Battaglia (Amsterdam) Bruce McNaughton (Lethbridge), Gyuri Buzsaki (Newark, USA), T Ono and H Nishijo (Toyama), J Taube (Dartmouth Coll. USA) as well as numerous collaborations with robotics groups, notably Agnes Guillot and Jean-Arcady Meyer of the ISIR (Univ Paris 6).
He is on the editorial board of the journal Hippocampus, directed a CNRS-National Science Foundation (US) collaborative research program, and led an Incitative Concerted Action research collaborative project funded by the French Ministry of Research.

2011-now : Group Leader in the Brain and Spine institute (ICM)
2005-2010: Assistant specialist in UC Berkeley
2000-2004: PhD in Louis Pasteur University, Strasbourg

Field of expertise : circuit breaking, behavior, optophysiology, locomotion, sensorimotor integration

Technical approaches : optogenetics, behavior, patch clamp, imaging of population activity in vivo, zebrafish

Awards and prizes :
2011 : Emergences de la Mairie de Paris
2011 : International Reintegration Grant
2010 : Chaire of Excellence of Ecole des Neurosciences de Paris (ENP)
2010 : Atip-Avenir Award
2010 : Prix de la foundation FYSSEN
2010 : Prize of the Bettencourt-Schueller foundation
2009 : Society for Neuroscience Chapter Award
2009 : Zebrafish Meeting Best Poster Award
2007-10 : Marie Curie Outgoing International Post-doctorate Fellowship (OIF)
2005 : Prize “Fondation Blancmesnil” for the documentary Terma
2004 : Prize “Défi Jeunes” for the science project Terma
2004 : Prize for the best PhD thesis from the scientific council of the ULP

Recruited as a Chargé de Recherches at 31 year old for studying the 3D morphology of neurons and the stereotactic cartography of the basal ganglia in primates. Promoted Directeur de Recherches at 42 year old, integrate the research unit of Yves Agid to apply the methods of quantitative anatomy of the basal ganglia to the study of human Parkinson’disease. Develops a 3D deformable atlas of the human basal ganglia for the localization of the electrodes of deep brain stimulation in parkinsonian patients.
    Creates with Luc Mallet, Psychiatrist and Chargé de Recherches Inserm, a new team in the Centre de Recherche de l’Institut du Cerveau et de la Moelle Epinière (CRICM) devoted to the study of  the role of the basal ganglia in the processing of emotions in patients with obsessive compulsive disorders and Gilles de la Tourette disease.

Michaël Zugaro has been a Principal Investigator at the CNRS since 2006. He leads the team "Brain Rhythms and Neural Coding of Memory" at the Laboratoire de Physiologie de la Perception et de l'Action (CNRS – Collège de France). Engineer by training, he obtained a PhD in Cognitive Science in 2001 (advisors: Sidney Wiener and Alain Berthoz) at the LPPA (CNRS – Collège de France), then performed post-doctoral research from 2002 to 2005 in the laboratory of György Buzsáki (Rutgers University, Newark, NJ, USA).

In 2007, he was awarded a grant Career Development Award by the International Human Frontiers Science Program Organization (HFSP) to setup a research team. In 2009, together with his PhD student Gabrielle Girardeau, he was awarded a 'Major Advance in Biology' prize by the French Academy of Sciences, for their study on the neural mechanisms of memory consolidation during sleep.

He teaches hippocampal neurophysiology within the CogMaster and Master BIP at the UPMC. He is a referee for several scientific journals, including Neuron, The Journal of Neuroscience, Journal of Neurophysiology, European Journal of Neuroscience, etc.

Daniel Zytnicki is an expert in the electrophysiological study of motoneurons in vivo. He was the first to use the dynamic clamp technique in vivo (Brizzi et al. 2004). He has been collaborating for more than ten years with C. Meunier, a theoretical physicist. They published together a series of interdisciplinary studies where they progressively unravel the mechanisms underlying the functional properties of spinal motoneurons. He recently developped with Marin Manuel a new preparation allowing for the first time ever to make stable in vivo intracellular recordings of spinal motoneurons in mice. He is now studying the mechanisms of motoneuron degeneration in mutant mice exhibiting amyotrophic lateral sclerosis.
D. Zytnicki trained several students (Boris Lamotte d’Incamps, Jean-François Perrier, Marin Manuel) and post-docs (Lena Ting, Caroline Iglesias) who have become recognized experts.
He obtained the Foulon prize of the french Academy of Sciences for his contributions to our understanding of proprioception.

Dr. Nathalie Cartier is director of research at Inserm and is running the cell and gene therapy programs in adrenoleukodystrophy, metachromatic leukodystrophy and Alzheimer disease since 1995 at UMR745. Through her achievements in the field and active participation to many international committees in gene therapy, Dr. Nathalie Cartier has gained a worldwilde recognition in the field. Dr. Nathalie Cartier is member of the board of the European Society of Gene Therapy, The French Society of Cellular and Gene Therapy,  COSSEC (Inserm) and DIM-STEM (Stem cells and cellular medecine).

CAULI Bruno (09/07/1970)

CNRS Associate scientist (CR1)

Education :
2000 PhD "Study of neocortical interneuron diversity by patch-clamp and RT-PCR", UPMC
2009 Habilitation "Roles of GABAergic interneurons in neurovascular coupling", UPMC

Positions :
2008- Leader of team “Cortical Network and Neurovascular Coupling” UMR 7102
2004-2007 Leader of team “Adaptative Physiology of  Neocortical interneurons” UMR 7637
2005 Associate scientist CNRS (CR1)
2002-2004 Associate scientist, CNRS UMR 7637, ESPCI
2001-2002 Associate scientist, CNRS UPR 2216, Gif/Yvette
2001 Associate scientist CNRS (CR2)

Commitments and awards :
• HFSP Young Investigator Award 2007
• CNRS bronze medal 2007
• Review and host Editor for Frontiers in Neuroenergetics and Frontiers in Neural Circuits
• Member of the Petilla Interneuron Nomenclature Group.
• Program Committee, IFR83 Annual Meeting "Oxidative metabolism in Health and Disease".

Publications :
20 original articles, 4 review articles, 3 book chapters, h-index 15, number citations 1374, average citations 45.80 (ISI)

Sophie Denève, normalienne, chargée de recherche CNRS, Senior Research Fellow au Gatsby Computational Neuroscience Unit de l’University College London de 2002 à 2003, est aujourd’hui au département d’études cognitives de l’ENS où elle est co-responsable avec Boris Gutkin du Groupe de neurosciences théoriques, prix d’excellence Marie Curie. La Royal Society (UK) lui a décerné, en 2003, le Prix Dorothy Hodgkins.

Invitée comme conférencière dans de nombreux colloques, elle a organisé plusieurs ateliers parmi lesquels « Neural representation of uncertainty » au Neural Information processing system, Whistler, Canada, en 2003, « Computing with spikes: more than spike-counts - every spike counts? » au Cosyne 2005 à Salt Lake City, et le «UCL/ENS/CdF meeting in theoretical Neuroscience: From biophysics to computation and back » en 2006 et «Temporal processing and processing of time» au Cosyne 2008 (Utah).

Stéphane Haïk, MD, PhD is Research Director at INSERM. As a neurologist and neuroscientist, he has a long-time interest in prion diseases. “Prix de l’Internat/Paris -2000”, he received an “Inserm Avenir” Award in 2005. He is co-directing since 2009 a team that focuses on Alzheimer’s and prion diseases at the Salpêtrière. He is the coordinator of the French National Center of Reference for Unconventional Transmissible Agents. He is a referee for numerous international journals and National agencies.

Denis Hervé, ancien normalien, directeur de recherche Inserm, co-dirige avec Jean-Antoine Girault l’équipe « Neurotransmission et Signalisation» au sein de l’Institut du Fer à Moulin.

Son domaine de recherche est la neuropharmacologie et concerne les bases neuronales de l’apprentissage, de la motivation et de la récompense. Ses recherches en cours visent à mieux comprendre les mécanismes de l’addiction aux drogues et les effets de la L-DOPA chez le Parkinsonien.

Thèse avec Jean-Pol Tassin dans le laboratoire de Jacques Glowinski au Collège de France. Post-doc dans le laboratoire d’Alain Beaudet à l’Institut Neurologique de Montréal. De 1983 à 1999, chercheur dans le laboratoire de Jacques Glowinski. De 2000 à 2008, responsable de l’équipe « Signalisation des signaux dopaminergiques » dans le laboratoire de Jean-Antoine Girault (Inserm U536)

Responsable de l’animalerie de l’Institut du Fer à Moulin. Ancien membre de plusieurs comités d’évaluation de projets en Europe et en France. Membre de la Society for Neurosciences et de la Société des Neurosciences. Enseignant du Master « Biologie cellulaire physiologie pathologie » de l’Université René Descartes de 2005 à 2007. Participation à plusieurs jurys de thèse ou d’HDR.

M.D., PH.D.
Professor In Psychiatry, University Paris Descartes
Praticien Hospitalier, Service Hospitalo Universitaire, Centre Hospitalier Sainte-Anne
Team leader in the Center for Psychiatry and Neurosciences, Sainte-Anne Hospital, Paris : laboratory on ‘Pathophysiology of Psychiatric Diseases’
President of the Clinical Research Committee of l’Hôpital Sainte-Anne (2007- actuel)
Coordinator of CERC (Clinical research Center)

Education
1990 MD, University Paris 6
1991 Qualification in Psychiatry, UP 6, France,
1992 PhD in Cellular and Molecular Neuropharmacology, Neurobiology, College de France, Pr J . Glowinski, UP 6, France
1994 Qualification as Director of Research, UP 5
Selected Honors : Silver Medal Award UP 6 (1990); Lundbeck Young Investigator Award (1994)
Selected Committees, and Study Groups
- Member of Scientific Counsil of Fondation pour la Recherche Médicale (2010-)
- INSERM Scientific Counsil (1999-2003) and committee on Psychiatry and Mental Health (2002-08)
- Expert in Ethical Committee Pitié Salpétrière (mars 1998-2003)
- Scientific counsil of private foundations FRM (2000-02 ; 2010- ); UNAFAM (user’s organisation)
- Executive Committee of IFR 77 (Since 2001-2009); of CPN (2010- ); of URC Cochin Tarnier (unité de recherche clinique)

- Society of Neurosciences, Member of the Board of French ’Association of Biological Psychiatry’, National College National of Universitary Psychiatrists, Collegium Internationale NeuroPsychopharmacologicum (CINP), Association Européenne de psychiatrie (AEP) , International Early Psychosis Association (IEPA, 2007), Schizophrenia International Research Society (SIRS).
- Experts for Grant fundings in French and International programs: Eur Community, Inserm, French Ministry of Health and of Education and Research, Wellcome trust, Israel, Australia, Germany, Swiss; .

- Coordinator of Clinical and Genetic Family Study Network
- Coordinator of a collaborative consortium on psychosis transition

Grants and fundings
2004- 2006 MGEN Inserm: « Détection et intervention chez des sujets à haut-risque de psychose»
2004- 2006 Collection Inserm/ 2004 « Collection clinico-biologique et radiologique dans les troubles psychiatriques»
2005-2007 MiRE/DRESS « Handicap psychique : un déficit d’autonomie, cognitif ou relationnel ? »
2006 Fondation Wyeth for child and adolescent health : Cannabis et adolescence : peut-on prédire les risques ?
2006 ANR Neurosciences : Long term consequence of peripubertal exposure to cannabinoids
2007-2010 : PHRC Influence of cannabis on psychosis onset
2007-2010 : Ile de France: Influence of prenatal exposure to hormonal treatment on psychiatric disease vulnerability
2008-2011 : ANR EPINEP : Epigenetic, Neurite and Psychosis
2008-2009 : Subvention IRIS MEMSTAR : Memory and stress in subject at ultra high risk of psychosis

Editorial activity
- Regular reviewer (approx 30 per year) for the best journals of the domain : Mol Psychiatry, Biol Psychiatry, Neuropsychopharmacology, Schizophrenia Res, Am J Psychiatry, Am J Med Genetics, BMC, Arch Pharmacol
- Editorial Board : Encephale

The scientific core of our research program is to study the exact nature of the processing that the basal ganglia (BG) apply to cortical information with three perspectives: 1) improve our fundamental knowledge of the cerebral mechanisms of information processing; 2) better understand the pathophysiology of human diseases which are related to BG dysfunction; and 3) develop innovative treatments for neuropsychiatric refractory disorders notably by means of the deep brain stimulation (DBS) functional neurosurgery. This research is based on a confrontation between phenomenological and psychopathological studies of disturbances involving the BG and the electrophysiological, neuroimaging and anatomical studies of these structures.
This research program is carried out in patients with Parkinson Disease, Tourette Syndrome, Obsessive Compulsive Disorder, Depression, Cocaine Dependence. Changes in the neuronal activity of BG and related cortical areas provoked by emotional or cognitive processing are examined by using dedicated experiments by means of electrophysiology and neuroimaging techniques. Precise anatomical localization of both electrophysiological and imaging data are performed using a validated 3D deformable atlas, allowing to model the circuits implicated and their interactions in these processes.

J MCINTYRE :

Current position :
DR CNRS, co-team leader at UMR 8194

Prior positions :
2006-2009 CR CNRS, Université Paris Descartes
2000-2005 CR CNRS, Collège de France
1996-2000 Research scientist, joint appointment: Collège de France / Ricerche Fisiologia Umana, Rome

Expertise : Human motor control, Multi-sensory control of movement, Computational Neuroscience
Specialties : Biological systems and robotics, Rehabilitation engineering, Virtual Reality, Microgravity research

Research and Professional Experiences
2001-2002  Research Assistant Professor, Mount Sinai School of Medicine, Department of Molecular, Cellular and Developmental Biology, New York.
2002-2004 Senior scientist (CR1) at INSERM. INSERM UMR-S 546, Paris.
2005-2008 Senior scientist (CR1) at INSERM. INSERM/UPMC UMR-S 546, Co-team leader of the group «Fundamental  Approaches of CNS remyelination»
2009-present Senior scientist (CR1) and team leader “Cellular and Molecular Approaches for Myelin Repair” at INSERM. CRICM, UPMC/INSERM UMR-S 975, CNRS UMR 7225,.

Awards and Honours
- Fellowship of the Myelin Project USA (1992-1995).
- Advance post-doctoral fellowship award, National Multiple Sclerosis Society, USA (1999-2001).
- Fellowship award of the European Leucodystropy Association, ELA (2002).
- Scientific award of the Foundation NRJ-Institute de France, Project coordinated by C Lubetzki/A. Baron (2008).

Scientific councils, Scientific Committees, Expertises
- Scientific Board of the French Glial Club,
- French MS tissue Bank,
- Scientific Advisor for the French MS Foundation (ARSEP)

Summary
Brahim Nait Oumesmar was educated at Pierre and Marie Curie University, where is received a PhD in Neurosciences in 1997. After a post-doc in developmental biology at Mount Sinai Medical School (New York, NY, USA), he was recruited as an Inserm researcher (CR1 Inserm). Brahim Nait Oumesmar has a strong experience in cellular and molecular mechanisms of oligodendrocyte development and myelin repair both in animal models of demyelination and in multiple sclerosis lesions. Since 2005, he is co-directing the team “Cellular and Molecular Approaches for Myelin Repair”, which is part of the Research Center of the Brain and Spine Institute (CRICM, Pitié-Salpêtrière, Hospital, Paris). B. Nait Oumesmar is a coordinator of several research projects, member of the scientific board of the French Glial Club and the scientific committee of the French MS tissue Bank.

Nicole ROPERT
Born February 24, 1950, France

Since 2002  :  Directeur de Recherche, DR2, CNRS, Principal investigator, Team leader
Education

1980 :   PhD Physiologie, Laval Univ, Canada. Dir Dr. M. Steriade.
1980-83  :  Post-doctorat. Dir. Dr K. Krnjevic, McGill Univ., Canada.
Professional experience
1983-85  :  Assistant Professor, Psychiatry Dpt, McGill Univ. Canada.
1985-89  :  CR2, CNRS, INSERM U261, Institut Pasteur, Paris. Dir. : Dr. Henri Korn.
1990-2002  :  CR1, CNRS
Current grants
2012-2014  :  ANR Blanche Neurosciences « OptoGlia » Coordinator : N. Ropert

Selected publications :
42 publications in journals with review committee

Li D, et al. Proc Natl Acad Sci U S A,, 2009 106: 21960-65.
Evrard A, Ropert N. J Neurosci, 2009 29:9930-40.
Li D, et al. J Neurosci 2008 28:7648-7658.
Rateau Y, Ropert N  J Neurophysiol 2008 95:3073-3085.
Masson J, J Neurosci 2006 26:4660-4671.